IJMS, Vol. 21, Pages 1182: Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21041182 Authors: Hosoi Yao Hasegawa Yoshimura Akamatsu AQP5 plays an important role in the salivary gland function. The mRNA and protein for aquaporin 5 (AQP5) are expressed in the acini from embryonic days E13-16 and E17-18, respectively and for entire postnatal days. Ligation-reopening of main excretory duct...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1185: Establishment and Characterization of a Brca1−/−, p53−/− Mouse Mammary Tumor Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21041185 Authors: Hámori Kudlik Szebényi Kucsma Szeder Póti Uher Várady Szüts Tóvári Füredi Szakács Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. By the age of 80, the estimated risk for breast cancer for women...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1184: Beyond PSA: The Role of Prostate Health Index (phi) International Journal of Molecular Sciences doi: 10.3390/ijms21041184 Authors: Ferro De Cobelli Lucarelli Porreca Busetto Cantiello Damiano Autorino Musi Vartolomei Muto Terracciano Background: Widespread use of prostate specific antigen (PSA) in screening procedures allowed early identification of an increasing number of prostate cancers (PCas), mainly including...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1181: Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative International Journal of Molecular Sciences doi: 10.3390/ijms21041181 Authors: Petersen Gandhi Buchardt Alanentalo Fels Johansen Helding-Kvist Vad Thygesen Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life....
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1178: Bone Control of Muscle Function International Journal of Molecular Sciences doi: 10.3390/ijms21041178 Authors: Battafarano Rossi Marampon Minisola Del Fattore Bone and muscle represent a single functional system and are tightly connected to each other. Indeed, diseases characterized by alterations of muscle physiology have effects on bone remodeling and structure and vice versa. Muscle influence on bone has been deeply studied, and recent studies...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1179: Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator International Journal of Molecular Sciences doi: 10.3390/ijms21041179 Authors: Murakami Yoshimura Nakagawa Kume Kondo Inoue Irie Amyloid β42 (Aβ42), a causative agent of Alzheimer’s disease (AD), is derived extracellularly from Aβ precursor protein...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1176: Microbial Degradation of Plastic in Aqueous Solutions Demonstrated by CO2 Evolution and Quantification International Journal of Molecular Sciences doi: 10.3390/ijms21041176 Authors: Rose Richardson Latvanen Hanson Resmini Sanders The environmental accumulation of plastics worldwide is a consequence of the durability of the material. Alternative polymers, marketed as biodegradable, present a potential solution to mitigate their ecological...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1177: DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms21041177 Authors: Popp Kohl Naumann Flach Brendel Kleiner Weiss Seifarth Saussele Hofmann Fabarius DNA damage and alterations in the DNA damage response (DDR) are critical sources of genetic instability that might be involved in BCR-ABL1 kinase-mediated blastic transformation of chronic myeloid...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1180: Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21041180 Authors: Sunzini De Stefano Chimenti Melino The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H2S) were...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1175: Assessment of the Phenolic Profiles, Hypoglycemic Activity, and Molecular Mechanism of Different Highland Barley (Hordeum vulgare L.) Varieties International Journal of Molecular Sciences doi: 10.3390/ijms21041175 Authors: Deng Zheng Li Liu The phenolic profiles, hypoglycemic activity, and molecular mechanism of the effect on type 2 diabetes mellitus (T2DM) of four highland barley varieties were investigated in the present study. The fundamental...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1174: The MICELI (MICrofluidic, ELectrical, Impedance): Prototyping a Point-of-Care Impedance Platelet Aggregometer International Journal of Molecular Sciences doi: 10.3390/ijms21041174 Authors: Roka-Moiia Bozzi Ferrari Mantica Dimasi Rasponi Santoleri Scavone Consolo Cattaneo Slepian Redaelli As key cellular elements of hemostasis, platelets represent a primary target for thrombosis and bleeding management. Currently,...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 504: Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study Journal of Clinical Medicine doi: 10.3390/jcm9020504 Authors: Picca Guerra Calvani Marini Biancolillo Landi Beli Landi Bernabei Bentivoglio Monaco Bucci Marzetti Systemic inflammation and mitochondrial dysfunction are involved in neurodegeneration...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 505: Clinical Impact of Atypical Chest Pain and Diabetes Mellitus in Patients with Acute Myocardial Infarction from Prospective KAMIR-NIH Registry Journal of Clinical Medicine doi: 10.3390/jcm9020505 Authors: Lee Moon Kang Lee Son Youn Ahn Ahn Kim Yoo Lee Kim Jung Park Chae Hur Cho Rha Cha Chae Choi Seong Oh Hwang Yoon Atypical chest pain and diabetic autonomic neuropathy...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 501: Management and Prognosis of Heart Failure in Octogenarians: Final Report from the KorAHF Registry Journal of Clinical Medicine doi: 10.3390/jcm9020501 Authors: Oh Cho Lee Kim Kim Choi Jeon Hwang Chae Baek Kang Yoo Choi Ahn Kim Cho Oh Lee Treatment of heart failure (HF) in the elderly face many difficulties due to lack of robust evidence. We analyzed the outcome of HF in octogenarians using a...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 502: The Complex Balance between Analgesic Efficacy, Change of Dose and Safety Profile Over Time, in Cancer Patients Treated with Opioids: Providing the Clinicians with an Evaluation Tool Journal of Clinical Medicine doi: 10.3390/jcm9020502 Authors: Corli Porcu Santucci Bosetti Background: Scanty data exist on the integration between the analgesic effect of opioids, dose changes, and adverse events in cancer patients. Methods: To provide further information...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 500: The Benefits of emotion Regulation Interventions in Virtual Reality for the Improvement of Wellbeing in Adults and Older Adults: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9020500 Authors: Montana Matamala-Gomez Maisto Mavrodiev Cavalera Diana Mantovani Realdon The impact of emotion regulation interventions on wellbeing has been extensively documented in literature, although only in recent years virtual reality...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 503: Impact of Hyponatremia on COPD Exacerbation Prognosis Journal of Clinical Medicine doi: 10.3390/jcm9020503 Authors: García-Sanz Martínez-Gestoso Calvo-Álvarez Doval-Oubiña Camba-Matos Rábade-Castedo Rodríguez-García González-Barcala The most common electrolyte disorder among hospitalized patients, hyponatremia is a predictor of poor prognosis in various diseases. The aim of this study was to establish the prevalence of hyponatremia...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 497: Salivary Redox Biomarkers in Selected Neurodegenerative Diseases Journal of Clinical Medicine doi: 10.3390/jcm9020497 Authors: Maciejczyk Zalewska Gerreth Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, are disorders, which cause irreversible and progressive deterioration of the central nervous system. The pathophysiology of NDDs is still not fully explained;...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 499: Evaluating the Performance of the WHO International Reference Standard for Osteoporosis Diagnosis in Postmenopausal Women of Varied Polygenic Score and Race Journal of Clinical Medicine doi: 10.3390/jcm9020499 Authors: Wu Xiao Xu Background: Whether the bone mineral density (BMD) T-score performs differently in osteoporosis classification in women of different genetic profiling and race background remains unclear. Methods: The genomic data in the Women’s...
Wed Feb 12, 2020 02:00
JCM, Vol. 9, Pages 491: Pulp-Derived Exosomes in a Fibrin-Based Regenerative Root Filling Material Journal of Clinical Medicine doi: 10.3390/jcm9020491 Authors: Ivica Ghayor Zehnder Valdec Weber Regenerative endodontics has been described as a paradigm shift in dentistry, despite its current limitation to immature teeth and reparative rather than regenerative outcomes. Cell-free treatments are favored because of regulatory issues. However, the recruitment of host-derived...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 493: Lidocaine vs. Other Local Anesthetics in the Development of Transient Neurologic Symptoms (TNS) Following Spinal Anesthesia: A Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9020493 Authors: Koo Shin Han Ryu The use of lidocaine in spinal anesthesia may increase the risk of transient neurological symptoms (TNS) according to previous meta-analyses. However, the previous meta-analyses lacked data on some other...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 494: A New Site Preparation Protocol That Supports Bone Quality Evaluation and Provides Predictable Implant Insertion Torque Journal of Clinical Medicine doi: 10.3390/jcm9020494 Authors: Velikov Susin Heuberger Irastorza-Landa When preparing an implant site, clinicians often base their assessment of the bone on subjective tactile and visual cues. This assessment is used to plan the surgical procedure for site preparation, including how many drilling steps...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 496: Recurrence Patterns after Surgery in Patients with Different Endometriosis Subtypes: A Long-Term Hospital-Based Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9020496 Authors: Nirgianakis Ma McKinnon Mueller Recurrence of endometriosis after surgery constitutes a serious challenge. Whether there is an evolution of lesion subtypes with each recurrence and whether certain lesions subtypes tend to recur faster than others is not adequately...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 495: The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer's Disease: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9020495 Authors: Dioguardi Crincoli Laino Alovisi Sovereto Mastrangelo Russo Muzio The evidence of a connection between the peripheral inflammatory processes and neurodegenerative diseases of the central nervous system is becoming more apparent. This review of the related...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 492: Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans Journal of Clinical Medicine doi: 10.3390/jcm9020492 Authors: Burska Giannoudis Tan Ilas Jones Ponchel To characterise the dynamic of events during the early phases of fracture repair in humans, we investigated molecular events using gene expression profiling of bone fragments from the fracture site at different time points...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 490: Using the Personalized Advantage Index for Individual Treatment Allocation to Blended Treatment or Treatment as Usual for Depression in Secondary Care Journal of Clinical Medicine doi: 10.3390/jcm9020490 Authors: Friedl Krieger Chevreul Hazo Holtzmann Hoogendoorn Kleiboer Mathiasen Urech Riper Berger A variety of effective psychotherapies for depression are available, but patients who suffer from depression vary in their...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 498: Novel Coronavirus Outbreak in Wuhan, China, 2020: Intense Surveillance Is Vital for Preventing Sustained Transmission in New Locations Journal of Clinical Medicine doi: 10.3390/jcm9020498 Authors: Thompson The outbreak of pneumonia originating in Wuhan, China, has generated 24,500 confirmed cases, including 492 deaths, as of 5 February 2020. The virus (2019-nCoV) has spread elsewhere in China and to 24 countries, including South Korea, Thailand, Japan and USA....
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 489: Soluble ST2 is a Useful Biomarker for Grading Cerebral–Cardiac Syndrome in Patients after Acute Ischemic Stroke Journal of Clinical Medicine doi: 10.3390/jcm9020489 Authors: Sung Lin Chen Chiang Ko Shao Chiang Chu Li Chai Lin Yip This study tested whether the soluble (s)ST2 is a superb biomarker predictive of moderate to severe cerebral–cardiac syndrome (CCS) (defined as coexisting National Institute of Health...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 488: Initial Cluster of Novel Coronavirus (2019-nCoV) Infections in Wuhan, China Is Consistent with Substantial Human-to-Human Transmission Journal of Clinical Medicine doi: 10.3390/jcm9020488 Authors: Nishiura Linton Akhmetzhanov Reanalysis of the epidemic curve from the initial cluster of cases with novel coronavirus (2019-nCoV) in December 2019 indicates substantial human-to-human transmission. It is possible that the common exposure history at a seafood...
Tue Feb 11, 2020 02:00
JCM, Vol. 9, Pages 487: Increased Intra-Abdominal Pressure During Laparoscopic Pneumoperitoneum Enhances Albuminuria via Renal Venous Congestion, Illustrating Pathophysiological Aspects of High Output Preeclampsia Journal of Clinical Medicine doi: 10.3390/jcm9020487 Authors: Dreesen Schoutteten Velde Kaminski Heylen Moor Malbrain Gyselaers Intra-abdominal hypertension (IAH) causes severe organ dysfunction. Our aim is to evaluate the effect of increased intra-abdominal...
Tue Feb 11, 2020 02:00
JDB, Vol. 8, Pages 4: Bu-M-P-ing Iron: How BMP Signaling Regulates Muscle Growth and Regeneration Journal of Developmental Biology doi: 10.3390/jdb8010004 Authors: Borok Mademtzoglou Relaix The bone morphogenetic protein (BMP) pathway is best known for its role in promoting bone formation, however it has been shown to play important roles in both development and regeneration of many different tissues. Recent work has shown that the BMP proteins have a number of functions in...
Tue Feb 11, 2020 02:00
JFB, Vol. 11, Pages 7: Cerium Dioxide Particles to Tune Radiopacity of Dental Adhesives: Microstructural and Physico-Chemical Evaluation Journal of Functional Biomaterials doi: 10.3390/jfb11010007 Authors: Garcia Leitune Takimi Bergmann Samuel Melo Collares The insufficient radiopacity of dental adhesives applied under composite restorations makes the radiographic diagnosis of recurrent caries challenging. Consequently, the misdiagnosis may lead to unnecessary...
Tue Feb 11, 2020 02:00
J. Imaging, Vol. 6, Pages 4: Three-Dimensional Block Matching Using Orthonormal Tree-Structured Haar Transform for Multichannel Images Journal of Imaging doi: 10.3390/jimaging6020004 Authors: Izumi Ito Aleksandra Pižurica Multichannel images, i.e., images of the same object or scene taken in different spectral bands or with different imaging modalities/settings, are common in many applications. For example, multispectral images contain several wavelength bands and hence, have richer...
Tue Feb 11, 2020 02:00
Life, Vol. 10, Pages 16: Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis Life doi: 10.3390/life10020016 Authors: Gajdács Bátori Ábrók Lázár Burián Classical resistance classifications (multidrug resistance [MDR], extensive drug resistance [XDR], pan-drug resistance [PDR]) are very useful for epidemiological purposes, however, they may not correlate well with clinical outcomes,...
Tue Feb 11, 2020 02:00
Medical Sciences, Vol. 8, Pages 11: The Interplay between Vascular Function and Sexual Health in Prostate Cancer: The Potential Benefits of Exercise Training Medical Sciences doi: 10.3390/medsci8010011 Authors: Vear Coombes Bailey Skinner Prostate cancer and its associated treatments can cause significant and lasting morbidities, such as cardiovascular and sexual dysfunctions. Various interventions have attempted to prevent or mitigate these dysfunctions. This review summarises...
Tue Feb 11, 2020 02:00
Medicina, Vol. 56, Pages 73: Predicting the Risk of Ischemic Stroke among Patients with Rheumatoid Arthritis Using a Simplified RA-CHADSV Score Based on the CHA2DS2-VASc Score Medicina doi: 10.3390/medicina56020073 Authors: Hsu Ng Lu Koo Background and Objectives: The aim of this retrospective cohort study was to develop a new score (RA-CHADSV) (rheumatoid arthritis - congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke/transient ischemic...
Wed Feb 12, 2020 02:00
Medicina, Vol. 56, Pages 71: Immunological Effects of a Single Hemodialysis Treatment Medicina doi: 10.3390/medicina56020071 Authors: Angeletti Zappulo Donadei Cappuccilli Di Certo Conte Comai Donati La Manna Immune disorders, involving both innate and adaptive response, are common in patients with end-stage renal disease under chronic hemodialysis. Endogenous and exogenous factors, such as uremic toxins and the extracorporeal treatment itself, alter...
Wed Feb 12, 2020 02:00
Medicina, Vol. 56, Pages 72: Bmi-1 Immunohistochemical Expression in Endometrial Carcinoma is Correlated with Prognostic Activity Medicina doi: 10.3390/medicina56020072 Authors: Kayo Horie Chihiro Iseki Moe Kikuchi Keita Miyakawa Mao Yoshizaki Haruhiko Yoshioka Jun Watanabe Background and objectives: B-lymphoma Mo-MLV insertion region 1 (Bmi-1) is a stem cell factor that is overexpressed in various human cancer tissues. It has been implicated in cancer cell proliferation,...
Wed Feb 12, 2020 02:00
Medicina, Vol. 56, Pages 70: Oxidant/Antioxidant Status of Breast Cancer Patients in Pre- and Post-Operative Periods Medicina doi: 10.3390/medicina56020070 Authors: Didžiapetrienė Kazbarienė Tikuišis Dulskas Dabkevičienė Lukosevičienė Kontrimavičiūtė Sužiedėlis Ostapenko Background and Objectives: The purpose of this study is to evaluate the level of oxidative stress before and after breast cancer surgery. Materials and Methods: Malondialdehyde (MDA)...
Tue Feb 11, 2020 02:00
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