Antibiotics, Vol. 9, Pages 99: Synthesis and Bioactivity of Thiazolethioacetamides as Potential Metallo-β-Lactamase InhibitorsAntibiotics doi: 10.3390/antibiotics9030099Authors: Zhang Yan Wang YangMetallo-β-lactamase (MβLs) mediated antibiotic resistance seriously threatens the treatment of bacterial diseases. Recently, we found that thioacetamides can be a potential MβL inhibitor skeleton. In order to improve the information of the skeleton, twelve new thiazolethioacetamides...
Wed Feb 26, 2020 02:00
Antioxidants, Vol. 9, Pages 196: Oxidative Stress and Atopic Dermatitis Antioxidants doi: 10.3390/antiox9030196 Authors: Lucrezia Bertino Fabrizio Guarneri Serafinella Patrizia Cannavò Marco Casciaro Giovanni Pioggia Sebastiano Gangemi Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects....
Wed Feb 26, 2020 02:00
Antioxidants, Vol. 9, Pages 198: Spiraea prunifolia var. simpliciflora Attenuates Oxidative Stress and Inflammatory Responses in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury and TNF-α-Stimulated NCI-H292 Cells Antioxidants doi: 10.3390/antiox9030198 Authors: Ba-Wool Lee Ji-Hye Ha Han-Gyo Shin Seong-Hun Jeong Da-Bin Jeon Ju-Hong Kim Ji-Young Park Hyung-Jun Kwon Kyungsook Jung Woo-Song Lee Hyeon-Young Kim Sung-Hwan Kim Hyun-Jae Jang Young-Bae...
Wed Feb 26, 2020 02:00
Antioxidants, Vol. 9, Pages 195: Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis Antioxidants doi: 10.3390/antiox9030195 Authors: Beverley E. Minter Damon A. Lowes Nigel R. Webster Helen F. Galley Sepsis is a life-threatening response to infection associated with inflammation, oxidative stress and mitochondrial dysfunction....
Wed Feb 26, 2020 02:00
Antioxidants, Vol. 9, Pages 197: Inhibitory Effects of Urtica thunbergiana Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice Antioxidants doi: 10.3390/antiox9030197 Authors: Hien T.T. Ngo Minzhe Fang Eunson Hwang Yoosung Kim Bom Park Seul A Seo Nhung Quynh Do Quynh T.N. Nguyen Tae-Hoo Yi Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. Urtica thunbergiana (UT) is an aroma...
Wed Feb 26, 2020 02:00
Arts, Vol. 9, Pages 30: Diverse Perspectives. A Review of Women Architects: Mode(s) of (R)existing. Reflections Based on a Cycle of Talks Arts doi: 10.3390/arts9010030 Authors: Barros dos Reis The book Women Architects: Mode(s) of (R)existing. Reflections Based on a Cycle of Talks (2018, edited by Patrícia Santos Pedrosa, Joana Pestana Lages, and Lia Gil Antunes, Lisbon, Women in Architecture Association, 100p), published as a bilingual collection (Portuguese and English),...
Wed Feb 26, 2020 02:00
Atmosphere, Vol. 11, Pages 228: Possible Effects of Greenhouse Gases to Ozone Profiles and DNA Active UV-B Irradiance at Ground Level Atmosphere doi: 10.3390/atmos11030228 Authors: Kostas Eleftheratos John Kapsomenakis Christos S. Zerefos Alkiviadis F. Bais Ilias Fountoulakis Martin Dameris Patrick Jöckel Amund S. Haslerud Sophie Godin-Beekmann Wolfgang Steinbrecht Irina Petropavlovskikh Colette Brogniez Thierry Leblanc J. Ben Liley Richard Querel...
Wed Feb 26, 2020 02:00
Atmosphere, Vol. 11, Pages 229: Assessment of Extreme and Metocean Conditions in the Swedish Exclusive Economic Zone for Wave Energy Atmosphere doi: 10.3390/atmos11030229 Authors: Erik Nilsson Linus Wrang Anna Rutgersson Adam Dingwell Erland Strömstedt Here, accessibility to near-shore and offshore marine sites is evaluated based on wave and ice conditions. High-resolution third-generation wave model results are used to examine the operation and maintenance conditions for...
Wed Feb 26, 2020 02:00
Atmosphere, Vol. 11, Pages 227: Internal Model Variability of the Regional Coupled System Model GCOAST-AHOI Atmosphere doi: 10.3390/atmos11030227 Authors: Ha Thi Minh Ho-Hagemann Stefan Hagemann Sebastian Grayek Ronny Petrik Burkhardt Rockel Joanna Staneva Frauke Feser Corinna Schrum Simulations of a Regional Climate Model (RCM) driven by identical lateral boundary conditions but initialized at different times exhibit the phenomenon of so-called internal model variability...
Wed Feb 26, 2020 02:00
Atmosphere, Vol. 11, Pages 226: Evaluation of the Efficiency of Arundo donax L. Leaves as Biomonitors for Atmospheric Element Concentrations in an Urban and Industrial Area of Central Italy Atmosphere doi: 10.3390/atmos11030226 Authors: Ristorini Astolfi Frezzini Canepari Massimi Washed and unwashed Arundo donax L. (A. donax) leaves were analyzed for elements, and results were compared with element concentrations detected in river water and particulate matter (PM) Samples...
Wed Feb 26, 2020 02:00
Atmosphere, Vol. 11, Pages 225: Investigations on the Influence of Chemical Compounds on Fog Microphysical Parameters Atmosphere doi: 10.3390/atmos11030225 Authors: Ivanov Todorov Gultepe Lab experiments related to artificial fog studies are limited due to instrument sensitivity to small fog and aerosol particles; therefore, the goal of this work is to evaluate aerosol solute effects on fog physical properties in a lab environment. To reach the goal, an automated fog-generating...
Wed Feb 26, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 60: Compressed Life Review: Extreme Manifestation of Autobiographical Memory in Eye-Tracker Behavioral Sciences doi: 10.3390/bs10030060 Authors: Veronika V. Nourkova The compressed life review (CLR) is a mnemonic illusion of having “your entire life flashing before your eyes”. This research was guided by concerns over the retrospective methodology used in CLR studies. To depart from this methodology, I considered the long-term working...
Wed Feb 26, 2020 02:00
Biology, Vol. 9, Pages 42: A Perspective on Body Size and Abundance Relationships across Ecological Communities Biology doi: 10.3390/biology9030042 Authors: Vojsava Gjoni Douglas Stewart Glazier Recently, several studies have reported relationships between the abundance of organisms in an ecological community and their mean body size (called cross-community scaling relationships: CCSRs) that can be described by simple power functions. A primary focus of these studies has been on the...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 360: Bispecific Antibodies and Antibody–Drug Conjugates for Cancer Therapy: Technological Considerations Biomolecules doi: 10.3390/biom10030360 Authors: Hyunbo Shim The ability of monoclonal antibodies to specifically bind a target antigen and neutralize or stimulate its activity is the basis for the rapid growth and development of the therapeutic antibody field. In recent years, traditional immunoglobulin antibodies have been further engineered for better...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 356: Association of Multiple Sclerosis Phenotypes with Single Nucleotide Polymorphisms of IL7R, LAG3, and CD40 Genes in a Jordanian Population: A Genotype-Phenotype Study Biomolecules doi: 10.3390/biom10030356 Authors: Laith AL-Eitan Malak Al Qudah Majdi Al Qawasmeh It is thought that genetic variations play a vital role in the Multiple Sclerosis (MS) etiology. However, the role of genetic factors that influence the clinical features of MS remains unclear....
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 359: Expression of MMP-2, MMP-9, and NGAL in Tissue and Serum of Patients with Vascular Aneurysms and Their Modulation by Statin Treatment: A Pilot Study Biomolecules doi: 10.3390/biom10030359 Authors: Erika Cione Elena Piegari Giuseppe Gallelli Maria Cristina Caroleo Elena Lamirata Francesca Curcio Federica Colosimo Roberto Cannataro Nicola Ielapi Manuela Colosimo Stefano de Franciscis Luca Gallelli Background: Matrix metalloproteinases...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 357: Untargetted Metabolomic Exploration of the Mycobacterium tuberculosis Stress Response to Cinnamon Essential Oil Biomolecules doi: 10.3390/biom10030357 Authors: Elwira Sieniawska Rafał Sawicki Joanna Golus Milen I. Georgiev The antimycobacterial activity of cinnamaldehyde has already been proven for laboratory strains and for clinical isolates. What is more, cinnamaldehyde was shown to threaten the mycobacterial plasma membrane integrity and...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 358: NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview Biomolecules doi: 10.3390/biom10030358 Authors: Alvinsyah Adhityo Pramono Gulam M. Rather Herry Herman Keri Lestari Joseph R. Bertino Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species. As both normal and cancer cells share the same NAD biosynthetic...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 361: Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells Biomolecules doi: 10.3390/biom10030361 Authors: Marco Cordani Giovanna Butera Raffaella Pacchiana Francesca Masetto Nidula Mullappilly Chiara Riganti Massimo Donadelli The TP53 tumor suppressor gene is the most frequently altered gene in tumors and an increasing number of studies highlight that mutant p53 proteins can acquire oncogenic properties, referred...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 354: COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model Biomolecules doi: 10.3390/biom10030354 Authors: Aya M. Yassin Huda O. AbuBakr Ahmed I. Abdelgalil Marwa S. Khattab Adel M. EL-Behairy Eman M. Gouda Osteoarthritis (OA) is one of the most degenerative joint diseases in both human and veterinary medicine. The objective of the present study was the early diagnosis of OA in donkeys using a reliable...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 355: Proteomic Analysis of Mucopolysaccharidosis IIIB Mouse Brain Biomolecules doi: 10.3390/biom10030355 Authors: Valeria De Pasquale Michele Costanzo Rosa Siciliano Maria Mazzeo Valeria Pistorio Laura Bianchi Emanuela Marchese Margherita Ruoppolo Luigi Pavone Marianna Caterino Mucopolysaccharidosis IIIB (MPS IIIB) is an inherited metabolic disease due to deficiency of α-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage...
Wed Feb 26, 2020 02:00
Biomolecules, Vol. 10, Pages 353: Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice Biomolecules doi: 10.3390/biom10030353 Authors: Moises Freitas-Andrade John Bechberger Jasmine Wang Ken Yeung Shawn Whitehead Rie Hansen Christian Naus Ischemic stroke is a complex and devastating event characterized by cell death resulting from a transient or permanent arterial occlusion. Astrocytic connexin43 (Cx43) gap junction...
Wed Feb 26, 2020 02:00
Brain Sciences, Vol. 10, Pages 130: Inter-Rater Reliability, Concurrent Validity and Sensitivity of Current Methods to Assess Trunk Function in Boccia Player with Cerebral Palsy Brain Sciences doi: 10.3390/brainsci10030130 Authors: Alba Roldan David Barbado Francisco J. Vera-Garcia José M. Sarabia Raul Reina Trunk function is a core factor to allocate Boccia players with cerebral palsy in BC1 and BC2 sport classes, according to the Boccia International Sports Federation (BISFed)....
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 542: CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents Cancers doi: 10.3390/cancers12030542 Authors: Pallavicini Iegiani Berto Calamia Trevisiol Veltri Allis Di Cunto Medulloblastoma (MB) is the most common malignant brain tumor in children, and it is classified into four biological subgroups: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. The current treatment is surgery,...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 539: Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer Cancers doi: 10.3390/cancers12030539 Authors: Stuckel Zhang Zhang Zeng Dougherty Mustafi Zhang Perreand Khare Joshi West-Szymanski Bissonnette Khare In colorectal cancer (CRC), upregulation of the C-X-C motif chemokine receptor 4 (CXCR4) is correlated...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 537: Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures Cancers doi: 10.3390/cancers12030537 Authors: Sriram Van Criekinge DeLos Santos Ahamed Qin Nolley Santos Tabatabai Bok Keshari Vigneron Peehl Kurhanewicz Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is needed...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 534: Moving the Target on the Optimal Adjuvant Strategy for Resected Pancreatic Cancers: A Systematic Review with Meta-Analysis Cancers doi: 10.3390/cancers12030534 Authors: Galvano Castiglia Rizzo Silvestris Brunetti Vaccaro Gristina Barraco Bono Guercio Graceffa Fulfaro Gori Bazan Russo Combination regimens have shown superiority over single agents in the adjuvant treatment of resected pancreatic cancer...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 536: The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors Cancers doi: 10.3390/cancers12030536 Authors: Malarz Mularski Pacholczyk Musiol Isocitrate dehydrogenases constitute a class of enzymes that are crucial for cellular metabolism. The overexpression or mutation of isocitrate dehydrogenases are often found in leukemias, glioblastomas, lung cancers, and ductal pancreatic cancer among others. Mutation R132H, which changes the functionality...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 535: Mass Spectrometry-Based Identification of MHC-Associated Peptides Cancers doi: 10.3390/cancers12030535 Authors: Kote Pirog Bedran Alfaro Dapic Neoantigen-based immunotherapies promise to improve patient outcomes over the current standard of care. However, detecting these cancer-specific antigens is one of the significant challenges in the field of mass spectrometry. Even though the first sequencing of the immunopeptides was done decades ago,...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 538: Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial Cancers doi: 10.3390/cancers12030538 Authors: Haderlein Speer Ott Lettmaier Hecht Semrau Frey Scherl Iro Kesting Fietkau Aim: Evaluating radiotherapy treatment plans of the prospective...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 540: MDM2, MDM4 and EGFR Amplifications and Hyperprogression in Metastatic Acral and Mucosal Melanoma Cancers doi: 10.3390/cancers12030540 Authors: Forschner Hilke Bonzheim Gschwind Demidov Amaral Ossowski Riess Schroeder Martus Klumpp Gonzalez-Menendez Garbe Niessner Sinnberg Background: Mucosal and acral melanoma respond worse to immune checkpoint inhibitors (ICI) than cutaneous melanoma. MDM2/4 as well...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 541: Molecular Profiling of Keratinocyte Skin Tumors Links Staphylococcus aureus Overabundance and Increased Human β-Defensin-2 Expression to Growth Promotion of Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12030541 Authors: Madhusudhan Pausan Halwachs Durdević Windisch Kehrmann Patra Wolf Boukamp Moissl-Eichinger Cerroni Becker Gorkiewicz The skin microbiota plays a prominent role in health and disease;...
Wed Feb 26, 2020 02:00
Cancers, Vol. 12, Pages 533: A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2 Cancers doi: 10.3390/cancers12030533 Authors: Man-Hong Leung Ho Tsoi Chun Gong Ellen PS Man Stefania Zona Shang Yao Eric W.-F. Lam Ui-Soon Khoo Breast cancer is the most common type of female cancer. Reactive oxygen species (ROS) are vital in regulating signaling pathways that control cell survival and cell proliferation. Chemotherapeutic...
Wed Feb 26, 2020 02:00
Cells, Vol. 9, Pages 550: The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set Cells doi: 10.3390/cells9030550 Authors: Kotov Godneeva Olenkina Adashev Trostnikov Olenina DDX3 subfamily DEAD-box RNA helicases are essential developmental regulators of RNA metabolism in eukaryotes. belle, the single DDX3 ortholog in Drosophila, is required for fly viability, fertility, and germline stem cell...
Wed Feb 26, 2020 02:00
Cells, Vol. 9, Pages 551: Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion Cells doi: 10.3390/cells9030551 Authors: Brenner Makkos Nagy Onódi Sayour Gergely Kiss Görbe Sághy Zádori Lázár Baranyai Varga Husti Varró Tóthfalusi Schulz Baczkó Giricz Ferdinandy Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal...
Wed Feb 26, 2020 02:00
Cells, Vol. 9, Pages 549: CD4+FOXP3+ T Cells in Rheumatoid Arthritis Bone Marrow Are Partially Impaired Cells doi: 10.3390/cells9030549 Authors: Massalska Radzikowska Kuca-Warnawin Plebanczyk Prochorec-Sobieszek Skalska Kurowska Maldyk Kontny Gober Maslinski There is evolving evidence that dysregulation of immune homeostasis in the bone marrow (BM) adjacent to the inflamed joints is involved in the pathogenesis of. In this study, we are addressing...
Wed Feb 26, 2020 02:00
Cells, Vol. 9, Pages 545: Optical Tweezers in Studies of Red Blood Cells Cells doi: 10.3390/cells9030545 Authors: Ruixue Zhu Tatiana Avsievich Alexey Popov Igor Meglinski Optical tweezers (OTs) are innovative instruments utilized for the manipulation of microscopic biological objects of interest. Rapid improvements in precision and degree of freedom of multichannel and multifunctional OTs have ushered in a new era of studies in basic physical and chemical properties of living...
Wed Feb 26, 2020 02:00
Cells, Vol. 9, Pages 539: Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions Cells doi: 10.3390/cells9030539 Authors: Vasquez-Montes Kyrychenko Vargas-Uribe Rodnin Ladokhin The inhibition of mitochondrial permeabilization by the anti-apoptotic protein Bcl-xL is crucial for cell survival and homeostasis. Its inhibitory role requires the partitioning of Bcl-xL to the mitochondrial outer...
Wed Feb 26, 2020 02:00
Cells, Vol. 9, Pages 540: Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers Cells doi: 10.3390/cells9030540 Authors: Jaud Philippe Di Bella Tang Pyronnet Laurell Mazzolini Rouault-Pierre Touriol Abstract: During carcinogenesis, almost all the biological processes are modified in one way or another. Among these biological processes affected, anomalies in protein synthesis are common in cancers. Indeed, cancer cells are subjected...
Wed Feb 26, 2020 02:00
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