Publication date: Available online 26 February 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Thiagarajan
Thu Feb 27, 2020 19:00
Publication date: Available online 26 February 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J.S. Smith
Thu Feb 27, 2020 19:00
Publication date: Available online 26 February 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): L. Nokovitch, J.-F. Brantus, G. Vaz, S. Deneuve
Thu Feb 27, 2020 19:00
Purpose of review To review recent evidence on the capacity of vitamin D to prevent atopic disease, focussing on food allergy and asthma, and potential underlying mechanisms. Recent findings The incidence of allergic disease continues to increase worldwide. Vitamin D status is influenced by sun exposure and dietary intake. Vitamin D deficiency is linked to an increased incidence of allergic disease and asthma. These associations are generally strongest in early life. The capacity of vitamin...
Thu Feb 27, 2020 18:54
Purpose of review The present work represents an update of the review published in this journal by Corradi et al., regarding the use of exhaled breath condensate (EBC) to investigate occupational lung diseases. Recent findings The relevant literature was searched in the Medline database, assessed through PubMed using key terms such as ‘breath AND condensate AND occupational’. Eleven pertinent publications were retrieved between January 2018 and October 2019. One article only was related to...
Thu Feb 27, 2020 18:54
Purpose of review Childhood asthma is a heterogeneous inflammatory disease comprising different phenotypes and endotypes and, particularly in its severe forms, has a large impact on the quality-of-life of patients and caregivers. The application of advanced omics technologies provides useful insights into underlying asthma endotypes and may provide potential clinical biomarkers to guide treatment and move towards a precision medicine approach. Recent findings The current article addresses...
Thu Feb 27, 2020 18:54
Purpose of review The aim of this article is to provide an update on occupational aspects of irritable larynx syndrome (ILS). Recent findings It is being increasingly recognized that ILS is common amongst certain occupations. This is particularly true of occupations that require frequent voice use such as teachers; where there is exposure to workplace irritants such as World Trade Center responders; or mechanical factors that cause laryngeal dysfunction such as elite athletes. Work associated...
Thu Feb 27, 2020 18:54
Purpose of review To present and discuss key design concepts for optimizing the impact of observational studies in the field of allergy and to highlight recent findings from NIAID-funded research networks. Recent findings We discuss three concepts. First, the benefit of prospective, longitudinal observational studies exemplified by recent findings on the seasonal nature of all rhinitis phenotypes in children with asthma and the protective effects of high house dust allergen content during...
Thu Feb 27, 2020 18:54
Purpose of review Baker's allergy and asthma continue to represent an important contributor of occupational asthma globally. This review identified recent studies related to the prevention of baker's allergy and asthma. Recent findings Studies with respect to regulatory exposure standards, workplace control measures aimed at reduction of flour dust exposures, surveillance programmes (exposure monitoring, medical surveillance) and workplace information, education and training programmes were...
Thu Feb 27, 2020 18:54
Purpose of review First described in the mid 20th century, it was just in the last decade that diagnostic and treatment guidelines for food protein-induced enterocolitis syndrome (FPIES) were established. Awareness of the diagnosis is improving, and epidemiologic data are emerging. Recent findings Recent studies suggest that FPIES may affect as many as 0.5% of children worldwide. FPIES in adults is usually triggered by seafood and may be more common than previously thought. Many patients...
Thu Feb 27, 2020 18:54
Purpose of review A recent meta-analysis of data from international case–control studies reports a population attributable fraction of 16% for occupational factors in the cause of idiopathic pulmonary fibrosis (IPF). Smoking, genetic factors and other prevalent diseases only partly explain IPF, and so this review aims to summarize recent progress in establishing which occupational exposures are important in cause. Recent findings IPF is a rare disease, although it is the commonest idiopathic...
Thu Feb 27, 2020 18:54
Purpose of review The purpose of this review is to provide a brief discussion on the differential diagnosis for peripheral eosinophilia. We will then focus on targeted immunotherapies for atopic disease, their effects on absolute peripheral eosinophil counts, and use of peripheral eosinophils as a predictor of treatment response. Recent findings In atopic disease, lower absolute peripheral eosinophil counts are typically associated with improved outcomes. Much of the current evidence on eosinophils...
Thu Feb 27, 2020 18:54
Purpose of review During the 1980s, natural rubber latex (NRL) emerged as a major cause of occupational allergy and asthma, especially in healthcare workers using powdered NRL gloves. Increased recognition of NRL allergies and transfer of research findings into prevention strategies resulted into an almost elimination of this health problem. Here, the current knowledge on allergens, their use in diagnostics, prevalence data of occupational NRL allergy and the status of prevention strategy are...
Thu Feb 27, 2020 18:54
Purpose of review Protein contact dermatitis (PCD) is a chronic eczema because of immediate hypersensitivity to protein and not related to haptens. As it has to be diagnosed by prick tests, it is probably under-recorded and under-estimated that is why it is important for dermatologists, allergists and occupational physicians to better know this peculiar contact dermatitis. Recent findings Some recent series have emphasized that PCD is mainly an occupational dermatosis, mainly observed in...
Thu Feb 27, 2020 18:54
Purpose of review The introduction of high-quality and standardized extracts for immunotherapy has renewed the interest in the treatment of pediatric allergic asthma that represents a high-prevalence disease. Recent findings In addition to clinical trials, several systematic reviews and metaanalyses were published, confirming overall the clinical efficacy of allergen immunotherapy in pediatric asthma. In addition, new data on the preventive effect of the treatment on asthma onset were published....
Thu Feb 27, 2020 18:54
Purpose of review The diagnosis of occupational rhinitis is a challenge. Underdiagnosis is substantial as the clinical presentation is nonspecific and often no occupational history is taken. Detection of occupational rhinitis can be improved by including screening questions on occupational exposure in the assessment of every patient with adult-onset rhinitis. Recent findings Case reports, case series and epidemiological studies continuously demonstrate new sensitizers and irritants capable...
Thu Feb 27, 2020 18:54
Purpose of review Clinical conditions associated with hypereosinophilia represent a field of particular interest, taking into account the epidemiological impact of the different primary and secondary forms. In addition to a classical Th1 response, also Th2 cells can be involved in the pathogenesis of autoimmune diseases, among them eosinophilic forms such as eosinophilic granulomatosis with polyangiitis. Recent findings In patients with severe asthma, recent evidence highlights the role of...
Thu Feb 27, 2020 18:54
Purpose of review Asthma is the most common chronic disease in pediatric age. Childhood-onset asthma, as opposed to adult-onset asthma, is typically characterized by a personal and often a family history of atopy and related markers of type 2-mediated inflammation. However, the interplay between atopy and asthma development is more complex than a linear dose–response relationship. Recent findings Family and personal history of atopic diseases have been confirmed as major risk factors for...
Thu Feb 27, 2020 18:54
Purpose of review Food allergy remains a disease of global public health significance well known to impact social, emotional, and financial well being. This review aims to summarize the existing literature focused on the direct, indirect, and intangible costs of food allergy at the household and healthcare system levels, and begin to discuss how emerging treatment and prevention strategies may be leveraged to comprehensively care for the food allergic population with the efficient use of health...
Thu Feb 27, 2020 18:54
Purpose of review The body's largest microbial community, the gut microbiome, is in contact with mucosal surfaces populated with epithelial, immune, endocrine and nerve cells, all of which sense and respond to microbial signals. These mutual interactions have led to a functional coevolution between the microbes and human physiology. Examples of coadaptation are anaerobes Bifidobacteria and Bacteroides, which have adjusted their metabolism to dietary components of human milk, and infant immune...
Thu Feb 27, 2020 18:54
Purpose of review Severe asthma remains a debilitating disease and a challenge for the clinicians. Novel therapies have been introduced and have greatly improved asthma control and more are under development or in clinical studies. These include anti-IL5/IL5R, anti-IL4/IL4R, anti IL13, anti- thymic stromal lymphopoietin (TSLP) and more, and severe asthma is currently managed in personalized medicine approach. However, there is still an unmet need to discover new, clinically available biomarkers...
Thu Feb 27, 2020 18:54
Purpose of review In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases. Recent findings Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex assays, mainly performed through microarrays or macroarrays. It is important to collect...
Thu Feb 27, 2020 18:54
Purpose of review The aim of this article is to characterize the present state-of-the-art on the topic of food allergies across Europe. Recent findings A systematic review and metaanalysis on the epidemiology of food allergy in Europe have been performed by the Food Allergy and Anaphylaxis Guidelines Group of the European Academy of Allergology and Clinical Immunology. The authors had made an extensive search of four different electronic databases which retrieved thousands of hits. A critical...
Thu Feb 27, 2020 18:54
OBJECTIVE: To investigate the relationship between the meniscal defect area and OA progression and explore the effect and mechanism of SMSCs cell therapy in knee osteoarthritis (OA) rat model. MATERIALS AND METHODS: For animal experiments, knee osteoarthritis (OA) model was constructed in Sprague Dawley (SD) rats by removing the medial meniscus of the right knee. Synovial mesenchymal stem cells (SMSCs) were engrafted by injecting into the right knee cavity. For in vitro experiments, CCK-8 assay...
Thu Feb 27, 2020 18:07
Corticosteroid treatment has been widely used in the treatment of septic shock, influenza, and ARDS, although some previous studies discourage its use in severe influenza patients. This multicenter retrospecti...
Thu Feb 27, 2020 02:00
Thu Feb 27, 2020 02:00
Publication date: Available online 26 February 2020Source: Hearing ResearchAuthor(s): Maryna V. Ivanchenko, Killian S. Hanlon, Maya K. Devine, Kelly Tenneson, Frederick Emond, Jean-François Lafond, Margaret A. Kenna, David P. Corey, Casey A. Maguire
Thu Feb 27, 2020 18:41
Synchronous renal cell carcinoma metastasizing to the pancreas and subcutaneous tissue is very rare. Unusual metastatic sites require attention during follow-up of renal cell carcinoma. It is extremely rare fo...
Wed Feb 26, 2020 02:00
Abstract Giant congenital melanocytic nevi (GCMN) are benign cutaneous lesions associated with increased risk for developing melanoma. Genomic studies of congenital melanocytic nevi revealed NRAS mutation as the sole mutational event in these lesions. However, studies to date have focused on mutations of benign lesions but not the malignant counterparts. Here, we performed genomic analysis of metastatic melanoma in a patient with a GCMN. We used whole exome sequencing to confirm an identical NRASQ61R...
Thu Feb 27, 2020 18:27
L'articolo Childhood obesity: right diagnosis and treatment, a current challenge sembra essere il primo su European Review.
Thu Feb 27, 2020 18:07
OBJECTIVE: Increasing evidence has shown that HSF1 is involved in glycemia regulation, and SIRPα plays a pivotal role in islet β-cell viability. However, it is still unknown whether SIRPα is associated with HSF1 in regulating the cell viability and cell death of islet β-cells. MATERIALS AND METHODS: Western blot and qPCR were applied to determine protein and mRNA levels of HSF1 and SIRPα. Cell viability and death were investigated by cell counting kit-8 and trypan blue exclusion assay. Meanwhile,...
Thu Feb 27, 2020 18:07
OBJECTIVE: Atherosclerosis (AS), with high risk of stroke or cerebrovascular disease, is one of the most common causes of death worldwide. Increasing evidence shows that long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) is related to atherothrombotic stroke susceptibility and contributes to AS progression. However, the underlying mechanism was not explained yet. PATIENTS AND METHODS: Human aorta vascular smooth muscle cells (HA-VSMCs) and human umbilical vein endothelial...
Thu Feb 27, 2020 18:07
OBJECTIVE: We evaluated the beneficial effect of miR-20a mimic against diabetic angiopathy (DA) in rats by regulating intracellular antioxidant enzymes and vascular endothelial growth factor (VEGF). MATERIALS AND METHODS: Diabetes was induced by intraperitoneal administration of streptozotocin (STZ; 65 mg/kg). Rats were then treated with miR-20a mimic (250 nmol/kg orally) for 8 weeks after STZ administration. The effect of miR-20a mimic against DA in rats was evaluated by estimating serum glucose...
Thu Feb 27, 2020 18:06
Publication date: Available online 26 February 2020Source: Medical HypothesesAuthor(s): Lin Peng, Yuhao Luo, Xianrong Huang, Zhong Li
Thu Feb 27, 2020 18:12
Publication date: Available online 26 February 2020Source: Medical HypothesesAuthor(s): Huseyin Aktas, İbrahim Selcuk Esin, Onur Burak Dursun
Thu Feb 27, 2020 18:12
Publication date: Available online 26 February 2020Source: Medical HypothesesAuthor(s): DL Katz, LQ Rhee, CS Katz, DL Aronson, GC Frank, CD Gardner, WC Willett, ML Dansinger
Thu Feb 27, 2020 18:12
Publication date: Available online 26 February 2020Source: Medical HypothesesAuthor(s): Anish Kapadia, Adam A. Dmytriw
Thu Feb 27, 2020 18:12
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου