Cancers, Vol. 12, Pages 499: Mesothelial-to-Mesenchymal Transition Contributes to the Generation of Carcinoma-Associated Fibroblasts in Locally Advanced Primary Colorectal Carcinomas Cancers doi: 10.3390/cancers12020499 Authors: Carlos H. Gordillo Pilar Sandoval Patricia Muñoz-Hernández Lucía Pascual-Antón Manuel López-Cabrera José A. Jiménez-Heffernan During peritoneal metastasis, cancer cells spread from abdominal solid tumors, disseminate through the peritoneal fluid...
Fri Feb 21, 2020 02:00
Cancers, Vol. 12, Pages 498: Lipid–Saporin Nanoparticles for the Intracellular Delivery of Cytotoxic Protein to Overcome ABC Transporter-Mediated Multidrug Resistance In Vitro and In Vivo Cancers doi: 10.3390/cancers12020498 Authors: Guan-Nan Zhang Pranav Gupta Ming Wang Anna Maria Barbuti Charles R. Ashby Yun-Kai Zhang Leli Zeng Qiaobing Xu Ying-Fang Fan Zhe-Sheng Chen Although the judicious use of anticancer drugs that target one or more receptor tyrosine...
Fri Feb 21, 2020 02:00
Cells, Vol. 9, Pages 524: Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope Cells doi: 10.3390/cells9030524 Authors: Khushboo S. Gala Vatsalya Vatsalya Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers...
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Cells, Vol. 9, Pages 523: MYC’s Fine Line Between B Cell Development and Malignancy Cells doi: 10.3390/cells9020523 Authors: de Barrios Meler Parra The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of expression are maintained, and its protein levels are not completely silenced...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 521: Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy Cells doi: 10.3390/cells9020521 Authors: O'Neill Dwyer Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 522: Detection of MET Alterations Using Cell Free DNA and Circulating Tumor Cells from Cancer Patients Cells doi: 10.3390/cells9020522 Authors: Patricia Mondelo-Macía Carmela Rodríguez-López Laura Valiña Santiago Aguín Luis León-Mateos Jorge García-González Alicia Abalo Oscar Rapado-González Mercedes Suárez-Cunqueiro Angel Díaz-Lagares Teresa Curiel Silvia Calabuig-Fariñas Aitor Azkárate Antònia Obrador-Hevia Ihab Abdulkader Laura...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 514: Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer
Cells, Vol. 9, Pages 514: Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer Cells doi: 10.3390/cells9020514 Authors: Roberto Diaz-Peña Patricia Mondelo-Macía Antonio José Molina de la Torre Rebeca Sanz-Pamplona Víctor Moreno Vicente Martín Natural killer cells (NK cells) play a major role in the immune response to cancer. An important element of NK target recognition is the binding of human leucocyte antigen (HLA) class I molecules by killer immunoglobulin-like...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 516: Transcriptional and Ultrastructural Analyses Suggest Novel Insights into Epithelial Barrier Impairment in Celiac Disease Cells doi: 10.3390/cells9020516 Authors: Sowińska Morsy Czarnowska Oralewska Konopka Woynarowski Szymańska Ejmont Scharl Bierła Wawrzyniak Cukrowska Disruption of epithelial junctional complex (EJC), especially tight junctions (TJ), resulting in increased intestinal permeability, is supposed to...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 519: Microfluidic Device for On-Chip Immunophenotyping and Cytogenetic Analysis of Rare Biological Cells Cells doi: 10.3390/cells9020519 Authors: M. Weerakoon-Ratnayake Vaidyanathan Larkey Dathathreya Hu Jose Mog August Godwin L. Hupert A. Witek A. Soper The role of circulating plasma cells (CPCs) and circulating leukemic cells (CLCs) as biomarkers for several blood cancers, such as multiple myeloma and leukemia, respectively,...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 520: Computational Identification and Analysis of Ubiquinone-Binding Proteins Cells doi: 10.3390/cells9020520 Authors: Lu Jiang Wang Jiang Ma Wang Ubiquinone is an important cofactor that plays vital and diverse roles in many biological processes. Ubiquinone-binding proteins (UBPs) are receptor proteins that dock with ubiquinones. Analyzing and identifying UBPs via a computational approach will provide insights into the pathways associated with...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 515: Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin Cells doi: 10.3390/cells9020515 Authors: Dilruba Grondana Schiedel Ueno Bartholomeusz Cinatl Jr. McLaughlin Wass Michaelis Kalayda The efficacy of cisplatin-based chemotherapy in ovarian cancer is often limited by the development of drug resistance. In most ovarian cancer cells, cisplatin activates extracellular signal-regulated kinase1/2 (ERK1/2)...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 517: Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain Cells doi: 10.3390/cells9020517 Authors: Seigo Usuki Yoshiaki Yasutake Noriko Tamura Tomohiro Tamura Kunikazu Tanji Takashi Saitoh Yuta Murai Daisuke Mikami Kohei Yuyama Kenji Monde Katsuyuki Mukai Yasuyuki Igarashi Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and a-hydroxyl fatty acids. The...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 518: Protein Translocation Acquires Substrate Selectivity Through ER Stress-Induced Reassembly of Translocon Auxiliary Components Cells doi: 10.3390/cells9020518 Authors: Lee Shin Kim Song Kim Kang Protein import across the endoplasmic reticulum membrane is physiologically regulated in a substrate-selective manner to ensure the protection of stressed ER from the overload of misfolded proteins. However, it is poorly understood how different types...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 511: (R)-Salbutamol Improves Imiquimod-Induced Psoriasis-Like Skin Dermatitis by Regulating the Th17/Tregs Balance and Glycerophospholipid Metabolism Cells doi: 10.3390/cells9020511 Authors: Fei Liu Shanping Wang Bo Liu Yukun Wang Wen Tan Psoriasis is a skin disease that is characterized by a high degree of inflammation caused by immune dysfunction. (R)-salbutamol is a bronchodilator for asthma and was reported to alleviate immune system reactions in...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 512: The Translocator Protein (TSPO) in Mitochondrial Bioenergetics and Immune Processes Cells doi: 10.3390/cells9020512 Authors: Betlazar Middleton Banati Liu The translocator protein (TSPO) is an outer mitochondrial membrane protein that is widely used as a biomarker of neuroinflammation, being markedly upregulated in activated microglia in a range of brain pathologies. Despite its extensive use as a target in molecular imaging studies, the exact cellular...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 510: Lactate in Sarcoma Microenvironment: Much More than just a Waste Product Cells doi: 10.3390/cells9020510 Authors: Taddei Pietrovito Leo Chiarugi Sarcomas are rare and heterogeneous malignant tumors relatively resistant to radio- and chemotherapy. Sarcoma progression is deeply dependent on environmental conditions that sustain both cancer growth and invasive abilities. Sarcoma microenvironment is composed of different stromal cell types and extracellular...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 513: Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions Cells doi: 10.3390/cells9020513 Authors: Marina Leite Miguel S. Marques Joana Melo Marta T. Pinto Bruno Cavadas Miguel Aroso Maria Gomez-Lazaro Raquel Seruca Ceu Figueiredo Helicobacter pylori, a stomach-colonizing Gram-negative bacterium, is the main etiological factor of various gastroduodenal diseases, including gastric...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 507: Vasculogenic Mimicry: A Promising Prognosticator in Head and Neck Squamous Cell Carcinoma and Esophageal Cancer? A Systematic Review and Meta-Analysis Cells doi: 10.3390/cells9020507 Authors: Roosa Hujanen Rabeia Almahmoudi Sini Karinen Bright I. Nwaru Tuula Salo Abdelhakim Salem Vasculogenic mimicry (VM) is an intratumoral microcirculation pattern formed by aggressive cancer cells, which mediates tumor growth. In this study, we compiled the evidence...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 509: NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate Cells doi: 10.3390/cells9020509 Authors: Pauline Colombier Boris Halgand Claire Chédeville Caroline Chariau Valentin François-Campion Stéphanie Kilens Nicolas Vedrenne Johann Clouet Laurent David Jérôme Guicheux Anne Camus The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 508: Convolutional Neural Networks–Based Image Analysis for the Detection and Quantification of Neutrophil Extracellular Traps Cells doi: 10.3390/cells9020508 Authors: Aneta Manda-Handzlik Krzysztof Fiok Adrianna Cieloch Edyta Heropolitanska-Pliszka Urszula Demkow Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs...
Mon Feb 24, 2020 02:00
Cells, Vol. 9, Pages 506: G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits Cells doi: 10.3390/cells9020506 Authors: Shofiul Azam Md. Ezazul Haque Md. Jakaria Song-Hee Jo In-Su Kim Dong-Kug Choi Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and pathological phenomena. However, current therapeutics rely mostly on symptomatic...
Sun Feb 23, 2020 02:00
Cells, Vol. 9, Pages 505: Microtubule-Based Mechanisms of Pronuclear Positioning Cells doi: 10.3390/cells9020505 Authors: Johnathan L. Meaders David R. Burgess The zygote is defined as a diploid cell resulting from the fusion of two haploid gametes. Union of haploid male and female pronuclei in many animals occurs through rearrangements of the microtubule cytoskeleton into a radial array of microtubules known as the sperm aster. The sperm aster nucleates from paternally-derived centrioles...
Sun Feb 23, 2020 02:00
Cells, Vol. 9, Pages 503: Telomeres and Telomerase in Heart Ontogenesis, Aging and Regeneration Cells doi: 10.3390/cells9020503 Authors: Denis Nalobin Svetlana Alipkina Anna Gaidamaka Alexander Glukhov Zaza Khuchua The main purpose of the review article is to assess the contributions of telomere length and telomerase activity to the cardiac function at different stages of development and clarify their role in cardiac disorders. It has been shown that the telomerase complex...
Sat Feb 22, 2020 02:00
Cells, Vol. 9, Pages 504: RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells Cells doi: 10.3390/cells9020504 Authors: Paula Mueller Markus Wolfien Katharina Ekat Cajetan Immanuel Lang Dirk Koczan Olaf Wolkenhauer Olga Hahn Kirsten Peters Hermann Lang Robert David Heiko Lemcke Multipotent adult mesenchymal stromal cells (MSCs) could represent an elegant source for the generation of patient-specific cardiomyocytes needed for...
Sat Feb 22, 2020 02:00
Cells, Vol. 9, Pages 502: The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord Cells doi: 10.3390/cells9020502 Authors: Baris Genc Oge Gozutok Nuran Kocak P. Hande Ozdinler Understanding the cellular and molecular basis of selective vulnerability has been challenging, especially for motor neuron diseases. Developing drugs that improve the health of neurons that display selective...
Sat Feb 22, 2020 02:00
Cells, Vol. 9, Pages 501: Arteriogenesis of the Spinal Cord—The Network Challenge Cells doi: 10.3390/cells9020501 Authors: Florian Simon Markus Udo Wagenhäuser Albert Busch Hubert Schelzig Alexander Gombert Spinal cord ischemia (SCI) is a clinical complication following aortic repair that significantly impairs the quality and expectancy of life. Despite some strategies, like cerebrospinal fluid drainage, the occurrence of neurological symptoms, such as paraplegia and paraparesis,...
Sat Feb 22, 2020 02:00
Cells, Vol. 9, Pages 500: Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma Cells doi: 10.3390/cells9020500 Authors: Katherine C. Wai Madeleine P. Strohl Annemieke van Zante Patrick K. Ha The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV– tumors represent two unique biological and clinical...
Sat Feb 22, 2020 02:00
Cells, Vol. 9, Pages 499: High Levels of Class I Major Histocompatibility Complex mRNA Are Present in Epstein–Barr Virus-Associated Gastric Adenocarcinomas Cells doi: 10.3390/cells9020499 Authors: Ghasemi Gameiro Tessier Maciver Mymryk Epstein–Barr virus (EBV) is responsible for approximately 9% of stomach adenocarcinomas. EBV-encoded microRNAs have been reported as reducing the function of the class I major histocompatibility complex (MHC-I) antigen presentation...
Fri Feb 21, 2020 02:00
Cells, Vol. 9, Pages 498: Plasma Membrane Transporters as Biomarkers and Molecular Targets in Cholangiocarcinoma Cells doi: 10.3390/cells9020498 Authors: Jose J.G. Marin Rocio I.R. Macias Candela Cives-Losada Ana Peleteiro-Vigil Elisa Herraez Elisa Lozano The dismal prognosis of patients with advanced cholangiocarcinoma (CCA) is due, in part, to the extreme resistance of this type of liver cancer to available chemotherapeutic agents. Among the complex mechanisms accounting...
Fri Feb 21, 2020 02:00
Cells, Vol. 9, Pages 496: The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5) Cells doi: 10.3390/cells9020496 Authors: Simone Torretta Giorgia Colombo Cristina Travelli Sara Boumya Dmitry Lim Armando A. Genazzani Ambra A. Grolla (1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory...
Fri Feb 21, 2020 02:00
Cells, Vol. 9, Pages 497: Ribosome and Translational Control in Stem Cells Cells doi: 10.3390/cells9020497 Authors: Gabut Bourdelais Durand Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated...
Fri Feb 21, 2020 02:00
Cells, Vol. 9, Pages 494: TLR2 Signaling Pathway Combats Streptococcus uberis Infection by Inducing Mitochondrial Reactive Oxygen Species Production Cells doi: 10.3390/cells9020494 Authors: Bin Li Zhixin Wan Zhenglei Wang Jiakun Zuo Yuanyuan Xu Xiangan Han Vanhnaseng Phouthapane Jinfeng Miao Mastitis caused by Streptococcus uberis (S. uberis) is a common and difficult-to-cure clinical disease in dairy cows. In this study, the role of Toll-like receptors (TLRs) and...
Fri Feb 21, 2020 02:00
Cells, Vol. 9, Pages 495: Novel Therapeutic Approach to Induce Autophagy in a Drosophila Model for Huntington’s Disease Cells doi: 10.3390/cells9020495 Authors: Martinez-Vicente Autophagy induction is an attractive therapeutic approach to ameliorate aggregate accumulation in many neurodegenerative diseases. In Huntington’s disease (HD) in vivo models, a number of genetic and pharmacological mechanisms aimed to induce autophagy have been successfully tested [1], demonstrating...
Fri Feb 21, 2020 02:00
Challenges, Vol. 11, Pages 4: The Mismatch between Anthropogenic CO2 Emissions and Their Consequences for Human Zinc and Protein Sufficiency Highlights Important Environmental Justice Issues Challenges doi: 10.3390/challe11010004 Authors: Elizabeth R. H. Moore Matthew R. Smith Debbie Humphries Robert Dubrow Samuel S. Myers The impacts of climate change are not equally distributed globally. We examined the global distribution of CO2 emissions and the ensuing distribution of...
Sat Feb 22, 2020 02:00
Chemosensors, Vol. 8, Pages 15: Silver Chloride/Ferricyanide-Based Quasi-Reference Electrode for Potentiometric Sensing Applications Chemosensors doi: 10.3390/chemosensors8010015 Authors: Brainina Tarasov Vidrevich Processes’ occurring at the Ag/AgCl/Cl–, ([Fe(CN)6]3–/4–) ions interface study results are presented. Conditions are selected for the mixed salts’ precipitate formation on the silver surface. It has been shown that...
Sun Feb 23, 2020 02:00
Chemosensors, Vol. 8, Pages 14: Chemical Sensors for Heavy Metals/Toxin Detection Chemosensors doi: 10.3390/chemosensors8010014 Authors: Larisa Lvova Nowadays, the huge release of pollutants into the environment has become a significant problem in many countries and entire regions [...]
Sat Feb 22, 2020 02:00
Chemosensors, Vol. 8, Pages 13: Microfluidic Mixer with Automated Electrode Switching for Sensing Applications Chemosensors doi: 10.3390/chemosensors8010013 Authors: Braunger Fier Rodrigues Arratia Riul Jr. An electronic tongue (e-tongue) is a multisensory system usually applied to complex liquid media that uses computational/statistical tools to group information generated by sensing units into recognition patterns, which allow the identification/distinction of samples....
Fri Feb 21, 2020 02:00
Climate, Vol. 8, Pages 36: Environmental Heat Stress on Indoor Environments in Shallow, Deep and Covered Atrium Plan Form Office Buildings in Tropics Climate doi: 10.3390/cli8020036 Authors: Rajapaksha Environmental heat stress on buildings through façades contributes to indoor overheating and thus increases demand for energy consumption. The study analyzed the problem, heat gain risk, of modern air-conditioned multi-level office buildings in tropics, for example Colombo....
Sat Feb 22, 2020 02:00
Dentistry Journal, Vol. 8, Pages 22: Pre-Outplacement Perceptions of Dental Students Regarding Rural Oral Health Practice and Associated Factors Dentistry Journal doi: 10.3390/dj8010022 Authors: Menaka Abuzar Felicity Crombie Karin Bishara Annesley Bryan Kenneth Chan Brendan Chang Denise Chang Wei-I (Elizabeth) Cheng Ryan Chu Rural outplacement programs have been offered by Australian universities to encourage dental students to consider rural careers. The dental...
Sun Feb 23, 2020 02:00
Dentistry Journal, Vol. 8, Pages 21: Primary Stability of Three Different Osteotomy Techniques in Medullary Bone: An in Vitro Study Dentistry Journal doi: 10.3390/dj8010021 Authors: Ferdinando Attanasio Alessandro Antonelli Ylenia Brancaccio Fiorella Averta Michele Mario Figliuzzi Leonzio Fortunato Amerigo Giudice Background: The aim of this in vitro study was to analyse the primary stability of 20 implants placed with Twist drills (TD) versus 20 implants placed with...
Fri Feb 21, 2020 02:00
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