IJMS, Vol. 21, Pages 1516: Understanding Mechanisms of Salinity Tolerance in Barley by Proteomic and Biochemical Analysis of Near-Isogenic Lines International Journal of Molecular Sciences doi: 10.3390/ijms21041516 Authors: Juan Zhu Yun Fan Sergey Shabala Chengdao Li Chao Lv Baojian Guo Rugen Xu Meixue Zhou Salt stress is one of the major environmental factors impairing crop production. In our previous study, we identified a major QTL for salinity tolerance on chromosome...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1515: A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21041515 Authors: Wang Yang Liu Chun-kit Tong Zhu Malampati Gopalkrishnashetty Sreenivasmurthy Cheung Iyaswamy Su Lu Song Li Abstract: TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, is considered to be a new...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1514: Influence of Exercise Training on Skeletal Muscle Insulin Resistance in Aging: Spotlight on Muscle Ceramides International Journal of Molecular Sciences doi: 10.3390/ijms21041514 Authors: Reidy Mahmassani McKenzie Petrocelli Summers Drummond : Intramuscular lipid accumulation has been associated with insulin resistance (IR), aging, diabetes, dyslipidemia, and obesity. A substantial body of evidence has implicated ceramides, a sphingolipid...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1512: Dynamics of the Transcriptome Response to Heat in the Moss, Physcomitrella patens International Journal of Molecular Sciences doi: 10.3390/ijms21041512 Authors: Elzanati Mouzeyar Roche Thermal stress negatively impacts crop yields, and as the overall temperature of the earth’s atmosphere is gradually increasing, the identification of the temperature transduction pathway of the heat signal is essential in developing new strategies in order...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1513: Root Response to Drought Stress in Rice (Oryza sativa L.) International Journal of Molecular Sciences doi: 10.3390/ijms21041513 Authors: Kim Chung Lee Tripathi Heo Kim The current unpredictable climate changes are causing frequent and severe droughts. Such circumstances emphasize the need to understand the response of plants to drought stress, especially in rice, one of the most important grain crops. Knowledge of the drought stress response...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1510: Green Synthesis of Silver Nanoparticles Using Pseudoduganella eburnea MAHUQ-39 and Their Antimicrobial Mechanisms Investigation against Drug Resistant Human Pathogens International Journal of Molecular Sciences doi: 10.3390/ijms21041510 Authors: Md. Amdadul Huq Silver nanoparticles (AgNPs) have shown great promise in biomedical applications. The exact mechanism and mode of action of AgNPs regarding antimicrobial activity are still not well known. Moreover,...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1511: The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection International Journal of Molecular Sciences doi: 10.3390/ijms21041511 Authors: Nícia Rosário-Ferreira António J. Preto Rita Melo Irina S. Moreira Rui M. M. Brito Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1509: GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease–A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21041509 Authors: Mori Matsui Hirano Yamagishi Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut hormones that are secreted from enteroendocrine L cells and K cells in response to digested nutrients, respectively. They are also referred to...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1507: Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme International Journal of Molecular Sciences doi: 10.3390/ijms21041507 Authors: Marek Mazurek Jakub Litak Piotr Kamieniak Ida Osuchowska Ryszard Maciejewski Jacek Roliński Wiesława Grajkowska Cezary Grochowski Based on genome sequencing, it is estimated that over 90% of genes stored in human genetic...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1508: LDAI-ISPS: LncRNA–Disease Associations Inference Based on Integrated Space Projection Scores International Journal of Molecular Sciences doi: 10.3390/ijms21041508 Authors: Yi Zhang Min Chen Ang Li Xiaohui Cheng Hong Jin Yarong Liu Long non-coding RNAs (long ncRNAs, lncRNAs) of all kinds have been implicated in a range of cell developmental processes and diseases, while they are not translated into proteins. Inferring diseases associated lncRNAs...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1506: From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork International Journal of Molecular Sciences doi: 10.3390/ijms21041506 Authors: Antonio Maffia Cecilia Ranise Simone Sabbioneda Replicating the entire genome is one of the most complex tasks for all organisms. Research carried out in the last few years has provided us with a clearer picture on how cells preserve genomic information from the numerous insults that may endanger...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1505: Lipids and Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21041505 Authors: Yu-Chia Kao Pei-Chuan Ho Yuan-Kun Tu I-Ming Jou Kuen-Jer Tsai Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases such as Alzheimer’s...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1503: Targeting Neurovascular Interaction in Retinal Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21041503 Authors: Zhongjie Fu Ye Sun Bertan Cakir Yohei Tomita Shuo Huang Zhongxiao Wang Chi-Hsiu Liu Steve S. Cho William Britton Timothy S. Kern David A. Antonetti Ann Hellström Lois E.H. Smith The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1504: Muscle Hyperplasia in Japanese Quail by Single Amino Acid Deletion in MSTN Propeptide International Journal of Molecular Sciences doi: 10.3390/ijms21041504 Authors: Joonbum Lee Dong-Hwan Kim Kichoon Lee Mutation in myostatin (MSTN), a negative regulator of muscle growth in skeletal muscle, resulted in increased muscle mass in mammals and fishes. However, MSTN mutation in avian species has not been reported. The objective of this study was to generate...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1500: Transcriptome Analysis Reveals Differences in Key Genes and Pathways Regulating Carbon and Nitrogen Metabolism in Cotton Genotypes under N Starvation and Resupply International Journal of Molecular Sciences doi: 10.3390/ijms21041500 Authors: Asif Iqbal Qiang Dong Xiangru Wang Huiping Gui Hengheng Zhang Xiling Zhang Meizhen Song Nitrogen (N) is the most important limiting factor for cotton production worldwide. Genotype-dependent ability to...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1502: ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion International Journal of Molecular Sciences doi: 10.3390/ijms21041502 Authors: Almudena García-Ortiz Juan Manuel Serrador Ezrin, radixin and moesin proteins (ERMs) are plasma membrane (PM) organizers that link the actin cytoskeleton to the cytoplasmic tail of transmembrane proteins, many of which are adhesion receptors, in order to regulate the formation of F-actin-based...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1499: Identification of MOR-Positive B Cell as Possible Innovative Biomarker (Mu Lympho-Marker) for Chronic Pain Diagnosis in Patients with Fibromyalgia and Osteoarthritis Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21041499 Authors: William Raffaeli Valentina Malafoglia Antonello Bonci Michael Tenti Sara Ilari Paola Gremigni Cristina Iannuccelli Chiara Gioia Manuela Di Franco Vincenzo Mollace Laura Vitiello Carlo...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1498: Beyond IgE: Alternative Mast Cell Activation Across Different Disease States International Journal of Molecular Sciences doi: 10.3390/ijms21041498 Authors: David O. Lyons Nicholas A. Pullen Mast cells are often regarded through the lens of IgE-dependent reactions as a cell specialized only for anti-parasitic and type I hypersensitive responses. However, recently many researchers have begun to appreciate the expansive repertoire of stimuli that mast cells...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1497: Genetic Dissection of Phomopsis Stem Canker Resistance in Cultivated Sunflower Using High Density SNP Linkage Map International Journal of Molecular Sciences doi: 10.3390/ijms21041497 Authors: Zahirul I. Talukder William Underwood Guojia Ma Gerald J. Seiler Christopher G. Misar Xiwen Cai Lili Qi Phomopsis stem canker (PSC) caused by Diaporthe helianthi is increasingly becoming a global threat for sunflower production. In this study, the genetic...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1496: Manipulating the In Vivo Behaviour of 68Ga with Tris(Hydroxypyridinone) Chelators: Pretargeting and Blood Clearance International Journal of Molecular Sciences doi: 10.3390/ijms21041496 Authors: Cinzia Imberti Pierre Adumeau Julia E. Blower Fahad Al Salemee Julia Baguña Torres Jason S. Lewis Brian M. Zeglis Samantha Y. A. Terry Philip J. Blower Pretargeting is widely explored in immunoPET as a strategy to reduce radiation exposure of...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1494: M(VI) Oxidation State Stabilization in Iron, Cobalt and Nickel Heteroligand Metal Chelates Containing 3,7,11,15-Tetraazaporphine and Two Axial Oxo Ligands: Quantum-Chemical Simulation International Journal of Molecular Sciences doi: 10.3390/ijms21041494 Authors: Oleg V. Mikhailov Denis V. Chachkov The quantum-chemical calculation of iron, cobalt and nickel heteroligand complexes with the double deprotonated form of (NNNN)-donor atomic ligand—3,7,11,15-tetraazaporphine—and...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1486: Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms21041486 Authors: Narjès Hafsia Marine Forien Félix Renaudin Delphine Delacour Pascal Reboul Peter Van Lent Martine Cohen-Solal Frédéric Lioté Françoise Poirier Hang Korng Ea Mechanical overload and aging are the main risk factors of osteoarthritis...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1495: Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21041495 Authors: Pinar Uysal-Onganer Amy MacLatchy Rayan Mahmoud Igor Kraev Paul R. Thompson Jameel M. Inal Sigrun Lange Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with...
Sat Feb 22, 2020 02:00
IJMS, Vol. 21, Pages 1493: Alpha 1-Antitrypsin Deficiency: A Disorder of Proteostasis-Mediated Protein Folding and Trafficking Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21041493 Authors: Esra Karatas Marion Bouchecareilh Human cells express large amounts of different proteins continuously that must fold into well-defined structures that need to remain correctly folded and assemble in order to ensure their cellular and biological functions. The integrity...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1492: microRNAs in Ex Vivo Human Adipose Tissue Derived Mesenchymal Stromal Cells (ASC) Undergo Rapid Culture-Induced Changes in Expression, Including miR-378 which Promotes Adipogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21041492 Authors: Megan Iminitoff Tanvi Damani Eloise Williams Anna E. S. Brooks Vaughan Feisst Hilary M. Sheppard There is clinical interest in using human adipose tissue-derived mesenchymal stromal cells...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1491: GALNT14: An Emerging Marker Capable of Predicting Therapeutic Outcomes in Multiple Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21041491 Authors: Wey-Ran Lin Chau-Ting Yeh Members of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family function as the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their dysregulated expression can alter cancer cell behaviors such as de novo occurrence, proliferation,...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1490: Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model International Journal of Molecular Sciences doi: 10.3390/ijms21041490 Authors: Matilde Merolle Maria Patrizia Mongiardi Maurizia Piras Andrea Levi Maria Laura Falchetti Axitinib is an orally available inhibitor of tyrosine kinases, with high specificity for vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3. It is approved for the...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1488: Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia International Journal of Molecular Sciences doi: 10.3390/ijms21041488 Authors: Gianotti Capurro Delpiano Mielczarek García-Valverde Carreira-Barral Ludovico Fiore Baroni Moran Quesada Caci Cystic fibrosis (CF) is a genetic disease characterized by the lack of cystic fibrosis transmembrane conductance...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1487: Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Erythropoietin Alone, and Erythropoietin Combined with Hypothermia: History, Current Status, and Future Research International Journal of Molecular Sciences doi: 10.3390/ijms21041487 Authors: Oorschot Sizemore Amer Perinatal hypoxic-ischemic encephalopathy (HIE) remains a major cause of morbidity and mortality. Moderate hypothermia (33.5 °C) is currently the sole established standard...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1477: Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women? International Journal of Molecular Sciences doi: 10.3390/ijms21041477 Authors: Mauro Vaccarezza Veronica Papa Daniela Milani Arianna Gonelli Paola Secchiero Giorgio Zauli Donato Gemmati Veronica Tisato In the last two decades, new insights have been gained regarding sex/gender-related differences in...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1479: The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle International Journal of Molecular Sciences doi: 10.3390/ijms21041479 Authors: Cristina Romero-López Alfredo Berzal-Herranz RNA virus genomes are multifunctional entities endowed with conserved structural elements that control translation, replication and encapsidation, among other processes. The preservation of these structural RNA elements constraints the genomic sequence variability....
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1478: FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants International Journal of Molecular Sciences doi: 10.3390/ijms21041478 Authors: Caroline Eozenou Audrey Lesage-Padilla Vincent Mauffré Gareth D. Healey Sylvaine Camous Philippe Bolifraud Corinne Giraud-Delville Daniel Vaiman Takashi Shimizu Akio Miyamoto Iain Martin Sheldon Fabienne Constant Maëlle Pannetier Olivier Sandra Forkhead Box L2 (FOXL2) is a member...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1485: The Influence of Statins on the Aerobic Metabolism of Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041485 Authors: Izabela Broniarek Karolina Dominiak Lukasz Galganski Wieslawa Jarmuszkiewicz Endothelial mitochondrial dysfunction is considered to be the main cause of cardiovascular disease. The aim of this research was to elucidate the effects of cholesterol-lowering statins on the aerobic metabolism of endothelial...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1484: CLIC1 Protein Accumulates in Circulating Monocyte Membrane during Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21041484 Authors: Carlini Verduci Cianci Cannavale Fenoglio Galimberti Mazzanti Pathologies that lead to neurodegeneration in the central nervous system (CNS) represent a major contemporary medical challenge. Neurodegenerative processes, like those that occur in Alzheimer’s disease...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1483: Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature International Journal of Molecular Sciences doi: 10.3390/ijms21041483 Authors: Hyeun Sung Kim Pang Hung Wu Il-Tae Jang Degenerative disc disease is a leading cause of chronic back pain in the aging...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1475: Analysis of Single Circulating Tumor Cells in Renal Cell Carcinoma Reveals Phenotypic Heterogeneity and Genomic Alterations Related to Progression International Journal of Molecular Sciences doi: 10.3390/ijms21041475 Authors: Vera Cappelletti Elena Verzoni Raffaele Ratta Marta Vismara Marco Silvestri Rosanna Montone Patrizia Miodini Carolina Reduzzi Melanie Claps Pierangela Sepe Maria Grazia Daidone Giuseppe Procopio Circulating...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1482: The Roles and Mechanisms of lncRNAs in Liver Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21041482 Authors: Zhi He Deying Yang Xiaolan Fan Mingwang Zhang Yan Li Xiaobin Gu Mingyao Yang Many studies have revealed that circulating long noncoding RNAs (lncRNAs) regulate gene and protein expression in the process of hepatic fibrosis. Liver fibrosis is a reversible wound healing response followed by excessive extracellular...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1474: New Perspectives in Food Allergy International Journal of Molecular Sciences doi: 10.3390/ijms21041474 Authors: De Martinis Sirufo Suppa Ginaldi The improvement of the knowledge of the pathophysiological mechanisms underlying the tolerance and sensitization to food antigens has recently led to a radical change in the clinical approach to food allergies. Epidemiological studies show a global increase in the prevalence of food allergy all over the...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1481: Distinct Metabolome Changes during Seed Germination of Lettuce (Lactuca sativa L.) in Response to Thermal Stress as Revealed by Untargeted Metabolomics Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21041481 Authors: Shiwei Wei Xiao Yang Guotao Huo Guojun Ge Hongyan Liu Lijun Luo Jinguo Hu Danfeng Huang Ping Long Temperature strongly influences lettuce (Lactuca sativa L.) seed germination. Different lettuce genotypes...
Fri Feb 21, 2020 02:00
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