Raj Kumar Shrimali, Yakhub Mohammed KhanIndian Journal of Cancer 2020 57(1):108-109
Wed Feb 26, 2020 00:00
Murat Sari, Pınar SaipIndian Journal of Cancer 2020 57(1):55-61 Background and Aim: Our retrospective, single-center study aimed at evaluating the efficacy and safety of eribulin in heavily pretreated metastatic breast cancer (MBC) in routine clinical practice. Subjects and Methods: Twenty-eight patients treated with eribulin for MBC between May 2014 and November 2017 were included in our study. Clinical and biological assessment of toxicity was controlled at each visit. Tumor response was...
Wed Feb 26, 2020 00:00
Abstract Chronic obstructive pulmonary disease (COPD) is one of the most important factors in the progress of cardiovascular disease (CVD) which is associated with limited airflow and alveolar demolition. The aim of this study is to investigate the possible protective effect of ellagic acid (EA), as a natural anti-oxidant, against pulmonary arterial hypertension (PAH) and development of lung and heart injuries induced by elastase. Sixty...
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Tissue Engineering Part A, Ahead of Print.
Wed Feb 26, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Wed Feb 26, 2020 10:00
The 1918 influenza pandemic was the deadliest event in human history (50 million or more deaths, equivalent in proportion to 200 million in today’s global population). For more than a century, it has stood as a benchmark against which all other pandemics and disease emergences have been measured.…
Wed Feb 26, 2020 02:00
The Affordable Care Act (ACA), known colloquially as Obamacare, is almost certainly one of the most consequential — and controversial — pieces of enacted health care legislation in U.S. history. To the delight of some observers and the consternation of others, the ACA has now survived 10 years…
Wed Feb 26, 2020 02:00
Among the provisions of the Affordable Care Act (ACA), its coverage and access provisions have attracted by far the most attention and controversy. However, as health professionals are well aware, the ACA also launched potentially groundbreaking changes in how health care is paid for and delivered…
Wed Feb 26, 2020 02:00
When I earned my first academic-faculty appointment, it was the second-greatest accomplishment of my life. For more than a decade, I dedicated myself to residency training, two fellowships, and numerous manuscript and grant submissions. In parallel, I underwent repeated fertility treatment cycles,…
Wed Feb 26, 2020 02:00
To the Editor: As of February 4, 2020, electronic-cigarette, or vaping, product use–associated lung injury (EVALI) has resulted in the hospitalization of 2758 people across the United States and has been linked to at least 64 deaths…
Wed Feb 26, 2020 02:00
Thyroid, Ahead of Print.
Wed Feb 26, 2020 10:00
Thyroid, Ahead of Print.
Wed Feb 26, 2020 10:00
Thyroid, Ahead of Print.
Wed Feb 26, 2020 10:00
Thyroid, Ahead of Print.
Wed Feb 26, 2020 10:00
In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: Lambru G, Rantell K, Levy A, Matharu MS. A prospective comparative study and analysis of predictors of SUNA and SUNCT. Neurology. 2019;93:e1127–e1137.Gruener AM, Poostchi A, Carey AR, Eberhart CG, Henderson AD, Chang JR, McCulley TJ. Association of giant cell arteritis with race. JAMA Ophthalmol. [published ahead of print August 8, 2019] doi: 10.1001/jamaophthalmol.2019.2919.Ferro...
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Background: The benefit of thymectomy in reducing requirement for corticosteroids, symptom severity, need for immunosuppression, and hospitalization rates in patients with seropositive generalized myasthenia has recently been established. It is unclear whether this benefit applies to patients with myasthenia and purely ocular manifestations (ocular myasthenia gravis [OMG]). Methods: We conducted a retrospective single-center cohort study of patients with OMG. Patients were included if their...
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Abstract: A 73-year-old woman presented with 3 years of monocular visual distortion and progressive binocular diplopia. She was found to have a comitant left hypertropia due to an epiretinal membrane causing inferior foveal drag. Displacement of the fovea from an epiretinal membrane is a likely under-recognized cause ocular cause of a comitant binocular diplopia.
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Background: The visual prognosis in Leber hereditary optic neuropathy (LHON) is generally poor. However, some individuals can have spontaneous visual recovery (VR) in one or both eyes by a mechanism that is not yet clearly understood. The purpose of this study was to determine whether certain clinical and optic disc features are associated with VR in patients with LHON. Methods: We retrospectively examined 80 eyes of 40 patients with LHON using clinical databases, fundus photographs, and...
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No abstract available
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Purpose: Clinical trials of gene therapy for Leber hereditary optic neuropathy (LHON) were conducted in 9 volunteers with the mitochondrial mutation, G11778A in ND4. The purpose of this study was to investigate whether multilocus mitochondrial mutations directly influence the efficacy of gene therapy for LHON. Methods: Nine volunteers with LHON participated in a clinical trial with intravitreal injection of an adenoviral vector expressing wild-type ND4. Patients were subsequently divided...
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Abstract: Lisch nodules are melanocytic hamartomas that have been hypothesized to grow larger in the presence of sunlight. A 17-year-old boy with neurofibromatosis Type 1 and congenital ptosis in one eye presented and was found to have a distinct asymmetry of Lisch nodules between eyes with less under the ptotic lid. This case supports the theory that Lisch nodules form at least partially due to a direct trophic effect of sunlight.
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Objective: The primary aim of this study was to describe clinical features of Chinese sporadic Leber hereditary optic neuropathy (LHON) caused by rare primary mitochondrial DNA (mtDNA) mutations. Methods: We characterized a Chinese patient cohort with rare primary mtDNA mutations at Beijing Tongren Hospital between 2015 and 2018. The clinical features of these patients were retrospectively recorded and analyzed. Results: Sixteen patients with LHON who had the selected rare primary mutations,...
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No abstract available
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Background: Patients with multiple sclerosis (MS) experience progressive thinning in optical coherence tomography (OCT) measures of neuroaxonal structure regardless of optic neuritis history. Few prospective studies have investigated the effects of disease-modifying therapies on neuroaxonal degeneration in the retina. Alemtuzumab is a monoclonal antibody shown to be superior to interferon β-1a in treating relapsing–remitting MS (RRMS). The purpose of this study was to assess the effects of alemtuzumab...
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Background: Cerebrovascular disease (CeVD), including stroke, is a leading cause of death globally. The retina is an extension of the cerebrum, sharing embryological and vascular pathways. The association between different retinal signs and CeVD has been extensively evaluated. In this review, we summarize recent studies which have examined this association. Evidence Acquisition: We searched 6 databases through July 2019 for studies evaluating the link between retinal vascular signs and diseases...
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Background: Stroke is a common neurological disorder and may present with visual symptoms. A thorough workup is warranted to determine the underlying cause of stroke to optimize secondary prevention. Despite a full workup, a high-risk mechanism may not be identified. Optimal treatment in this patient population has been the subject of recent research, particularly with regard to low-risk stroke mechanisms such as patent foramen ovale (PFO). Evidence acquisition: Using PubMed and published...
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Abstract: Myelinated nerve fibers (MNF) are characterized as whitish, relatively sharply demarcated, feather-like structures located in the retinal nerve fiber layer. MNF are located quite frequently in contiguity with the optic nerve head. This may lead to a diagnostic dilemma by preventing clear visualization of the optic disc margins. We herein describe the utility of multicolor imaging (MCI) in identifying optic disc anatomy in a case of MNF contiguous to the disc. MCI and infrared reflectance...
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Background: Craniofacial autonomic signs and symptoms (CASS) are relatively underrecognized in the evaluation of migraine headache. Yet, these features provide insight into diagnostic criterion, therapeutic approaches, and overarching disease burden. Evidence Acquisition: This review aims to summarize relevant literature evaluating autonomic dysfunction, with focus on CASS, in migraine through targeted literature searches in PubMed. Full articles of original data published between 1974 and...
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Abstract: An 83-year-old man presented with a 1-year history of abducens palsy. Brain MRA revealed arterial dolichoectasia of most cerebral vessels, including the basilar, internal carotid, and middle cerebral arteries. Abducens nerve palsy as a sole manifestation of diffuse intracranial dolichoectasia is unusual but may occur in diffuse intracranial dolichoectasia.
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Abstract: Thyroid-associated ophthalmopathy (TAO) is an autoimmune component of Graves' disease for which no currently available medical therapy provides reliable and safe benefit. Based on insights generated experimentally over the past several decades, the insulin-like growth factor–I receptor (IGF-IR) has been implicated in the pathogenesis of TAO. Furthermore, an IGF-IR inhibitor, teprotumumab, has emerged from 2 clinical trials as a promising treatment for active, moderate to severe TAO....
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Abstract: A 19-year-old man presented with a 3-year history of episodic headaches, right hemiparesis, and progressive vision loss in both eyes. Initially, extensive laboratory testing was unrevealing. MRI later demonstrated progressive enlargement and enhancement of the left optic nerve poorly correlated with the timing of his clinical manifestations. There was no clinical or radiological response to treatment with corticosteroids, mycophenolate mofetil, or rituximab administered empirically for...
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Background: Spaceflight-associated neuro-ocular syndrome (SANS) was first described in 2011 and is associated with structural ocular changes found to occur in astronauts after long-duration missions. Despite multiple insufficient potential terrestrial models, an understanding of the etiology has yet to be described. Evidence Acquisition: A systematic review was conducted on literature published about the pathophysiology of cerebral edema. Databases searched include PubMed, Scopus, and the...
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In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: Adderley NJ, Subramanian A, Nirantharakumar K, Yiangou A, Gokhale KM, Mollan SP, Sinclair AJ. Association between idiopathic intracranial hypertension and risk of cardiovascular diseases in women in the United Kingdom. JAMA Neurol. [published ahead of print July 8, 2019] doi: 10.1001/jamaneurol.2019.1812.Touzé R, Gravellier B, Rolla-Bigliani C, Touitou V, Shotar E,...
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No abstract available
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