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Πέμπτη 27 Φεβρουαρίου 2020


Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Neurocysticercosis
Publication date: Available online 26 February 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Xiaofei Fei, Chaoyang Li, Yun Zhang, Hongya Zhang, Xuewu Liu, Xinchao Ji, Yajun Shi, Na Liu, Mengli Wu, Fang Du, Yining Yang, Wen Dai, TingTing Liu, Ying He, Ting Bian, Huimin Zhou, Xingyue An, Zheng Cai, Jian Shi, Guodong Feng
Clinical Neurology and Neurosurgery
Thu Feb 27, 2020 13:37
Use of Combined Electroencephalography and Tilt Table Testing to Determine Etiology of Loss of Consciousness.
Related ArticlesUse of Combined Electroencephalography and Tilt Table Testing to Determine Etiology of Loss of Consciousness. Neurodiagn J. 2020 Mar;60(1):36-40 Authors: Singh N, Lynch T, Ritaccio A Abstract Tilt table testing is a common noninvasive diagnostic test performed to reproduce and evaluate syncope in a vulnerable patient and subsequently guide therapy. Electroencephalography (EEG) is typically useful for identifying interictal and ictal abnormalities...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
Medication Utilization Patterns 90 Days Before Initiation of Treatment with Repository Corticotropin Injection in Patients with Infantile Spasms.
Related ArticlesMedication Utilization Patterns 90 Days Before Initiation of Treatment with Repository Corticotropin Injection in Patients with Infantile Spasms. Pediatric Health Med Ther. 2019;10:195-207 Authors: Gold LS, Nazareth TA, Yu TC, Fry KR, Mahler NH, Rava A, Waltrip Ii RW, Hansen RN Abstract Introduction: Infantile spasms (IS) is a rare and devastating form of early childhood epilepsy. Two drugs are approved in the United States for treatment...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy.
Related ArticlesmicroRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy. Neuropsychiatr Dis Treat. 2020;16:327-338 Authors: Dong H, Dong B, Zhang N, Liu S, Zhao H Abstract Purpose: To explore the neuroprotective effects and mechanisms of Apelin (APLN), and to study the regulation of APLN expression by microRNA (miRNA) in epilepsy. Materials and Methods: In vitro and in vivo epileptic models...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy.
Related ArticlesMetabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy. Acta Med Okayama. 2020 Feb;74(1):65-72 Authors: Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K Abstract To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Related ArticlesROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability. J Neurosci. 2020 Feb 24;: Authors: Busti I, Allegra M, Spalletti C, Panzi C, Restani L, Billuart P, Caleo M Abstract Oligophrenin-1 (Ophn1) encodes a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID) in humans. Loss of function...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity.
Related ArticlesDistinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity. Brain Sci. 2020 Feb 22;10(2): Authors: Frerker B, Rohde M, Müller S, Bien CG, Köhling R, Kirschstein T Abstract Background: The conversion of glutamic acid into γ-aminobutyric acid (GABA) is catalyzed by the glutamic acid decarboxylase...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
Severe neonatal hypoxic-ischaemic brain injury: still an important cause of infantile spasms.
Related ArticlesSevere neonatal hypoxic-ischaemic brain injury: still an important cause of infantile spasms. Dev Med Child Neurol. 2020 01;62(1):9 Authors: Vollmer B PMID: 31677161 [PubMed - indexed for MEDLINE]
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms.
Related ArticlesTaurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms. Redox Biol. 2019 06;24:101223 Authors: Jakaria M, Azam S, Haque ME, Jo SH, Uddin MS, Kim IS, Choi DK Abstract Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is produced chiefly by the liver and kidney. It presents in different organs, including retina, brain, heart and placenta and demonstrates...
pubmed: epilepsy treatment
Thu Feb 27, 2020 13:36
Gene expression patterns of novel visual and non-visual opsin families in immature and mature Japanese eel males
This study was carried out to identify and estimate physiological function of a new type of opsin subfamily present in the retina and whole brain tissues of Japanese eel using RNA–Seq transcriptome method. A total of 18 opsin subfamilies were identified through RNA–seq. The visual opsin family included Rh2, SWS2, FWO, DSO, and Exo-Rhod. The non-visual opsin family included four types of melanopsin subfamily (Opn4x1, Opn4x2, Opn4m1, and Opn4m2), peropsin, two types of neuropsin subfamily (Opn5-like,...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
DISCo-microbe: design of an identifiable synthetic community of microbes
Background Microbiomes are extremely important for their host organisms, providing many vital functions and extending their hosts’ phenotypes. Natural studies of host-associated microbiomes can be difficult to interpret due to the high complexity of microbial communities, which hinders our ability to track and identify individual members along with the many factors that structure or perturb those communities. For this reason, researchers have turned to synthetic or constructed communities...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Three-dimensional nephrometry scoring system: a precise scoring system to evaluate complexity of renal tumors suitable for partial nephrectomy
Purpose Several nephrometry scoring systems have been developed based on two-dimensional computerized tomography images to quantify anatomical features of renal tumors. We have developed an accurate three-dimensional nephrometry scoring system to respond to the urgent need for advanced systems based on three-dimensional images. Materials and Methods We retrospectively reviewed 135 patients who underwent partial nephrectomy...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Modelling the effective reproduction number of vector-borne diseases: the yellow fever outbreak in Luanda, Angola 2015–2016 as an example
The burden of vector-borne diseases (Dengue, Zika virus, yellow fever, etc.) gradually increased in the past decade across the globe. Mathematical modelling on infectious diseases helps to study the transmission dynamics of the pathogens. Theoretically, the diseases can be controlled and eventually eradicated by maintaining the effective reproduction number, ( ${\mathcal{R}}_{\mathrm{eff}}$ ...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimp Litopenaeus vannamei against White Spot Syndrome Virus infection
In this study, four experimental assays were conducted to evaluate the use of a new silver nanoparticle formulation named Argovit-4, which was prepared with slight modifications to enhance its biological activity against white spot syndrome virus (WSSV) in shrimp culture. The goals of these assays were to (1) determine the protective effect of Argovit-4 against WSSV, (2) determine whether Argovit-4 supplemented in feed exhibits toxicity towards shrimp, (3) determine whether Argovit-4 as antiviral...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Macrostylis metallicola spec. nov.—an isopod with geographically clustered genetic variability from a polymetallic-nodule area in the Clarion-Clipperton Fracture Zone
Background The Clarion-Clipperton Fracture Zone (CCFZ) in the Northeast Central Pacific Ocean is a region of heightened scientific and public interest because of its wealth in manganese nodules. Due to a poor ecological understanding at the abyssal seafloor and limited knowledge of the organisms inhabiting this area, huge efforts in alpha taxonomy are required. To predict and manage potential hazards associated with future mining, taxonomy is an essential first step to grasp fundamental ecosystem...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Lactoferrin quantification in cattle faeces by ELISA
Background Promoting and maintaining health is critical to ruminant welfare and productivity. Within human medicine, faecal lactoferrin is quantified for routine assessment of various gastrointestinal illnesses avoiding the need for blood sampling. This approach might also be adapted and applied for non-invasive health assessments in animals. Methods In this proof-of-concept study, a bovine lactoferrin enzyme-linked immunosorbent assays (ELISA), designed for serum and milk, was applied...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Antimicrobial resistance and genetic relationships of enterococci from siblings and non-siblings Heliconius erato phyllis caterpillars
Background Studies evaluating bacteria in insects can provide information about host–microorganism–environment interactions. The gut microbial community has a profound effect on different physiological functions of insects. Enterococcus spp. are part of the gut community in humans and other animals, as well as in insects. The presence and antimicrobial resistance profile of enterococci are well studied in different animals; however, data for Heliconius erato phyllis (Lepidoptera:...
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Comprehensive phenotyping and transcriptome profiling to study nanotoxicity in C. elegans
Engineered nanoparticles are used at an increasing rate in both industry and medicine without fully understanding their impact on health and environment. The nematode Caenorhabditis elegans is a suitable model to study the toxic effects of nanoparticles as it is amenable to comprehensive phenotyping, such as locomotion, growth, neurotoxicity and reproduction. In this study, we systematically evaluated the effects of silver (Ag) and five metal oxide nanoparticles: SiO2, CeO2, CuO, Al2O3 and TiO2....
PeerJ Computer Science
Thu Feb 27, 2020 02:00
Meiotic block with roscovitine improves competence of porcine oocytes by fine-tuning activities of different cyclin-dependent kinases.
Related ArticlesMeiotic block with roscovitine improves competence of porcine oocytes by fine-tuning activities of different cyclin-dependent kinases. J Cell Physiol. 2020 Feb 26;: Authors: Zhu S, Jia YJ, Pan LZ, Gong S, Sun MJ, Wang GL, Luo MJ, Tan JH Abstract Successful use of oocytes from small follicles (SFs) is of great importance for animal embryo production and human in vitro fertilization with reduced hormone-related side effects. How in vitro...
pubmed: "j cell physiol"[jou...
Thu Feb 27, 2020 13:34
Loss of p62 impairs bone turnover and inhibits PTH-induced osteogenesis.
Related ArticlesLoss of p62 impairs bone turnover and inhibits PTH-induced osteogenesis. J Cell Physiol. 2020 Feb 26;: Authors: Agas D, Amaroli A, Lacava G, Yanagawa T, Sabbieti MG Abstract The p62 (also named sequestosome1/SQSTM1) is multidomain and multifunctional protein associated with several physiological and pathological conditions. A number of studies evidenced an involvement of p62 on the disruptive bone scenarios due to its participation in...
pubmed: "j cell physiol"[jou...
Thu Feb 27, 2020 13:34
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Related ArticlesClinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review. JAMA Dermatol. 2020 Feb 26;: Authors: Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C Abstract Importance: The clinical and dermoscopic features of the vast majority of uncommon variants of cutaneous melanoma have been rarely reported, leading to difficulty...
Rare Cancers
Thu Feb 27, 2020 13:29
Salvage carbon ion radiotherapy for recurrent solitary fibrous tumor: A case report and literature review.
Related ArticlesSalvage carbon ion radiotherapy for recurrent solitary fibrous tumor: A case report and literature review. J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(1):2309499019896099 Authors: Murata K, Endo K, Aihara T, Matsuoka Y, Nishimura H, Suzuki H, Sawaji Y, Yamamoto K, Fukami S, Tanigawa M, Matsubayashi J, Nagao T, Imai R Abstract BACKGROUND: Malignant solitary fibrous tumor (MSFT) arising from the spinal cord is extremely rare and poorly understood...
Rare Cancers
Thu Feb 27, 2020 13:29
Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.
Related ArticlesDual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma. Sci Rep. 2020 Feb 25;10(1):3391 Authors: Hirotsu Y, Otake S, Ohyama H, Amemiya K, Higuchi R, Oyama T, Mochizuki H, Goto T, Omata M Abstract Conventional next generation sequencing analysis has provided important insights into cancer genetics. However, the detection of rare (low allele fraction) variants remains difficult because of the error-prone...
Rare Cancers
Thu Feb 27, 2020 13:29
Gastrointestinal stromal tumour of stomach: Feasibility of laparoscopic resection in large lesions and its long-term outcomes.
Related ArticlesGastrointestinal stromal tumour of stomach: Feasibility of laparoscopic resection in large lesions and its long-term outcomes. J Minim Access Surg. 2020 Feb 26;: Authors: Parthasarathi, Dhawal S, Chittawadagi B, Cumar B, Kumar S, Palanivelu C Abstract Background: Gastric gastrointestinal stromal tumours (GISTs) are rare neoplasms that require excision for cure. Although the feasibility of laparoscopic resection of smaller gastric GIST...
Rare Cancers
Thu Feb 27, 2020 13:29
Laparoscopic adrenalectomy for giant adrenal tumours: Technical considerations and surgical outcome.
Related ArticlesLaparoscopic adrenalectomy for giant adrenal tumours: Technical considerations and surgical outcome. J Minim Access Surg. 2020 Feb 26;: Authors: Giordano A, Alemanno G, Bergamini C, Valeri A, Prosperi P Abstract Background: Giant adrenal tumours are tumours with size ≥6 cm. These are rare cancer associated with malignancy in 25% of cases. Patients and Methods: A retrospective review was conducted on the medical records of patients...
Rare Cancers
Thu Feb 27, 2020 13:29
Adjuvant Therapy in Adrenocortical Carcinoma: Reflections and Future Directions.
Related ArticlesAdjuvant Therapy in Adrenocortical Carcinoma: Reflections and Future Directions. Cancers (Basel). 2020 Feb 22;12(2): Authors: Bedrose S, Daher M, Altameemi L, Habra MA Abstract Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with high risk of recurrence despite macroscopically complete surgical resection. The main predictors of ACC recurrence include advanced disease stage, incomplete surgical resection, cortisol production,...
Rare Cancers
Thu Feb 27, 2020 13:29
[Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?]
Related Articles[Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?] Arkh Patol. 2020;82(1):62-67 Authors: Barinova IV, Buyanova SN, Kondrikov NI, Shchukina NA, Voloshchuk IN, Mgeliashvili MV, Petrakova SA, Aksenova AA Abstract OBJECTIVE: To reveal the morphological characteristics of simultaneously diagnosed leiomyoma of the corpus uteri and vulva. SUBJECT AND METHODS: The paper describes a case of multiple uterine leiomyomas...
Rare Cancers
Thu Feb 27, 2020 13:29
Clinical, histopathologic, subtype, and immunohistochemical analysis of jaw phosphaturic mesenchymal tumors.
Related ArticlesClinical, histopathologic, subtype, and immunohistochemical analysis of jaw phosphaturic mesenchymal tumors. Medicine (Baltimore). 2020 Feb;99(7):e19090 Authors: Li D, Zhu R, Zhou L, Zhong D Abstract Jaw phosphaturic mesenchymal tumors (PMTs) are a rare neoplasm with uncertain histogenesis. This study aimed to clarify the clinical and pathological features of jaw PMTs.We reviewed the clinical records of 39 patients diagnosed with PMTs...
Rare Cancers
Thu Feb 27, 2020 13:29
Warthin's tumor with necrotizing tuberculous granulomatous inflammation causing severe facial nerve adhesion in parotid gland: A case report and literature review.
Related ArticlesWarthin's tumor with necrotizing tuberculous granulomatous inflammation causing severe facial nerve adhesion in parotid gland: A case report and literature review. Medicine (Baltimore). 2020 Feb;99(7):e18763 Authors: Chen SL, Hwang CC, Liu YC, Chen WT, Yang SW Abstract RATIONALE: Warthin's tumor is the second most common tumor arising from the parotid gland, but it rarely occurs concomitantly with tuberculous granulomatous inflammation...
Rare Cancers
Thu Feb 27, 2020 13:29
Case Report of acute myeloid leukemia with "WT1, ATRX, CEBPA, CSMD1, IKZF1, and LRP1B mutation and translocation between chromosome 1 and 19" developing from Philadelphia-negative chronic myeloid leukemia after TKI therapy.
Related ArticlesCase Report of acute myeloid leukemia with "WT1, ATRX, CEBPA, CSMD1, IKZF1, and LRP1B mutation and translocation between chromosome 1 and 19" developing from Philadelphia-negative chronic myeloid leukemia after TKI therapy. Medicine (Baltimore). 2020 Jan;99(3):e18888 Authors: Zhu H, Yang B, Liu J, Wu W, Ling Y Abstract RATIONALE: The success of tyrosine kinase inhibitor (TKI) therapy has greatly prolonged the survival time of patients...
Rare Cancers
Thu Feb 27, 2020 13:29
Rare clinical presentations of pleomorphic xanthoastrocytoma with a high proliferative index: Two case reports.
Related ArticlesRare clinical presentations of pleomorphic xanthoastrocytoma with a high proliferative index: Two case reports. Medicine (Baltimore). 2020 Jan;99(3):e18880 Authors: Nagaishi M, Nakae R, Fujii Y, Inoue Y, Sugiura Y, Takano I, Tanaka Y, Suzuki K Abstract INTRODUCTION: Pleomorphic xanthoastrocytomas (PXA) are rare, typically benign, slow-growing tumors that commonly occur in the cerebral hemispheres. We describe two cases of clinically...
Rare Cancers
Thu Feb 27, 2020 13:29
[Lymphoma presenting as cardiac symptoms and cardiac mass: a report of two rare cases].
Related Articles[Lymphoma presenting as cardiac symptoms and cardiac mass: a report of two rare cases]. Zhonghua Nei Ke Za Zhi. 2019 11 01;58(11):838-840 Authors: Jin XS, Bo J, Ma C, Zhao Y PMID: 31665864 [PubMed - indexed for MEDLINE]
Rare Cancers
Thu Feb 27, 2020 13:29
The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data.
Related ArticlesThe use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data. BMC Cancer. 2019 Oct 26;19(1):1005 Authors: Fernández-Navarro P, López-Nieva P, Piñeiro-Yañez E, Carreño-Tarragona G, Martinez-López J, Sánchez Pérez R, Aroca Á, Al-Shahrour F, Cobos-Fernández MÁ, Fernández-Piqueras J Abstract BACKGROUND: Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from...
Rare Cancers
Thu Feb 27, 2020 13:29
Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review.
Related ArticlesSynchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review. BMC Cancer. 2019 Oct 17;19(1):966 Authors: Bennani A, Kharrasse G, Achraf M, Wafa K, Zahi I, Imane K, Mohamed B Abstract BACKGROUND: Lymphoma and dysplasia are rare complications of long-standing Crohn's disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma...
Rare Cancers
Thu Feb 27, 2020 13:29
Poorly differentiated neuroendocrine rectal carcinoma with uncommon immune-histochemical features and clinical presentation with a subcutaneous metastasis, treated with first line intensive triplet chemotherapy plus bevacizumab FIr-B/FOx regimen: an experience of multidisciplinary management in clinical practice.
Related ArticlesPoorly differentiated neuroendocrine rectal carcinoma with uncommon immune-histochemical features and clinical presentation with a subcutaneous metastasis, treated with first line intensive triplet chemotherapy plus bevacizumab FIr-B/FOx regimen: an experience of multidisciplinary management in clinical practice. BMC Cancer. 2019 Oct 16;19(1):960 Authors: Bruera G, Giuliani A, Romano L, Chiominto A, Di Sibio A, Mastropietro S, Cosenza P, Ricevuto E,...
Rare Cancers
Thu Feb 27, 2020 13:29
Recurrence of linear basal cell carcinoma.
Related ArticlesRecurrence of linear basal cell carcinoma. Cutis. 2019 Aug;104(2):114-116 Authors: Ward JM, Russell M Abstract Linear basal cell carcinoma (LBCC) is a rare morphologic variant of basal cell carcinoma. We report a case of a patient with a recurrent linear lesion on the supraclavicular neck with prior repeated mild trauma to the area. The patient was diagnosed with recurrent LBCC after a prior excision of an LBCC in the same area. A review...
Rare Cancers
Thu Feb 27, 2020 13:29
Fostering open collaboration in drug development for paediatric brain tumours.
Related ArticlesFostering open collaboration in drug development for paediatric brain tumours. Biochem Soc Trans. 2019 10 31;47(5):1471-1479 Authors: Wong JF, Brown EJ, Williams E, Bullock AN Abstract Brain tumours have become the leading cause of child mortality from cancer. Indeed, aggressive brainstem tumours, such as diffuse intrinsic pontine glioma (DIPG), are nearly uniformly fatal. These tumours display a unique set of driver mutations that...
Rare Cancers
Thu Feb 27, 2020 13:29
Multiple intraneural glomus tumors in different digital nerve fascicles.
Related ArticlesMultiple intraneural glomus tumors in different digital nerve fascicles. BMC Cancer. 2019 Sep 05;19(1):888 Authors: Wang Y, Lu H Abstract BACKGROUND: Glomus tumors in the digital nerve are extremely rare. Multiple intraneural glomus tumors in different digital nerve fascicles have not been previously reported. CASE PRESENTATION: We report the case of a 54-year-old male with a 1-year history of progressive numbness of the middle...
Rare Cancers
Thu Feb 27, 2020 13:29
INPART - a psycho-oncological intervention for partners of patients with haemato-oncological disease - study protocol.
Related ArticlesINPART - a psycho-oncological intervention for partners of patients with haemato-oncological disease - study protocol. BMC Cancer. 2019 Sep 05;19(1):885 Authors: Lorenz I, Bodschwinna D, Hallensleben N, Döhner H, Niederwieser D, Zimmermann T, Mehnert A, Gündel H, Ernst J, Hoenig K Abstract BACKGROUND: Suffering from cancer confronts both the patient and their partner with a number of psychosocial challenges in various aspects of their...
Rare Cancers
Thu Feb 27, 2020 13:29

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