Pathogens, Vol. 9, Pages 152: Simultaneous Immunization with Omp25 and L7/L12 Provides Protection against Brucellosis in Mice. Pathogens doi: 10.3390/pathogens9020152 Authors: Gupta Mohan Somani Aggarwal Bhatnagar Currently used Brucella vaccines, Brucella abortus strain 19 and RB51, comprises of live attenuated Brucella strains and prevent infection in animals. However, these vaccines pose potential risks to recipient animals such as attenuation reversal and virulence...
Mon Feb 24, 2020 02:00
Pathogens, Vol. 9, Pages 150: Evaluation of Disease Causality of Rare Ixodes ricinus-Borne Infections in Europe Pathogens doi: 10.3390/pathogens9020150 Authors: Azagi Hoornstra Kremer Hovius Sprong In Europe, Ixodes ricinus ticks transmit pathogens such as Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV). In addition, there is evidence for transmission to humans from I. ricinus of Anaplasma phagocytophilum, Babesia divergens, Babesia microti,...
Mon Feb 24, 2020 02:00
Pathogens, Vol. 9, Pages 149: Methylobacterium spp. as Emerging Opportunistic Premise Plumbing Pathogens Pathogens doi: 10.3390/pathogens9020149 Authors: Kyle J. Szwetkowski Joseph O. Falkinham Methylobacterium spp. are emerging opportunistic premise plumbing pathogens. Human infections linked to premise plumbing provide evidence of their routes of infection. Cells of a collection of representative strains of different Methylobacterium species were tested for hydrophobicity by contact...
Sat Feb 22, 2020 02:00
Pathogens, Vol. 9, Pages 148: Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development Pathogens doi: 10.3390/pathogens9020148 Authors: Balamurugan Shanmugaraj Ashwini Malla Waranyoo Phoolcharoen Novel Coronavirus (2019-nCoV) is an emerging pathogen that was first identified in Wuhan, China in late December 2019. This virus is responsible for the ongoing outbreak that causes severe respiratory illness and pneumonia-like infection in humans. Due...
Sat Feb 22, 2020 02:00
Pathogens, Vol. 9, Pages 147: Recognition of Lipoproteins by Toll-like Receptor 2 and DNA by the AIM2 Inflammasome Is Responsible for Production of Interleukin-1β by Virulent Suilysin-negative Streptococcus suis Serotype 2 Pathogens doi: 10.3390/pathogens9020147 Authors: Agustina Lavagna Jean-Philippe Auger Stephen E. Giradin Nicolas Gisch Mariela Segura Marcelo Gottschalk Streptococcus suis serotype 2 is an important porcine bacterial pathogen and zoonotic agent causing...
Fri Feb 21, 2020 02:00
Pathogens, Vol. 9, Pages 145: Comparative Transcriptome Analysis of Two Cucumber Cultivars with Different Sensitivity to Cucumber Mosaic Virus Infection Pathogens doi: 10.3390/pathogens9020145 Authors: Zdeno Šubr Lukáš Predajňa Katarína Šoltys Boris Bokor Jaroslav Budiš Miroslav Glasa Cucumber mosaic virus (CMV), with extremely broad host range including both monocots and dicots around the world, belongs to most important viral crop threats. Either natural or genetically...
Fri Feb 21, 2020 02:00
Pathogens, Vol. 9, Pages 146: The Old and the New on Viral Diseases in Sturgeon Pathogens doi: 10.3390/pathogens9020146 Authors: Davide Mugetti Paolo Pastorino Vasco Menconi Claudio Pedron Marino Prearo Although sturgeon production by aquaculture has increased worldwide, a major factor limiting its expansion are infectious diseases, although few data about viral diseases are available however. This review provides a rapid overview of viral agents detected and described to...
Fri Feb 21, 2020 02:00
Pathogens, Vol. 9, Pages 144: Isolation of Acanthamoeba T5 from Water: Characterization of Its Pathogenic Potential, Including the Production of Extracellular Vesicles Pathogens doi: 10.3390/pathogens9020144 Authors: Lissette Retana Moreira Daniel Vargas Ramírez Fátima Linares Alexa Prescilla Ledezma Annette Vaglio Garro Antonio Osuna Jacob Lorenzo Morales Elizabeth Abrahams Sandí Acanthamoeba is a genus of free-living amoebae widely distributed in nature, associated...
Fri Feb 21, 2020 02:00
Pharmaceuticals, Vol. 13, Pages 33: Advances in CXCR7 Modulators Pharmaceuticals doi: 10.3390/ph13020033 Authors: Nicole Lounsbury CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12). It interacts with CXCR4, and the two are associated with various cancers, as well as other disease states such...
Fri Feb 21, 2020 02:00
Pharmaceutics, Vol. 12, Pages 195: Stability Study of Isoniazid and Rifampicin Oral Solutions Using Hydroxypropyl-Β-Cyclodextrin to Treat Tuberculosis in Paediatrics Pharmaceutics doi: 10.3390/pharmaceutics12020195 Authors: Santoveña-Estévez Suárez-González Cáceres-Pérez Ruiz-Noda Machado-Rodríguez Echezarreta Soriano Fariña (1) Background: First-line antituberculosis treatment in paediatrics entails the administration of Isoniazid, Pyrazinamide, and Rifampicin....
Mon Feb 24, 2020 02:00
Pharmaceutics, Vol. 12, Pages 194: Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data Pharmaceutics doi: 10.3390/pharmaceutics12020194 Authors: Gils Roex Tom Feys Yves Beguin Tessa Kerre Xavier Poiré Philippe Lewalle Peter Vandenberghe Dominique Bron Sébastien Anguille Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy that has revolutionized the...
Mon Feb 24, 2020 02:00
Pharmaceutics, Vol. 12, Pages 193: Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer Pharmaceutics doi: 10.3390/pharmaceutics12020193 Authors: Ana Luiza C. de S. L. Oliveira Raimundo Fernandes de Araújo Júnior Thaís Gomes de Carvalho Alan B. Chan Timo Schomann Filippo Tamburini Lioe-Fee de Geus-Oei Luis J. Cruz Apoptosis...
Sun Feb 23, 2020 02:00
Pharmaceutics, Vol. 12, Pages 192: Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System Pharmaceutics doi: 10.3390/pharmaceutics12020192 Authors: Ana P. Spencer Marília Torrado Beatriz Custódio Sara C. Silva-Reis Sofia D. Santos Victoria Leiro Ana P. Pêgo Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical...
Sun Feb 23, 2020 02:00
Pharmaceutics, Vol. 12, Pages 182: A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of Self-Assembling Nano Co-Crystals Pharmaceutics doi: 10.3390/pharmaceutics12020182 Authors: Bwalya A. Witika Vincent J. Smith Roderick B. Walker Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT....
Sun Feb 23, 2020 02:00
Pharmaceutics, Vol. 12, Pages 191: Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia Pharmaceutics doi: 10.3390/pharmaceutics12020191 Authors: Kambere Amerigos Daddy J.C. Minglei Chen Faisal Raza Yanyu Xiao Zhigui Su Qineng Ping Multidrug resistance (MDR) due to P-glycoprotein (P-gp) overexpression is a major obstacle to successful leukemia chemotherapy. The combination of anticancer chemotherapy with...
Sun Feb 23, 2020 02:00
Pharmaceutics, Vol. 12, Pages 190: Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review Pharmaceutics doi: 10.3390/pharmaceutics12020190 Authors: Ana Baumgartner Katarina Drame Stijn Geutjens Marja Airaksinen Many patients, especially those with a high pill burden and multiple chronic illnesses, are less adherent to medication. In medication treatments utilizing polypills, this problem might be diminished since multiple drugs...
Sat Feb 22, 2020 02:00
Pharmaceutics, Vol. 12, Pages 189: Sphingomyelin-Based Nanosystems (SNs) for the Development of Anticancer miRNA Therapeutics Pharmaceutics doi: 10.3390/pharmaceutics12020189 Authors: Surasa Nagachinta Belen Lopez Bouzo Abi Judit Vazquez-Rios Rafael Lopez Maria de la Fuente Gene replacement therapy with oncosuppressor microRNAs (miRNAs) is a promising alternative to interfere with cancer progression. However, miRNAs are highly inefficient in a biological environment, hampering...
Sat Feb 22, 2020 02:00
Pharmaceutics, Vol. 12, Pages 187: Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity Pharmaceutics doi: 10.3390/pharmaceutics12020187 Authors: Oisín Kavanagh Fiona Hogan Caoimhe Murphy Denise Croker Gavin Walker Mannitol infusion is commonly used in the treatment of intracranial hypertension following traumatic brain injury. It has long been known to have stability issues, specifically, mannitol recrystallises from solutions greater than 10% w/v in...
Fri Feb 21, 2020 02:00
Pharmaceutics, Vol. 12, Pages 186: MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles Pharmaceutics doi: 10.3390/pharmaceutics12020186 Authors: Osorio-Querejeta Carregal-Romero Ayerdi-Izquierdo Mäger A. Wood Egimendia Betanzos Alberro Iparraguirre Moles Llarena Möller Goñi-de-Cerio Bijelic Ramos-Cabrer Muñoz-Culla Otaegui ...
Fri Feb 21, 2020 02:00
Pharmaceutics, Vol. 12, Pages 188: A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225 Pharmaceutics doi: 10.3390/pharmaceutics12020188 Authors: Evangelia-Alexandra Salvanou Dimitris Stellas Charalampos Tsoukalas Barbara Mavroidi Maria Paravatou-Petsotas Nikolaos Kalogeropoulos Stavros Xanthopoulos Franck Denat Gautier Laurent Rana Bazzi Stephane Roux Penelope Bouziotis Actinium-225...
Fri Feb 21, 2020 02:00
Pharmaceutics, Vol. 12, Pages 184: Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives Pharmaceutics doi: 10.3390/pharmaceutics12020184 Authors: Kashif Ahmad Ghaffar Rolf Daniels Triterpenes from the outer bark of birch have many beneficial biological and pharmacological activities. In particular, its wound healing efficacy is of paramount importance. Apart from that, particles of a birch bark dry extract aggregate into a three dimensional...
Fri Feb 21, 2020 02:00
Pharmaceutics, Vol. 12, Pages 183: Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar! Pharmaceutics doi: 10.3390/pharmaceutics12020183 Authors: Bono Ponti Mantovani Candiani Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene delivery. Despite the resources poured into the development of ever more effective transfectants, improvement is still slow and limited. Of note, the performance of any gene delivery vector in vitro...
Fri Feb 21, 2020 02:00
Pharmaceutics, Vol. 12, Pages 185: Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells Pharmaceutics doi: 10.3390/pharmaceutics12020185 Authors: Montero Seras-Franzoso Andrade Martinez-Trucharte Vilar-Hernández Quesada Xandri Arango Abasolo Rafael Schwartz Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem...
Fri Feb 21, 2020 02:00
Pharmacy, Vol. 8, Pages 26: Assessing Performance and Engagement on a Computer-Based Education Platform for Pharmacy Practice Pharmacy doi: 10.3390/pharmacy8010026 Authors: Grindrod Morris Killeen A computer-based education platform was developed using a theory-based approach to help Canadian pharmacy professionals adopt their full scope of practice. Data from the platform were used to identify factors that impacted user performance and engagement. A de-identified dataset included...
Mon Feb 24, 2020 02:00
Pharmacy, Vol. 8, Pages 24: Prescriber-Initiated Engagement of Pharmacists for Information and Intervention in Programs of All-Inclusive Care for the Elderly Pharmacy doi: 10.3390/pharmacy8010024 Authors: David L. Bankes Richard O. Schamp Calvin H. Knowlton Kevin T. Bain Little is known about the types of drug information inquiries (DIIs) prescribers caring for older adults ask pharmacists during routine practice. The objective of this research was to analyze the types of DIIs...
Fri Feb 21, 2020 02:00
Pharmacy, Vol. 8, Pages 25: Preliminary Investigation of Pharmacist-Delivered, Direct-to-Provider Interventions to Reduce Co-Prescribing of Opioids and Benzodiazepines among a Medicare Population Pharmacy doi: 10.3390/pharmacy8010025 Authors: Jennifer M. Bingham Ann M. Taylor Kevin P. Boesen David R. Axon Co-prescribing of opioids and benzodiazepines can lead to overdoses and mortality. This retrospective study analyzed prescription claims data collected in 2016. A national...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 286: Complete Chloroplast Genomes of Three Medicinal Alpinia Species: Genome Organization, Comparative Analyses and Phylogenetic Relationships in Family Zingiberaceae Plants doi: 10.3390/plants9020286 Authors: Dong-Mei Li Gen-Fa Zhu Ye-Chun Xu Yuan-Jun Ye Jin-Mei Liu Alpinia katsumadai (A. katsumadai), Alpinia oxyphylla (A. oxyphylla) and Alpinia pumila (A. pumila), which belong to the family Zingiberaceae, exhibit multiple medicinal properties. The...
Mon Feb 24, 2020 02:00
Plants, Vol. 9, Pages 285: Use of Nitric Oxide and Hydrogen Peroxide for Better Yield of Wheat (Triticum aestivum L.) under Water Deficit Conditions: Growth, Osmoregulation, and Antioxidative Defense Mechanism Plants doi: 10.3390/plants9020285 Authors: Noman Habib Qasim Ali Shafaqat Ali Muhammad Tariq Javed Muhammad Zulqurnain Haider Rashida Perveen Muhammad Rizwan Shahid Muhammad Rizwan Mohamed M. Abdel-Daim Amr Elkelish May Bin-Jumah The present experiment...
Sat Feb 22, 2020 02:00
Plants, Vol. 9, Pages 281: Exogenous Kinetin Promotes the Nonenzymatic Antioxidant System and Photosynthetic Activity of Coffee (Coffea arabica L.) Plants Under Cold Stress Conditions Plants doi: 10.3390/plants9020281 Authors: ACIDRI SAWAI SUGIMOTO HANDA SASAGAWA MASUNAGA YAMAMOTO NISHIHARA Coffee plants are seasonally exposed to low chilling temperatures in many coffee-producing regions. In this study, we investigated the ameliorative effects of kinetin—a...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 282: Exploring Heterosis in Melon (Cucumis melo L.) Plants doi: 10.3390/plants9020282 Authors: Marco Napolitano Niccolò Terzaroli Subash Kashyap Luigi Russi Elen Jones-Evans Emidio Albertini Heterosis is the superiority of an F1 hybrid over its parents. Since this phenomenon is still unclear in melon, a half diallel experiment based on eight genetically distant breeding lines was conducted in six environments of Central Italy, assessing commercially...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 279: Prospects of Arbuscular Mycorrhizal Fungi Utilization in Production of Allium Plants Plants doi: 10.3390/plants9020279 Authors: Golubkina Krivenkov Sekara Vasileva Tallarita Caruso The need to improve crop yield and quality, decrease the level of mineral fertilizers and pesticides/herbicides supply, and increase plants’ immunity are important topics of agriculture in the 21st century. In this respect, arbuscular mycorrhizal fungi...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 280: The Analysis of the Editing Defects in the dyw2 Mutant Provides New Clues for the Prediction of RNA Targets of Arabidopsis E+-Class PPR Proteins Plants doi: 10.3390/plants9020280 Authors: Malbert Burger Lopez-Obando Baudry Launay-Avon Härtel Verbitskiy Jörg Berthomé Lurin Takenaka Delannoy C to U editing is one of the post-transcriptional steps which are required for the proper expression of chloroplast and mitochondrial...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 283: Natural Variation in Volatile Emissions of the Invasive Weed Calluna vulgaris in New Zealand Plants doi: 10.3390/plants9020283 Authors: Evans Effah D. Paul Barrett Paul G. Peterson A. Jonathan R. Godfrey Murray A. Potter Jarmo K. Holopainen Andrea Clavijo McCormick Invasive plants pose a threat to natural ecosystems, changing the community composition and ecological dynamics. One aspect that has received little attention is the production...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 284: First Phylogeny of Bitterbush Family, Picramniaceae (Picramniales) Plants doi: 10.3390/plants9020284 Authors: Shipunov Carr Furniss Pay Pirani Picramniaceae is the only member of Picramniales which is sister to the clade (Sapindales (Huerteales (Malvales, Brassicales))) in the rosidsmalvids. Not much is known about most aspects of their ecology, geography, and morphology. The family is restricted to American tropics. Picramniaceae representatives...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 278: Effects of Genotype and Culture Conditions on Microspore Embryogenesis and Plant Regeneration in Brassica Rapa ssp. Rapa L. Plants doi: 10.3390/plants9020278 Authors: Daria Shumilina Dmitry Kornyukhin Elena Domblides Alexey Soldatenko Anna Artemyeva Turnip is a biennial crop and, consequently, the creation of pure lines for breeding is a time-consuming process. The production of pure turnip lines using doubled haploids produced in isolated microspore...
Fri Feb 21, 2020 02:00
Plants, Vol. 9, Pages 277: A PCR, qPCR, and LAMP Toolkit for the Detection of the Wheat Blast Pathogen in Seeds Plants doi: 10.3390/plants9020277 Authors: Maud Thierry Axel Chatet Elisabeth Fournier Didier Tharreau Renaud Ioos Wheat blast is a devastating disease caused by the pathogenic fungus Pyricularia oryzae. Wheat blast first emerged in South America before more recently reaching Bangladesh. Even though the pathogen can spread locally by air-dispersed spores, long-distance...
Fri Feb 21, 2020 02:00
Religions, Vol. 11, Pages 101: Inculturation, Anthropology, and the Empirical Dimension of Evangelization Religions doi: 10.3390/rel11020101 Authors: Vivencio Ballano Using anthropological and theological perspectives and secondary literature, this paper argues that the scientific study of culture by professional anthropologists and social scientists is an essential component in the Catholic Church’s mission of evangelization through inculturation. Inculturation, the process of inserting...
Sun Feb 23, 2020 02:00
Religions, Vol. 11, Pages 100: “Fantastic Tricks before High Heaven,” Measure for Measure and Performing Triads Religions doi: 10.3390/rel11020100 Authors: Emily Bryan Reading Measure for Measure through the logic of substitution has been a long-standing critical tradition; the play seems to invite topical, political, and religious parallels at every turn. What if the logic of substitution in the play goes beyond exchange and seeks out a triadic logic instead? This insistent searching...
Sat Feb 22, 2020 02:00
Religions, Vol. 11, Pages 99: Seven Faces of a Fatwa: Organ Transplantation and Islam Religions doi: 10.3390/rel11020099 Authors: Mansur Ali Usman Maravia A new fatwa was announced by the British National Health Service (NHS) in June 2019 to clarify the Islamic position on organ donation. Additionally, the NHS promotional material presents brief arguments for and against organ donation in Islam. However, to date, research into the various fatwas on organ donation is required. This...
Fri Feb 21, 2020 02:00
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