Antibiotics, Vol. 9, Pages 93: Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight ComplexesAntibiotics doi: 10.3390/antibiotics9020093Authors:Lanqing YingHongkun ZhuMarina Y. FossoSylvie Garneau-TsodikovaKurt FredrickAminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6”-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C12 or C14 linear alkyl...
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Antioxidants, Vol. 9, Pages 176: Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder Antioxidants doi: 10.3390/antiox9020176 Authors: Lourdes Alvarez-Arellano Nadia González-García Marcela Salazar-García Juan Carlos Corona Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked...
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Antioxidants, Vol. 9, Pages 174: Role of Sirt3 in Differential Sex-Related Responses to a High-Fat Diet in Mice Antioxidants doi: 10.3390/antiox9020174 Authors: Pinterić Podgorski Hadžija Bujak Dekanić Bagarić Farkaš Sobočanec Balog Metabolic homeostasis is differently regulated in males and females. Little is known about the mitochondrial Sirtuin 3 (Sirt3) protein in the context of sex-related differences in the development of metabolic dysregulation....
Thu Feb 20, 2020 02:00
Antioxidants, Vol. 9, Pages 175: Bladder Cancer Chemosensitivity is Affected by Paraoxonase-2 Expression Antioxidants doi: 10.3390/antiox9020175 Authors: Fumarola Cecati Sartini Ferretti Milanese Galosi Pozzi Campagna Morresi Emanuelli Bacchetti The goal of the current study was to identify potential roles of paraoxonase-2 in bladder carcinogenesis. T24 bladder cancer cells were transfected with plasmids inducing paraoxonase-2 silencing or overexpression....
Thu Feb 20, 2020 02:00
Antioxidants, Vol. 9, Pages 173: Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions from Cassia fistula L. Leaves Antioxidants doi: 10.3390/antiox9020173 Authors: Kaur Kumar Thakur Kumar Sharma Sharma Singh Sharma Kumar Landi Brestič Kaur : Cassia fistula L. is a highly admirable traditional medicinal plant used for the treatment of various diseases and disorders. The present study was performed to divulge the antioxidant,...
Thu Feb 20, 2020 02:00
Antioxidants, Vol. 9, Pages 172: The Effect of Nano-Epigallocatechin-Gallate on Oxidative Stress and Matrix Metalloproteinases in Experimental Diabetes Mellitus Antioxidants doi: 10.3390/antiox9020172 Authors: Adriana Elena Bulboaca Paul-Mihai Boarescu Alina Silvia Porfire Gabriela Dogaru Cristina Barbalata Madalina Valeanu Constantin Munteanu Ruxandra Mioara Râjnoveanu Cristina Ariadna Nicula Ioana Cristina Stanescu Background: The antioxidant properties of...
Thu Feb 20, 2020 02:00
Arts, Vol. 9, Pages 26: Women Architects outside the Spanish Borders: Patriarchal Models at International Congresses (1939–1975) Arts doi: 10.3390/arts9010026 Authors: Josenia Hervás Silvia Blanco-Agüeira In the complex political scene surrounding the death of Francisco Franco, Spanish female architects were crossing borders to try and understand what was happening abroad. This article provides unpublished data on the various experiences of female graduates in Spain when they shared...
Thu Feb 20, 2020 02:00
Atmosphere, Vol. 11, Pages 213: Estimating Turbulent Fluxes in the Tropical Andes Atmosphere doi: 10.3390/atmos11020213 Authors: Mario Córdova Linda Bogerd Paul Smeets Galo Carrillo-Rojas The correct estimation of Sensible Heat Flux (H) and Latent Heat Flux (LE) (i.e., turbulent fluxes) is vital in the understanding of exchange of energy and mass among hydrosphere, atmosphere, and biosphere in an ecosystem. One of the most popular methods to measure these fluxes is the Eddy...
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Atmosphere, Vol. 11, Pages 214: Ambient Air Quality in the Czech Republic: Past and Present Atmosphere doi: 10.3390/atmos11020214 Authors: Hůnová Based on an analysis of related core papers and reports, this review presents a historical perspective on ambient air pollution and ambient air quality development in the modern-day Czech Republic (CR) over the past seven decades, i.e., from the 1950s to the present. It offers insights into major air pollution problems, reveals the main hot...
Thu Feb 20, 2020 02:00
Atmosphere, Vol. 11, Pages 215: A Synergistic Effect of Blockings on a Persistent Strong Cold Surge in East Asia in January 2018 Atmosphere doi: 10.3390/atmos11020215 Authors: Dong Zhao Zhou Shen A persistent strong cold surge occurred in East Asia in late January 2018, causing mean near-surface air temperature in China to hit the second lowest since 1984. Moreover, the daily mean air temperature remained persistently negative for more than 20 days. Here, we find that a...
Thu Feb 20, 2020 02:00
Atmosphere, Vol. 11, Pages 216: Uncertainties in the Annual Cycle of Rainfall Characteristics over West Africa in CMIP5 Models Atmosphere doi: 10.3390/atmos11020216 Authors: Magatte Sow Moussa Diakhaté Ross D. Dixon Françoise Guichard Diarra Dieng Amadou Thierno Gaye We analyse uncertainties associated with the main features of the annual cycle of West African rainfall (amplitude, timing, duration) in 15 CMIP5 simulations over the Sahelian and Guinean regions with satellite...
Thu Feb 20, 2020 02:00
Bioengineering, Vol. 7, Pages 18: MMP24 as a Target of YAP is a Potential Prognostic Factor in Cancer Patients Bioengineering doi: 10.3390/bioengineering7010018 Authors: Wataru Sugimoto Katsuhiko Itoh Hiroaki Hirata Yoshinori Abe Takeru Torii Yasumasa Mitsui Yemima Budirahardja Nobuyuki Tanaka Keiko Kawauchi The extracellular matrix (ECM) surrounding cancer cells becomes stiffer during tumor progression, which influences cancer cell behaviors such as invasion...
Thu Feb 20, 2020 02:00
Biomedicines, Vol. 8, Pages 39: Correlations between Microbiota Bioactivity and Bioavailability of Functional Compounds: A Mini-Review Biomedicines doi: 10.3390/biomedicines8020039 Authors: Emanuel Vamanu Florentina Gatea Numerous studies have demonstrated the role of the microbiota in supporting the physiological functions, owing to its metabolomic component. The presence of biocomponents generally leads to the correction of the microbial pattern correlated with the reduction of...
Thu Feb 20, 2020 02:00
Biomedicines, Vol. 8, Pages 38: Long-Term Oral Administration of LLHK, LHK, and HK Alters Gene Expression Profile and Restores Age-Dependent Atrophy and Dysfunction of Rat Salivary Glands Biomedicines doi: 10.3390/biomedicines8020038 Authors: Yasuko Ishikawa Tomasz D Pieczonka Aneta M Bragiel-Pieczonka Harumichi Seta Tadahiro Ohkuri Yumi Sasanuma Yuji Nonaka Xerostomia, also known as dry mouth, is caused by a reduction in salivary secretion and by changes in the composition...
Thu Feb 20, 2020 02:00
Biomolecules, Vol. 10, Pages 339: New Lipidyl-Cyclodextrins Obtained by Ring Opening of Methyl Oleate Epoxide Using Ball Milling Biomolecules doi: 10.3390/biom10020339 Authors: Estefania Oliva David Mathiron Sébastien Rigaud Eric Monflier Emmanuel Sevin Hervé Bricout Sébastien Tilloy Fabien Gosselet Laurence Fenart Véronique Bonnet Serge Pilard Florence Djedaini-Pilard Bearing grafts based on fatty esters derivatives, lipidyl-cyclodextrins (L-CDs) are...
Thu Feb 20, 2020 02:00
Brain Sciences, Vol. 10, Pages 116: Image Segmentation of Brain MRI Based on LTriDP and Superpixels of Improved SLIC Brain Sciences doi: 10.3390/brainsci10020116 Authors: Yu Wang Qi Qi Xuanjing Shen Non-uniform gray distribution and blurred edges often result in bias during the superpixel segmentation of medical images of magnetic resonance imaging (MRI). To this end, we propose a novel superpixel segmentation algorithm by integrating texture features and improved simple linear...
Thu Feb 20, 2020 02:00
Brain Sciences, Vol. 10, Pages 115: Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures Brain Sciences doi: 10.3390/brainsci10020115 Authors: Chella Kamarajan Babak A. Ardekani Ashwini K. Pandey Sivan Kinreich Gayathri Pandey David B. Chorlian Jacquelyn L. Meyers Jian Zhang Elaine Bermudez Arthur T. Stimus Bernice Porjesz Individuals with alcohol use disorder (AUD)...
Thu Feb 20, 2020 02:00
Brain Sciences, Vol. 10, Pages 113: Electrophysiological Differentiation of the Effects of Stress and Accent on Lexical Integration in Highly Fluent Bilinguals Brain Sciences doi: 10.3390/brainsci10020113 Authors: Jennifer Lewendon Anouschka Foltz Guillaume Thierry Individuals who acquire a second language (L2) after infancy often retain features of their native language (L1) accent. Cross-language priming studies have shown negative effects of L1 accent on L2 comprehension, but...
Thu Feb 20, 2020 02:00
Brain Sciences, Vol. 10, Pages 114: Brain Processing of Complex Geometric Forms in a Visual Memory Task Increases P2 Amplitude Brain Sciences doi: 10.3390/brainsci10020114 Authors: Héctor A. Cepeda-Freyre Gregorio Garcia-Aguilar Jose R. Eguibar Carmen Cortes We study the cognitive processing of visual working memory in three different conditions of memory load and configuration change. Altering this features has been shown to alter the brain’s processing in memory...
Thu Feb 20, 2020 02:00
Brain Sciences, Vol. 10, Pages 111: Mindfulness and Psychological Flexibility are Inversely Associated with Caregiver Burden in Parkinson’s Disease Brain Sciences doi: 10.3390/brainsci10020111 Authors: Martin Klietz Simon C. Drexel Theresa Schnur Florian Lange Adrian Groh Lejla Paracka Stephan Greten Dirk Dressler Günter U. Höglinger Florian Wegner Parkinson’s disease (PD) is a neurodegenerative movement disorder with progressiveimpairments in...
Thu Feb 20, 2020 02:00
Brain Sciences, Vol. 10, Pages 112: Hyperarousal Is Associated with Socioemotional Processing in Individuals with Insomnia Symptoms and Good Sleepers Brain Sciences doi: 10.3390/brainsci10020112 Authors: Reuben D. M. Howlett Kari A. Lustig Kevin J. MacDonald Kimberly A. Cote Despite complaints of difficulties in waking socioemotional functioning by individuals with insomnia, only a few studies have investigated emotion processing performance in this group. Additionally, the...
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 497: Genomic Signature of the Standardized Uptake Value in 18F-Fluorodeoxyglucose Positron Emission Tomography in Breast Cancer Cancers doi: 10.3390/cancers12020497 Authors: Kim Ahn Mun Jeong Bae Lee Jeong Leem Chu The standardized uptake value (SUV), an indicator of the degree of glucose uptake in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), has been used for predicting the clinical behavior of malignant tumors....
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 496: Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12020496 Authors: Hatzl Perfler Wurm Uhl Quehenberger Ebner Troppmair Reinisch Wölfler Sill Zebisch Resistance to chemotherapy is one of the primary obstacles in acute myeloid leukemia (AML) therapy. Micro-RNA-23a (miR-23a) is frequently deregulated in AML and has been linked to chemoresistance...
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 494: Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12020494 Authors: Sakata Hirosue Yoshida Matsuoka Kawahara Arita Nakashima Yamamoto Nagata Kawaguchi Gohara Nagao Yamana Toya Murakami Kuwahara Fukumoto Nakayama Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) modulates various...
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 492: Depth of Remission Following First-Line Treatment Is an Independent Prognostic Marker for Progression-Free Survival in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Cancers doi: 10.3390/cancers12020492 Authors: Barbara Kiesewetter Ingrid Simonitsch-Klupp Werner Dolak Marius E. Mayerhoefer Markus Raderer Gastric mucosa-associated lymphoid tissue (MALT) lymphoma responding to upfront treatment has an excellent outcome and no further...
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 493: Knockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression Cancers doi: 10.3390/cancers12020493 Authors: Jiang Wang Mitochondrial transcription factor A (TFAM) is required for mitochondrial DNA replication and transcription, which are essential for mitochondrial biogenesis. Previous studies reported that depleting mitochondrial functions by genetic deletion of TFAM impaired autophagic activities....
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 495: A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin Cancers doi: 10.3390/cancers12020495 Authors: Pádua Barros Amaral Mesquita Freire Sousa Maia Caiado Fernandes Pombinho Pereira Almeida Gastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic...
Thu Feb 20, 2020 02:00
Cancers, Vol. 12, Pages 491: Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12020491 Authors: Manali Dimri Ande Satyanarayana Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at advanced stages with no effective treatment options. With advances in tumor biology and molecular genetic profiling, several different signaling pathways and molecular mechanisms have been identified as responsible...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 492: Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness Cells doi: 10.3390/cells9020492 Authors: Menezes Silva Gomes Rosa Spina Carloni Alves Melendez Almeida Silva Clara da Cunha Hajj Jones Bidinotto Reis The 5’-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 493: Emerging Diagnostic Tools to Decide When to Discontinue Nucleos(t)ide Analogues in Chronic Hepatitis B Cells doi: 10.3390/cells9020493 Authors: Papatheodoridi Papatheodoridis The aim of this review is to outline emerging biomarkers that can serve as diagnostic tools to identify non-cirrhotic chronic hepatitis B (CHB) patients who could safely discontinue nucleos(t)ide analogues (NAs) before HBsAg loss. Regarding possible predictors of post-NAs outcomes,...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 491: Is Desmin Propensity to Aggregate Part of its Protective Function? Cells doi: 10.3390/cells9020491 Authors: Singh Kadioglu Patel Carrier Agnetti Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF). These desmin alterations are reversed by therapy, suggesting a causal role for the...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 490: Exploring Novel Molecular Targets for the Treatment of High-Grade Astrocytomas Using Peptide Therapeutics: An Overview Cells doi: 10.3390/cells9020490 Authors: Giulia Guidotti Liliana Brambilla Daniela Rossi Diffuse astrocytomas are the most aggressive and lethal glial tumors of the central nervous system (CNS). Their high cellular heterogeneity and the presence of specific barriers, i.e., blood–brain barrier (BBB) and tumor barrier, make these...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 487: Technical Considerations in Ex Vivo Human Regulatory T Cell Migration and Suppression Assays Cells doi: 10.3390/cells9020487 Authors: Irekeola E. A. R. Lazim Mohamud Yean Shueb Regulatory T cells (Tregs) are renowned for maintaining homeostasis and self-tolerance through their ability to suppress immune responses. For over two decades, Tregs have been the subject of intensive research. The immunosuppressive and migratory potentials of Tregs...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 488: A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death Cells doi: 10.3390/cells9020488 Authors: Romanova Sharapova Telegin Minakov Chernov Ivanova Bychkov Sashchenko Yashin Investigation of interactions between a pro-inflammatory cytokine tumor necrosis factor (TNFα) and its receptor is required for the development of new treatments for autoimmune diseases associated...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 486: Expression of the microRNA-200 Family, microRNA-205, and Markers of Epithelial–Mesenchymal Transition as Predictors for Endoscopic Submucosal Dissection over Esophagectomy in Esophageal Adenocarcinoma: A Single-Center Experience Cells doi: 10.3390/cells9020486 Authors: Neureiter Mayr Winkelmann Neumayer Klieser Wagner Hufnagl Emmanuel Holzinger Koch Kiesslich Varga Endoscopic submucosal dissection (ESD) is an effective...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 489: Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure Cells doi: 10.3390/cells9020489 Authors: Hong Pan Xu Xue Wang Guo Jia Qiao Li Zhai Misalignment between natural light rhythm and modern life activities induces disruption of the circadian rhythm. It is mainly evident that light at night (LAN) interferes with the human endocrine system and contributes...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 485: WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line Cells doi: 10.3390/cells9020485 Authors: Ana Laura Vieira Alves Angela Margarida Costa Olga Martinho Vinicius Duval da Silva Peter Jordan Viviane Aline Oliveira Silva Rui Manuel Reis Autophagy is a cell-survival pathway with dual role in tumorigenesis, promoting either tumor survival or tumor death. WNK2 gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor...
Thu Feb 20, 2020 02:00
Cells, Vol. 9, Pages 484: An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis Cells doi: 10.3390/cells9020484 Authors: Veronica Gatti Manuela Ferrara Ilaria Virdia Silvia Matteoni Laura Monteonofrio Simona di Martino Maria Grazia Diodoro Giuliana Di Rocco Cinzia Rinaldo Silvia Soddu HIPK2 is a DYRK-like kinase involved in cellular stress response pathways, development, and cell division. Two alternative splice variants of...
Thu Feb 20, 2020 02:00
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