IJMS, Vol. 21, Pages 1489: Metformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model International Journal of Molecular Sciences doi: 10.3390/ijms21041489 Authors: Woori Jo Kyung-Ku Kang Sehyun Chae Woo-Chan Son An increased incidence of myocardial infarction (MI) has recently emerged as the cause of cardiovascular morbidity and mortality worldwide. In this study, cardiac function was investigated in a rat myocardial ischemia/reperfusion...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1476: Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition International Journal of Molecular Sciences doi: 10.3390/ijms21041476 Authors: Jacek Baj Elżbieta Sitarz Alicja Forma Katarzyna Wróblewska Hanna Karakuła-Juchnowicz The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1480: Insight into the Role of Epigenetic Processes in Abiotic and Biotic Stress Response in Wheat and Barley International Journal of Molecular Sciences doi: 10.3390/ijms21041480 Authors: Lingyao Kong Yanna Liu Xiaoyu Wang Cheng Chang Environmental stresses such as salinity, drought, heat, freezing, heavy metal and even pathogen infections seriously threaten the growth and yield of important cereal crops including wheat and barley. There is growing evidence...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1473: CG200745, a Novel HDAC Inhibitor, Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21041473 Authors: Sang Heon Suh Hong Sang Choi Chang Seong Kim In Jin Kim Hyunju Cha Joong Myung Cho Seong Kwon Ma Soo Wan Kim Eun Hui Bae Histone deacetylases have been a target of therapy for organ fibrosis. Here, we report the protective effect of CG200745 (CG), a novel histone...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1472: Metabolomics as an Approach to Characterise the Contrasting Roles of CCR5 in the Presence and Absence of Disease International Journal of Molecular Sciences doi: 10.3390/ijms21041472 Authors: Anandi Rautenbach Aurelia A. Williams Chemokine receptors such as C-C chemokine receptor 5 (CCR5) are activated through interaction with their ligands and are well known for their role in chemotaxis and signal transduction. While serving these roles, cellular responses...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1471: Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration International Journal of Molecular Sciences doi: 10.3390/ijms21041471 Authors: Huayu Zhang Dianne Vreeken Abidemi Junaid Gangqi Wang Wendy M. P. J. Sol Ruben G. de Bruin Anton Jan van Zonneveld Janine M. van Gils In normal physiology, endothelial cells (ECs) form a vital barrier between the blood and underlying tissue controlling leukocyte diapedesis...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1470: Hybridization with Insect Cecropin A (1–8) Improve the Stability and Selectivity of Naturally Occurring Peptides International Journal of Molecular Sciences doi: 10.3390/ijms21041470 Authors: Yang Yang Di Wu Chenxi Wang Anshan Shan Chongpeng Bi Yanbing Li Wenping Gan Antimicrobial peptides (AMPs) offer great hope and a promising opportunity to overcome the rapid development of drug-resistant pathogenic microbes. However, AMPs often lack the...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1469: Interactome and F-Actin Interaction Analysis of Dictyostelium discoideum Coronin A International Journal of Molecular Sciences doi: 10.3390/ijms21041469 Authors: Tohnyui Ndinyanka Fabrice Thomas Fiedler Vera Studer Adrien Vinet Francesco Brogna Alexander Schmidt Jean Pieters Coronin proteins are evolutionary conserved WD repeat containing proteins that have been proposed to carry out different functions. In Dictyostelium, the short coronin...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1467: Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041467 Authors: Vitalii Kryvenko Miriam Wessendorf Rory E. Morty Susanne Herold Werner Seeger Olga Vagin Laura A. Dada Jacob I. Sznajder István Vadász Alveolar edema, impaired alveolar fluid clearance, and elevated CO2 levels (hypercapnia)...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1468: A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs) International Journal of Molecular Sciences doi: 10.3390/ijms21041468 Authors: Maria G. G. Pittalà Rosaria Saletti Simona Reina Vincenzo Cunsolo Vito De Pinto Salvatore Foti The voltage-dependent anion-selective channels (VDACs), which are also known as eukaryotic porins, are...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1465: Secretory Production of Functional Grouper Type I Interferon from Epinephelus septemfasciatus in Escherichia coli and Bacillus subtilis International Journal of Molecular Sciences doi: 10.3390/ijms21041465 Authors: Hsuan-Ju Lin Joan Tang Xiao Joe Wen-Jung Lu Mei-Ying Huang Ting-Hsuan Sun Sheng-Pao Lin Yi-Chuan Li Ya-Chin Tsui Ming-Wei Lu Hong-Ting Victor Lin Nervous necrosis virus (NNV) results in high mortality rates of infected...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1466: Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies International Journal of Molecular Sciences doi: 10.3390/ijms21041466 Authors: Maurizio Mangolini Ingo Ringshausen All B cell leukaemias and a substantial fraction of lymphomas display a natural niche residency in the bone marrow. While the bone marrow compartment may only be one of several sites of disease manifestations, the strong clinical significance of minimal residual disease (MRD)...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1463: WNT3A Promotes Neuronal Regeneration upon Traumatic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21041463 Authors: Chu-Yuan Chang Min-Zong Liang Ching-Chih Wu Pei-Yuan Huang Hong-I Chen Shaw-Fang Yet Jin-Wu Tsai Cheng-Fu Kao Linyi Chen The treatment of traumatic brain injury (TBI) remains a challenge due to limited knowledge about the mechanisms underlying neuronal regeneration. This current study compared...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1464: Development of a Modified Three-Day T-maze Protocol for Evaluating Learning and Memory Capacity of Adult Zebrafish International Journal of Molecular Sciences doi: 10.3390/ijms21041464 Authors: Bui Thi Ngoc Hieu Nguyen Thi Ngoc Anh Gilbert Audira Stevhen Juniardi Rhenz Alfred D. Liman Oliver B. Villaflores Yu-Heng Lai Jung-Ren Chen Sung-Tzu Liang Jong-Chin Huang Chung-Der Hsiao A T-maze test is an experimental approach that is...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1462: Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury International Journal of Molecular Sciences doi: 10.3390/ijms21041462 Authors: Wonhwa Lee Moon-Chang Baek Kyung-Min Kim Jong-Sup Bae The screening of biologically active chemical compound libraries can be an efficient way to reposition Food and Drug Adminstration (FDA)-approved drugs or to discover new therapies for human diseases. Particulate matter...
Fri Feb 21, 2020 02:00
IJMS, Vol. 21, Pages 1461: PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21041461 Authors: Gianluca Lopez Marianna Noale Chiara Corti Gabriella Gaudioso Elham Sajjadi Konstantinos Venetis Donatella Gambini Letterio Runza Jole Costanza Chiara Pesenti Francesco Grossi Stefania Maggi Stefano Ferrero Silvano Bosari Nicola Fusco Mismatch repair...
Fri Feb 21, 2020 02:00
IJNS, Vol. 6, Pages 13: Universal Screening for CCHD in Saudi Arabia: The Road to a ‘State of the Art’ Program International Journal of Neonatal Screening doi: 10.3390/ijns6010013 Authors: AlAql Khaleel Peter Critical congenital heart disease (CCHD) has been defined as structural heart defects that are usually associated with hypoxia in the newborn period and have potential for significant morbidity and mortality early in life. CCHD has been estimated to be present in ∼3...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 611: Correlations between Sleep Bruxism and Temporomandibular Disorders Journal of Clinical Medicine doi: 10.3390/jcm9020611 Authors: Ohlmann Waldecker Leckel Bömicke Behnisch Rammelsberg Schmitter The aim of this study was to identify correlations between sleep bruxism (SB) and temporomandibular disorders (TMD) as diagnosed by means of the research diagnostic criteria for temporomandibular disorders (RDC/TMD). Sleep bruxism was diagnosed on...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 610: A Mortality Prediction Rule for Hematology Patients with Invasive Aspergillosis Based on Serum Galactomannan Kinetics Journal of Clinical Medicine doi: 10.3390/jcm9020610 Authors: Mercier Wera Chai Lagrou Maertens In invasive aspergillosis (IA), an early and adequate assessment of the response to the initial antifungal therapy remains problematic. We retrospectively analyzed 206 hematology patients with proven or probable IA, and collected serial...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 607: Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease Journal of Clinical Medicine doi: 10.3390/jcm9020607 Authors: Dai Plunde Qureshi Lindholm Brismar Schurgers Söderberg Ripsweden Bäck Stenvinkel Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD)....
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 609: Risk Factors for Postural and Functional Balance Impairment in Patients with Chronic Obstructive Pulmonary Disease Journal of Clinical Medicine doi: 10.3390/jcm9020609 Authors: Park Deutz Cruthirds Kirschner Park Madigan Engelen Reduced balance function has been observed during balance challenging conditions in the chronic obstructive pulmonary disease (COPD) population and is associated with an increased risk of falls. This study aimed...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 606: Characterization of Burn Eschar Pericytes Journal of Clinical Medicine doi: 10.3390/jcm9020606 Authors: Alexander Evdokiou Onur Kanisicak Stephanie Gierek Amanda Barry Malina J. Ivey Xiang Zhang Richard J. Bodnar Latha Satish Pericytes are cells that reside adjacent to microvasculature and regulate vascular function. Pericytes gained great interest in the field of wound healing and regenerative medicine due to their multipotential fate and...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 608: Impact of Having a Planned Additional Operation at Time of Liver Transplant on Graft and Patient Outcomes Journal of Clinical Medicine doi: 10.3390/jcm9020608 Authors: Salimi Pandya Sastry West Virtue Wells Crawford Pulitano McCaughan Majumdar Strasser Liu Advances in liver transplantation (LT) have allowed for expanded indications and increased surgical complexity. In select cases, additional surgery may be performed...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 604: Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography Safely Defers Invasive Coronary Angiography in Patients with Stable Coronary Artery Disease Journal of Clinical Medicine doi: 10.3390/jcm9020604 Authors: Mark Rabbat Jonathon Leipsic Jeroen Bax Brian Kauh Rina Verma Demetrios Doukas Sorcha Allen Gianluca Pontone David Wilber Verghese Mathew Campbell Rogers John Lopez Objectives: In the United States,...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 603: First Multi-Center All-Comers Study for the Aquablation Procedure Journal of Clinical Medicine doi: 10.3390/jcm9020603 Authors: Thorsten Bach Peter Gilling Albert El Hajj Paul Anderson Neil Barber Waterjet-based prostate resection (Aquablation procedure) is an increasingly recognized treatment for symptomatic benign prostatic hyperplasia (BPH). We confirmed the safety and effectiveness of the Aquablation procedure in the commercial setting in 178 men...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 605: A Multiplex Test Assessing MiR663ame and VIMme in Urine Accurately Discriminates Bladder Cancer from Inflammatory Conditions Journal of Clinical Medicine doi: 10.3390/jcm9020605 Authors: Sara Monteiro-Reis Ana Blanca Joana Tedim-Moreira Isa Carneiro Diana Montezuma Paula Monteiro Jorge Oliveira Luís Antunes Rui Henrique António Lopez-Beltran Carmen Jerónimo Bladder cancer (BlCa) is a common malignancy with significant morbidity and...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 602: Instruments of Choice for Assessment and Monitoring Diabetic Foot: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9020602 Authors: Raúl Fernández-Torres María Ruiz-Muñoz Alberto J. Pérez-Panero Jerónimo García-Romero Manuel Gónzalez-Sánchez Diabetic foot is the most frequent disorder among the chronic complications of diabetes, happening in 25% of patients. Objective clinical outcome measures are tests or clinical instruments that...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 601: Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) Journal of Clinical Medicine doi: 10.3390/jcm9020601 Authors: Asami Anzai Tetsuro Kobayashi Natalie M. Linton Ryo Kinoshita Katsuma Hayashi Ayako Suzuki Yichi Yang Sung-mok Jung Takeshi Miyama Andrei R. Akhmetzhanov Hiroshi Nishiura The impact of the drastic reduction in travel volume within mainland China in January and February...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 600: Microinvasive Fungal Rhinosinusitis: Proposal of a New Subtype in the Classification Journal of Clinical Medicine doi: 10.3390/jcm9020600 Authors: Min Young Seo Hyeri Seok Seung Hoon Lee Ji Eun Choi Sang Duk Hong Seung-Kyu Chung Kyong Ran Peck Hyo Yeol Kim Background: Fungal rhinosinusitis (FRS) with mucosal invasion is not classified by the current criteria, and clinical reports on the topic are limited. The aim of this study was to present...
Mon Feb 24, 2020 02:00
JCM, Vol. 9, Pages 598: p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture Journal of Clinical Medicine doi: 10.3390/jcm9020598 Authors: Aline Rangel-Pozzo Samuel Booth Pak Lok Ivan Yu Madhurendra Singh Galina Selivanova Sabine Mai The TP53 gene is a key tumor suppressor. Although the tumor suppressor p53 was one of the first to be characterized as a transcription factor, with its main function potentiated by its interaction with DNA, there are still many...
Sat Feb 22, 2020 02:00
JCM, Vol. 9, Pages 599: Gestational Diabetes Mellitus and the Long-Term Risk for Glucose Intolerance and Overweight in the Offspring: A Narrative Review Journal of Clinical Medicine doi: 10.3390/jcm9020599 Authors: Nijs Benhalima Gestational diabetes mellitus (GDM) is a common condition with increasing prevalence worldwide. GDM is associated with an increased risk for maternal and neonatal complications. In this review we provide an overview of the most recent evidence on the long-term...
Sat Feb 22, 2020 02:00
JCM, Vol. 9, Pages 596: Short-term Forecasts of the COVID-19 Epidemic in Guangdong and Zhejiang, China: February 13–23, 2020 Journal of Clinical Medicine doi: 10.3390/jcm9020596 Authors: Kimberlyn Roosa Yiseul Lee Ruiyan Luo Alexander Kirpich Richard Rothenberg James M. Hyman Ping Yan Gerardo Chowell The ongoing COVID-19 epidemic continues to spread within and outside of China, despite several social distancing measures implemented by the Chinese government. Limited...
Sat Feb 22, 2020 02:00
JCM, Vol. 9, Pages 597: Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series Journal of Clinical Medicine doi: 10.3390/jcm9020597 Authors: Ioannis Iakovou Panagiotis Symeonidis Dimitrios Kotrotsios Evanthia Giannoula Christos Sachpekidis Pigmented villonodular synovitis (PVNS) of the ankle is a very rare, locally aggressive, proliferative disorder. Although surgical excision represents the standard curative...
Sat Feb 22, 2020 02:00
JCM, Vol. 9, Pages 594: Lysosomal Ceramide Metabolism Disorders: Implications in Parkinson’s Disease
JCM, Vol. 9, Pages 594: Lysosomal Ceramide Metabolism Disorders: Implications in Parkinson’s Disease Journal of Clinical Medicine doi: 10.3390/jcm9020594 Authors: Paciotti Albi Parnetti Beccari Ceramides are a family of bioactive lipids belonging to the class of sphingolipids. Sphingolipidoses are a group of inherited genetic diseases characterized by the unmetabolized sphingolipids and the consequent reduction of ceramide pool in lysosomes. Sphingolipidoses include several...
Fri Feb 21, 2020 02:00
JCM, Vol. 9, Pages 593: Role of Non-Coding RNAs in the Development of Targeted Therapy and Immunotherapy Approaches for Chronic Lymphocytic Leukemia Journal of Clinical Medicine doi: 10.3390/jcm9020593 Authors: Pepe Balatti In the past decade, novel targeted therapy approaches, such as BTK inhibitors and Bcl2 blockers, and innovative treatments that regulate the immune response against cancer cells, such as monoclonal antibodies, CAR-T cell therapy, and immunomodulatory molecules,...
Fri Feb 21, 2020 02:00
JCM, Vol. 9, Pages 592: Collaborating with Complementary and Alternative Medicine (CAM) Providers When Writing HPV Vaccine Review Articles Journal of Clinical Medicine doi: 10.3390/jcm9020592 Authors: Deml Dietrich Wingeier Etter Gallmann Berger Suggs Huber Tarr Novel strategies are needed to address vaccine hesitancy (VH), which correlates with complementary and alternative medicine (CAM). In Switzerland, CAM providers play important roles in vaccine...
Fri Feb 21, 2020 02:00
JCM, Vol. 9, Pages 591: Sleep Apnea, Hypertension and the Sympathetic Nervous System in the Adult Population Journal of Clinical Medicine doi: 10.3390/jcm9020591 Authors: Shreyas Venkataraman Soumya Vungarala Naima Covassin Virend K. Somers Sleep apnea is very common in patients with cardiovascular disease, especially in patients with hypertension. Over the last few decades a number of discoveries have helped support a causal relationship between the two and even resistant hypertension....
Fri Feb 21, 2020 02:00
JCM, Vol. 9, Pages 595: Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter Journal of Clinical Medicine doi: 10.3390/jcm9020595 Authors: Claudio Iovino Marco Pellegrini Federico Bernabei Enrico Borrelli Riccardo Sacconi Andrea Govetto Aldo Vagge Antonio Di Zazzo Matteo Forlini Lucia Finocchio Adriano Carnevali Giacinto Triolo Giuseppe Giannaccare Remarkable improvements in optical coherence tomography...
Fri Feb 21, 2020 02:00
JCM, Vol. 9, Pages 588: Natural History and Management of Familial Paraganglioma Syndrome Type 1: Long-Term Data from a Large Family Journal of Clinical Medicine doi: 10.3390/jcm9020588 Authors: Puliani Sesti Feola Di Leo Polti Verrico Modica Colao Lenzi Isidori Cantisani Giannetta Faggiano Head and neck paragangliomas are the most common clinical features of familial paraganglioma syndrome type 1 caused by succinate dehydrogenase complex...
Fri Feb 21, 2020 02:00
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