Related ArticlesPattern of allergic sensitization in chronic rhinitis: A 19-year retrospective study. Asian Pac J Allergy Immunol. 2020 Mar 29;: Authors: Tantilipikorn P, Pinkaew B, Talek K, Assanasen P, Triphoon Suwanwech TS, Bunnag C Abstract BACKGROUND: The pattern of allergic sensitization provides data for physicians to take appropriate care of allergic patients. OBJECTIVE: To analyze the long-term pattern of allergen skin prick test (SPT)...
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JFB, Vol. 11, Pages 23: Skin-Compatible Biobased Beauty Masks Prepared by Extrusion Journal of Functional Biomaterials doi: 10.3390/jfb11020023 Authors: Coltelli Panariello Morganti Danti Baroni Lazzeri Fusco Donnarumma In the cosmetic sector, natural and sustainable products with a high compatibility with skin, thus conjugating wellness with a green-oriented consumerism, are required by the market. Poly(hydroxyalkanoate) (PHA)/starch blends represent...
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Abstract Human sperm cryopreservation is a common technique which is used in assisted reproductive technologies. Despite the existence of evidence supporting the production of ROS and DNA fragmentation during sperm cryopreservation, there is little and equivocal information about the cryopreservation effects on methylation of imprinted genes and imprinting control regions. In this study, we have investigated the effects of cryopreservation on DNA methylation in promoter regions...
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Telomere G‐tail length correlates with the presence of breast cancer. Abstract The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant shortening of the median G‐tail length was observed in BC patients compared with cancer‐free individuals and was found in...
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Abstract HER2‐targeting antibodies (trastuzumab, pertuzumab) and a HER2‐directed antibody‐drug conjugate (trastuzumab emtansine: T‐DM1) are used for the treatment of HER2‐overexpressing breast cancer. However, these treatments eventually become ineffective due to acquired resistance and there is an urgent need for alternative therapies. TAS0728 is a small‐molecule, irreversible selective HER2 kinase inhibitor. In the present study, we established new in vivo models of cancer resistance by continuous...
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Abstract Platelet‐rich plasma (PRP) is a promising treatment for androgenetic alopecia (AGA), but is not efficacious in all patients. Dynamic, quantitative trichoscopy can longitudinally follow hair regrowth during and after treatment,1‐4 thus characterizing clinical response to PRP as continued, non‐productive treatment sessions may lead to large patient burden. To appropriately counsel patients on adjuvant PRP treatment success, clinical results must be accurately described. The objective of...
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Abstract The skin adipose tissue participates in energy storage, thermogenesis, endocrine secretion, fibrosis and scarring, and innate immune defense.1 Furthermore, the facial subcutaneous fat is important for skin aging such as elasticity and wrinkle formation.2,3 The subcutaneous layer as well as epidermal‐dermal layer is modified with age through changes in its thickness, preadipocytes’ differentiation, and size of adipocytes.4 It has been established that the age‐dependent changes of fat layer...
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Abstract Triple‐negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non‐coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis...
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Abstract Allergen‐specific immunotherapy (AIT) is an allergen‐specific form of treatment for patients suffering from immunoglobulin E (IgE)‐associated allergy, the most common and important immunologically‐mediated hypersensitivity disease. AIT is based on the administration of the disease‐causing allergen with the goal to induce a protective immunity consisting of allergen‐specific blocking IgG antibodies and alterations of the cellular immune response so that the patient can tolerate allergen...
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ABSTRACT FINDbase (http://www.findbase.org) is a comprehensive data resource recording the prevalence of clinically relevant genomic variants in various populations worldwide, such as pathogenic variants underlying genetic disorders as well as pharmacogenomic biomarkers that can guide drug treatment. Here, we report significant new developments and technological advancements in the database architecture, leading to a completely revamped database structure, querying interface, accompanied with substantial...
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Abstract We coincidently detected an atypical deletion of at least 1.3‐Mb encompassing the NF1 tumor suppressor gene and several adjacent genes at an apparent heterozygous level in blood of a 65 years old female patient. She had multiple subcutaneous tumors which appeared with certain similarity of subcutaneous neurofibromas which however revealed as lipomas by histological examination. Comprehensive and exhaustive clinical and radiological examinations did not detect any neurofibromatosis type...
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Summary Substantial differences in the response of gut microbial composition to metabolic and bariatric surgery have been reported. Therefore, the goal of the present review is to evaluate if methodological differences could be driving this lack of consistency. A search was conducted using PUBMED, Web of Science, Science Direct and COCHRANE using the following inclusion criteria: human studies written in English with a baseline sampling point, using gut microbiota as an outcome and either Roux‐n‐Y...
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Abstract Improvement in managing HPV positive women is urgently needed. Based on a population‐based study which included 2112 women aged 49–69 from Shanxi, China, we aimed to evaluate the clinical performance of multiple triage strategies based on liquid‐based cytology (LBC), p16INK4a, viral load, and partial genotyping, as a single or combined strategy for detecting cervical intraepithelial neoplasia grade 2/3 or higher (CIN2+/CIN3+) in women who tested positive by Hybrid Capture 2 (HC2). Among...
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Abstract The treatment of melanoma has been markedly improved by the introduction of targeted therapies and checkpoint blockade immunotherapy. Unfortunately, resistance to these therapies remains a limitation. Novel anti‐cancer therapeutics targeting the MCL1 anti‐apoptotic protein have shown impressive responses in haematological cancers but are yet to be evaluated in melanoma. To assess the sensitivity of melanoma to new MCL1 inhibitors, we measured the response of 51 melanoma cell lines to the...
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