Biomolecules, Vol. 10, Pages 341: Effects of Salicylic Acid on the Metabolism of Mitochondrial Reactive Oxygen Species in Plants Biomolecules doi: 10.3390/biom10020341 Authors: Péter Poór Different abiotic and biotic stresses lead to the production and accumulation of reactive oxygen species (ROS) in various cell organelles such as in mitochondria, resulting in oxidative stress, inducing defense responses or programmed cell death (PCD) in plants. In response to oxidative stress, cells...
Fri Feb 21, 2020 02:00
Biomolecules, Vol. 10, Pages 340: Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging Biomolecules doi: 10.3390/biom10020340 Authors: Simona Neri Rosa Maria Borzì Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have also emerged in the last years as extremely promising therapeutic agents for a wide variety of clinical conditions. MSC use frequently...
Fri Feb 21, 2020 02:00
Brain Sciences, Vol. 10, Pages 128: Leg Dominance Effects on Postural Control When Performing Challenging Balance Exercises Brain Sciences doi: 10.3390/brainsci10030128 Authors: Arunee Promsri Thomas Haid Inge Werner Peter Federolf Leg dominance reflects the preferential use of one leg over another and is typically attributed to asymmetries in the neural circuitry. Detecting leg dominance effects on motor behavior, particularly during balancing exercises, has proven difficult....
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Brain Sciences, Vol. 10, Pages 127: Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress Brain Sciences doi: 10.3390/brainsci10020127 Authors: Simona Cabib Paolo Campus David Conversi Cristina Orsini Stefano Puglisi-Allegra In this brief review, we present evidence of the primary role of learning-associated plasticity in the development of either adaptive or maladaptive coping strategies. Successful interactions with novel stressors foster plasticity...
Mon Feb 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 126: Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice Brain Sciences doi: 10.3390/brainsci10020126 Authors: Dargahi Matsoukas Apostolopoulos Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted...
Sun Feb 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 125: Could Transcranial Direct Current Stimulation Join the Therapeutic Armamentarium in Obsessive-Compulsive Disorder? Brain Sciences doi: 10.3390/brainsci10020125 Authors: Moussa A. Chalah Samar S. Ayache Obsessive-compulsive disorder (OCD) is a mental disorder that can affect around 1–3% of individuals [...]
Sun Feb 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 123: Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity Brain Sciences doi: 10.3390/brainsci10020123 Authors: Bernd Frerker Marco Rohde Steffen Müller Christian G. Bien Rüdiger Köhling Timo Kirschstein Background: The conversion of glutamic acid into γ-aminobutyric acid (GABA) is...
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 124: Evaluating Preschool Visual Attentional Selective-Set: Preliminary ERP Modeling and Simulation of Target Enhancement Homology Brain Sciences doi: 10.3390/brainsci10020124 Authors: Amedeo D'Angiulli Dao Anh Thu Pham Gerry Leisman Gary Goldfield We reanalyzed, modeled and simulated Event-Related Potential (ERP) data from 13 healthy children (Mean age = 5.12, Standard Deviation = 0.75) during a computerized visual sustained target detection task....
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 119: Management of Neuroinflammatory Responses to AAV-Mediated Gene Therapies for Neurodegenerative Diseases Brain Sciences doi: 10.3390/brainsci10020119 Authors: Barbara A. Perez Alison Shutterly Ying Kai Chan Barry J. Byrne Manuela Corti Recently, adeno-associated virus (AAV)-mediated gene therapies have attracted clinical interest for treating neurodegenerative diseases including spinal muscular atrophy (SMA), Canavan disease (CD), Parkinson’s...
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 121: ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain Brain Sciences doi: 10.3390/brainsci10020121 Authors: Alexei A. Surguchev Andrei Surguchov Identification of genetic markers of a human disease, which is generally sporadic, may become an essential tool for the investigation of its molecular mechanisms. The role of ABCA7 in Alzheimer’s disease (AD) was discovered less than ten years ago when meta-analyses provided...
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 120: Behavioral and Neuropsychological Evaluation of Executive Functions in Children with Autism Spectrum Disorder in the Gulf Region Brain Sciences doi: 10.3390/brainsci10020120 Authors: Rehab H. Alsaedi Suzanne Carrington James J. Watters This study examined the executive functioning abilities and development profiles of children with autism spectrum disorder (ASD). The participants were 119 children with ASD and 30 typically developing children...
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 122: Enhancing α-secretase Processing for Alzheimer’s Disease—A View on SFRP1 Brain Sciences doi: 10.3390/brainsci10020122 Authors: Bor Luen Tang Amyloid β (Aβ) peptides generated via sequential β- and γ-secretase processing of the amyloid precursor protein (APP) are major etiopathological agents of Alzheimer’s disease (AD). However, an initial APP cleavage by an α-secretase, such as the a disintegrin...
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 117: Assessing the Role of Cannabis Use on Cortical Surface Structure in Adolescents and Young Adults: Exploring Gender and Aerobic Fitness as Potential Moderators Brain Sciences doi: 10.3390/brainsci10020117 Authors: Ryan M. Sullivan Alexander L. Wallace Natasha E. Wade Ann M. Swartz Krista M. Lisdahl Cannabis use in adolescents and young adults is linked with aberrant brain structure, although findings to date are inconsistent. We examined...
Sat Feb 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 118: Brain Tumor Analysis Empowered with Deep Learning: A Review, Taxonomy, and Future Challenges Brain Sciences doi: 10.3390/brainsci10020118 Authors: Muhammad Waqas Nadeem Mohammed A. Al Ghamdi Muzammil Hussain Muhammad Adnan Khan Khalid Masood Khan Sultan H. Almotiri Suhail Ashfaq Butt Deep Learning (DL) algorithms enabled computational models consist of multiple processing layers that represent data with multiple levels of abstraction....
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 523: Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3 Cancers doi: 10.3390/cancers12020523 Authors: Chiharu Sogawa Takanori Eguchi Manh Tien Tran Masayuki Ishige Kilian Trin Yuka Okusha Eman Ahmed Taha Yanyin Lu Hotaka Kawai Norio Sogawa Masaharu Takigawa Stuart K. Calderwood Kuniaki Okamoto Ken-ichi Kozaki Tumor growth, progression,...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 522: Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment Cancers doi: 10.3390/cancers12020522 Authors: Vanessa T. Chivere Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 521: The Labyrinth of Renal Cell Carcinoma Cancers doi: 10.3390/cancers12020521 Authors: Manini López Renal cell carcinoma (RCC) ranks in the top‐ten list of malignancies both in males and females [...]
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 524: Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role Cancers doi: 10.3390/cancers12020524 Authors: Allegra Musolino Tonacci Pioggia Casciaro Gangemi B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 519: Monitoring Immune Responses in Neuroblastoma Patients during Therapy Cancers doi: 10.3390/cancers12020519 Authors: Celina L. Szanto Annelisa M. Cornel Saskia V. Vijver Stefan Nierkens Neuroblastoma (NBL) is the most common extracranial solid tumor in childhood. Despite intense treatment, children with this high-risk disease have a poor prognosis. Immunotherapy showed a significant improvement in event-free survival in high-risk NBL patients receiving...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 520: Intratumoral Heterogeneity and Longitudinal Changes in Gene Expression Predict Differential Drug Sensitivity in Newly Diagnosed and Recurrent Glioblastoma Cancers doi: 10.3390/cancers12020520 Authors: Ella L. Kim Maxim Sorokin Sven Rainer Kantelhardt Darius Kalasauskas Bettina Sprang Julian Fauss Florian Ringel Andrew Garazha Eugene Albert Nurshat Gaifullin Christian Hartmann Nicole Naumann Sven-Ernö Bikar Alf Giese Anton...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 518: The Impact of Normalization Approaches to Automatically Detect Radiogenomic Phenotypes Characterizing Breast Cancer Receptors Status Cancers doi: 10.3390/cancers12020518 Authors: Castaldo Pane Nicolai Salvatore Franzese In breast cancer studies, combining quantitative radiomic with genomic signatures can help identifying and characterizing radiogenomic phenotypes, in function of molecular receptor status. Biomedical imaging processing lacks...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 517: Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas Cancers doi: 10.3390/cancers12020517 Authors: Karuna Mittal Da Hoon Choi Guanhao Wei Jaspreet Kaur Sergey Klimov Komal Arora Christopher C. Griffith Mukesh Kumar Precious Imhansi-Jacob Brian D. Melton Sonal Bhimji-Pattni Remus M. Osan Padmashree Rida Paweł Golusinski Ritu Aneja Human...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 516: Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application Cancers doi: 10.3390/cancers12020516 Authors: Sonali Nayak Ashorne Mahenthiran Yongyong Yang Mark McClendon Barbara Mania-Farnell Charles David James John A. Kessler Tadanori Tomita Shi-Yuan Cheng Samuel I. Stupp Guifa Xi Malignant gliomas are heterogeneous neoplasms. Glioma stem-like...
Mon Feb 24, 2020 02:00
Cancers, Vol. 12, Pages 515: New Deployable Expandable Electrodes in the Electroporation Treatment in a Pig Model: A Feasibility and Usability Preliminary Study Cancers doi: 10.3390/cancers12020515 Authors: Francesco Izzo Franco Ionna Vincenza Granata Vittorio Albino Renato Patrone Francesco Longo Agostino Guida Paolo Delrio Daniela Rega Dario Scala Roberto Pezzuto Roberta Fusco Elio Di Bernardo Valeria D’Alessio Roberto Grassi Deyanira Contartese...
Sun Feb 23, 2020 02:00
Cancers, Vol. 12, Pages 514: How to Classify the Pituitary Neuroendocrine Tumors (PitNET)s in 2020 Cancers doi: 10.3390/cancers12020514 Authors: Trouillas Jaffrain-Rea Vasiljevic Raverot Roncaroli C Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 512: Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma Cancers doi: 10.3390/cancers12020512 Authors: Mohamad Krayem Philippe Aftimos Ahmad Najem Tim van den Hooven Adriënne van den Berg Liesbeth Hovestad-Bijl Rik de Wijn Riet Hilhorst Rob Ruijtenbeek Malak Sabbah Joseph Kerger...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 513: The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer
Cancers, Vol. 12, Pages 513: The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer Cancers doi: 10.3390/cancers12020513 Authors: Carla Solé Ibai Goicoechea Alai Goñi Maike Schramm María Armesto María Arestin Lorea Manterola Maitena Tellaetxe Aitor Alberdi Leonor Nogueira Mathieu Roumiguie Jose Ignacio López Juan Pablo Sanz Jaka Ander Urruticoechea Itziar Vergara Ana Loizaga-Iriarte Miguel Unda Arkaitz Carracedo Bernard...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 508: Adjuvant Therapy in Adrenocortical Carcinoma: Reflections and Future Directions Cancers doi: 10.3390/cancers12020508 Authors: Sara Bedrose Marilyne Daher Lina Altameemi Mouhammed Amir Habra Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with high risk of recurrence despite macroscopically complete surgical resection. The main predictors of ACC recurrence include advanced disease stage, incomplete surgical resection, cortisol production,...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 510: Genomic Characterization of Non-Invasive Differentiated-Type Gastric Cancer in the Japanese Population Cancers doi: 10.3390/cancers12020510 Authors: Koki Nakamura Yuji Urabe Kenichi Kagemoto Ryo Yuge Ryohei Hayashi Atsushi Ono C. Nelson Hayes Shiro Oka Masanori Ito Takashi Nishisaka Kazuaki Tanabe Koji Arihiro Hideki Ohdan Shinji Tanaka Kazuaki Chayama Background and aims: Recent genomic characterization of gastric...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 511: Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients Cancers doi: 10.3390/cancers12020511 Authors: Natalia Samolyk-Kogaczewska Ewa Sierko Dorota Dziemianczyk-Pakiela Klaudia Beata Nowaszewska Malgorzata Lukasik Joanna Reszec (1) Background: The novel hybrid of positron emission tomography/magnetic resonance (PET/MR) examination has been introduced to clinical practice. The aim of our study was to evaluate PET/MR...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 507: Successful Identification of Nasopharyngeal Carcinoma in Nasopharyngeal Biopsies Using Deep Learning Cancers doi: 10.3390/cancers12020507 Authors: Wen-Yu Chuang Shang-Hung Chang Wei-Hsiang Yu Cheng-Kun Yang Chi-Ju Yeh Shir-Hwa Ueng Yu-Jen Liu Tai-Di Chen Kuang-Hua Chen Yi-Yin Hsieh Yi Hsia Tong-Hong Wang Chuen Hsueh Chang-Fu Kuo Chao-Yuan Yeh Pathologic diagnosis of nasopharyngeal carcinoma (NPC) can be challenging...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 509: Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death Cancers doi: 10.3390/cancers12020509 Authors: Senyi Benti Purushottam B. Tiwari Dustin W. Goodlett Leily Daneshian Grant B. Kern Mark D. Smith Aykut Uren Maksymilian Chruszcz Linda S. Shimizu Geeta Upadhyay Elevated gene expression of Lymphocyte antigen 6K (LY6K) in cancer cells is associated with poor survival outcomes in multiple different cancer types...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 506: Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors Cancers doi: 10.3390/cancers12020506 Authors: Emilia Modolo Pinto Fabio R. Faucz Luana Z. Paza Gang Wu Elizabeth S. Fernandes Jerome Bertherat Constantine A. Stratakis Enzo Lalli Raul C. Ribeiro Carlos Rodriguez-Galindo Bonald C. Figueiredo Gerard P. Zambetti Phosphodiesterases (PDEs) form a superfamily of enzymes that...
Sat Feb 22, 2020 02:00
Cancers, Vol. 12, Pages 505: Neutrophil Extracellular Trap Formation Correlates with Favorable Overall Survival in High Grade Ovarian Cancer Cancers doi: 10.3390/cancers12020505 Authors: Besnik Muqaku Dietmar Pils Johanna C. Mader Stefanie Aust Andreas Mangold Liridon Muqaku Astrid Slany Giorgia Del Favero Christopher Gerner It is still a question of debate whether neutrophils, often found in the tumor microenvironment, mediate tumor-promoting or rather tumor-inhibiting...
Fri Feb 21, 2020 02:00
Cancers, Vol. 12, Pages 502: Obesity Promotes Cooperation of Cancer Stem-Like Cells and Macrophages to Enhance Mammary Tumor Angiogenesis Cancers doi: 10.3390/cancers12020502 Authors: Hillers-Ziemer McMahon Hietpas Paderta LeBeau McCready Arendt Obesity is correlated with worsened prognosis and treatment resistance in breast cancer. Macrophage-targeted therapies are currently in clinical trials, however, little is known about how obesity may impact treatment...
Fri Feb 21, 2020 02:00
Cancers, Vol. 12, Pages 500: Protein Tyrosine Phosphatase-1B Inhibition Disrupts IL13Rα2-Promoted Invasion and Metastasis in Cancer Cells Cancers doi: 10.3390/cancers12020500 Authors: Bartolomé Martín-Regalado Jaén Zannikou Zhang de los Ríos Balyasnikova Casal Background: Interleukin 13 receptor alpha 2 subunit (IL13Rα2) is overexpressed in glioblastoma (GBM), metastatic colorectal cancer (CRC) and ovarian cancer (OC). Here, we investigated the...
Fri Feb 21, 2020 02:00
Cancers, Vol. 12, Pages 501: The c-Myc/AKT1/TBX3 Axis Is Important to Target in the Treatment of Embryonal Rhabdomyosarcoma Cancers doi: 10.3390/cancers12020501 Authors: Sims Maranyane Damerell Govender Isaacs Peres Prince Rhabdomyosarcoma is a highly aggressive malignant cancer that arises from skeletal muscle progenitor cells and is the third most common solid tumour in children. Despite significant advances, rhabdomyosarcoma still presents a therapeutic challenge,...
Fri Feb 21, 2020 02:00
Cancers, Vol. 12, Pages 503: A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment Cancers doi: 10.3390/cancers12020503 Authors: Fu-Ying Shih Wen-Ping Jiang Xiaojie Lin Sheng-Chu Kuo Guan-Jhong Huang Yu-Chi Hou Chih-Shiang Chang Yang Liu Yi-Ting Chiang In this study, for the first time, we precisely assembled the poly-γ-benzyl-l-glutamate and an amphiphilic copolymer d-α-tocopherol polyethylene glycol...
Fri Feb 21, 2020 02:00
Cancers, Vol. 12, Pages 504: Blood-Based SOX2-Promoter Methylation in Relation to Exercise and PM2.5 Exposure among Taiwanese Adults Cancers doi: 10.3390/cancers12020504 Authors: Su Tantoh Chou Wang Ho Chen Lee Nfor Hsu Liang Liaw Increased ventilation during exercise in polluted areas could trigger airway inflammation. We evaluated blood DNA methylation of the SOX2-promoter region in relation to exercise and PM2.5 in Taiwanese adults. Data of...
Fri Feb 21, 2020 02:00
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