Publication date: Available online 26 February 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Cai-Ling Chen, Yin Yao, Li Pan, Si-Tao Hu, Jin Ma, Zhi-Chao Wang, Robert C. Kern, Robert P. Schleimer, Zheng Liu
Thu Feb 27, 2020 14:18
Publication date: Available online 26 February 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Liliana Portales-Cervantes, Owen M. Crump, Sarah Dada, Christopher R. Liwski, Jelena Gotovina, Ian D. Haidl, Jean S. Marshall
Thu Feb 27, 2020 14:18
Related ArticlesGenipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway. Drug Des Devel Ther. 2020;14:395-405 Authors: Wei M, Wu Y, Liu H, Xie C Abstract Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck, and it accounts for more than 90% of oral cancer. Due to high mortality, limitations of traditional treatment and many complications, new treatment...
Thu Feb 27, 2020 14:17
Related ArticlesDefining research priorities in dystonia. Neurology. 2020 Feb 25;: Authors: Lungu C, Ozelius L, Standaert D, Hallett M, Sieber BA, Swanson-Fisher C, Berman BD, Calakos N, Moore JC, Perlmutter JS, Pirio Richardson SE, Saunders-Pullman R, Scheinfeldt L, Sharma N, Sillitoe R, Simonyan K, Starr PA, Taylor A, Vitek J, participants and organizers of the NINDS Workshop on Research Priorities in Dystonia Abstract OBJECTIVE: Dystonia is a complex...
Thu Feb 27, 2020 14:17
Related ArticlesMolecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma. Cells. 2020 Feb 22;9(2): Authors: Wai KC, Strohl MP, van Zante A, Ha PK Abstract The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different...
Thu Feb 27, 2020 14:17
Related ArticlesAn Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. Mol Ther. 2019 07 03;27(7):1286-1298 Authors: Cho A, Park SR, Kim SR, Nam S, Lim S, Park CH, Lee HY, Hong IS Abstract Endometrial stem cells are located in the basal layer of the endometrium, and they are responsible for the cyclic regeneration of the uterus during the menstrual cycle. Recent studies have revealed that recurrent...
Thu Feb 27, 2020 14:17
Related Articles[Airway management of COVID-19 patients with severe pneumonia]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Feb 26;55(4):E001 Authors: Abstract Patients with severe and critical COVID-19 will develop into acute respiratory distress syndrome in a short time. Noninvasive or invasive positive pressure ventilation will be important means for those patients, which will help to improve the clinical cure rate and reduce the mortality....
Thu Feb 27, 2020 14:13
Related ArticlesThe protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):687-694 Authors: Jiao P, Li W, Shen L, Li Y, Yu L, Liu Z Abstract Lung diseases are common health problems in many countries. The dysfunction of bronchial epithelial cells is important for the development of lung...
Thu Feb 27, 2020 14:12
Placentas From Women of Advanced Maternal Age: An Independent Indication for Pathologic Examination?
Related ArticlesPlacentas From Women of Advanced Maternal Age: An Independent Indication for Pathologic Examination? Arch Pathol Lab Med. 2020 Feb 26;: Authors: Torous VF, Roberts DJ Abstract CONTEXT.—: The percentage of pregnant women with advanced maternal age (AMA) has increased during the past several decades due to various socioeconomic factors and advances in assisted reproduction. These pregnancies are associated with adverse maternal and fetal...
Thu Feb 27, 2020 14:08
Related ArticlesApixaban Does Not Interfere With Protein S or Activated Protein C Resistance (Factor V Leiden) Testing Using aPTT-Based Methods. Arch Pathol Lab Med. 2020 Feb 26;: Authors: Maryamchik E, Van Cott EM Abstract CONTEXT.—: Apixaban causes a false increase in activated protein C resistance (APCR) ratios and possibly protein S activity. OBJECTIVE.—: To investigate whether this increase can mask a diagnosis of factor V Leiden (FVL)...
Thu Feb 27, 2020 14:08
Related ArticlesHER2 Dual In Situ Hybridization: Correlations and Cautions. Arch Pathol Lab Med. 2020 Feb 26;: Authors: Troxell M, Sibley RK, West RB, Bean GR, Allison KH Abstract CONTEXT.—: Accurate HER2 testing in breast cancer is crucial for appropriate precision therapy. HER2 testing is most commonly accomplished by a combination of immunohistochemistry and in situ hybridization techniques, as gene amplification is closely tied to protein overexpression....
Thu Feb 27, 2020 14:08
Related ArticlesChallenges for Data Extraction From Narrative Pathology Reports. Arch Pathol Lab Med. 2020 Mar;144(3):273 Authors: Qu Z PMID: 32101060 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 14:08
Related ArticlesApplication and Pitfalls of Immunohistochemistry in Diagnosis of Challenging Genitourinary Cases. Arch Pathol Lab Med. 2020 Mar;144(3):290-304 Authors: Ross J, Li G, Yang XJ Abstract CONTEXT.—: Immunohistochemistry (IHC) has become increasingly important in the evaluation of pathologic conditions in the genitourinary (GU) organs. In addition to careful evaluation of hematoxylin-eosin sections and generation of a differential diagnosis,...
Thu Feb 27, 2020 14:08
Related ArticlesUpdates in Histologic Grading of Urologic Neoplasms. Arch Pathol Lab Med. 2020 Mar;144(3):335-343 Authors: Rice-Stitt T, Valencia-Guerrero A, Cornejo KM, Wu CL Abstract CONTEXT.—: Tumor histology offers a composite view of the genetic, epigenetic, proteomic, and microenvironmental determinants of tumor biology. As a marker of tumor histology, histologic grading has persisted as a highly relevant factor in risk stratification and management...
Thu Feb 27, 2020 14:08
Related ArticlesFrontiers in Genitourinary Pathology. Arch Pathol Lab Med. 2020 Mar;144(3):275-276 Authors: Huang J, Zhang L Abstract This special section includes 4 articles as the proceedings of the Fifth Princeton Integrated Pathology Symposium (PIPS): Genitourinary Pathology, and an update on neuroendocrine tumor of the prostate. The symposium took place at the Princeton Medical Center, Plainsboro, New Jersey, on Sunday April 15, 2018. We hope again...
Thu Feb 27, 2020 14:08
Related ArticlesUpdates in Staging and Reporting of Genitourinary Malignancies. Arch Pathol Lab Med. 2020 Mar;144(3):305-319 Authors: Cornejo KM, Rice-Stitt T, Wu CL Abstract CONTEXT.—: The 8th edition of the American Joint Committee on Cancer (AJCC) staging manual changed the tumor, node, metastasis (TNM) classification systems of genitourinary malignancies in 2017. However, some of the changes appear not well appreciated or recognized by practicing...
Thu Feb 27, 2020 14:08
Related ArticlesIn Reply. Arch Pathol Lab Med. 2020 Mar;144(3):273-274 Authors: Renshaw AA, Gould EW PMID: 32101055 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 14:08
Related ArticlesElective neck dissection in T1/T2 oral squamous cell carcinoma with N0 neck: essential or not? A systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2020 Feb 25;: Authors: Ibrahim SA, Ahmed ANA, Elsersy HA, Darahem IMH Abstract INTRODUCTION: Oral squamous cell carcinoma (SCC) is characterized by a high risk of cervical lymph node metastasis with a high incidence of occult metastasis. A strong debate is still present regarding...
Thu Feb 27, 2020 14:06
Related ArticlesThe vascularized fascia lata free flap: an anatomical study and clinical considerations. Eur Arch Otorhinolaryngol. 2020 Feb 25;: Authors: Janik S, Hirtler L, Traxler H, Weninger WJ, Seemann R, Erovic BM Abstract PURPOSE: Fascia lata (FL) is often used as fascial component of the anterolateral thigh (ALT) flap in head and neck reconstruction. No distinct data exist on whether the FL has its own reliable vascular supply and whether the...
Thu Feb 27, 2020 14:06
Related ArticlesThe elevation of the mucosal flap without additional anterior canal wall incisions for repairing anterior perforations using endoscopic cartilage tympanoplasty. Eur Arch Otorhinolaryngol. 2020 Feb 25;: Authors: Lou Z PMID: 32100131 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 14:06
Related ArticlesTumor control of cervical lymph node metastases of unknown primary origin: the impact of the radiotherapy target volume. Eur Arch Otorhinolaryngol. 2020 Feb 25;: Authors: Straetmans JMJAA, Stuut M, Wagemakers S, Hoebers F, Kaanders JHAM, Speel EJM, Melchers WJG, Slootweg P, Kremer B, Lacko M, Takes RP Abstract PURPOSE: Debate on the extent of treatment of neck metastasis of cancer of unknown primary tumors (CUPs) is still ongoing. In...
Thu Feb 27, 2020 14:06
Publication date: Available online 27 February 2020Source: Allergology InternationalAuthor(s): Yuji Higashimoto, Akiko Sano, Osamu Nishiyama, Hiroyuki Sano, Takashi Iwanaga, Ryuta Haraguchi, Yasutaka Chiba, Kanji Fukuda, Yuji Tohda
Thu Feb 27, 2020 14:04
Related ArticlesNeoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases. Cancer Biol Ther. 2020 Feb 26;:1-9 Authors: Dagenborg VJ, Marshall SE, Yaqub S, Grzyb K, Boye K, Lund-Iversen M, Høye E, Berstad AE, Fretland ÅA, Edwin B, Ree AH, Flatmark K Abstract Patients with colorectal liver metastases (CLM) commonly receive neoadjuvant chemotherapy (NACT) prior to...
Thu Feb 27, 2020 14:01
Related ArticlesReply to Desikan et al.: Micelle formation among various mechanisms of toxin pore formation. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Vögele M, Bhaskara RM, Mulvihill E, van Pee K, Yildiz Ö, Kühlbrandt W, Müller DJ, Hummer G PMID: 32098852 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 14:00
Related ArticlesTopological data analysis of zebrafish patterns. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: McGuirl MR, Volkening A, Sandstede B Abstract Self-organized pattern behavior is ubiquitous throughout nature, from fish schooling to collective cell dynamics during organism development. Qualitatively these patterns display impressive consistency, yet variability inevitably exists within pattern-forming systems on both microscopic and macroscopic...
Thu Feb 27, 2020 14:00
Related ArticlesPhotoperiod and temperature separately regulate nymphal development through JH and insulin/TOR signaling pathways in an insect. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Miki T, Shinohara T, Chafino S, Noji S, Tomioka K Abstract Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific...
Thu Feb 27, 2020 14:00
Related ArticlesTiming of fungal spore release dictates survival during atmospheric transport. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Lagomarsino Oneto D, Golan J, Mazzino A, Pringle A, Seminara A Abstract Fungi disperse spores to move across landscapes and spore liberation takes different patterns. Many species release spores intermittently; others release spores at specific times of day. Despite intriguing evidence of periodicity, why (and...
Thu Feb 27, 2020 14:00
Related ArticlesRadiative absorption enhancements by black carbon controlled by particle-to-particle heterogeneity in composition. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Fierce L, Onasch TB, Cappa CD, Mazzoleni C, China S, Bhandari J, Davidovits P, Fischer DA, Helgestad T, Lambe AT, Sedlacek AJ, Smith GD, Wolff L Abstract Black carbon (BC) absorbs solar radiation, leading to a strong but uncertain warming effect on climate. A key challenge...
Thu Feb 27, 2020 14:00
Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis.
Related ArticlesAlterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Lion M, Muhire B, Namiki Y, Tolstorukov MY, Oettinger MA Abstract Developing lymphocytes diversify their antigen receptor (AgR) loci by variable (diversity) joining (V[D]J) recombination. Here, using the micrococcal nuclease (MNase)-based chromatin accessibility (MACC) assay with low-cell...
Thu Feb 27, 2020 14:00
Related ArticlesFootprints of natural selection at the mannose-6-phosphate isomerase locus in barnacles. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Nunez JCB, Flight PA, Neil KB, Rong S, Eriksson LA, Ferranti DA, Rosenblad MA, Blomberg A, Rand DM Abstract The mannose-6-phosphate isomerase (Mpi) locus in Semibalanus balanoides has been studied as a candidate gene for balancing selection for more than two decades. Previous work has shown that Mpi...
Thu Feb 27, 2020 14:00
Related ArticlesDesigning heterotropically activated allosteric conformational switches using supercharging. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Schnatz PJ, Brisendine JM, Laing CC, Everson BH, French CA, Molinaro PM, Koder RL Abstract Heterotropic allosteric activation of protein function, in which binding of one ligand thermodynamically activates the binding of another, different ligand or substrate, is a fundamental control mechanism...
Thu Feb 27, 2020 14:00
Related ArticlesLate-life costs of raising sons in bighorn sheep. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Froy H, Gamelon M PMID: 32098844 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 14:00
Related ArticlesThe habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Antolin-Fontes B, Li K, Ables JL, Riad MH, Görlich A, Williams M, Wang C, Lipford SM, Dao M, Liu J, Molina H, Heintz N, Kenny PJ, Ibañez-Tallon I Abstract The habenula, an ancient small brain area in the epithalamus, densely expresses nicotinic acetylcholine receptors and is critical for nicotine...
Thu Feb 27, 2020 14:00
Related ArticlesOpening of smaller toxin pores by lipid micelle formation. Proc Natl Acad Sci U S A. 2020 Feb 25;: Authors: Desikan R, Padmanabhan P, Ayappa KG PMID: 32098842 [PubMed - as supplied by publisher]
Thu Feb 27, 2020 14:00
Related ArticlesImpact of radiological morphology of clinical T1 renal cell carcinoma on the prediction of upstaging to pathological T3. Jpn J Clin Oncol. 2020 Feb 26;: Authors: Teishima J, Hayashi T, Kitano H, Sadahide K, Sekino Y, Goto K, Inoue S, Honda Y, Sentani K, Awai K, Yasui W, Matsubara A Abstract OBJECTIVES: Previous studies have reported that cases with clinical T1 renal cell cancer upstaging to pathological T3 are a risk factor to predicting...
Thu Feb 27, 2020 13:59
Related ArticlesProphylactic donor lymphocyte infusion for relapse prevention: a meta-analysis. Jpn J Clin Oncol. 2020 Feb 25;: Authors: Poonsombudlert K, Kewcharoen J, Prueksapraopong C, Limpruttidham N Abstract OBJECTIVE: Primary disease relapse (PDR) of malignant hematologic conditions after standard hematopoietic stem cell transplant (HSCT) is one of the most challenging diseases; therefore ongoing researches are aiming at relapse prevention and...
Thu Feb 27, 2020 13:59
A 62-year-old woman presented to the emergency department with a 2-month history of jaundice 3 months after having undergone orthotopic liver transplantation for primary biliary cirrhosis. Laboratory studies showed a total bilirubin level of 14.3 mg per deciliter (245 μmol per liter) (normal range,…
Thu Feb 27, 2020 02:00
A 66-year-old man presented to the emergency department with a 4-day history of shortness of breath and swelling in the legs. He also reported feeling fatigued and having had a recent 15-kg weight loss. A transthoracic echocardiogram showed a mass in the right atrium that appeared to be…
Thu Feb 27, 2020 02:00
Related ArticlesLongitudinal impacts of an online safety and health intervention for women experiencing intimate partner violence: randomized controlled trial. BMC Public Health. 2020 Feb 26;20(1):260 Authors: Ford-Gilboe M, Varcoe C, Scott-Storey K, Perrin N, Wuest J, Wathen CN, Case J, Glass N Abstract BACKGROUND: Responding to intimate partner violence (IPV) and its consequences is made complex by women's diverse needs, priorities and contexts. Tailored...
Thu Feb 27, 2020 13:57
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