Introduction. Neonatal sepsis is a systemic infection occurring in infants during the first 4 weeks of life and is a major cause of mortality and morbidities of newborns due to their age-related weak and immature immune systems. In Ethiopia, despite many studies being conducted on neonatal sepsis, the reported findings are inconsistent. The aim of this study is to determine the prevalence of neonatal sepsis to enhance the utility and interpretation of the evidence. Methods. An extensive systematic...
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Background. Chronic HCV infection affects 80 million people globally and may progress to advanced liver disease. The present study aims to investigate the present epidemiology of HCV infection in a southeastern Chinese surgical patient cohort. Methods. Blood samples obtained from 78,484 surgical patients from 18 different city and county hospitals were enrolled. The incidence of serum HCV antibody positivity, HCV RNA load, and HCV genotyping, as well as demographics and relevant clinical history,...
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A series of TiO2, TiO2/Pd, and TiO2/PdO hollow sphere photocatalysts was successfully prepared via a combination of hydrothermal, sol-immobilization, and calcination methods. The structure and optical properties of the as-prepared samples were characterized by X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, Brunauer-Emmett-Telleranalysis, Barrett-Joyner-Halenda measurement, and UV-Vis diffuse reflectance spectroscopy. The photocatalysis efficiencies...
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Background. Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepregnancy overweight/obesity and GDM and at clarifying the relationship between the WISP1 level and clinical cardiometabolic parameters. Methods. A total of 313 participants were screened...
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Hepatic protective effects of Ligularia fischeri (LF) and Aronia melanocarpa (AM) against alcohol were investigated in vitro and in vivo test. LF, AM, and those composed mixing material (LF+AM) were treated in HepG2 cell. Alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly increased in each singleness extract and mixed composite. The protective effect on alcoholic liver damage was investigated by animal models. Serum alcohol level and acetaldehyde level...
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Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives contribute to reduction of cytotoxicity and suppression of drug-induced hepatic steatosis. Uridine is mostly present in blood and cerebrospinal fluid, where it contributes to the maintenance of basic cellular functions affected by UPase enzyme activity, feeding habits, and ATP depletion. Uridine metabolism depends...
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Purpose. To analyze the clinical characteristics and visual prognoses of patients with ocular trauma treated in Shandong Eye Hospital. Methods. The inpatient data of patients with eye injuries hospitalized in our institution from January 2014 to December 2018 were retrospectively reviewed, including demographic information, types of trauma, causes of injury, treatment, and initial and final visual acuities. Results. A total of 1,425 patients (1,622 eyes), aged 39.5 ± 18.5 years, were included. The...
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Oxidative stress reflects an imbalance between oxidants and antioxidants in favor of the oxidants capable of evoking tissue damage. Like hydrogen sulfide (H2S) and nitric oxide (NO), carbon monoxide (CO) is an endogenous gaseous mediator recently implicated in the physiology of the gastrointestinal (GI) tract. CO is produced in mammalian tissues as a byproduct of heme degradation catalyzed by the heme oxygenase (HO) enzymes. Among the three enzymatic isoforms, heme oxygenase-1 (HO-1) is induced under...
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Purpose. To report the occurrence of endophthalmitis and other complications after intravitreal injections (IVIs) in the Arc Sterile setting. Methods. A retrospective study that enrolled all patients who underwent IVIs between November 2017 and March 2019, collecting data about the patient’s gender and age, type of injected drug, diagnosis, other ocular pathologies, physician and possible occurrence of endophthalmitis, or other complications. Results. Ten thousand and eighty-three IVIs were performed...
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Purpose. To seek for a small interfering RNA (siRNA) sequence targeting a cynomolgus monkey inhibitor of nuclear factor kappa B α (IκBα) that can specifically and effectively suppress IκBα gene expression of cynomolgus monkey ciliary muscle (CM) cells and trabecular meshwork (TM) cells in vitro and screen for optimal siRNA transfection concentration. Methods. Three IκBα-specific double-stranded siRNAs were designed and synthesized. They were transfected into primarily cultured cynomolgus monkey CM...
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Patients with sickle cell disease (SCD) suffer from anemia and painful vaso-occlusive crisis (VOC) and sometimes need blood transfusions. Delayed hemolytic transfusion reaction (DHTR) is a rare life-threatening complication observed in SCD and mimics VOC. We describe a female SCD patient undergoing three surgical procedures during which DHTR developed following the first two. Prior to a planned tonsillectomy, she received transfusion and three days after surgery developed severe hemolysis as well...
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In this study, we construct a convergent algorithm for generating an approximate analytic solution for the fractional HIV infection of T cells with Atangana–Baleanu fractional derivatives in the Caputo sense. We compute the solution by utilizing the fractional homotopy analysis transform method (FHATM) and achieved a convergence region of the solution by employing an auxiliary parameter. Moreover, we apply a numerical scheme proposed by Toufik and Atangana for solving this kind of problem and compared...
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VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice
Background. Traumatic brain injury (TBI) refers to temporary or permanent damage to brain function caused by penetrating objects or blunt force trauma. TBI activates inflammasome-mediated pathways and other cell death pathways to remove inactive and damaged cells, however, they are also harmful to the central nervous system. The newly discovered cell death pattern termed pyroptosis has become an area of interest. It mainly relies on caspase-1-mediated pathways, leading to cell death. Methods. Our...
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Introduction. Currently available outcome data for cataract surgery include mostly patients from public health systems. The purpose of this study was to report the visual and refractive outcomes of cataract procedures performed during one year in a private practice center, which may include a different spectrum of patients. Methods. Our center’s database was used to identify all isolated cataract procedures performed during 2017. The electronic records were reviewed to collect the preoperative information,...
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Introduction. Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for infections in patients both inside and outside of the hospital and causes outbreaks. Here, we demonstrate the characteristics and control of a MRSA outbreak related to a carbon dioxide hydrotherapy bathtub. Methods. We conducted an outbreak investigation and performed a molecular typing of the outbreak strains with pulsed-field gel electrophoresis (PFGE). In addition, we reviewed PubMed and the Outbreak Database for...
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Background. Heterotopic ossification (HO) is a common disease happened in soft tissues after injury. The present study utilized the bioinformatics method to analyze the HO samples in a mouse burn/tenotomy-induced HO model to identify the possible key points and treatment targets. Methods. The transcriptome profiles of GSE126118 were obtained from the Gene Expression Omnibus (GEO) database. The study was based on a mouse burn/tenotomy-induced HO model, and 2 tenotomy samples and 3 uninjured contralateral...
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Introduction. Low back pain and disc degeneration could be linked to global spinal geometry. Our study aimed to develop a reliable new mathematical method to assess the local distribution of total lumbar lordosis with a single numeric parameter and compare it with lumbar intervertebral disc degeneration using routine MRI scans. Methods. An online, open access, easy-to-use platform for measurements was developed based on a novel mathematical approach using MRIs of 60 patients. Our Spinalyze Software...
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A graph is called unicyclic if the graph contains exactly one cycle. Unicyclic graphs with the fourth extremal Wiener indices are characterized. It is shown that, among all unicyclic graphs with vertices, and attain the fourth minimum Wiener index, whereas attains the fourth maximum Wiener index.
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Background. Erdheim-Chester disease is a rare histiocytic neoplasm associated with MAPK pathway mutations. Disease manifestation is variable often involving many different organs, mainly bone, retroperitoneum, the heart, and the central nervous system. Histological findings include foamy histiocytes in a fibrous stroma with scattered inflammatory infiltrate. Histiocytes are CD68 positive and S100 negative. Case Report. We report a case of Erdheim-Chester disease associated with small lymphocytic...
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In this paper, the quantitative evaluation of the explosion effect based on the fuzzy comprehensive evaluation method is proposed to describe the qualitative evaluation results. The selected state characteristic parameters are expressed by two kinds of membership functions, fuzzy normal and triangular distribution membership functions, and preliminary evaluation results are obtained. The validity index of the maximum membership principle is used to assess the accuracy of the evaluation results of...
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We report a case of a woman who experienced psychiatric disorders after switching her antiretroviral therapy (c-ART) to dolutegravir (DTG). She is a 59-year-old HIV-1 positive woman with a recent story of cardiovascular disorders treated with beta-blockers, clopidogrel, and rosuvastatin. She underwent a c-ART switch from darunavir/cobicistat and maraviroc to emtricitabine/tenofovir alafenamide fumarate in association with dolutegravir due to drug-drug interactions. One week later, she started to...
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Given the limited fuel capacity of an on-orbit service vehicle (OSV), proper OSV allocation to satellites during each service mission is critical for economic fuel consumption. This allocation problem can be formulated as an optimization problem with many continuous and discrete design variables of wide domains. This problem can be effectively handled through the proposed approach that combines the tabu search with the discrete particle swarm optimization algorithm (DPSO-TS). First of all, Pontryagin’s...
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The fiber optical current transformer (FOCT) with sine wave modulation has been widely used in the DC transmission project, while its fault rate is much higher than that of an electromagnetic current transformer, which seriously threatens the safe operation of power grid. In order to investigate the fault mechanism of FOCT, the output signal model of the FOCT photodetector is established, and its basic methods of modulation and demodulation are analyzed to explore the influencing factors of the signal...
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Psoriasis is a chronic autoimmune disease. Identification of the biomarkers responsible for Traditional Chinese Medicine (TCM) syndromes of psoriasis can help researchers recognize the different aspects of psoriasis and find novel therapeutic targets for the treatment of psoriasis. The current study investigated the levels of circulating Mo-MDSCs and Mo-MDSC-associated immune factors in the peripheral blood of psoriasis patients with different TCM syndromes. We found that the frequency of Mo-MDSCs...
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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte...
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Multispectral image classification has long been the domain of static learning with nonstationary input data assumption. The prevalence of Industrial Revolution 4.0 has led to the emergence to perform real-time analysis (classification) in an online learning scenario. Due to the complexities (spatial, spectral, dynamic data sources, and temporal inconsistencies) in online and time-series multispectral image analysis, there is a high occurrence probability in variations of spectral bands from an input...
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Squalene (SQ), a natural precursor of many steroids, can inhibit tumor progression and decrease serum cholesterol levels. However, it is difficult to discern the effect of highly active molecules in the treatment of diseases because not enough active compounds reach the site of pathology in crowded biosystems. Therefore, it is necessary to design artificial probes that work effectively within crowded systems. In this study, to facilitate cell penetration, the ethylene glycol moiety (used as a probe)...
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Studies have demonstrated the prognosis potential of long noncoding RNAs (lncRNAs) for hepatocellular carcinoma (HCC), but specific lncRNAs for hepatitis B virus- (HBV-) related HCC have rarely been reported. This study was aimed at identifying a lncRNA prognostic signature for HBV-HCC and exploring their underlying functions. The sequencing dataset was collected from The Cancer Genome Atlas database as the training set, while the microarray dataset was obtained from the European Bioinformatics Institute...
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We study scattering theory for parameter models of finitely many relativistic -sphere and -sphere plus Coulomb interactions. We provide the mathematical definitions of the Hamiltonians, solve the resolvent equations, and compute the nonrelativistic limits for both models. We obtain new results related to spectral properties and scattering data.
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The phytoplankton-fish model for catching fish with impulsive feedback control is established in this paper. Firstly, the Poincaré map for the phytoplankton-fish model is defined, and the properties of monotonicity, continuity, differentiability, and fixed point of Poincaré map are analyzed. In particular, the continuous and discontinuous properties of Poincaré map under different conditions are discussed. Secondly, we conduct the analysis of the necessary and sufficient conditions for the existence,...
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It provided a powerful new way for predicting the growth trend of malignant tumor and assisting the treatment of cancer patients. Firstly, a one-dimensional mathematical model for the dynamic proliferation of malignant tumors is established on the premise of related simplification and hypothesis. Secondly, according to the Lie symmetry theory, we deduce the multigroup allowed infinitely small generating elements of partial differential equations and obtain the analytic form of the exact invariant...
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Humans in modern industrial and postindustrial societies face sustained challenges from environmental pollutants, which can trigger tissue damage from xenotoxic stress through different mechanisms. Thus, the identification and characterization of compounds capable of conferring antioxidant effects and protection against these xenotoxins are warranted. Here, we report that the natural extract of Polypodium leucotomos named Fernblock®, known to reduce aging and oxidative stress induced by solar radiations,...
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In the present study, an experimental research was conducted on square steel tube confined steel reinforced concrete column under eccentric load. The major parameters of the specimens included slenderness ratio, eccentricity ratio, and structural steel reinforced ratio. According to the tested results, the eccentricity ratio, from 0 to 0.55, significantly affects the structural bearing capacity. The slenderness ratio, from 3 to 8, and steel reinforced ratio, from 0.3 to 0.41, slightly affect the...
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Background/Aims. NLRP3 inflammasome, an inflammasome which consists of nucleotide-binding oligomerization domain- (Nod-) like receptor3 (NLRP3) scaffold, apoptosis-associated speck-like protein (ASC) containing a CARD adaptor, and pro-caspase-1, is assembled after the cytoplasmic leucine-rich repeats (LRRs) of NLRP3 sense pathogens or danger signals. In recent years, the role of inflammasome in cardiovascular diseases has attracted mounting attention, and the in-depth study of its mechanism is gradually...
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Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate...
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Let , in this paper, by using the method of weight functions and technique of real analysis; it is proved that the equivalent parameter condition for the validity of multiple integral Hilbert-type inequality with homogeneous kernel of order is , and the calculation formula of its optimal constant factor is obtained. The basic theory and method of constructing a Hilbert-type multiple integral inequality with the homogeneous kernel and optimal constant factor are solved.
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Globally, cardiovascular diseases are the leading cause of death in the aging population. While the clinical pathology of the aging heart is thoroughly characterized, underlying molecular mechanisms are still insufficiently clarified. The aim of the present study was to establish an in vitro model system of cardiomyocyte premature senescence, culturing heart muscle cells derived from neonatal C57Bl/6J mice for 21 days. Premature senescence of neonatal cardiac myocytes was induced by prolonged culture...
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Brain aging is one of the major risk factors for the development of several neurodegenerative diseases. Therefore, mitochondrial dysfunction plays an important role in processes of both, brain aging and neurodegeneration. Aged mice including NMRI mice are established model organisms to study physiological and molecular mechanisms of brain aging. However, longitudinal data evaluated in one cohort are rare but are important to understand the aging process of the brain throughout life, especially since...
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