Squamous cell carcinoma (SCC) of the tongue is the most common oral cancer. Because of the tongue’s frequent movement, abundant lymphatic drainage, and rich blood supply, the SCC is prone to regional lymph nodes and distant metastases, and its prognosis is worse than that of the other oral cancers.1 In addition, because of its special location, it and its secondary tissue defect postperatively may impair the patient’s pronunciation and swallowing. Reliable and stable therapeutic targets can improve...
Thu Feb 27, 2020 02:00
The aim of this retrospective cohort study was to evaluate the relative amount of cancellous bone in the mandibular ramus as a predictor of lingual fracture patterns after bilateral sagittal split osteotomy (BSSO). The study including 78 consecutive patients (156 osteotomy sites). In preoperative cone-beam computed tomographic (CT) scans, the volumes of cancellous and cortical bone in the BSSO surgical field were estimated. Patients were divided into two groups based on the cortico:cancellous bone...
Thu Feb 27, 2020 02:00
When I read the method of the above paper in detail it seemed likely that the ASIS would be included for <9cm and >9cm bone lengths as described by Taylor1 although this was not clearly stated. As a result I was not surprised that the pain score for longer defects was higher (6.71 v 4.64, p value not included, Table 1), the time to walking (6.64 v 4.72 weeks p value 0.002, Table 2) longer, as well as abnormality of the donor site (very abnormal >9cm 13/27(48%) v <9cm 6/35(17%), Table...
Thu Feb 27, 2020 02:00
Obstructive sleep apnoea syndrome (OSAS), which is characterised by repetitive episodes of pharyngeal collapse during sleep, is gaining much attention because of the important deleterious consequences it might have on the patient’s health. We therefore organised a retrospective longitudinal study to report the long-term follow-up of maxillomandibular advancement (MMA) as a treatment for OSAS. A total of 19 patients with severe OSAS was treated during the period 2007–2016. They were followed up six...
Thu Feb 27, 2020 02:00
The aim of this study was to perform a statistical evaluation of the risk factors for postoperative delirium after oral tumor resection and reconstructive surgery. The records of 69 consecutive patients who underwent major head and neck tumor resection and reconstructive surgery, and who received postoperative management in the high care unit (HCU) or intensive care unit (ICU) of Tsukuba University Hospital between January 2013 and December 2017, were analysed retrospectively. Delirium was diagnosed...
Thu Feb 27, 2020 02:00
Human chromosome 19 has many unique characteristics including gene density more than double the genome-wide average and 20 large tandemly clustered gene families. It also has the highest GC content of any chro...
Thu Feb 27, 2020 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13573
Thu Feb 27, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13356
Thu Feb 27, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00043
Thu Feb 27, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11838
Thu Feb 27, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00356
Thu Feb 27, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00127
Thu Feb 27, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13883
Thu Feb 27, 2020 07:00
BACKGROUND AND PURPOSE:Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.MATERIALS AND METHODS:Patients with no signal in the ICA on MRA were retrospectively reviewed. Two neuroradiologists independently reviewed their...
Thu Feb 27, 2020 17:02
BACKGROUND AND PURPOSE:Nephrogenic systemic fibrosis following administration of intravenous gadobenate during MR imaging is rare. This study aimed to analyze any nephrogenic systemic fibrosis–related risks and quantify skin gadolinium levels in patients with impaired renal function but without nephrogenic systemic fibrosis who had received gadobenate.MATERIALS AND METHODS:In this retrospective study with a prospective skin biopsy phase, patients with estimated glomerular filtration rates of <60...
Thu Feb 27, 2020 16:58
BACKGROUND AND PURPOSE:Flow diversion for the posterior circulation remains a promising treatment option for selected posterior circulation aneurysms. The Flow-Redirection Intraluminal Device (FRED) system has not been previously assessed in a large cohort of patients with posterior circulation aneurysms. The purpose of the present study was to assess safety and efficacy of FRED in this location.MATERIALS AND METHODS:Consecutive patients with posterior circulation aneurysms treated at 8 centers participating...
Thu Feb 27, 2020 16:57
BACKGROUND AND PURPOSE:The massa intermedia is a normal midline transventricular thalamic connection. Massa intermedia aberrations are common in schizophrenia, Chiari II malformation, X-linked hydrocephalus, Cornelia de Lange syndrome, and diencephalic-mesencephalic junction dysplasia, among others. We have noticed that massa intermedia abnormalities often accompany other midline malformations. The massa intermedia has never been formally evaluated in a group of exclusively pediatric patients, to...
Thu Feb 27, 2020 16:56
BACKGROUND AND PURPOSE:Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.MATERIALS AND METHODS:We analyzed the rates and severity of stroke and death in patients who underwent embolization only. Events were identified...
Thu Feb 27, 2020 16:55
BACKGROUND AND PURPOSE:The natural history and optimal treatment of extracranial carotid artery aneurysms are unknown. Gadolinium enhancement of the aneurysm wall may reflect aneurysm wall inflammation and instability. In this study, we investigated the feasibility of extracranial carotid artery aneurysm wall imaging and explored a potential relationship of aneurysm wall enhancement with aneurysm growth and the presence of (silent) brain infarcts and white matter lesions.MATERIALS AND METHODS:Fourteen...
Thu Feb 27, 2020 16:55
BACKGROUND AND PURPOSE:Conventional angiography is the criterion standard for measuring intracranial arterial stenosis. We evaluated signal intensity ratios from TOF-MRA as a measure of intracranial stenosis and infarct risk in pediatric stroke.MATERIALS AND METHODS:A retrospective study was undertaken in children with intracranial arterial stenosis, who had TOF-MRA and conventional angiography performed within 6 months. Arterial diameters were measured for percentage stenosis. ROI analysis on TOF-MRA...
Thu Feb 27, 2020 16:54
BACKGROUND AND PURPOSE:Arterial spin-labeling-derived CBF values may be affected by arterial transit time artefacts. Thus, our aim was to assess to what extent arterial spin-labeling–derived CBF and cerebrovascular reserve capacity values in major vascular regions are overestimated due to the arterial transit time artifacts in patients with Moyamoya disease.MATERIALS AND METHODS:Eight patients with Moyamoya disease were included before or after revascularization surgery. CBF maps were acquired using...
Thu Feb 27, 2020 16:53
Publication date: Available online 26 February 2020Source: Sleep MedicineAuthor(s): Laura Pérez-Carbonell, Elaine Lyons, Valentina Gnoni, Sean Higgins, Abidemi I. Otaiku, Guy D. Leschziner, Panagis Drakatos, Grainne d’Ancona, Brian D. Kent
Thu Feb 27, 2020 22:42
Publication date: Available online 26 February 2020Source: Gait & PostureAuthor(s): Ezgi Ergin, Sema Savcı, Buse Ozcan Kahraman, Aylin Tanriverdi, Ismail Ozsoy, Gizem Atakul, Ayşe Volkan, Suna Asilsoy, Nevin Uzuner
Thu Feb 27, 2020 22:16
Publication date: Available online 26 February 2020Source: Gait & PostureAuthor(s): Virginia L Little, Lindsay A Perry, Mae WV Mercado, Steven A Kautz, Carolynn Patten
Thu Feb 27, 2020 22:16
Publication date: Available online 26 February 2020Source: Gait & PostureAuthor(s): Erin E Butler, Nathaniel J Dominy
Thu Feb 27, 2020 22:16
Abstract The Cry48Aa/Cry49Aa binary toxin from Lysinibacillus sphaericus is composed of a three-domain Cry-like toxin (Cry48Aa) and a binary-like protein (Cry49Aa) that work together to kill Culex quinquefasciatus mosquito larvae through a novel interaction between its two components. The aim of this study was to identify the functional regions of Cry48Aa that were involved in the interaction with Cry49Aa. Eight Cry48Aa truncated fragments were constructed from both N- and C-termini...
Thu Feb 27, 2020 02:00
Abstract The aim of the research was to explore qualitative and quantitative phytochemical constituents of different extracts from Agrimonia eupatoria L., Hypericum alpestre subsp. polygonifolium (Rupr.) Avet. & Takht., Rumex obtusifolius Willd and Sanguisorba officinalis L. and analyze their bioactive constituents using TLC-bioautography technique. In TLC analysis different solvent systems as mobile phases were used in order to make assumptions about the nature of active antibacterial...
Thu Feb 27, 2020 02:00
The study of toxicities induced by sorafenib, as well as the identification of possible mechanisms and biomarkers of these toxicities, is important to improve the treatment and quality of life of hepatocellular carcinoma (HCC) patients. This study focused on toxicities, cellular oxidative stress, adherence, and quality of life of 11 patients with HCC treated with sorafenib. Dermatotoxicity, myelotoxicity, gastro toxicity, nephrotoxicity, pain, and fatigue were investigated. For oxidative stress analysis,...
Tue Feb 25, 2020 02:00
Abstract Background The standard of care for CNS lymphoma typically includes high dose methotrexate followed by whole brain radiation therapy, but there is an increased risk of neurotoxicity with this regimen. In our institution, we offered stereotactic radiosurgery (SRS) for disease refractory to HD-MTX in a subset of patients. A search of the literature on this modality for CNS lymphoma was also conducted. ...
Thu Feb 27, 2020 02:00
Abstract Purpose Immunotherapy, activation of the immune system to target tumor cells, represents a paradigm shift in the treatment of cancer. Immune checkpoint therapies, which target immunomodulatory molecules expressed on T-lymphocytes, have demonstrated improved survival in a variety of malignancies. However, benefit in glioblastoma, the most common and devastating malignant brain tumor, remains to be seen. With several recent clinical...
Thu Feb 27, 2020 02:00
Abstract Introduction Malignancies involving the temporal bone are increasingly common and require specialized multi-disciplinary care. Given this complex location, involvement of the lateral skull base and local neurovascular structures is common. In this review we discuss general principles for temporal bone resection, as well as alternative and complementary surgical approaches that should be considered in the management of patients...
Thu Feb 27, 2020 02:00
Selumetinib for plexiform neurofibromas in neurofibromatosis type 1: a single-institution experience
Abstract Background Plexiform neurofibromas (PN) are the most frequent tumors associated with Neurofibromatosis type 1 (NF-1). PN can cause significant complications, including pain, functional impairment, and disfigurement. There is no efficient medical treatment and, surgical resection of large PN is frequently infeasible. Selumetinib (AZD6244/ARRY-142886) is a mitogen-activated protein kinase enzyme (MEK1/2) inhibitor and works by targeting...
Thu Feb 27, 2020 02:00
Publication date: Available online 26 February 2020Source: European Journal of Surgical OncologyAuthor(s): Keiichi Fujiya, Keiichi Ohshima, Yuko Kitagawa, Keiichi Hatakeyama, Takeshi Nagashima, Daisuke Aizawa, Takeshi Sugino, Kenichi Urakami, Ken Yamaguchi, Masanori Terashima
Thu Feb 27, 2020 21:22
Abstract Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer, and novel therapies are urgently needed to prolong patient survival and improve clinical outcomes. Very few scientific reviews have examined the literature on combination therapies with the goal of describing the available preclinical and clinical data and suggesting future clinical combination treatment schedules. The present review focuses on preclinical and clinical studies of drug combination...
Thu Feb 27, 2020 02:00
The National Institute for Occupational Safety and Health (NIOSH) partnered with the National Hearing Conservation Association (NHCA) to create the Safe-in-Sound Excellence in Hearing Loss Prevention Awards™, to recognize organizations that document measurable achievements in hearing loss prevention, and to obtain information on their real-world successes. This year's award ceremony takes place at the Annual National Hearing Conservation Conference on February 21st 2020. The recipient of the 2020...
Wed Feb 26, 2020 10:15
CRISPR-Cas9 gene editing provides a powerful tool to enhance the natural ability of human T cells to fight cancer. We report a first-in-human phase 1 clinical trial to test the safety and feasibility of multiplex CRISPR-Cas9 editing to engineer T cells in three patients with refractory cancer. Two genes encoding the endogenous T cell receptor (TCR) chains, TCRα (TRAC) and TCRβ (TRBC), were deleted in T cells to reduce TCR mispairing and to enhance the expression of a synthetic, cancer-specific TCR...
Thu Feb 27, 2020 20:39
The New Horizons spacecraft’s encounter with the cold classical Kuiper Belt object (486958) Arrokoth (provisional designation 2014 MU69) revealed a contact-binary planetesimal. We investigated how Arrokoth formed and found that it is the product of a gentle, low-speed merger in the early Solar System. Its two lenticular lobes suggest low-velocity accumulation of numerous smaller planetesimals within a gravitationally collapsing cloud of solid particles. The geometric alignment of the lobes indicates...
Thu Feb 27, 2020 20:39
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