Cancers, Vol. 12, Pages 533: A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2 Cancers doi: 10.3390/cancers12030533 Authors: Man-Hong Leung Ho Tsoi Chun Gong Ellen PS Man Stefania Zona Shang Yao Eric W.-F. Lam Ui-Soon Khoo Breast cancer is the most common type of female cancer. Reactive oxygen species (ROS) are vital in regulating signaling pathways that control cell survival and cell proliferation. Chemotherapeutic...
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Cancers, Vol. 12, Pages 531: Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover Cancers doi: 10.3390/cancers12030531 Authors: Thompson Baergen Lichtensztejn McManus Chromosome instability (CIN), or progressive changes in chromosome numbers, is an enabling feature of many cancers; however, the mechanisms giving rise to CIN remain poorly understood. To expand our mechanistic understanding of the molecular determinants of CIN...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 532: Role of Akt Activation in PARP Inhibitor Resistance in Cancer Cancers doi: 10.3390/cancers12030532 Authors: Gallyas Jr Sumegi Szabo Poly(ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the therapy of several types of cancers not responding to conventional treatments. However, de novo and acquired PARP inhibitor resistance is a significant limiting factor in the clinical therapy, and the underlying mechanisms are not fully...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 530: The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth Cancers doi: 10.3390/cancers12030530 Authors: Schnetz Meier Rehwald Mertens Urbschat Tomat Akam Baer Roos Brüne Jung Accumulating evidence suggests that iron homeostasis is disturbed in tumors. We aimed at clarifying the distribution of iron in renal cell carcinoma (RCC). Considering the pivotal role of macrophages...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 528: The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative Cancers doi: 10.3390/cancers12030528 Authors: Gao Ge Wang Xu Feng Li Wang Wang Dai Xie Colorectal cancer (CRC) is one of the most prevalent cancers due to its frequency and high rate of mortality. Polyamine-vectorized anticancer drugs possess multiple biological properties. Of these...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 529: Highly Expressed miR-375 is not an Intracellular Oncogene in Merkel Cell Polyomavirus-Associated Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12030529 Authors: Fan Zebisch Horny Schrama Becker miR-375 is a highly abundant miRNA in Merkel cell carcinoma (MCC). In other cancers, it acts as either a tumor suppressor or oncogene. While free-circulating miR-375 serves as a surrogate marker for tumor burden in patients with advanced MCC, its...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 526: Efficacy of Crizotinib, Ceritinib, and Alectinib in ALK-Positive Non-Small Cell Lung Cancer Treatment: A Meta-Analysis of Clinical Trials Cancers doi: 10.3390/cancers12030526 Authors: Hoang Myung Pham Park This study aimed to evaluate the efficacy of anaplastic lymphoma kinase (ALK)-inhibitors in the treatment of ALK-positive non-small cell lung cancer (NSCLC) by using a meta-analysis of clinical trials. We searched PubMed, EMBASE, Cochrane Library,...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 525: Cannabinoids and Hormone Receptor-Positive Breast Cancer Treatment Cancers doi: 10.3390/cancers12030525 Authors: Dobovišek Krstanović Borštnar Debeljak Breast cancer (BC) is the most common cancer in women worldwide. Approximately 70–80% of BCs express estrogen receptors (ER), which predict the response to endocrine therapy (ET), and are therefore hormone receptor-positive (HR+). Endogenous cannabinoids together with cannabinoid receptor...
Tue Feb 25, 2020 02:00
Cancers, Vol. 12, Pages 527: Animal Models in Microbeam Radiation Therapy: A Scoping Review Cancers doi: 10.3390/cancers12030527 Authors: Fernandez-Palomo Fazzari Trappetti Smyth Janka Laissue Djonov Background: Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred...
Tue Feb 25, 2020 02:00
Abstract Release of titanium ions (Ti ions) frequently occurs around dental implants and, as a consequence, higher content of Ti is typically present in peri-implantitis tissue. Unlike chronic periodontitis, Ti ions may play a role in the development of peri-implantitis. Inflammasomes are multiprotein signal transduction complexes, involved in inflammation and immune response, which lead to the secretion of mature cytokines associated with...
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Abstract Chronic inflammatory diseases affect bone and teeth health tremendously. Characterized by osteolytic lesion and hyperactive osteoclastogenesis, inflammatory bone diseases are short of effective therapeutics and therefore highlight the importance of understanding pathogenesis and developing ideal medications. Reactive oxygen species (ROS) play a prominent role in the innate immune response of activated macrophages, as well as in...
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Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Tue Feb 25, 2020 10:00
AbstractAmong the 5 taste qualities, salt is the least understood. The receptors, their expression pattern in taste cells, and the transduction mechanisms for salt taste are still unclear. Previous studies have suggested that low concentrations of NaCl are detected by the amiloride-sensitive epithelial Na+ channel (ENaC), which in other systems requires assembly of 3 homologous subunits (α, β, and γ) to form a functional channel. However, a new study from Lossow and colleagues, published in this...
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Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundAcne can adversely impact those affected in multiple dimensions. The purpose of this study was to determine the most prominent impacts identified by acne patients and by clinicians.MethodsIndependent Delphi surveys for acne patients and clinicians were conducted to achieve consensus regarding acne impacts within each group. Acne patients were recruited from outpatient clinics of authors (AL, JT, and DT). The first phase involved...
Tue Feb 25, 2020 13:06
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundRhinophyma surgery is commonly associated with prolonged wound healing and the need for multiple wound dressings.ObjectivesTo evaluate clinical outcome with a porcine extracellular matrix (ECM) after shave excision of rhinophyma compared with common wound care procedure.Materials and methodsRetrospective analysis of patients with common dressings (CD) compared with patients with additional ECM (OASIS) application. Clinical findings...
Tue Feb 25, 2020 12:12
Abstract Purpose of Review It is well known that combination of sensitization and exposure to inhaled environmental allergens is related to both the development and elicitation of symptoms of asthma and that avoidance of allergens would exert beneficial effects in the prevention and control of the disease. Other important factors include the relevance of other allergens, exposure to sensitizing agents also outside patient’s home,...
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Abstract Purpose Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been suggested to be associated with an increased risk of pancreatitis and pancreatic cancer. The aim of this meta-analysis was to collect data from large-scale cardiovascular outcome trials (CVOTs) to assess the effect of GLP-1RAs on the incidence of acute pancreatitis and pancreatic cancer. Methods ...
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Abstract Purpose To determine whether published disease penetrance estimates of 50% for pheochromocytoma and 20–30% for primary hyperparathyroidism in multiple endocrine neoplasia (MEN 2A), conceivably reflecting overrepresentation of index patients with completely developed MEN 2A, may be too high. Methods Cross-sectional study of carriers at high risk of...
Tue Feb 25, 2020 02:00
Abstract Oral tumor microenvironment is characterized by chronic inflammation signified with infiltrating leukocytes and soluble mediators which cause immune suppression. However, how immunosuppressive cells like myeloid-derived suppressor cells (MDSCs) maintain the immunosuppressive tumor microenvironment and influence T cell function in oral squamous cell carcinoma (OSCC) patients remains poorly understood. In the present study, we found that percentages of MDSCs were higher...
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Abstract Purpose The goal of this study is to identify the pathological findings and expression of immune checkpoint marker (PD-1, PD-L1, and CTLA-4) in the tumor microenvironment of both primary and chemoreduced retinoblastoma and correlate them with clinicopathological parameters and patient outcome. Methods Total of 262 prospective cases was included prospectively...
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Abstract Objective Reflux promotes esophageal adenocarcinomas (EACs) creating a chronic inflammatory environment. Survival rates are low due to early local recurrences and distant metastasis. Hence, there is a need for new potential treatment options like immunotherapies. However, the inflammatory microenvironment in EACs and its impact on patient outcome remain to be fully understood. ...
Tue Feb 25, 2020 02:00
Abstract Background Immunotherapy could trigger durable response in advanced gastric cancer, but it only benefits a minority of patients. We aimed to propose a robust molecular classification of gastric cancer microenvironment to identify ideal candidates for tailoring effective immunotherapy. Methods A training cohort of 375 gastric cancer samples...
Tue Feb 25, 2020 02:00
Abstract Mature dendritic cells (DCs) represent cellular adjuvants for optimal antigen presentation in cancer vaccines. Recently, a combination of prostaglandin E2 (PGE2) with Toll-like receptor agonists (TLR-P) was proposed as a new standard to generate superior cytokine-producing DCs with high migratory capacity. Here, we compare TLR-P DCs with conventional DCs matured only with the proinflammatory cytokines TNFα and IL-1ß (CDCs), focussing on the interaction of resulting DCs...
Tue Feb 25, 2020 02:00
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Tue Feb 25, 2020 11:22
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Tue Feb 25, 2020 03:13
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 14:34
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 14:32
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 14:22
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 14:14
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 13:29
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 12:50
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 12:23
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 10:29
Journal of International Medical Research, Volume 48, Issue 2, February 2020.
Mon Feb 24, 2020 09:28
High Altitude Medicine &Biology, Ahead of Print.
Tue Feb 25, 2020 10:00
Future Oncology, Ahead of Print.
Tue Feb 25, 2020 05:16
Stem Cells and Development, Ahead of Print.
Tue Feb 25, 2020 10:00
. Indian Journal of Cancer 2020 57(5):26-36
Tue Feb 25, 2020 00:00
Pankaj Chaturvedi, Kumar Prabhash, Govind Babu, Moni Kuriakose, Praveen Birur, Anil K Anand, Ashish Kaushal, Abhishek Mahajan, Judita Syiemlieh, Manish Singhal, Munish Gairola, Prakash Ramachandra, Sumit Goyal, Subashini John, Rohit Nayyar, Vijay M Patil, Vishal Rao, Vikas Roshan, GK RathIndian Journal of Cancer 2020 57(5):6-8
Tue Feb 25, 2020 00:00
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