Antibiotics, Vol. 9, Pages 165: Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase Antibiotics doi: 10.3390/antibiotics9040165 Authors: Hayes Satiaputra Sternicki Paparella Feng Lee Rodriguez Tieu Eijkelkamp Shearwin Pukala Abell Booker Polyak Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target...
Mon Apr 06, 2020 03:00
Antibiotics, Vol. 9, Pages 164: Acquisition of Colistin Resistance Links Cell Membrane Thickness Alteration with a Point Mutation in the lpxD Gene in Acinetobacter baumannii Antibiotics doi: 10.3390/antibiotics9040164 Authors: Saleh Hesham Amin Samir Mohamed Acinetobacter baumannii is one of the most common causes of nosocomial infections in intensive care units. Its ability to acquire diverse mechanisms of resistance limits the therapeutic choices for its treatment. This...
Mon Apr 06, 2020 03:00
Antibiotics, Vol. 9, Pages 163: Dispensing Antibiotics without a Prescription for Acute Cough Associated with Common Cold at Community Pharmacies in Shenyang, Northeastern China: A Cross-Sectional Study Antibiotics doi: 10.3390/antibiotics9040163 Authors: Shi Chang Liu Zhai Hu Li Hayat Kabba Feng Yang Jiang Zhao Hu Fang : The inappropriate use of antibiotics is a major health issue in China. We aimed to assess nonprescription antibiotic...
Mon Apr 06, 2020 03:00
Antibiotics, Vol. 9, Pages 162: Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles Antibiotics doi: 10.3390/antibiotics9040162 Authors: Monica Francesca Blasi Luciana Migliore Daniela Mattei Alice Rotini Maria Cristina Thaller Rosa Alduina Sea turtles have been proposed as health indicators of marine habitats and carriers of antibiotic-resistant bacterial strains, for their longevity and migratory lifestyle. Up to now, a few studies...
Mon Apr 06, 2020 03:00
Antioxidants, Vol. 9, Pages 302: Metabolomic Study to Evaluate the Transformations of Extra-Virgin Olive Oil’s Antioxidant Phytochemicals During In Vitro Gastrointestinal Digestion Antioxidants doi: 10.3390/antiox9040302 Authors: Rocchetti Senizza Giuberti Montesano Trevisan Lucini In this work, different commercial extra-virgin olive oils (EVOO) were subjected to in vitro gastrointestinal digestion and the changes in bioactive compounds were evaluated by ultra-high-pressure...
Mon Apr 06, 2020 03:00
Biology, Vol. 9, Pages 73: Spaghetti to a Tree: A Robust Phylogeny for Terebelliformia (Annelida) Based on Transcriptomes, Molecular and Morphological Data Biology doi: 10.3390/biology9040073 Authors: Josefin Stiller Ekin Tilic Vincent Rousset Fredrik Pleijel Greg W. Rouse Terebelliformia—“spaghetti worms” and their allies—are speciose and ubiquitous marine annelids but our understanding of how their morphological and ecological diversity evolved is hampered by an uncertain...
Mon Apr 06, 2020 03:00
Biomolecules, Vol. 10, Pages 561: Intervention in Neuropsychiatric Disorders by Suppressing Inflammatory and Oxidative Stress Signal and Exploration of In Silico Studies for Potential Lead Compounds from Holigarna caustica (Dennst.) Oken leaves Biomolecules doi: 10.3390/biom10040561 Authors: Md. Adnan Md. Nazim Uddin Chy A.T.M. Mostafa Kamal Kazi Asfak Ahmed Chowdhury Md. Atiar Rahman A. S. M. Ali Reza Md. Moniruzzaman Satyajit Roy Rony Mst. Samima Nasrin Md. Obyedul...
Mon Apr 06, 2020 03:00
Biomolecules, Vol. 10, Pages 560: Grass Carp Reovirus Major Outer Capsid Protein VP4 Interacts with RNA Sensor RIG-I to Suppress Interferon Response Biomolecules doi: 10.3390/biom10040560 Authors: Su Fan Liao Yang Clarke Zhang Su Diseases caused by viruses threaten the production industry and food safety of aquaculture which is a great animal protein source. Grass carp reovirus (GCRV) has caused tremendous loss, and the molecular function of viral proteins during...
Mon Apr 06, 2020 03:00
Biomolecules, Vol. 10, Pages 559: Variation in ω-3 and ω-6 Polyunsaturated Fatty Acids Produced by Different Phytoplankton Taxa at Early and Late Growth Phase Biomolecules doi: 10.3390/biom10040559 Authors: Taipale Peltomaa Salmi Phytoplankton synthesizes essential ω-3 and ω-6 polyunsaturated fatty acids (PUFA) for consumers in the aquatic food webs. Only certain phytoplankton taxa can synthesize eicosapentaenoic (EPA; 20:5ω3) and docosahexaenoic...
Mon Apr 06, 2020 03:00
Biomolecules, Vol. 10, Pages 558: Grape-Leaf Extract Attenuates Alcohol-Induced Liver Injury via Interference with NF-κB Signaling Pathway Biomolecules doi: 10.3390/biom10040558 Authors: Amen Sherif Shawky Abdelrahman Wink Sobeh Grape (Vitis vinifera) leaf extracts (GLEs) are known to be rich in phenolic compounds that exert potent antioxidant effects. Given the vulnerability of the liver to oxidative damage, antioxidants have been proposed as therapeutic agents...
Mon Apr 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 217: Glutamatergic Activation of Neuronostatin Neurons in the Periventricular Nucleus of the Hypothalamus Brain Sciences doi: 10.3390/brainsci10040217 Authors: Serter Kocoglu Gok Yurtseven Cakir Minbay Eyigor Neuronostatin, a newly identified anorexigenic peptide, is present in the central nervous system. We tested the hypothesis that neuronostatin neurons are activated by feeding as a peripheral factor and that the glutamatergic system...
Mon Apr 06, 2020 03:00
Cancers, Vol. 12, Pages 891: Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue Cancers doi: 10.3390/cancers12040891 Authors: Ninna C. S. Voss Thomas Dreyer Mikkel B. Henningsen Pernille Vahl Bent Honoré Ebbe Boedtkjer The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast...
Mon Apr 06, 2020 03:00
Cancers, Vol. 12, Pages 889: Immunotherapy in Metastatic Colorectal Cancer: Could the Latest Developments Hold the Key to Improving Patient Survival? Cancers doi: 10.3390/cancers12040889 Authors: Emmanouil Damilakis Dimitrios Mavroudis Maria Sfakianaki John Souglakos Immunotherapy has considerably increased the number of anticancer agents in many tumor types including metastatic colorectal cancer (mCRC). Anti-PD-1 (programmed death 1) and cytotoxic T-lymphocyte–associated...
Mon Apr 06, 2020 03:00
Cancers, Vol. 12, Pages 890: A Fluorescence-Based Wireless Capsule Endoscopy System for Detecting Colorectal Cancer Cancers doi: 10.3390/cancers12040890 Authors: Mohammad Wajih Alam Seyed Shahim Vedaei Khan A. Wahid Wireless capsule endoscopy (WCE) has been widely used in gastrointestinal (GI) diagnosis that allows the physicians to examine the interior wall of the human GI tract through a pain-free procedure. However, there are still several limitations of the technology, which...
Mon Apr 06, 2020 03:00
Cancers, Vol. 12, Pages 888: Tumor Ulceration, Reduced Infiltration of CD8-Lymphocytes, High Neutrophil-to-CD8-Lymphocyte Ratio and Absence of MC Virus are Negative Prognostic Markers for Patients with Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12040888 Authors: Simon Naseri Torben Steiniche Jeanette Bæhr Georgsen Rune Thomsen Morten Ladekarl Martin Heje Tine Engberg Damsgaard Marie Louise Bønnelykke-Behrndtz (1) Background: Merkel cell carcinoma (MCC) is...
Mon Apr 06, 2020 03:00
Cancers, Vol. 12, Pages 887: Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target Cancers doi: 10.3390/cancers12040887 Authors: Theo Battista Annarita Fiorillo Valerio Chiarini Ilaria Genovese Andrea Ilari Gianni Colotti The development of drug resistance is one of the main causes of failure in anti-cancer treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic agents,...
Mon Apr 06, 2020 03:00
Cancers, Vol. 12, Pages 886: Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer Cancers doi: 10.3390/cancers12040886 Authors: Alfonso Parrilla Marta Barber Blanca Majem Josep Castellví Juan Morote José Luis Sánchez Asunción Pérez-Benavente Miguel F. Segura Antonio Gil-Moreno Anna Santamaria Identifying novel actionable factors that critically contribute to tumorigenesis is essential in ovarian cancer,...
Mon Apr 06, 2020 03:00
Cells, Vol. 9, Pages 896: Lack of Overt Retinal Degeneration in a K42E Dhdds Knock-In Mouse Model of RP59 Cells doi: 10.3390/cells9040896 Authors: Sriganesh Ramachandra Rao Steven J. Fliesler Mai N. Nguyen Pravallika Kotla Steven J. Pittler Dehydrodolichyl diphosphate synthase (DHDDS) is required for protein N-glycosylation in eukaryotic cells. A K42E point mutation in the DHDDS gene causes an autosomal recessive form of retinitis pigmentosa (RP59), which has been classified...
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Cells, Vol. 9, Pages 895: Extracellular Vesicle Biomarkers Reveal Inhibition of Neuroinflammation by Infliximab in Association with Antidepressant Response in Adults with Bipolar Depression Cells doi: 10.3390/cells9040895 Authors: Rodrigo B. Mansur Francheska Delgado-Peraza Mehala Subramaniapillai Yena Lee Michelle Iacobucci Nelson Rodrigues Joshua D. Rosenblat Elisa Brietzke Victoria E. Cosgrove Nicole E. Kramer Trisha Suppes Charles L. Raison Sahil Chawla...
Mon Apr 06, 2020 03:00
Cells, Vol. 9, Pages 894: Matrix Mechanosensation in the Erythroid and Megakaryocytic Lineages Cells doi: 10.3390/cells9040894 Authors: Christina M. Ward Katya Ravid The biomechanical properties of the bone marrow microenvironment emerge from a combination of interactions between various extracellular matrix (ECM) structural proteins and soluble factors. Matrix stiffness directs stem cell fate, and both bone marrow stromal and hematopoietic cells respond to biophysical cues. Within...
Mon Apr 06, 2020 03:00
Cells, Vol. 9, Pages 892: Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy Cells doi: 10.3390/cells9040892 Authors: Alexander Kabakov Anna Yakimova Olga Matchuk Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these self-renewing tumorigenic cell fractions are thought to be responsible for metastasis dissemination and cases of tumor recurrence. In comparison with non-stem cancer cells,...
Mon Apr 06, 2020 03:00
Cells, Vol. 9, Pages 891: Development of Mucosal PNAd+ and MAdCAM-1+ Venules during Disease Course in Ulcerative Colitis Cells doi: 10.3390/cells9040891 Authors: Britt Roosenboom Ellen G. van Lochem Jos Meijer Carolijn Smids Stefan Nierkens Eelco C. Brand Liselot W. van Erp Larissa G.J.M. Kemperman Marcel J.M. Groenen Carmen S. Horjus Talabur Horje Peter J. Wahab PNAd and MAdCAM-1 addressins on venules are of importance in T-cell homing and potential therapeutic...
Mon Apr 06, 2020 03:00
Cells, Vol. 9, Pages 893: Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise Cells doi: 10.3390/cells9040893 Authors: Casper Soendenbroe Cecilie J. L. Bechshøft Mette F. Heisterberg Simon M. Jensen Emma Bomme Peter Schjerling Anders Karlsen Michael Kjaer Jesper L. Andersen Abigail L. Mackey The decline in muscle mass and function with age is partly caused by a loss of muscle fibres through denervation....
Mon Apr 06, 2020 03:00
Cells, Vol. 9, Pages 890: Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum Cells doi: 10.3390/cells9040890 Authors: Mário Šereš Lucia Pavlíková Viera Boháčová Tomáš Kyca Ivana Borovská Boris Lakatoš Albert Breier Zdena Sulová P-glycoprotein (P-gp, ABCB1 member of the ABC (ATP-binding cassette) transporter family) localized in leukemia cell plasma...
Mon Apr 06, 2020 03:00
Children, Vol. 7, Pages 30: Associations between Public Transport Accessibility around Homes and Schools and Walking and Cycling among Adolescents Children doi: 10.3390/children7040030 Authors: Syafiqah Hannah Binte Zulkefli Alison Barr Ankur Singh Alison Carver Suzanne Mavoa Jan Scheurer Hannah Badland Rebecca Bentley Good public transport accessibility is associated with active travel, but this is under-researched among adolescents. We tested associations between...
Mon Apr 06, 2020 03:00
Cosmetics, Vol. 7, Pages 23: Effects of Chewing Training on Orofacial and Cognitive Function in Healthy Individuals: A Systematic Review Cosmetics doi: 10.3390/cosmetics7020023 Authors: Ricardo B. Viana Wellington F. da Silva Claudio A.B. de Lira Background: There is some evidence showing significant correlations between acute chewing gum and orofacial function, and between acute chewing gum and cognitive function; however, as far as we are aware, little is known about the chronic...
Mon Apr 06, 2020 03:00
Diversity, Vol. 12, Pages 144: News from the Sea: A New Genus and Seven New Species in the Pleosporalean Families Roussoellaceae and Thyridariaceae Diversity doi: 10.3390/d12040144 Authors: Anna Poli Elena Bovio Lucrezia Ranieri Giovanna Cristina Varese Valeria Prigione Nineteen fungal strains associated with the seagrass Posidonia oceanica, with the green alga Flabellia petiolata, and the brown alga Padina pavonica were collected in the Mediterranean Sea. These strains were...
Mon Apr 06, 2020 03:00
Diversity, Vol. 12, Pages 145: Assessing the Nature Reserve Management Effort Using an Expert-Based Threat Analysis Approach Diversity doi: 10.3390/d12040145 Authors: Corrado Battisti Giuliano Fanelli Francesca Marini Giovanni Amori Luca Luiselli In this note, we suggest the adoption of expert-based approaches for threat analysis to allow an assessment of the magnitude of efforts of wildlife management actions. Similar to what is proposed for expert-based quantification of...
Mon Apr 06, 2020 03:00
Foods, Vol. 9, Pages 444: Changes in Aroma Profile of Shiitake Mushroom (Lentinus edodes) during Different Stages of Hot Air Drying Foods doi: 10.3390/foods9040444 Authors: Lei Qin Jing-Xuan Gao Jia Xue Dong Chen Song-Yi Lin Xiu-Ping Dong Bei-Wei Zhu To clarify the changes in the aroma characteristics of shiitake mushrooms (Lentinus edodes) during hot-air drying, volatile compounds of L. edodes were analyzed using sensory evaluation, electronic nose, and purge and trap...
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Foods, Vol. 9, Pages 443: Evolution of Volatile and Phenolic Compounds during Bottle Storage of Merlot Wines Vinified Using Pulsed Electric Fields-Treated Grapes Foods doi: 10.3390/foods9040443 Authors: Arcena Leong Hochberg Sack Mueller Sigler Silcock Kebede Oey This study aimed to elucidate changes in volatile, phenolic, and oenological profiles of wines vinified from Pulsed Electric Fields (PEF)-treated and untreated Merlot grapes during bottle storage...
Mon Apr 06, 2020 03:00
Foods, Vol. 9, Pages 442: Antimicrobial Activity and Prevention of Bacterial Biofilm Formation of Silver and Zinc Oxide Nanoparticle-Containing Polyester Surfaces at Various Concentrations for Use Foods doi: 10.3390/foods9040442 Authors: Fabio Fontecha-Umaña Abel Guillermo Ríos-Castillo Carolina Ripolles-Avila José Juan Rodríguez-Jerez Food contact surfaces are primary sources of bacterial contamination in food industry processes. With the objective of preventing bacterial adhesion...
Mon Apr 06, 2020 03:00
Foods, Vol. 9, Pages 441: Application of the Non-Destructive NIR Technique for the Evaluation of Strawberry Fruits Quality Parameters Foods doi: 10.3390/foods9040441 Authors: Manuela Mancini Luca Mazzoni Francesco Gagliardi Francesca Balducci Daniele Duca Giuseppe Toscano Bruno Mezzetti Franco Capocasa The determination of strawberry fruit quality through the traditional destructive lab techniques has some limitations related to the amplitude of the samples, the...
Mon Apr 06, 2020 03:00
Foods, Vol. 9, Pages 440: Bioaccessibility of Antioxidants and Fatty Acids from Fucus Spiralis Foods doi: 10.3390/foods9040440 Authors: João Francisco André Horta Rui Pedrosa Cláudia Afonso Carlos Cardoso Narcisa M. Bandarra Maria M. Gil Fucus spiralis is an edible brown seaweed (SW) found in the Portuguese Coast. It has been reported to have high antioxidant activity, which may elicit a potential use for the food industry. However, little information is available on...
Mon Apr 06, 2020 03:00
Foods, Vol. 9, Pages 439: Livestock-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) in Purulent Subcutaneous Lesions of Farm Rabbits Foods doi: 10.3390/foods9040439 Authors: Vanessa Silva Telma de Sousa Paula Gómez Carolina Sabença Madalena Vieira-Pinto Rosa Capita Carlos Alonso-Calleja Carmen Torres José L. Capelo Gilberto Igrejas Patrícia Poeta Methicillin-resistant Staphylococcus aureus (MRSA) are one of the main pathogens associated with...
Mon Apr 06, 2020 03:00
Foods, Vol. 9, Pages 438: An Investigation on Phenolic and Antioxidant Capacity of Under-utilized Food Legumes Consumed in China Foods doi: 10.3390/foods9040438 Authors: Yaqian Zhang Maninder Meenu Hansong Yu Baojun Xu China is a major producer of various kinds of food legumes. Some of the under-utilized food legumes are consumed by the local society from different areas in China. The antioxidant capacity and phytochemical profile of these under-utilized food legumes haven’t...
Mon Apr 06, 2020 03:00
Fractal Fract, Vol. 4, Pages 11: Fractal, Scale Free Electromagnetic Resonance of a Single Brain Extracted Microtubule Nanowire, a Single Tubulin Protein and a Single Neuron Fractal and Fractional doi: 10.3390/fractalfract4020011 Authors: Komal Saxena Pushpendra Singh Pathik Sahoo Satyajit Sahu Subrata Ghosh Kanad Ray Daisuke Fujita Anirban Bandyopadhyay Biomaterials are primarily insulators. For nearly a century, electromagnetic resonance and antenna–receiver...
Mon Apr 06, 2020 03:00
IJERPH, Vol. 17, Pages 2511: Dementia Literacy in the Greater Bay Area, China: Identifying the At-Risk Population and the Preferred Types of Mass Media for Receiving Dementia Information International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072511 Authors: Angela Y. M. Leung Alex Molassiotis June Zhang Renli Deng Ming Liu Iat Kio Van Cindy Siu U Leong Isaac S. H. Leung Doris Y. P. Leung Xiaoling Lin Alice Y. Loke Background:...
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IJERPH, Vol. 17, Pages 2508: Health-Literate Healthcare Organizations and Quality of Care in Hospitals: A Cross-Sectional Study Conducted in Tuscany International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072508 Authors: Bonaccorsi Romiti Ierardi Innocenti Riccio Frandi Bachini Zanobini Gemmi Lorini The concept of Health-Literate Healthcare Organization (HLHO) concerns the strategies by which healthcare organizations...
Mon Apr 06, 2020 03:00
IJERPH, Vol. 17, Pages 2509: Characteristics Associated with Improved Physical Performance among Community-Dwelling Older Adults in a Community-Based Falls Prevention Program International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072509 Authors: Scronce Zhang Smith Mercer This was a retrospective analysis of quasi-longitudinal data from an ongoing, community-based falls prevention program. The purpose was to identify participant characteristics...
Mon Apr 06, 2020 03:00
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