What's it really like working in a dedicated COVID-19 imaging facility? Radiologist...Read more on AuntMinnieEurope.comRelated Reading: Germany issues advice on use of CT in COVID-19 French expert offers 6 imaging tips to defeat COVID-19 Parma team shares experiences of COVID-19 pandemic Achenbach insists CT has role in COVID-19 cases VIDI joins forces with French public hospitals to deliver imaging
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The U.K. Royal College of Radiologists (RCR) has collaborated with the College...Read more on AuntMinnieEurope.comRelated Reading: RCR offers guidance on adopting AI during COVID-19 RCR issues advice on nonurgent imaging, trainees RCR sees no role for CT in coronavirus diagnosis RCR announces response to coronavirus threat RCR posts clinical, interventional radiology curricula
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The European Society of Radiology (ESR) marked World Health Day 2020 with a...Read more on AuntMinnieEurope.comRelated Reading: ECR 2020 will be online-only, not onsite ESR, ESTI issue joint advice on COVID-19 Parma team shares experiences of COVID-19 pandemic ESR creates YouTube playlist for COVID-19 events ESR to make educational courses available for free
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Quick recognition of the CT manifestations and evaluation of the patient's...Read more on AuntMinnieEurope.comRelated Reading: Germany issues advice on use of CT in COVID-19 French expert offers 6 imaging tips to defeat COVID-19 Radiologist joins Italy's tally of 87 doctors to die of COVID-19 COVID-19 signs on chest CT differ by patient age U.K. COVID-19 imaging database aims to improve care
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Abstract In the phase 3 OPTIMISMM trial, pomalidomide, bortezomib, and dexamethasone (PVd) significantly improved progression‐free survival (PFS) and overall response rate (ORR) versus bortezomib and dexamethasone (Vd) in patients with relapsed or refractory multiple myeloma. All patients were previously treated with lenalidomide (70% refractory to lenalidomide) and had received one to three prior regimens. Here we report the first efficacy and safety analysis of PVd versus Vd in Japanese patients...
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Key Points Transcatheter aortic valve replacement (TAVR) patients given pacemakers operating in mandatory DDD mode had more ventricular pacing, heart failure hospitalization, and mortality compared with AAI‐DDD or VVI modes. AV conduction disturbances are often transient after TAVR. Minimizing ventricular pacing where possible avoids the risk of pacemaker‐induced cardiomyopathy. Pacemaker specialists should be consulted for any TAVR patient with mild rhythm abnormalities given the high incidence...
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Key Points Over 21 years, 26 coronary artery fistulae were treated percutaneously, and 21 (81%) were successful. There is still much to be learned about the physiology of coronary fistulae. Transcatheter methods have improved over the years and permit a high success rate, but some cases still require a surgical approach.
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Abstract There is now increasing evidence demonstrating that obstructive sleep apnea (OSA) contributes to microvascular disorder. However, whether OSA is associated with impaired coronary flow reserve is still unclear. Therefore, we conducted this systematic review and meta‐analysis to summarize current evidence. In a systematic review, PubMed, Embase, the Cochrane Library and Web of Science were searched; five observational studies fulfilled the selection criteria and were included in this study....
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Abstract Procedural learning declines with age and appropriately timed light exposure can improve cognitive performance in older individuals. Because cataract reduces light transmission and is associated with cognitive decline in older adults, we explored whether lens replacement (intraocular blue‐blocking [BB] or UV‐only blocking) in older patients with cataracts enhances the beneficial effects of light on procedural learning. Healthy older participants (n = 16) and older patients with post‐cataract...
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Abstract This study used data from 2,222 mothers and infants participating in a population‐based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the Edinburgh Postnatal Depression Scale at 16–24 weeks of gestation and/or 3 months after delivery were considered perinatally depressed. The main outcome variable was poor infant sleep at 12 months of age, defined as >3 night wakings, nocturnal wakefulness...
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Abstract This study aims to construct a prognosis‐related immune phenotype classifier for predicting clinical prognosis and immune activity in triple‐negative breast cancer (TNBC). A total of 237 patients with TNBC from Sun Yat‐sen University Cancer Center (SYSUCC) and 533 patients with TNBC from public datasets were included in our study. A stromal immune quantified index was generated with a LASSO Cox regression model based on five prognosis‐related immune cells evaluated by CIBERSORT or IHC...
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Abstract While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and...
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Abstract Deficient intake of micronutrients involved in one‐carbon metabolism (e.g., choline, methionine, vitamin B12, and folic acid) leads to hepatocellular carcinoma (HCC) development in rodents, but it is under‐investigated in humans. We investigated the association between one‐carbon metabolism–related micronutrient intake and HCC risk in a prospective cohort of 494,860 participants with 16 years of follow‐up in the NIH‐AARP study. Dietary intakes and supplement use were ascertained at baseline...
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Abstract Anthropometric and lifestyle factors may influence cancer risks through hormonal changes. We investigated cross‐sectional associations between body size and composition, physical activity and sedentary time and serum concentrations of oestradiol (pre‐menopausal women only), testosterone, SHBG (sex hormone binding globulin) and IGF‐1 (insulin‐like growth factor‐1) in 20,758 pre‐menopausal and 71,101 post‐menopausal women in UK Biobank. In pre‐menopausal women, higher BMI (body mass index)...
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Abstract Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association on the basis of prospective cohort studies. Studies were identified by searching PubMed, EMBASE, and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative...
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Abstract Patients diagnosed with keratinocyte cancer experience heightened risk for melanoma, yet patients who go on to develop this malignancy have not been well‐characterized. We followed a population‐based cohort of 2,243 participants with histologically‐confirmed KC identified from dermatology and pathology practices who did not have a history of internal malignancy (1,363 BCC, 880 SCC). A total of 77 participants went on to develop melanoma. Individual‐level data was collected via personal...
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Abstract The first observations of altered metabolism in malignant cells were made nearly 100 years ago and therapeutic strategies targeting cell metabolism have been in clinical use for several decades. In this review, we summarize our current understanding of cell metabolism dysregulation in childhood acute lymphoblastic leukemia (cALL). Reprogramming of cellular bioenergetic processes can be expected in the three distinct stages of cALL: at diagnosis, during standard chemotherapy, and in cases...
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Abstract This report offers novel clinical and diagnostic aspects of the association between germline mutations in HAVCR2 and subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL). The patient presented with panniculitis‐like T‐cell lymphoma involving mesenteric fatty tissue associated with hemophagocytic lymphohistiocytosis (HLH). Five years later, he developed a clonally unrelated SPTCL and underwent hematopoietic stem cell transplantation. Retrospectively, he was found to carry germline mutations...
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Abstract Background Despite improved survival, many pediatric brain tumor survivors receiving radiation therapy (RT) experience late effects. Procedure To study calvarial lesions in this population, we retrospectively reviewed records of patients undergoing neurosurgical evaluation for calvarial bone lesions detected in posttreatment follow‐up imaging at St. Jude Children's Research Hospital. Primary tumor diagnosis, treatment, imaging, surgical intervention, and histopathology from...
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Abstract Purpose To study the efficacy and tolerability of valproic acid (VPA) and radiation, followed by VPA and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high‐grade glioma (HGG). Methods Children 3 to 21 years of age received radiation therapy and VPA at 15 mg/kg/day and dose adjusted to maintain a trough range of 85 to 115 μg/mL. VPA was continued post‐radiation, and bevacizumab was started at 10 mg/kg intravenously biweekly, four...
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Abstract The prevalence of spondyloarthritis (SpA) reported among patients with hidradenitis suppurativa (HS) ranges from 2.3 to 28.2 %, depending on the diagnostic method used.1 A key feature of SpA and one of the European Spondyloarthropathy Study Group (ESSG) diagnostic criteria for this group of diseases is enthesitis; inflammation at insertion of tendons, ligaments, and capsules. However, pain at an entheseal site is non‐specific and does not always indicate inflammation.
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Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory condition of apocrine gland‐bearing skin that is characterised by recurrent painful nodules, abscess and sinus tract formation. Estimates of the prevalence of HS are highly variable, but it is believed to affect around 1% of the population in Europe. Existing treatments for HS include antimicrobial, immunomodulatory and immunosuppressive agents.
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Abstract The continuously growing interest in the study of gender medicine in the last years has led to increased awareness of the differences between men and women in the clinical presentation, pathophysiology, management, and prognosis of a wide variety of diseases, including skin diseases. Gender differences in disease characteristics can be influenced by numerous factors, e.g. the effect of sex hormones, anatomy, physiology, and genetics. Variances in skin structure and physiology between the...
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Abstract It has been reported that obesity may be an aggravating factor for psoriasis. However, its pathological mechanism remains elusive. The adipocyte‐derived hormone leptin primarily controls energy homeostasis by regulating appetite and modulates immunity. Strikingly, serum leptin levels are elevated in obese patients and positively correlate with body mass index. Additionally, leptin levels also correlate with severity of psoriasis, and knocking out leptin suppresses imiquimod‐induced psoriatic...
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Abstract Hidradenitis suppurativa (HS) is a debilitating inflammatory disease that is understudied, underfunded, and notable for mean diagnostic delay of approximately 7 years. We aimed to characterize annual HS‐related publications across medical fields of study caring for HS in order to measure the extent of awareness, education and ongoing research in this area.
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Abstract Toxicodendron dermatitis (TD), or allergic contact dermatitis (ACD) due to poison ivy, oak, and sumac, is the most common cause of ACD in the United States (US). Affecting 10‐15 million people every year, TD causes a pruritic, erythematous rash 24‐48 hours following skin contact with urushiol, the compound found on poison ivy, oak, and sumac plants responsible for producing an allergic response.
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Abstract A 29‐year‐old Chinese male with recurrent alveolar soft part sarcoma of the tongue metastatic to lung presented with fever and rash (Figure 1a). He underwent glossectomy and adjuvant radiotherapy, complicated by recurrence and abscess with sinus tract formation on the right neck. Current therapy included ipilimumab 3mg/kg and nivolumab 1mg/kg (completed 9 cycles; last dose two days before admission), and cabozantinib 40mg daily (held for six weeks due to sinus tract in the neck).
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Summary Background Brodalumab is efficacious for the treatment of moderate‐to‐severe plaque psoriasis through 52 weeks. Objective To evaluate the efficacy and safety of brodalumab through 120 weeks, including following withdrawal and retreatment. Methods At baseline, patients were randomized to brodalumab (n=222) or placebo (n=220). At week 12, patients achieving static physician’s global assessment score of 0 or 1 (sPGA 0/1) with brodalumab were re‐randomized to brodalumab...
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Abstract The causative species of a total of 42 403 dermatophytosis cases that occurred during 1966–2015 were surveyed. The most prevalent clinical type was tinea pedis, followed by tinea unguium, corporis, cruris, manus, faciei and capitis. The prevalence of tinea faciei and capitis has increased since the late 1990s and the late 2000s, respectively. The most prevalent dermatophyte species was Trichophyton rubrum, followed by Trichophyton mentagrophytes (the majority of the isolates were Trichophyton...
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Abstract Various serious adverse events (AE) have been reported to occur at a high rate in patients treated with BRAF plus mitogen‐activated protein kinase kinase (MEK) inhibitor combination therapy, but their subtypes differ among the BRAF/MEK inhibitors. Pyrexia or a spike of fever are well‐known AE of BRAF inhibitors, with or without MEK inhibitors, and have been reported to have a high incidence after dabrafenib/trametinib, but not after encorafenib/binimetinib. In this report, we describe...
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Abstract Rosacea is a chronic facial skin disease involved in neurovascular dysregulation and neurogenic inflammation. Behavioral factors such as stress, anxiety, depression and sleep were identified to be associated with other inflammatory skin diseases. Few studies have reported sleep status in rosacea. Aiming to investigate the relationship between rosacea and sleep, a case–control survey was conducted, enrolling 608 rosacea patients and 608 sex‐ and age‐matched healthy controls. Sleep quality...
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Abstract New indications are being reported for intradermal botulinum toxin type A (BTX‐A) owing to its anti‐inflammatory and antipruritic actions. Its successful use for dyshidrotic hand eczema and lichen simplex has been reported in a few cases, while its utility in dry palmar eczema not associated with hyperhidrosis has not yet been investigated. The aim of this study was the assessment of the additive efficacy and tolerability of BTX‐A in chronic dry palmar eczema. This prospective non‐randomized...
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There are no reliable predictors of baked milk reactivity, including CM-IgE, casein-IgE, or SPT, and improved biomarkers are needed; baked milk OFCs should be considered in all CM allergic patients, but conducted with extreme caution.
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Our study showed TSLP promotes rapid primary Th2 driven airway inflammation, which provides a novel mechanism in development of inflammation in tissue; and more importantly, a potential explanation for efficacy of anti-TSLP therapy in moderate-to-severe asthmatic patients.
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