Related ArticlesSilencing of HOXB9 suppresses cellular proliferation, angiogenesis, migration and invasion of prostate cancer cells. J Biosci. 2020;45: Authors: Xu H, Wu S, Shen X, Wu D, Qin Z, Wang H, Chen X, Sun X Abstract The Homeobox B9 (HOXB9) is a homeodomain-containing transcription factor that participates in the progression of various malignancies. Nevertheless, the functional role of HOXB9 in prostate cancer cells is largely unknown. Hence,...
Thu Feb 27, 2020 13:14
Related ArticlesTherapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice. Molecules. 2020 Feb 22;25(4): Authors: Choi HJ, Song BR, Kim JE, Bae SJ, Choi YJ, Lee SJ, Gong JE, Lee HS, Lee CY, Kim BH, Hwang DY Abstract Positive physiological benefits of several plant oils on the UV-induced photoaging have been reported in some cell lines...
Thu Feb 27, 2020 13:14
Related ArticlesIntracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells. Pharmaceutics. 2020 Feb 21;12(2): Authors: Montero S, Seras-Franzoso J, Andrade F, Martinez-Trucharte F, Vilar-Hernández M, Quesada M, Xandri H, Arango D, Abasolo I, Rafael D, Schwartz S Abstract Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic...
Thu Feb 27, 2020 13:14
Related ArticlesBenzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells. Molecules. 2020 Feb 21;25(4): Authors: Zhong W, Tang X, Liu Y, Zhou C, Liu P, Li E, Zhong P, Lv H, Zou Q, Wang M Abstract Benzoxazole derivative K313 has previously been reported to possess anti-inflammatory effects in lipopolysaccharide-induced RAW264.7 macrophages. To date, there have...
Thu Feb 27, 2020 13:14
Related ArticlesIndomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433 Authors: Seetha A, Devaraj H, Sudhandiran G Abstract Colorectal cancer (CRC) is the third most common fatal cancer. Indomethacin, a nonsteroidal anti-inflammatory drug, is known to reduce the occurrence of CRC. This study evaluated the potential anticolon cancer effects of juglone (5-hydroxy-1,4-naphthoquinone)...
Thu Feb 27, 2020 13:14
Related ArticlesLuminescent PtII and PtIV Platinacycles with Anticancer Activity Against Multiplatinum-Resistant Metastatic CRC and CRPC Cell Models. Chemistry. 2020 Feb 11;26(9):1947-1952 Authors: Lázaro A, Balcells C, Quirante J, Badia J, Baldomà L, Ward JS, Rissanen K, Font-Bardia M, Rodríguez L, Crespo M, Cascante M Abstract Platinum-based chemotherapy persists to be the only effective therapeutic option against a wide variety of tumours. Nevertheless,...
Thu Feb 27, 2020 13:14
Related ArticlesComparative Study on the Effect of Aqueous and Ethanolic Mycelial Extracts from Polycephalomyces nipponicus (Ascomycetes) against Human Breast Cancer MCF-7 Cells. Int J Med Mushrooms. 2019;21(7):671-681 Authors: Buranrat B, Sangdee K, Sangdee A Abstract Recently, the entomopathogenic fungus Polycephalomyces nipponicus has been determined to be a prolific producer of bioactive compounds that have both antibacterial and antimarial activities,...
Thu Feb 27, 2020 13:14
Related ArticlesKnockdown of FAM64A suppresses proliferation and migration of breast cancer cells. Breast Cancer. 2019 Nov;26(6):835-845 Authors: Yao Z, Zheng X, Lu S, He Z, Miao Y, Huang H, Chu X, Cai C, Zou F Abstract BACKGROUND: FAM64A is a mitotic regulator promoting cell metaphase-anaphase transition, and it is frequently reported to be highly expressed in cancer cells. However, the role of FAM64A in human breast cancer (BrC) is poorly studied....
Thu Feb 27, 2020 13:14
Related ArticlesDirect CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs. Mol Cancer Ther. 2019 04;18(4):771-779 Authors: Green JL, Okerberg ES, Sejd J, Palafox M, Monserrat L, Alemayehu S, Wu J, Sykes M, Aban A, Serra V, Nomanbhoy T Abstract The interaction of a drug with its target is critical to achieve drug efficacy. In cases where cellular environment influences target engagement, differences between individuals and cell...
Thu Feb 27, 2020 13:14
Related ArticlesCDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression. Cell Death Dis. 2019 01 10;10(1):26 Authors: Yu J, Liu D, Sun X, Yang K, Yao J, Cheng C, Wang C, Zheng J Abstract Caudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear transcription factor, has been strongly implicated in the tumourigenesis...
Thu Feb 27, 2020 13:14
Related ArticlesIntegrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells. Aging Cell. 2019 02;18(1):e12841 Authors: Ogrodnik M, Salmonowicz H, Gladyshev VN Abstract Understanding the aging process and ways to manipulate it is of major importance for biology and medicine. Among the many aging theories advanced over the years, the concept most consistent with experimental evidence posits...
Thu Feb 27, 2020 13:14
Related ArticlesThiamethoxam inhibits blastocyst expansion and hatching via reactive-oxygen species-induced G2 checkpoint activation in pigs. Cell Signal. 2019 01;53:294-303 Authors: Nie ZW, Niu YJ, Zhou W, Kim YH, Shin KT, Cui XS Abstract Thiamethoxam (TMX) is a neonicotinoid insecticide. It has specific high toxicity to insects. Residues of TMX have been detected in various crops. Early embryo quality is vital for fertility. Excessive production of...
Thu Feb 27, 2020 13:14
Related ArticlesThe use of 3D virtual surgical planning and computer aided design in reconstruction of maxillary surgical defects. Curr Opin Otolaryngol Head Neck Surg. 2020 Feb 07;: Authors: Glas HH, Vosselman N, de Visscher SAHJ Abstract PURPOSE OF REVIEW: The present review describes the latest development of 3D virtual surgical planning (VSP) and computer aided design (CAD) for reconstruction of maxillary defects with an aim of fully prosthetic rehabilitation....
Thu Feb 27, 2020 13:14
Related ArticlesCurrent opinion in otolaryngology and head and neck surgery: clival chordoma and its management. Curr Opin Otolaryngol Head Neck Surg. 2020 Feb 07;: Authors: Snyderman CH, Gardner PA Abstract PURPOSE OF REVIEW: Chordomas of the clival region are challenging tumors to treat due to their location and infiltrative behavior. The primary goal of treatment remains a gross total resection (GTR). Advances in surgical techniques, especially the...
Thu Feb 27, 2020 13:14
Related ArticlesElectrochemotherapy in the head and neck area: an addition to the treatment armamentarium. Curr Opin Otolaryngol Head Neck Surg. 2020 Feb 07;: Authors: de Bree R, Wessel I Abstract PURPOSE OF REVIEW: Electrochemotherapy (ECT) is increasingly used in different settings in head and neck cancer patients when conventional treatment options are not available. RECENT FINDINGS: Recent improvements of electroporation and ECT include...
Thu Feb 27, 2020 13:14
Related ArticlesThe vessel-depleted neck in head and neck microvascular reconstruction: extreme solutions for extreme situations. Curr Opin Otolaryngol Head Neck Surg. 2020 Feb 07;: Authors: Breik O, Praveen P, Parmar S Abstract PURPOSE OF REVIEW: The vessel-depleted neck is the ultimate challenge for the head and neck reconstructive surgeon. In patients who have had previous neck dissections or radiotherapy, the arterial and venous options for future...
Thu Feb 27, 2020 13:14
Related ArticlesRobotic neck dissection: state of affairs. Curr Opin Otolaryngol Head Neck Surg. 2020 Feb 25;: Authors: Lira RB, Kowalski LP Abstract PURPOSE OF REVIEW: The progressive growth of endoscopic and robotic-assisted procedures provided the tools for development of remote approaches to the neck, which could avoid a visible large neck scar usually necessary for neck dissections. This review explores the current experience with robotic neck dissection,...
Thu Feb 27, 2020 13:14
Related ArticlesFrey syndrome-like developmental dysautonomia in a child with PHACE syndrome. Pediatr Dermatol. 2020 Feb 26;: Authors: Kurian SR, Siegfried EC Abstract PHACE syndrome classically presents with a large, segmental facial infantile hemangioma (IH) associated with structural and vascular abnormalities involving the head and neck, heart, and eyes. We evaluated an infant who presented with ptosis caused by a clinically subtle, deep right-sided...
Thu Feb 27, 2020 13:14
Related ArticlesBenefit from surgery with additional radiotherapy in N1 head and neck cancer at the time of IMRT: A population-based study on recent developments. PLoS One. 2020;15(2):e0229266 Authors: Evers C, Ostheimer C, Sieker F, Vordermark D, Medenwald D Abstract BACKGROUND: Currently, the role of adjuvant irradiation in head and neck cancer (HNC) patients with N1-lymph node status is not clarified. OBJECTIVES: To assess the population-based...
Thu Feb 27, 2020 13:14
Related ArticlesVideo Standards for Rhinoplasty Education: A Review and Recommended Guidelines. Facial Plast Surg Aesthet Med. 2020 Feb 26;: Authors: Hakimi AA, Prasad KR, Hong EM, Standiford L, Chang E, Cobo R, Jang YJ, Wong BJF Abstract Importance: Intraoperative videography is widely used to record rhinoplasty procedures, yet little is known about the optimal surgical vantage points at critical procedural steps. Objective: To assess commonly used...
Thu Feb 27, 2020 13:14
Related ArticlesScarless Neck Feminization: Transoral Transvestibular Approach Chondrolaryngoplasty. Facial Plast Surg Aesthet Med. 2020 Feb 26;: Authors: Khafif A, Shoffel-Havakuk H, Yaish I, Tordjman K, Assadi N Abstract Importance: Chondrolaryngoplasty or reduction of laryngeal prominence is a gender affirmation surgery for transgender women, or for male patients desiring an aesthetic surgery. Several variations of the procedure were suggested, yet...
Thu Feb 27, 2020 13:14
Related ArticlesOral squamous cell carcinoma involving the maxillae: Factors affecting local recurrence and the value of salvage treatment for overall survival. Head Neck. 2020 Feb 26;: Authors: Slieker FJB, de Bree R, Van Cann EM Abstract OBJECTIVE: To determine factors associated with local recurrence (LR) of oral squamous cell carcinoma involving the maxillae (MSCC) and overall survival (OS) after salvage treatment. SUBJECTS AND METHODS:...
Thu Feb 27, 2020 13:14
Related ArticlesRisk factors for human papillomavirus-positive nonoropharyngeal squamous cell carcinoma. Head Neck. 2020 Feb 26;: Authors: Windon MJ, D'Souza G, Waterboer T, Rooper L, Westra WH, Troy T, Pardoll D, Tan M, Yavvari S, Kiess AP, Miles B, Mydlarz WK, Ha PK, Bender N, Eisele DW, Fakhry C Abstract BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal cancer (HPV-OPC) is distinct from HPV-unassociated head and neck cancer. However, whether...
Thu Feb 27, 2020 13:14
Related ArticlesBiallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion. Elife. 2020 Feb 26;9: Authors: Lekszas C, Foresti O, Raote I, Lietdke D, König EM, Nanda I, Vona B, De Coster P, Cauwels R, Malhotra V, Haaf T Abstract The transport and Golgi organization 1 (TANGO1) proteins play pivotal roles in the secretory pathway. Full length TANGO1 is a transmembrane protein localised at endoplasmic reticulum...
Thu Feb 27, 2020 13:14
Related ArticlesMiR-214 Mediates Cell Proliferation and Apoptosis of Nasopharyngeal Carcinoma Through Targeting Both WWOX and PTEN. Cancer Biother Radiopharm. 2020 Feb 26;: Authors: Han JB, Huang ML, Li F, Yang R, Chen SM, Tao ZZ Abstract Background: Nasopharyngeal carcinoma (NPC) was highly prevalent with poor prognosis among the patients. MiR-214 reported as an important NPC biomarker was associated with regulation of biological functions. This study...
Thu Feb 27, 2020 13:14
Related ArticlesSterile traumatic panniculitis in a captive Brent goose. J Vet Diagn Invest. 2020 Feb 26;:1040638720907586 Authors: Benoit-Biancamano MO, Langlois I Abstract A captive, adult female Brent goose (Branta bernicla) with a history of severe feather picking by its mate, was presented with 0.5-2.5 cm skin nodules on the head and neck. Histologic examination revealed a well-delineated dermal mass that surrounded an intact feather follicle and...
Thu Feb 27, 2020 13:14
Related ArticlesDown-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in children. FEBS Open Bio. 2020 Feb 25;: Authors: Gao K, Li Y, Yue Z, Han J, Zhou X, Wang X Abstract Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring, and obstructive sleep apnea (OSA). Although the pathogenesis of AH has not been fully elucidated,...
Thu Feb 27, 2020 13:14
Related ArticlesSalivary biomarkers in the context of gingival inflammation in children with cystic fibrosis. J Periodontol. 2020 Feb 25;: Authors: Keles Yucel ZP, Silbereisen A, Emingil G, Tokgoz Y, Kose T, Sorsa T, Tsilingaridis G, Bostanci N Abstract BACKGROUND: Cystic fibrosis (CF) is a life-threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as reservoir of bacterial colonization and potentially...
Thu Feb 27, 2020 13:14
Related ArticlesIntegrin ανβ6 Protein Expression and Prognosis in Solid Tumors: A Meta-Analysis. Mol Diagn Ther. 2020 Feb 25;: Authors: Desnoyers A, González C, Pérez-Segura P, Pandiella A, Amir E, Ocaña A Abstract BACKGROUND AND OBJECTIVE: Integrins are a family of adhesion receptor proteins that provide signaling from the extracellular matrix to the cytoplasm. They have been associated with cancer by promoting migration, invasion, metastasis, and survival....
Thu Feb 27, 2020 13:14
Related ArticlesThe vascularized fascia lata free flap: an anatomical study and clinical considerations. Eur Arch Otorhinolaryngol. 2020 Feb 25;: Authors: Janik S, Hirtler L, Traxler H, Weninger WJ, Seemann R, Erovic BM Abstract PURPOSE: Fascia lata (FL) is often used as fascial component of the anterolateral thigh (ALT) flap in head and neck reconstruction. No distinct data exist on whether the FL has its own reliable vascular supply and whether the...
Thu Feb 27, 2020 13:14
Related ArticlesTumor control of cervical lymph node metastases of unknown primary origin: the impact of the radiotherapy target volume. Eur Arch Otorhinolaryngol. 2020 Feb 25;: Authors: Straetmans JMJAA, Stuut M, Wagemakers S, Hoebers F, Kaanders JHAM, Speel EJM, Melchers WJG, Slootweg P, Kremer B, Lacko M, Takes RP Abstract PURPOSE: Debate on the extent of treatment of neck metastasis of cancer of unknown primary tumors (CUPs) is still ongoing. In...
Thu Feb 27, 2020 13:14
Related ArticlesAsia Pacific Association of Allergy Asthma and Clinical Immunology White Paper 2020 on climate change, air pollution, and biodiversity in Asia-Pacific and impact on allergic diseases. Asia Pac Allergy. 2020 Jan;10(1):e11 Authors: Pawankar R, Wang JY, Wang IJ, Thien F, Chang YS, Latiff AHA, Fujisawa T, Zhang L, Thong BY, Chatchatee P, Leung TF, Kamchaisatian W, Rengganis I, Yoon HJ, Munkhbayarlakh S, Recto MT, Neo AGE, Le Pham D, Lan LTT, Davies JM, Oh...
Thu Feb 27, 2020 13:14
Related ArticlesDrug hypersensitivity reactions in Asia: regional issues and challenges. Asia Pac Allergy. 2020 Jan;10(1):e8 Authors: Thong BY, Lucas M, Kang HR, Chang YS, Li PH, Tang MM, Yun J, Fok JS, Kim BK, Nagao M, Rengganis I, Tsai YG, Chung WH, Yamaguchi M, Rerkpattanapipat T, Kamchaisatian W, Leung TF, Yoon HJ, Zhang L, Latiff AHA, Fujisawa T, Thien F, Castells MC, Demoly P, Wang JY, Pawankar R Abstract There are geographical, regional, and ethnic...
Thu Feb 27, 2020 13:14
Related ArticlesSuccessful Treatment of a Mixed Neuroendocrine-Nonneuroendocrine Neoplasm of the Colon with Metastases to the Thyroid Gland and Liver. Case Rep Otolaryngol. 2020;2020:5927610 Authors: Kanazawa Y, Kikuchi M, Imai Y, Katakami N, Kaihara S, Shinohara S Abstract Patients with mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) of the colon have poor prognosis. Herein, we report a patient with MiNEN of the colon with metastases to the...
Thu Feb 27, 2020 13:14
Related ArticlesPrognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma. Cancer Manag Res. 2020;12:731-741 Authors: Ye J, Liao B, Jiang X, Dong Z, Hu S, Liu Y, Xiao M Abstract Background: Peripheral blood inflammation factor neutrophil-lymphocyte ratio (NLR), platelet count (PLT) and nutritional factor serum albumin (ALB) have been proposed...
Thu Feb 27, 2020 13:14
Related ArticlesFrom Anemia to Erythropoietin Resistance in Head and Neck Squamous Cell Carcinoma Treatment: A Carousel Driven by Hypoxia. Onco Targets Ther. 2020;13:841-851 Authors: Lazzari G, Silvano G Abstract Anemia has been identified as a significant negative prognosticator in head and neck squamous cell carcinoma (HNSCC) concurrent chemoradiotherapy (CCRT). Irrespective of the causes, anemia in HNSCC is believed to contribute to intratumoral hypoxia,...
Thu Feb 27, 2020 13:14
Related ArticlesGenipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway. Drug Des Devel Ther. 2020;14:395-405 Authors: Wei M, Wu Y, Liu H, Xie C Abstract Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck, and it accounts for more than 90% of oral cancer. Due to high mortality, limitations of traditional treatment and many complications, new treatment...
Thu Feb 27, 2020 13:14
Related ArticlesDaily Time of Radiation Treatment is Associated with Subsequent Oral Mucositis Severity during radiotherapy in Head and Neck Cancer Patients. Cancer Epidemiol Biomarkers Prev. 2020 Feb 25;: Authors: Gu F, Farrugia MK, Duncan WD, Feng Y, Hutson AD, Schlecht NF, Repasky EA, Antoch MP, Miller A, Platek A, Platek ME, Iovoli AJ, Singh AK Abstract BACKGROUND: Limited treatment options are available for oral mucositis, a common, debilitating...
Thu Feb 27, 2020 13:14
Related ArticlesDefining research priorities in dystonia. Neurology. 2020 Feb 25;: Authors: Lungu C, Ozelius L, Standaert D, Hallett M, Sieber BA, Swanson-Fisher C, Berman BD, Calakos N, Moore JC, Perlmutter JS, Pirio Richardson SE, Saunders-Pullman R, Scheinfeldt L, Sharma N, Sillitoe R, Simonyan K, Starr PA, Taylor A, Vitek J, participants and organizers of the NINDS Workshop on Research Priorities in Dystonia Abstract OBJECTIVE: Dystonia is a complex...
Thu Feb 27, 2020 13:14
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