Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00209G, PaperErgin Yalcin, Cem Erkmen, Tuğba Taşkın-Tok, Mehmet Gokhan CaglayanIn this paper, we report a fluorescence sensor array approach for the urinary detection of a prohibited substance in sport, meldonium. Four chemosensors with ethidium bromide scaffold were employed in...The content of this RSS Feed (c) The Royal Society of Chemistry
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Related ArticlesEpiglottic granular cell tumour: a case report and literature review. J Surg Case Rep. 2020 Feb;2020(2):rjaa009 Authors: Bouayyad S, Ong J, Bouayyad H, Woodun H Abstract Granular cell tumour is a rare, benign tumour that may arise in the soft tissues of various locations. It is often asymptomatic; hence, it gets misdiagnosed as other conditions. This is a case of an asymptomatic 50-year-old male with an incidental finding of a supraglottic...
Thu Feb 27, 2020 13:49
Related ArticlesJuvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management - A Developing Country Review. Pediatric Health Med Ther. 2020;11:39-46 Authors: Seedat RY Abstract Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV), usually HPV types 6 and 11, which is characterized by recurrent papillomas of the respiratory tract, mainly the larynx. Patients usually present between the ages of...
Thu Feb 27, 2020 13:49
Related ArticlesThe Effect of Long-Term Use of an Eyewash Solution on the Ocular Surface Mucin Layer. Int J Mol Sci. 2019 Oct 13;20(20): Authors: Yazu H, Kozuki N, Dogru M, Shibasaki A, Fujishima H Abstract The use of eyewash solutions in Japan, especially in patients with allergic conjunctivitis and contact lens wearers, has been increasing. Our aim was to investigate how the use of preservative-free eyewash solution in healthy eyes for one month affects...
Thu Feb 27, 2020 13:49
Related ArticlesChronic obstructive pulmonary disease upper airway microbiome is associated with select clinical characteristics. PLoS One. 2019;14(7):e0219962 Authors: Pragman AA, Knutson KA, Gould TJ, Hodgson SW, Isaacson RE, Reilly CS, Wendt CH Abstract BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disorder associated with lung microbiome dysbiosis. Although the upper airway microbiome is the source of the lung...
Thu Feb 27, 2020 13:49
Related ArticlesPreterm birth: Born too soon for the developing airway epithelium? Paediatr Respir Rev. 2019 Aug;31:82-88 Authors: Looi K, Evans DJ, Garratt LW, Ang S, Hillas JK, Kicic A, Simpson SJ Abstract Birth prior to term interrupts the normal development of the respiratory system and consequently results in poor respiratory outcomes that persist throughout childhood. The mechanisms underpinning these poor respiratory outcomes are not well understood,...
Thu Feb 27, 2020 13:49
Related ArticlesNegative pressure pulmonary edema after vocal augmentation. J Formos Med Assoc. 2019 Jul;118(7):1166-1167 Authors: Huang YC, Lin HY, Huang TT, Lan MC PMID: 31014925 [PubMed - indexed for MEDLINE]
Thu Feb 27, 2020 13:49
Introduction: The determination of the tinnitus pitch-match (PM) frequency is not straightforward but an important audiological assessment recommended for clinical and research purposes. We evaluated repetitive recursive matching using an iPod-based matching procedure as a method to estimate a patient’s PM frequency without audiometric equipment. Methods: One hundred and seventeen patients with chronic tonal tinnitus (uni- and bilateral tinnitus) measured their tinnitus in 10 sessions using a self-administered...
Thu Feb 27, 2020 11:27
Abstract This study provided the benchmark statistics on medically treated patients with non‐small cell (NSCLC) and small cell (SCLC) lung cancer in Japan. Demographic background, treatment, and prognosis were obtained from patients with lung cancer pathologically diagnosed in 2012, who received non‐surgical treatment. Descriptive statistics and their associations with survival were analyzed. A total of 12320 patients were registered from 314 institutions in Japan. The median age was 70 years, and...
Thu Feb 27, 2020 13:47
Abstract The CDK4/6‐cyclin D1‐Rb‐p16/ink4a pathway is responsible for regulating cell progression past the G1 restriction point during the cell cycle. The development of a majority of human tumors is associated with dysregulation of this pathway, resulting in increased cancer cell proliferation. CDK4 and CDK6, well‐validated cancer drug targets, function primarily as catalytic enzymes which mediate the phosphorylation of retinoblastoma protein (Rb). Here, we performed SPH3643 as a novel potent anti‐proliferative...
Thu Feb 27, 2020 13:47
Thu Feb 27, 2020 13:47
Related ArticlesMemristive synapses connect brain and silicon spiking neurons. Sci Rep. 2020 Feb 25;10(1):2590 Authors: Serb A, Corna A, George R, Khiat A, Rocchi F, Reato M, Maschietto M, Mayr C, Indiveri G, Vassanelli S, Prodromakis T Abstract Brain function relies on circuits of spiking neurons with synapses playing the key role of merging transmission with memory storage and processing. Electronics has made important advances to emulate neurons and...
Thu Feb 27, 2020 13:46
Related ArticlesThe utility of thrombophilia testing in patients with newly diagnosed portal vein thrombosis. Blood Coagul Fibrinolysis. 2020 Feb 25;: Authors: Tremblay D, Naymagon L, Troy K, Cromwell C, Edwards C, Schiano T, Kremyanskaya M, Mascarenhas J Abstract : Thrombophilia testing is frequently performed in both seemingly provoked and unprovoked portal vein thrombosis (PVT), yet the clinical implications of these expensive laboratory tests are...
Thu Feb 27, 2020 13:45
Related ArticlesRadiomics: from qualitative to quantitative imaging. Br J Radiol. 2020 Feb 26;:20190948 Authors: Rogers W, Thulasi Seetha S, Refaee TAG, Lieverse RIY, Granzier RWY, Ibrahim A, Keek SA, Sanduleanu S, Primakov SP, Beuque MPL, Marcus D, van der Wiel AMA, Zerka F, Oberije CJG, van Timmeren JE, Woodruff HC, Lambin P Abstract Historically, medical imaging has been a qualitative or semi-quantitative modality. It is difficult to quantify what...
Thu Feb 27, 2020 13:45
Related ArticlesDosimetric characterization of a body-conforming radiochromic sheet. J Appl Clin Med Phys. 2020 Feb 26;: Authors: Wang YF, Dona O, Liu K, Adamovics J, Wuu CS Abstract PURPOSE: A novel radiochromic PRESAGE sheet (Heuris Inc.) with 3 mm thickness has been developed as a measurement tool for 2D dosimetry. Its inherent ability to conform to irregular surfaces makes this dosimeter advantageous for patient surface dosimetry. This study is a...
Thu Feb 27, 2020 13:45
Related ArticlesDeveloping agents for the therapeutic prevention of melanoma: can the assessment of cutaneous precursor lesions help? Future Oncol. 2020 Feb 26;: Authors: Maguire WF, Kirkwood JM PMID: 32100570 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 13:45
Related ArticlesMolecular mechanisms underlying rheumatoid arthritis and cancer development and treatment. Future Oncol. 2020 Feb 26;: Authors: Morand S, Staats H, Creeden JF, Iqbal A, Kahaleh B, Stanbery L, Dworkin L, Nemunaitis J Abstract Given recent advances in cancer immune therapy, specifically use of checkpoint inhibitors, understanding the link between autoimmunity and cancer is essential. Rheumatoid arthritis (RA) affects about 1% of the population,...
Thu Feb 27, 2020 13:45
Related ArticlesGut microbiota and cancer immunotherapy: prognostic and therapeutic implications. Future Oncol. 2020 Feb 26;: Authors: Guven DC, Aktas BY, Simsek C, Aksoy S Abstract The immune checkpoint inhibitors have opened new horizons in oncology. Although the indications for the use of Immune checkpoint inhibitors in cancer patients are expanding, there is still a need for markers that can aid in patient selection. Gastrointestinal microbiota can...
Thu Feb 27, 2020 13:45
Related ArticlesEstablishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. Cancer Cell Int. 2020;20:58 Authors: Oyama R, Kito F, Takahashi M, Hattori E, Noguchi R, Takai Y, Sakumoto M, Qiao Z, Toki S, Sugawara M, Tanzawa Y, Kobayashi E, Nakatani F, Iwata S, Yoshida A, Kawai A, Kondo T Abstract Background: Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of soft-tissue sarcoma,...
Thu Feb 27, 2020 13:45
Related ArticlesFeasibility Study of Adjuvant Chemotherapy with Carboplatin and Nab-Paclitaxel for Completely Resected NSCLC. Cancer Manag Res. 2020;12:777-782 Authors: Katsurada N, Tachihara M, Hatakeyama Y, Koyama K, Yumura M, Kiriu T, Dokuni R, Hazama D, Tokunaga S, Tamura D, Nakata K, Yamamoto M, Kamiryo H, Kobayashi K, Tanaka Y, Maniwa Y, Nishimura Y Abstract Purpose: Adjuvant chemotherapy with cisplatin (CDDP) plus vinorelbine is the standard regimen...
Thu Feb 27, 2020 13:45
Related ArticlesMicroRNA 885-5p Inhibits Hepatocellular Carcinoma Metastasis by Repressing AEG1. Onco Targets Ther. 2020;13:981-988 Authors: Li C, Wang X, Song Q Abstract Background: Hepatocellular carcinoma (HCC) is the third major cause of cancer-related death. Mounting evidence shows that microRNAs play critical roles in the initiation and progression of HCC and may potentially serve as diagnostic markers for HCC. Methods and Results: In...
Thu Feb 27, 2020 13:45
Related ArticlesRecent Progress of Nanoscale Metal-Organic Frameworks in Cancer Theranostics and the Challenges of Their Clinical Application. Int J Nanomedicine. 2019;14:10195-10207 Authors: Sun W, Li S, Tang G, Luo Y, Ma S, Sun S, Ren J, Gong Y, Xie C Abstract The growing incidence of cancer raises an urgent need to develop effective diagnostic and therapeutic strategies. With the rapid development of nanomedicine, nanoscale metal-organic frameworks...
Thu Feb 27, 2020 13:45
Related ArticlesCurrent evidence and future perspectives of immune-checkpoint inhibitors in unresectable malignant pleural mesothelioma. J Immunother Cancer. 2020 Feb;8(1): Authors: Hotta K, Fujimoto N Abstract Platinum-based chemotherapy is commonly used as the standard first-line treatment for unresectable malignant pleural mesothelioma (MPM). However, in recent times, immune-checkpoint inhibitors (ICIs) have led to a paradigm shift. Herein, we review...
Thu Feb 27, 2020 13:45
Related ArticlesCarcinogenic roles and therapeutic effects of EZH2 in gynecological cancers. Bioorg Med Chem. 2020 Feb 17;:115379 Authors: Wan Z, Jiang H, Li L, Zhu S, Hou J, Yu Y Abstract Enhancer of Zeste Homolog 2 (EZH2) is highly expressed in kinds of malignant tumors and related to tumor occurrence, development, and prognosis. EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which promotes cell proliferation, migration,...
Thu Feb 27, 2020 13:45
Related ArticlesFAM136A immunoreactivity is associated with nodal involvement and survival in lung adenocarcinoma in a Chinese case series. Bioengineered. 2020 Feb 26;: Authors: Zhao L, Ge C, Zhang Z, Hu H, Zhang Y, Zhao W, Li R, Zeng B, Song X, Li G Abstract Lung cancer patients with lymph node metastasis usually had short overall survival and occurred distant metastases at the early stage. However, some of these people did have more prolonged survival....
Thu Feb 27, 2020 13:45
Related ArticlesRegulated differentiation of stem cells into an artificial 3D liver as a transplantable source. Clin Mol Hepatol. 2020 Feb 27;: Authors: Chen F, Wang H, Xiao J Abstract End-stage liver disease is one of the leading causes of death around the world. Since insufficient sources of transplantable liver and possible immune rejection severely hinder the wide application of conventional liver transplantation therapy, artificial three-dimensional...
Thu Feb 27, 2020 13:45
Related ArticlesUnmet supportive care needs among people with cancer: A cross-cultural comparison between Indigenous and Non-Indigenous Australians. Eur J Cancer Care (Engl). 2019 Sep;28(5):e13080 Authors: Bernardes CM, Beesley V, Martin J, Sabesan S, Baade P, Meiklejohn JA, Garvey G, Valery PC Abstract OBJECTIVES: This study describes and compares the unmet supportive care needs between Indigenous and Non-Indigenous people with cancer. METHODS:...
Thu Feb 27, 2020 13:45
Related ArticlesRevisiting the Relationship Between Hospital Case Volume and Outcomes in Abdominally Based Free Flap Breast Reconstruction. Ann Plast Surg. 2020 Feb 25;: Authors: Chattha A, Chen AD, Muste J, Cohen JB, Lee BT, Lin SJ Abstract BACKGROUND: Increased operative volume has been associated with benefits in patient outcomes for a variety of surgical procedures. In autologous abdominally based breast reconstruction, however, there are few studies...
Thu Feb 27, 2020 13:42
Related ArticlesChanges in Lid Crease Measurements in Levator Advancement for Ptosis. Ann Plast Surg. 2020 Feb 25;: Authors: Alkeswani A, Hataway F, Westbrook B, Gulamani S, Collawn SS Abstract PURPOSE: Although previous reports addressed the differences in marginal reflex distance 1 (MRD-1) measurements based on various techniques of levator advancement, eyelid crease measurements have not been studied as markers in perioperative planning. In addition...
Thu Feb 27, 2020 13:42
Related ArticlesEvaluating the Necessity of Capsulectomy in Cases of Textured Breast Implant Replacement. Ann Plast Surg. 2020 Feb 25;: Authors: Swanson E Abstract BACKGROUND: Capsulectomy has traditionally been recommended as a treatment for capsular contracture after breast augmentation. With the advent of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL), and the Food and Drug Administration's decision to ban Biocell textured devices,...
Thu Feb 27, 2020 13:42
Related ArticlesThe Superiorly Based Partial Rectus Abdominis and External Oblique Flap for Lower Pole Coverage in Prosthetic Breast Reconstruction: A Prospective Cohort Study of 47 Consecutive Flaps. Ann Plast Surg. 2020 Feb 25;: Authors: Lam QTK, Nowicki J, Crittenden T, Howes BHL, Dean NR Abstract BACKGROUND: This study evaluated health related quality of life and morbidity in patients who had a superiorly based partial rectus abdominis and external...
Thu Feb 27, 2020 13:42
Related ArticlesThe Cost of the "July Effect" in Microsurgery. Ann Plast Surg. 2020 Feb 25;: Authors: Ayyala HS, Weisberger JS, Malhotra R, Lee ES Abstract The existence of the "July effect," or the idea that the new academic year intrinsically has an increased complication rate is evaluated in microsurgical free tissue transfer procedures. The National Surgical Quality Improvement Program registry was queried for all free flap procedures performed between...
Thu Feb 27, 2020 13:42
Related ArticlesMastopexy: Current Trends in Private Practice and Academic Practice and the Impact on Resident Training. Ann Plast Surg. 2020 Feb 25;: Authors: Cohen-Shohet R, Bloom J, Mast B Abstract INTRODUCTION: Training residents for cosmetic surgery is challenging. This study's goal is to identify the mastopexy spectrum, comparing private and academic practice, and determine the impact on resident training and readiness. METHODS: An institutional...
Thu Feb 27, 2020 13:42
Related ArticlesDiscovery of drugs that directly target the intrinsically disordered region of the androgen receptor. Expert Opin Drug Discov. 2020 Feb 26;:1-10 Authors: Sadar MD Abstract Introduction: Intrinsically disordered proteins (IDPs) and regions (IDRs) lack stable three-dimensional structure making drug discovery challenging. A validated therapeutic target for diseases such as prostate cancer is the androgen receptor (AR) which has a disordered...
Thu Feb 27, 2020 13:40
Related ArticlesEffects of Cocaine Exposure on Astrocytic Glutamate Transporters and Relapse-Like Ethanol-Drinking Behavior in Male Alcohol-Preferring Rats. Alcohol Alcohol. 2020 Feb 25;: Authors: Hammad AM, Sari Y Abstract AIM: Glutamate has been considered as neurotransmitter that is critical in triggering relapse to drugs of abuse, including ethanol and cocaine. Extracellular glutamate concentrations are tightly regulated by several mechanisms, including...
Thu Feb 27, 2020 13:39
Related ArticlesRapid adaptation of signaling networks in the fungal pathogen Magnaporthe oryzae. BMC Genomics. 2019 Oct 22;20(1):763 Authors: Bohnert S, Antelo L, Grünewald C, Yemelin A, Andresen K, Jacob S Abstract BACKGROUND: One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. "Loss of function" (lof) mutants from components of the high osmolarity glycerol (HOG) signaling pathway in the filamentous...
Thu Feb 27, 2020 13:39
Related ArticlesEffect of PEGylated Magnetic PLGA-PEI Nanoparticles on Primary Hippocampal Neurons: Reduced Nanoneurotoxicity and Enhanced Transfection Efficiency with Magnetofection. ACS Appl Mater Interfaces. 2019 Oct 16;11(41):38190-38204 Authors: Cui Y, Li X, Zeljic K, Shan S, Qiu Z, Wang Z Abstract Despite broad application of nanotechnology in neuroscience, the nanoneurotoxicity of magnetic nanoparticles in primary hippocampal neurons remains...
Thu Feb 27, 2020 13:39
Related ArticlesTopography of Simulated Intestinal Equilibrium Solubility. Mol Pharm. 2019 05 06;16(5):1890-1905 Authors: Dunn C, Perrier J, Khadra I, Wilson CG, Halbert GW Abstract Oral administration of a solid dosage form requires drug dissolution in the gastrointestinal tract before absorption. Solubility is a key factor controlling dissolution, and it is recognized that, within the intestinal tract, this is influenced by the luminal fluid pH,...
Thu Feb 27, 2020 13:39
Publication date: Available online 26 February 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Suissa Laurent, Panicucci Emilie, Perot Charline, Romero Gwendoline, Gazzola Sébastien, Laksiri Nadia, Rey Caroline, Doche Emilie, Mahagne Marie-Hélène, Pelletier Jean, Faivre Anthony, Robinet-Borgomano Emmanuelle
Thu Feb 27, 2020 13:37
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