Abstract High‐grade serous ovarian cancer (HGS‐EOCs) is generally sensitive to front‐line platinum (Pt)‐based chemotherapy although most patients at an advanced stage relapse with progressive resistant disease. Clinical or molecular data to identify primary resistant cases at diagnosis are not yet available. HGS‐EOC biopsies from 105 Pt‐sensitive (Pt‐s) and 89 Pt‐resistant (Pt‐r) patients were retrospectively selected from two independent tumor tissue collections. Pathway analysis was done integrating...
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Related ArticlesThe effect of lateral neck dissection on complication rate for total thyroidectomy. Am J Otolaryngol. 2020 Feb 13;:102421 Authors: Rocke DJ, Mulder H, Cyr D, Kahmke R, Lee WT, Puscas L, Schulz K, Witsell DL Abstract PURPOSE: To determine the complication profile for total thyroidectomy with and without concomitant lateral neck dissection using a large administrative database. MATERIALS AND METHODS: The IBM MarketScan® Commercial...
Tue Feb 25, 2020 13:01
Related ArticlesThe importance of FDG-PET/CT parameters for the assessment of the immune status in advanced HNSCC. Auris Nasus Larynx. 2020 Feb 20;: Authors: Ohashi T, Terasawa K, Aoki M, Akazawa T, Shibata H, Kuze B, Asano T, Kato H, Miyazaki T, Matsuo M, Inoue N, Ito Y Abstract OBJECTIVE: Cancer cells secrete large amounts of lactic acid via aerobic glycolysis. We have shown that lactic acid plays an important role as a proinflammatory and immunosuppressive...
Tue Feb 25, 2020 13:01
Related ArticlesReal-time imaging of head and neck squamous cell carcinomas using confocal micro-endoscopy and applicable dye: A preliminary study. Auris Nasus Larynx. 2020 Feb 20;: Authors: Shinohara S, Funabiki K, Kikuchi M, Takebayashi S, Hamaguchi K, Hara S, Yamashita D, Imai Y, Mizoguchi A Abstract OBJECTIVES: Confocal laser endomicroscopy (CLE) is a technology that enables microscopic visualization of lesions in real-time (optical biopsy) and has...
Tue Feb 25, 2020 13:01
Related ArticlesGreat auricular nerve schwannoma in neck region: a case report with the risk of medical disputes. BMC Neurol. 2019 Dec 01;19(1):308 Authors: Xu C, Sun Q Abstract BACKGROUND: Great auricular nerve schwannoma is extremely rare. Herein, we reported the first case of schwannoma arising from great auricular nerve trunk. CASE PRESENTATION: A 29 year-old female complained of a slowly-growing superfacial neck mass for 6 months. MRI...
Tue Feb 25, 2020 13:01
Related ArticlesDynamically Monitoring Vocal Fatigue and Recovery Using Aerodynamic, Acoustic, and Subjective Self-Rating Measurements. J Voice. 2019 Sep;33(5):809.e11-809.e18 Authors: Xue C, Kang J, Hedberg C, Zhang Y, Jiang JJ Abstract OBJECTIVES: This study aimed to quantify the effects of vocal loading and vocal rest using aerodynamic, acoustic, and self-rating measurements. METHODS: Ten participants were recruited to perform vocal loading...
Tue Feb 25, 2020 13:01
Related ArticlesEffects of Angle of Epiglottis on Aerodynamic and Acoustic Parameters in Excised Canine Larynges. J Voice. 2019 Sep;33(5):627-633 Authors: Zeng Q, Jiao Y, Huang X, Wang R, Bao H, Lamb JR, Le J, Zhuang P, Jiang J Abstract OBJECTIVES: The aim of this study is to explore the effects of the angle of epiglottis (Aepi) on phonation and resonance in excised canine larynges. METHODS: The anatomic Aepi was measured for 14 excised canine...
Tue Feb 25, 2020 13:01
Related ArticlesPrimary osteosarcoma of the skull in teenager. BMJ Case Rep. 2019 Sep 16;12(9): Authors: Vasquez L, Tejada V, Maza I, Mendoza R Abstract Osteosarcoma of the skull is a rare primary malignant bone tumour in children, representing 1-2% of all cranial tumours. We describe a case of a 17-year-old adolescent with chondroblastic osteosarcoma of the parietal-occipital bone and no distant metastases at presentation treated with neoadjuvant chemotherapy,...
Tue Feb 25, 2020 13:01
Related ArticlesExternal validation of a prognostic model to predict survival of patients with sentinel node-negative melanoma. Br J Surg. 2019 09;106(10):1319-1326 Authors: Ipenburg NA, Nieweg OE, Ahmed T, van Doorn R, Scolyer RA, Long GV, Thompson JF, Lo S Abstract BACKGROUND: Identifying patients with sentinel node-negative melanoma at high risk of recurrence or death is important. The European Organisation for Research and Treatment of Cancer (EORTC)...
Tue Feb 25, 2020 13:01
Related ArticlesEndoscopic transnasal resection of optic pathway pilocytic astrocytoma. Childs Nerv Syst. 2019 01;35(1):73-81 Authors: Bin Abdulqader S, Al-Ajlan Z, Albakr A, Issawi W, Al-Bar M, Recinos PF, Alsaleh S, Ajlan A Abstract PURPOSE: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely...
Tue Feb 25, 2020 13:01
Related ArticlesTumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. Cell Metab. 2019 01 08;29(1):124-140.e10 Authors: Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C Abstract Dysregulation of extracellular matrix (ECM) deposition and cellular metabolism promotes tumor aggressiveness by sustaining...
Tue Feb 25, 2020 13:01
Related ArticlesOral flurbiprofen spray for postoperative sore throat and hoarseness: a prospective, randomized, double-blind, placebo-controlled study. Minerva Anestesiol. 2019 01;85(1):21-27 Authors: Muderris T, Tezcan G, Sancak M, Gul F, Ugur G Abstract BACKGROUND: Sore throat and hoarseness are common complications after surgery. Flurbiprofen spray has been successfully used for treatment of oral inflammations, but its effects on postoperative sore...
Tue Feb 25, 2020 13:01
Related ArticlesA Grading System for Transnasal Flexible Laryngoscopy. J Voice. 2019 Sep;33(5):712-715 Authors: Tasli H, Karakoc O, Birkent H Abstract OBJECTIVE: Transnasal flexible laryngoscopy (TFL) is becoming more popular in laryngology clinical practice. There has not been any grading system for TFL to help the physician document and communicate the laryngeal view yet. In this study, we aimed to classify the laryngeal view based on the visualization...
Tue Feb 25, 2020 13:01
Publication date: Available online 24 February 2020Source: Seminars in OncologyAuthor(s): Konrad Bochennek, Marie Luckowitsch, Thomas Lehrnbecher
Tue Feb 25, 2020 12:59
Background: The modified Blair incision is the standard facial incision for the vast majority of parotid gland lesions. We utilize three types of incisions: “classic mini-Blair” for parotid body tumors, “cervical mini-Blair” for parotid tail tumors, and “vertical mini-Blair” for anterior parotid tumors. In this study, we describe the surgical and esthetic outcomes of these individually tailored incisions. Methods: Patients undergoing parotidectomy between 2011 and 2013 were included. The surgical...
Tue Feb 25, 2020 12:12
In order to help safeguard biodiversity from global changes, the Conference of the Parties developed a Strategic Plan for Biodiversity for the period 2011–2020 that included a list of twenty specific objectives known as the Aichi Biodiversity Targets. With the end of that timeframe in sight, and despite major advancements in biodiversity conservation, evidence suggests that the majority of the Targets are unlikely to be met. This article is part of a series of perspective pieces from the 4th World...
Tue Feb 25, 2020 02:00
Transcriptome analysis and transcription factors responsive to drought stress in Hibiscus cannabinus
Kenaf is an annual bast fiber crop. Drought stress influences the growth of kenaf stems and causes a marked decrease in fiber yield and quality. Research on the drought resistance of kenaf is therefore important, but limited information is available on the response mechanism of kenaf to drought stress. In this study, a transcriptome analysis of genes associated with the drought stress response in kenaf was performed. About 264,244,210 bp high-quality reads were obtained after strict quality inspection...
Tue Feb 25, 2020 02:00
Objective Machine learning methods may have better or comparable predictive ability than traditional analysis. We explore machine learning methods to predict the likelihood of acute kidney injury after liver cancer resection. Methods This is a secondary analysis cohort study. We reviewed data from patients who had undergone resection of primary hepatocellular carcinoma between January 2008 and October 2015. ...
Tue Feb 25, 2020 02:00
Background With the rapid progress of genetic engineering and gene therapy methods, the World Anti-Doping Agency has raised concerns regarding gene doping, which is prohibited in sports. However, there is no standard method available for detecting transgenes delivered by injection of naked plasmids. Here, we developed a detection method for detecting transgenes delivered by injection of naked plasmids in a mouse model that mimics gene doping. ...
Tue Feb 25, 2020 02:00
The tendons unite and transmit the strength of the muscles to the bones, allowing movement dexterity, the distribution of the strength of the limbs to the digits, and an improved muscle performance for a wide range of locomotor activities. Tissue differentiation and maturation of the structures involved in locomotion are completed during the juvenile stage; however, few studies have investigated the ontogenetic variation of the musculoskeletal-tendinous system. We ask whether all those integrated...
Tue Feb 25, 2020 02:00
Background In a recent paper, a new species of the crocodyliform genus Isisfordia was erected based on, in part, a specimen previously designated as the holotype of ‘Crocodylus (Bottosaurus)’ selaslophensis. This new species was given the name Isisfordia molnari. However, because the holotype of ‘Crocodylus (Bottosaurus)’ selaslophensis displays a unique combination of characters and does not overlap with the holotype of I. molnari, both names remain valid according to ICZN regulations....
Tue Feb 25, 2020 02:00
Wildlife demography is typically studied at a single point in time within a year when species, often during the reproductive season, are more active and therefore easier to find. However, this provides only a low-resolution glimpse into demographic temporal patterns over time and may hamper a more complete understanding of the population dynamics of a species over the full annual cycle. The full annual cycle is often influenced by environmental seasonality, which induces a cyclic behavior in many...
Tue Feb 25, 2020 02:00
Factors controlling the spread of invasive earthworms in Minnesota’s Boundary Waters Canoe Area Wilderness are poorly known. Believed to have been introduced by anglers who use them as bait, invasive earthworms can alter the physical and chemical properties of soil and modify forest plant communities. To examine factors influencing earthworm distribution and abundance, we sampled 38 islands across five lakes to assess the effects of campsites, fire and entry point distance on earthworm density, biomass...
Tue Feb 25, 2020 02:00
Background Activation of the immune system might affect the severity of depressive episodes as well as response to the antidepressant treatment. The purpose of this study was to investigate whether the occurrence of variant alleles of analyzed SNPs are involved in prevalence and progression of depression. Moreover, selected genes and SNPs have not been investigated in context of the disease severity and treatment. Therefore, six polymorphisms were selected: g.41354391A>G-TGFB1 (rs1800469), g.132484229C>A-IRF...
Tue Feb 25, 2020 02:00
The dromaeosaurid theropod Halszkaraptor escuilliei is characterized by several unusual features absent in other paravians, part of which has been interpreted as diagnostic of a novel lineage adapted to a semiaquatic ecology. Recently, these evolutionary and ecological interpretations have been challenged, and Halszkaraptor has been claimed to be a transitional form between non-dromaeosaurid maniraptoriforms and other dromaeosaurids: following that reevaluation, its peculiar body plan would represent...
Tue Feb 25, 2020 02:00
Background Home-based resistance training offers an alternative to traditional, hospital-based or rehabilitation center-based resistance training and has attracted much attention recently. However, without the supervision of a therapist or the assistance of an exercise monitoring system, one of the biggest challenges of home-based resistance training is that the therapist may not know if the patient has performed the exercise as prescribed. A lack of objective measurements limits the ability of...
Tue Feb 25, 2020 02:00
Publication date: Available online 24 February 2020Source: Archives of Oral BiologyAuthor(s): Xin Hu, Haofeng Xiong, Weiming Wang, Long Huang, Ting Mao, Liudi Yang, Can Wang, Danni Huang, Jin Wu, Kun Xia, Tong Su
Tue Feb 25, 2020 12:48
Publication date: Available online 24 February 2020Source: Archives of Oral BiologyAuthor(s): Rafaely Ferreira Severo, Cainá Corrêa do Amaral, Tiago Fernandez Garcia, Camila Perelló Ferrúa, Geovanna Peter Corrêa, Adriana Beiersdorff Klug, Karine Duarte da Silva, Clarissa Ribeiro Bastos, Marcos Britto Correa, Gabriele Cordenonzi Ghisleni, Ana Carolina Uchoa Vasconcelos, Sandra Beatriz Chaves Tarquinio, Fernanda Nedel
Tue Feb 25, 2020 12:48
Publication date: Available online 25 February 2020Source: TalantaAuthor(s): Maria António, Rita Ferreira, Rui Vitorino, Ana L. Daniel-da-Silva
Tue Feb 25, 2020 12:44
Publication date: Available online 24 February 2020Source: TalantaAuthor(s): Xuemei Wang, Juan Wang, Tongtong Du, Haixia Kou, Xinzhen Du, Xiaoquan Lu
Tue Feb 25, 2020 12:44
Publication date: Available online 24 February 2020Source: TalantaAuthor(s): Bing-Hui Wang, Xiao Lian, Bing Yan
Tue Feb 25, 2020 12:44
Publication date: Available online 24 February 2020Source: TalantaAuthor(s): Vera E. Sitnikova, Mariia A. Kotkova, Tatiana N. Nosenko, Tatiana N. Kotkova, Daria M. Martynova, Mayya V. Uspenskaya
Tue Feb 25, 2020 12:44
Abstract Objectives Ecological similarity between species can lead to interspecific trophic competition. However, when ecologically similar species coexist, they may differ in foraging strategies and habitat use, which can lead to niche partitioning. As the body tissues of consumers contain a stable isotope signature that reflects the isotopic composition of their diet, stable isotope analysis is a useful tool to study feeding behavior. We measured the isotopic niche width, which is a proxy for...
Tue Feb 25, 2020 12:01
Abstract Objectives Sodium, a vital micronutrient that is often in scarce supply for tropical herbivores, is sometimes found at high concentration in decaying wood. We tested two hypotheses for chimpanzees: first, that wood‐eating facilitates acquisition of sodium; second, that wood‐eating occurs in response to the low availability of sodium from other dietary sources. Materials and Methods We studied the behavior of more than 50 chimpanzees of all age‐sex classes in the Kanyawara community...
Tue Feb 25, 2020 12:01
Abstract Effective therapeutic targets for triple‐negative breast cancer (TNBC), a special type of breast cancer (BC) with rapid metastasis and poor prognosis, are lacking, especially for patients with chemotherapy resistance. Decitabine (DCA) is a Food and Drug Administration‐approved DNA methyltransferase inhibitor that has been proven effective for the treatment of tumors. However, its antitumor effect in cancer cells is limited by multidrug resistance. Cancer stem cells (CSCs), which are thought...
Tue Feb 25, 2020 11:35
בארכיון האקדמיה נמצא מכתב בעברית צחה משנת 1932 אל ועד הלשון מהנהלת בית ספר עממי. מה שלכד את עינינו הוא היעד שממנו נשלח המכתב: הכפר טורון היושב בהרי הקרפטים בין שני רכסי הרים באחד המקומות המבודדים באירופה, בין אוקראינה, פולין, סלובקיה והונגריה. אל הכפר מגיעה דרך יחידה והעיר הקרובה ביותר המרוחקת כ־100 קילומטרים. כעת חיים בכפר הזה 1300 תושבים; יש לשער שבשנות השלושים של המאה העשרים היו פחות. בכפר זה היה בית ספר יהודי־עברי, ומנהלו משה ליבוביץ' פנה לוועד הלשון בבקשה לכתוב את השמות העבריים לחפצים שהיו...
Tue Feb 25, 2020 10:53
Abstract Purpose To assess the neurocognitive function and neurological toxicity of frameless linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) in patients with 10 or more brain metastases (BM). Patients and methods Forty consecutive adult patients who received SRS for ten or more 10 BM < 3 cm in maximum size were evaluated. All plans were...
Tue Feb 25, 2020 02:00
Individuals with life-threatening food allergy (FA) often experience elevated anxiety as they avoid accidental exposure to allergens, modify daily routines, and undergo treatments: In sum, quality of life can be adversely impacted.1-5 Allergists providing diagnostic and treatment services for these patients frequently hear about these psychosocial struggles, however, little is known about the interaction of the medical and psychosocial needs of FA children and families.3 Therefore, this study was...
Tue Feb 25, 2020 02:00
High intra‐individual variation in mean scores of behavioral traits across time indicated no repeatability. Abstract Animal personality is defined as consistent individual differences across time and situations, but little is known about how or when those differences are established during development. Likewise, several studies described the personality structure of adult capuchin monkeys, without assessing the ontogeny of these personality traits. We analyzed the behavioral repertoire of 12 wild...
Tue Feb 25, 2020 11:14
According to Stanford Medical, It is indeed the one and ONLY reason this country's women get to live 10 years longer and weigh 42 lbs lighter than us.
ΑπάντησηΔιαγραφή(By the way, it is not about genetics or some secret-exercise and EVERYTHING to do with "how" they are eating.)
BTW, What I said is "HOW", and not "what"...
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