Abstract Background Diagnosis and treatment of presumed laryngopharyngeal reflux (LPR) remains controversial. Empiric medication trials remain widespread for suspected LPR despite emerging evidence against proton pump inhibitor (PPI) safety and for pepsin as a mediator of LPR symptoms. Ongoing concerns exist related to inaccurate diagnosis, the cost and morbidity of potentially unnecessary PPI prescriptions, and availability and interpretation of objective reflux testing. Objectives To...
Thu Feb 27, 2020 16:23
Syphilis was first recognized in Europe in the late 15th century; its cause, Treponema pallidum subspecies pallidum, was identified four centuries later. The advent of penicillin, together with effective public health measures, was responsible for a marked decline in syphilis in the United States…
Thu Feb 27, 2020 02:00
Publication date: Available online 26 February 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Lingyue Sun, Wendy Smith, Charles Kirkby
Thu Feb 27, 2020 16:17
Publication date: Available online 26 February 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Bjørg Y. Aksnessæther, Tor Åge Myklebust, Arne Solberg, Olbjørn H. Klepp, Eva Skovlund, Solveig Roth Hoff, Sophie D. Fosså, Anders Widmark, Jo-Åsmund Lund
Thu Feb 27, 2020 16:17
Publication date: Available online 26 February 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Sezin Yuce Sari, Aysenur Elmali, Serkan Arslan, Gokhan Ozyigit
Thu Feb 27, 2020 16:17
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Alina Zalounina Falborg, Peter Vedsted, Usha Menon, David Weller, Richard D. Neal, Irene Reguilon, Samantha Harrison, Henry Jensen, ICBP Module 4 Working Group
Thu Feb 27, 2020 16:10
Preheart failure comorbidities and impact on prognosis in heart failure patients: a nationwide study
Abstract Background Data regarding the impact of preheart failure (HF) comorbidities on the prognosis of HF are scarce, especially in the younger HF patients. Objectives To investigate pre‐existing comorbidities in HF patients versus matched controls and to assess their impact on mortality. Methods We included all first‐time in‐hospital and outpatient diagnoses of HF from 1995 to 2017, and comorbidities antedating the HF‐diagnosis in the Danish nationwide registries. HF...
Thu Feb 27, 2020 16:04
Background Aspirin‐exacerbated respiratory disease (AERD) refers to the combination of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute respiratory tract reactions to ingestion of aspirin and nonsteroidal anti‐inflammatory drugs (NSAIDs). There have been no in the literature investigating diagnostic delay in AERD. We aimed to investigate whether delay of diagnosis of AERD is associated with poorer clinical outcomes as well as to characterize the role of specialty evaluation...
Thu Feb 27, 2020 16:03
Background Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion‐dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis. Methods A modified Delphi method was used to establish a consensus opinion among rhinology experts of the current evidence for efficacy, potential harm,...
Thu Feb 27, 2020 16:03
Background The lateral nasal wall (LNW) flap provides vascularized endonasal reconstruction primarily in revision surgery. Although the harvesting technique and reconstructive surface have been reported, the arterial supply to the LNW flap and its clinical implications is not well defined. This study presents anatomical dissections to clarify the vascular supply to this flap, and the associated clinical outcomes from this reconstructive technique. Methods The course and branching pattern of...
Thu Feb 27, 2020 16:03
Background Inverted papilloma (IP) is a benign epithelial tumor of the sinonasal cavity that is locally aggressive and has a propensity for recurrence. Tumors involving the anterior maxillary sinus can be challenging to reach endoscopically, and have historically been approached through a Caldwell‐Luc or canine fossa trephination. We present a case series of 22 patients with maxillary IPs originating from the anterior wall, which were successfully resected using a modified endoscopic Denker (MED)...
Thu Feb 27, 2020 16:03
Background Patients undergoing endoscopic resection of neoplasms with both sinonasal and skull base involvement can develop chronic rhinosinusitis (CRS) after treatment and may occasionally benefit from additional endoscopic sinus surgery (ESS). We investigate risk factors and outcomes associated with revision ESS (rESS) after endoscopic skull‐base surgery (SBS) for neoplasms with combined sinonasal and skull base involvement. Methods A retrospective review of patients with neoplasms with...
Thu Feb 27, 2020 16:03
Background All‐trans retinoic acid (ATRA), a derivative of vitamin A, is known to have anti‐fibrogenic effects and regulates cell proliferation and differentiation. Therefore, these abilities of ATRA may influence tissue remodeling in the upper airway. The aims of the present study were to investigate the effects of ATRA on the myofibroblast differentiation, extracellular matrix (ECM) production, cell migration, and collagen gel contraction and to determine the molecular mechanisms of ATRA in TGF‐β1‐induced...
Thu Feb 27, 2020 16:03
Impact of induction chemotherapy and socioeconomics on sinonasal undifferentiated carcinoma survival
Background Sinonasal undifferentiated carcinoma (SNUC) is an uncommon malignancy of the nasal cavity and accessory sinuses with limited available studies evaluating role of induction chemotherapy (IC), demographics, and socioeconomic factors on overall survival (OS). Methods The 2004‐2015 National Cancer Database was queried for patients with histologically confirmed SNUC. IC was defined as chemotherapy administered 6 months to 2 weeks before surgery or ≥45 days before radiotherapy. Results...
Thu Feb 27, 2020 16:03
Background Both the prevalence of sinonasal inverted papilloma (IP) and the causal association with alpha‐human papillomaviruses (alpha‐HPVs) are controversial. In this study we aimed to determine HPV status in histologically selected, microdissected, formalin‐fixed, and paraffin‐embedded tissue samples of IP. Methods HPV status was assessed retrospectively by polymerase chain reaction (PCR)‐bead‒based multiplex genotyping on tissue samples of patients diagnosed with IP and consecutively treated...
Thu Feb 27, 2020 16:03
Background The 2016 International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS) is a collaborative distillation of available research and consensus recommendations for the management for chronic rhinosinusitis (CRS). However, implementation of the ICAR:RS recommendations in the reality of clinical practice is not clearly defined. Methods An anonymous, web‐based survey of the American Rhinologic Society membership was performed in October, 2018. Respondents were asked...
Thu Feb 27, 2020 16:03
Thu Feb 27, 2020 16:03
Background Chronic nasal congestion affects 20% of the population with significant impact on quality of life. This study investigated the simultaneous administration of nasal acoustic vibration and oscillating expiratory pressure for the treatment of nasal congestion. Methods Patients with chronic nasal congestion but without fixed anatomic obstruction participated in a prospective clinical study applying simultaneous acoustic vibrations and positive expiratory pressure to the nasal cavity...
Thu Feb 27, 2020 16:03
Publication date: Available online 26 February 2020Source: Academic RadiologyAuthor(s): Han-Wen Zhang, Juan Yu, Hua-Jian Xu, Yi Lei, Zu-Hui Pu, Wei-Cai Dai, Fan Lin, Yu-Li Wang, Xiao-Liu Wu, Li-Hong Liu, Min Li, Yong-Qian Mo, Hong Zhang, Si-Ping Luo, Huan Chen, Gui-Wen Lyu, Zhao-Guang Zhou, Wei-Min Liu, Xiao-Lei Liu, Hai-Yan Song
Thu Feb 27, 2020 15:57
Publication date: Available online 26 February 2020Source: Academic RadiologyAuthor(s): Xiao-Yan Sun, Tian-Xiang Chen, Cheng Chang, Hao-Hua Teng, Chun Xie, Mao-Mei Ruan, Bei Lei, Liu Liu, Li-Hua Wang, Yun-Hai Yang, Wen-Hui Xie
Thu Feb 27, 2020 15:57
Related ArticlesThe effect of age, sex, race/ethnicity, health insurance, and food specific serum immunoglobulin E on outcomes of oral food challenges. World Allergy Organ J. 2020 Feb;13(2):100100 Authors: Dang AT, Chundi PK, Mousa NA, Beyer AI, Chansakulporn S, Venter C, Mersha TB, Assa'ad AH Abstract Background: Although oral food challenge (OFC) is an important clinical procedure for diagnosing food allergy, there is a paucity of literature on...
Thu Feb 27, 2020 15:57
Related ArticlesNovel salivary gland allergens from tropical mosquito species and IgE reactivity in allergic patients. World Allergy Organ J. 2020 Feb;13(2):100099 Authors: Opasawatchai A, Yolwong W, Thuncharoen W, Inrueangsri N, Itsaradisaikul S, Sasisakulporn C, Jotikasthira W, Matangkasombut O, Reamtong O, Manuyakorn W, Songnuan W, Matangkasombut P Abstract Background: Mosquito allergy is common in tropical countries but remains under-diagnosed....
Thu Feb 27, 2020 15:57
Related ArticlesContribution of sexual desire and motives to the compulsive use of cybersex. J Behav Addict. 2019 Sep 01;8(3):442-450 Authors: Brahim FB, Rothen S, Bianchi-Demicheli F, Courtois R, Khazaal Y Abstract BACKGROUND AND AIMS: Cybersex is increasingly associated with concerns about compulsive use. The aim of this study was to assess the roles of motives and sexual desire in the compulsive use of cybersex. METHODS: The sample consisted...
Thu Feb 27, 2020 15:54
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Kai Zhong, Rou-Xin Wang, Xiao-Dong Qian, Ping Yu, Xin-Ying Zhu, Qi Zhang, Yi-Lu Ye
Thu Feb 27, 2020 15:51
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Yan-Feng Zhang, Chen-Chen Sun, Jia-Xi Duan, Hui-Hui Yang, Chen-Yu Zhang, Jian-Bing Xiong, Wen-Jing Zhong, Cheng Zu, Xin-Xin Guan, Hui-Ling Jiang, Bruce D. Hammock, Sung Hee Hwang, Yong Zhou, Cha-Xiang Guan
Thu Feb 27, 2020 15:51
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Zhe Cai, Ming Hong, Lei Xu, Kedi Yang, Chentian Li, Tianhao Sun, Yu Feng, Huasong Zeng, William Weijia Lu, Kwong-Yuen Chiu
Thu Feb 27, 2020 15:51
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Wei Miao, Yong Yan, Tian-hao Bao, Wen-ji Jia, Fei Yang, Ying Wang, Yu-hong Zhu, Mei Yin, Jian-hong Han
Thu Feb 27, 2020 15:51
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Arkadiusz Czerwonka, Marta J. Fiołka, Katarzyna Jędrzejewska, Elżbieta Jankowska, Adrian Zając, Wojciech Rzeski
Thu Feb 27, 2020 15:51
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Dafeng Xu, Xiangmei Liu, Yu Wang, Kailun Zhou, Jincai Wu, Jia cheng Chen, Cheng Chen, Liang Chen, Jinfang Zheng
Thu Feb 27, 2020 15:51
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Wen Lei, Shibing Wang, Nengwen Xu, Yu Chen, Gongqiang Wu, Aibin Zhang, Xiaomin Chen, Yin Tong, Wenbin Qian
Thu Feb 27, 2020 15:51
Abstract In 2019, no lumpy skin disease (LSD) outbreaks were reported in South‐Eastern Europe, the mass vaccination regional campaign with homologous LSD vaccine continued for the fourth year with over 1.8 million bovines vaccinated in the region, preventing further outbreaks since 2016. LSD outbreaks were reported in Turkey, including western Turkey, in Russia and in eastern Asia affecting China, Bangladesh and India for the first time. The use of homologous vaccine should be considered in the...
Thu Feb 27, 2020 15:48
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Austria and co‐rapporteur Member State Lithuania for the pesticide active substance blood meal and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Commission Implementing Regulation...
Thu Feb 27, 2020 15:48
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Availa®Cr (active compound: chromium chelate of DL‐methionine) as a feed additive for dairy cows. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel was assigned to this mandate. The tolerance study did not show adverse effects with respect to body weight, milk yield, haematology and blood biochemistry up to the 10‐fold overdose...
Thu Feb 27, 2020 15:48
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Natugrain® TS/TS L. The additive is a preparation of endo‐1,4‐beta‐xylanase and endo‐1,4‐beta‐glucanase produced by two genetically modified strains of Aspergillus niger, and it is authorised for use in piglets (weaned) and pigs for fattening, poultry species and ornamental birds. The applicant...
Thu Feb 27, 2020 15:48
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Nissan Chemical Europe S.A.S. submitted two requests to the competent national authority in the Netherlands, respectively to modify the existing maximum residue level (MRL) in sweet pepper/bell pepper and to set an import tolerance in tree nuts for the active substance pyridaben. The data submitted in support of the requests were found to be sufficient to derive the MRL proposals of 0.3 mg/kg for sweet peppers/bell...
Thu Feb 27, 2020 15:48
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 when used as a nutritional additive in feed and water for drinking for all animal species. The active substance is l‐lysine and it is produced in two different forms (monohydrochloride or sulfate salts). None of those...
Thu Feb 27, 2020 15:48
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with a genetically modified strain of Escherichia coli CGMCC 7.267 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain E. coli CGMCC 7.267 is safe for the production of l‐tryptophan. No viable cells or DNA...
Thu Feb 27, 2020 15:48
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of saponified paprika extract, containing capsanthin as main carotenoid source, for poultry for fattening and laying (except turkeys). The saponified paprika (Capsicum annuum) extract contains various carotenoids at a concentration of 25–90 g/kg of which capsanthin being the major one with quantity...
Thu Feb 27, 2020 15:48
Abstract We calibrate a mathematical model of renal tubulointerstitial fibrosis by Hao et al. [1], which is used to explore potential drugs for Lupus Nephritis, against a real data‐set of 84 patients. For this purpose, we present a general calibration procedure which can be used for the calibration analysis of other biological systems as well. Central to the procedure is the idea of designing a Bayesian Gaussian process (GP) emulator that can be used as a surrogate of the fibrosis mathematical model...
Thu Feb 27, 2020 15:39
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