In the present study, a Gram-positive bacterium was isolated from the intestine of healthy crucian carp Carassius auratus and named strain R8. It was initially identified as Enterococcus faecium according to its ...
Thu Feb 27, 2020 02:00
Abstract A long tortuous course of the abducens nerve (ABN) crossing a highly curved siphon of the internal carotid artery is of interest to neurosurgeons for cavernous sinus surgery. Although a “straight” intracavernous carotid artery in fetuses can change into an adult-like siphon in infants, there is no information on when or how the unique course of ABN is established. Histological observations of 18 near-term fetuses (12 specimens of frontal sections and 6 specimens of sagittal...
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Abstract Objectives This retrospective computed tomography (CT) study was aimed to assess the growth dynamic of the external aperture of the carotid canal (EACC) in children aged between 1 and 20 years. Methods Two hundred patients (sex 100 females/100 males, average age 10.50 ± 5.77 years) with good head CT image quality were included in this study. CT images...
Thu Feb 27, 2020 02:00
Syphilis was first recognized in Europe in the late 15th century; its cause, Treponema pallidum subspecies pallidum, was identified four centuries later. The advent of penicillin, together with effective public health measures, was responsible for a marked decline in syphilis in the United States…
Thu Feb 27, 2020 02:00
Allogeneic hematopoietic-cell transplantation is a curative therapy for hematologic cancers in which a patient receives a cytotoxic conditioning regimen followed by infusion of hematopoietic precursor cells from a donor matched for major histocompatibility antigens. Complications such as…
Thu Feb 27, 2020 02:00
Presentation of Case. Dr. Douglas S. Micalizzi (Medicine): A 52-year-old man was referred to the multidisciplinary breast clinic of this hospital for evaluation and management of invasive ductal carcinoma of the left breast. Seven weeks before the current evaluation, the patient felt a nontender…
Thu Feb 27, 2020 02:00
Oxygen-sensing pathways orchestrate phenotypic adjustments from the cellular to the whole-body level, allowing function and survival under a variety of conditions. The hypoxic response is exquisitely sensitive and dynamic, with relatively small changes in oxygen availability initiating…
Thu Feb 27, 2020 02:00
High-risk early triple-negative breast cancer is frequently associated with early recurrence and high mortality. Neoadjuvant chemotherapy is the preferred treatment approach. In addition to potentially increasing the likelihood of tumor resectability and breast conservation, patients who have a…
Thu Feb 27, 2020 02:00
Tumor growth is supported by oncogene-driven metabolic activities that allow cancer cells to take up nutrients, build macromolecules, and proliferate. A long-standing goal of cancer research has been to deprive tumors of the nutrients that supply the anabolic metabolism that promotes their growth.…
Thu Feb 27, 2020 02:00
ABSTRACT To find out the practice patterns, awareness and knowledge about Psychodermatology in Albanian dermatologists. A survey questionnaire was sent to Albanian dermatologists by mail and distributed during a regional dermatology conference. The dermatologists were requested to provide information on demographic variables, level of training, referral patterns, degree of comfort in managing psychocutaneous disorders, awareness of community resources and interest in continuing medical educational...
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Abstract Annular lichenoid dermatitis of youth (ALDY), first described in 2003, represents an uncommon entity whose etiopathogenesis is still debated. Futhermore, the optimal treatment for ALDY is yet to be established. We report a 9‐year‐old girl who presented with annular and oval erythematous lesions mostly on her trunk, with several lesions on the neck, groin, flanks and upper extremities. The lesions had histological and immunohistochemical features characteristic for ALDY. Treatment with H1‐antihistamines,...
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Abstract Erbium: YAG (Er:YAG) laser with RecoSMA technology. This laser emits thousands of microbeams of energy causing superficial epidermal ablation and a separation of dermal fibers due to a mechanical‐acoustic and resonance effect. The aim of this study is to evaluate the clinical efficacy of Erbium: YAG (Er:YAG) laser with RecoSMA in the treatment of stable psoriasis vulgaris lesions. A questionnaire completed by 112 patients enrolled in the study. Photographs taken before each session, the...
Thu Feb 27, 2020 16:09
Abstract Psoriasis (Pso) and psoriatic arthritis (PsA) are chronic and debilitating diseases which often develop in the same patient and are linked to a wide range of comorbid conditions. Dermatologists and Rheumatologists need to cooperate in combined clinics, especially when they deal with severe, recalcitrant disease and multiple comorbidities. The clinical and research benefits of this collaboration have been previously described to contribute to a better and more sustainable health care system....
Thu Feb 27, 2020 16:09
Abstract Atopic Dermatitis (AD) is a complex disease and can often be a clinical challenge for dermatologists. When standard immunosuppressive therapies fail, Extracorporeal phototherapy (ECP) can be considered as a therapeutic option. In recent years better understanding of the pathogenesis of AD allowed to improve treatment strategies with many emerging therapeutic options. Currently, Dupilumab, a monoclonal antibody that selectively inhibits IL‐4 and IL‐13, is the only biological drug authorized...
Thu Feb 27, 2020 16:09
Future Oncology, Ahead of Print.
Thu Feb 27, 2020 11:14
Abstract Objective The identification of sensitive biomarkers is essential to validate therapeutics for Huntington's disease (HD). We directly compare structural imaging markers across the largest collective imaging HD dataset, to identify a set of imaging markers robust to multi‐centre variation and to derive upper estimates on sample sizes for clinical trials in HD. Methods We used one post‐processing pipeline to retrospectively analyse T1‐weighted magnetic resonance imaging (MRI) scans...
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00135J, PaperH. Jamie Kim, Elyssia S GallagherHydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) is a well-established technique for structural analysis of proteins. In HDX experiments it is common to label for multiple, different lengths of time...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00097C, PaperYunlong Zhao, Igor KaltashovIdentifying structural elements within heparin (as well as other glycosaminoglycan) chains that enable their interaction with a specific client protein remains a challenging task due to the high degree of...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02638J, PaperYunpei Si, Yae Eun Park, Ji Eun Lee, Hye Jin LeeA sensitive electrochemical sensor featuring novel composites of gold and carbon nano complexes alongside a polymerized amino acid was developed for the determination of uric acid (UA) and dopamine (DA)...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Feb 27, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02503K, CommunicationJeong-Hyun Lee, Aline T. Santoso, Emily S Park, Kerryn Matthews, Simon P. Duffy, Hongshen MaImmunocytochemistry (ICC), or immunofluorescence microscopy, is an essential biological technique for phenotyping cells in both research and diagnostic applications. Standard ICC methods often do not work well when the cell...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Feb 27, 2020 02:00
After passage by the U.S. House of Representatives, the Senate is currently considering the Fairness for High-Skilled Immigrants Act (H.R.1044 and S.386), which would, among other things, remove the 7% cap on employment-based visas for immigrants from any single country and raise family caps from…
Thu Feb 27, 2020 02:00
People in low- and middle-income countries (LMICs) face entrenched problems of inadequate access to health care and inconsistent quality of care, stemming from weak funding mechanisms and shortages of well-trained health care workers. Poor health care quality in LMICs has been estimated to result…
Thu Feb 27, 2020 02:00
Abstract It was previously reported that the activation of antitumor immune response by photodynamic therapy (PDT) is crucial for its therapeutic outcome. Excessive PDT-mediated inflammation is accompanied by immunosuppressive mechanisms that protect tissues from destruction. Thus, the final effect of PDT strongly depends on the balance between the activation of an adoptive arm of immune response and a range of activated immunosuppressive mechanisms. Here, with flow cytometry and...
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This course will walk through a variety of recent technological developments, occurring in this industry and in ancillary industries, that pertain to hearing aids. We’ll then take a look at the implications of what’s transpired to understand what’s on the horizon for tomorrow’s hearing aids.
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Tissue Engineering Part A, Ahead of Print.
Thu Feb 27, 2020 10:00
Soft Robotics, Ahead of Print.
Thu Feb 27, 2020 10:00
Surgical Infections, Ahead of Print.
Thu Feb 27, 2020 10:00
Stem Cells and Development, Ahead of Print.
Thu Feb 27, 2020 10:00
Many non-coding RNAs are known to play a role in the cell directly linked to their structure. Structure prediction based on the sole sequence is however a challenging task. On the other hand, thanks to the low cost of sequencing technologies, a very large number of homologous sequences are becoming available for many RNA families. In the protein community, it has emerged in the last decade the idea of exploiting the covariance of mutations within a family to predict the protein structure using the...
Thu Feb 27, 2020 18:52
Long noncoding RNA molecules (lncRNAs) are estimated to account for the majority of eukaryotic genomic transcripts, and have been associated with multiple diseases in humans. However, our understanding of their structure-function relationships is scarce, with structural evidence coming mostly from indirect biochemical approaches or computational predictions. Here we describe direct visualization of the lncRNA HOTAIR (HOx Transcript AntIsense RNA) using atomic force microscopy (AFM) in nucleus-like...
Thu Feb 27, 2020 18:04
Abstract Objective Literature shows that emotional status can influence participation in screening/surveillance programs, and that screening/surveillance programs may alter the psychological wellbeing of subjects examined. This study aims to assess if participating in a surveillance program for pancreatic cancer early detection is associated with abnormal levels of psychological distress in high‐risk individuals, compared to the general population. Methods Fifty‐four high‐risk individuals...
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Abstract Purpose Women with breast cancer are exposed to various stressors, and self‐care behaviors play an important role in their recovery. However, very few studies have investigated self‐care behaviors specifically for women with breast cancer. The current study examined the relationship between perceived stress and self‐care behaviors, and explored whether self‐compassion moderated this relationship. Methods A sample of 210 women with breast cancer aged 27‐60 years old from three hospitals...
Thu Feb 27, 2020 14:27
Acute esophageal necrosis (AEN) is a rare clinical diagnosis that primarily affects the distal third of the esophagus. AEN causes odynophagia, leading to decreased oral intake and food avoidance. AEN can arise in critically ill patients with multiple comorbidities and is an uncommon complication of diabetic ketoacidosis (DKA). We present a case of a young female with poorly controlled, insulin-dependent diabetes mellitus type 2 who developed odynophagia, small volume coffee-ground emesis, and inability...
Thu Feb 27, 2020 18:05
Rosai–Dorfman disease (RDD) is a rare and benign pathology of sinus histiocytosis of unknown etiology. Lymphadenopathy is the predominant clinical manifestation, but diverse organs can also be affected. Histological features involve S-100+ histiocytes with characteristic nuclear features within the enlarged sinusoids of the lymph nodes. The clinical course is unpredictable, but is often benign with spontaneous resolution of disease in most patients. We report a patient with bilateral massive enlargement...
Thu Feb 27, 2020 18:05
We describe a case of new onset angioedema likely due to Ezetimibe therapy in an elderly patient with a prior history of drug-induced bradykinin reactions who had been on the medication for multiple years. This is the second reported incidence of Ezetimibe-associated angioedema in literature. A 90-year-old African American female presented with angioedema of the face and oral mucosa with associated difficulty speaking developing hours after taking Ezetimibe 10 mg PO. She denied adding any new or...
Thu Feb 27, 2020 16:05
Related Articles[Research progress of kisspeptin in female reproductive endocrine and assisted reproductive techniques]. Sheng Li Xue Bao. 2020 Feb 25;72(1):125-132 Authors: Zhang Y, Sun NX Abstract In recent years, it has been found that kisspeptin plays some key roles in the physiological processes of the brain, such as gender differentiation, positive and negative feedback of sex hormones, onset of puberty, and transduction of energy signals in the...
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Related Articles[Mechanisms for establishment of the placental defensive barrier]. Sheng Li Xue Bao. 2020 Feb 25;72(1):115-124 Authors: Zheng WS, Hu XQ, Wang YL, Cao B Abstract Placenta serves as a temporary fetal organ, which mediates maternal-fetal crosstalk and intrauterine fetal growth. Placental defensive barrier is a fundamental physiological function, which balances maternal immune tolerance to the fetus and resistance to pathogens. This review...
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