The 1918 influenza pandemic was the deadliest event in human history (50 million or more deaths, equivalent in proportion to 200 million in today’s global population). For more than a century, it has stood as a benchmark against which all other pandemics and disease emergences have been measured.…
Wed Feb 26, 2020 02:00
Publication date: Available online 25 February 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J. Liew, A.N. Beech
Wed Feb 26, 2020 18:38
Zusammenfassung Ergebnisse aus klinischen Studien unterliegen häufig einem Risiko für Bias (Abweichung von der Wahrheit, systematischer Fehler). Die kritische Bewertung von Studien nimmt deshalb einen hohen Stellenwert in der evidenzbasierten Medizin ein. Im vorliegenden Artikel werden häufige Biastypen vorgestellt, voneinander abgegrenzt und Strategien zur Vermeidung von systematischen Fehlern erläutert. Zudem werden die beiden etablierten Cochrane-Instrumente vorgestellt, mit...
Wed Feb 26, 2020 02:00
Publication date: April 2020Source: Brain Research Bulletin, Volume 157Author(s):
Wed Feb 26, 2020 17:59
Publication date: Available online 25 February 2020Source: Brain Research BulletinAuthor(s): Guan Wang, Yanan Fu, Kun Ma, Junli Liu, Xinjie Liu
Wed Feb 26, 2020 17:59
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Jiarui Zhao, Jia Jing, Wei Zhao, Xinrong Li, Lixuan Hou, Chunfeng Zheng, Qingfei Kong, Wenjin Li, Xiuhua Yao, Lulu Chang, Hulun Li, Lili Mu, Guangyou Wang, Jinghua Wang
Wed Feb 26, 2020 17:49
Neelam Sood, Ruchika Gupta, Sanjay GuptaIndian Journal of Pathology and Microbiology 2020 63(5):141-142
Wed Feb 26, 2020 00:00
Seyran Yigit, Eylul Gun, Bulent Yilmaz, Zafer KolsuzIndian Journal of Pathology and Microbiology 2020 63(5):98-101 Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm arising from the intermediate trophoblasts. Although usually seen in the reproductive period, it may be encountered during the postmenopausal period. A 56-year-old woman who had given her last birth 21 years ago presented to the hospital with a complaint of postmenopausal bleeding. She had a history of eight...
Wed Feb 26, 2020 00:00
Sangeeta B DesaiIndian Journal of Pathology and Microbiology 2020 63(5):3-4
Wed Feb 26, 2020 00:00
Kavneet Kaur, Madhu Rajeshwari, Niteeka Gurung, Hemanth Kumar, Mehar C Sharma, Rajni Yadav, Sunesh Kumar, Smita Manchanda, Seema Singhal, Sandeep R MathurIndian Journal of Pathology and Microbiology 2020 63(5):81-86 Introduction: Uterine tumors resembling ovarian sex cord tumor (UTROSCT) are a unique group of neoplasms with diverse morphology and immunophenotypic characteristics, coexpressing sex cord, epithelial, and smooth-muscle markers. To date, less than 100 cases have been reported and...
Wed Feb 26, 2020 00:00
Bharat RekhiIndian Journal of Pathology and Microbiology 2020 63(5):5-6
Wed Feb 26, 2020 00:00
BN Kumarguru, Anikode S Ramaswamy, Shahanuma Shaik, Aruna Karri, Venugopal Sandeep Srinivas, BM PrashantIndian Journal of Pathology and Microbiology 2020 63(5):117-122 Background: Tumor budding denotes a phenomenon in which the tumor cells, singly or in small aggregates, become detached from the neoplastic glands at the invasive front of adenocarcinoma. Tumors with budding cells have a significantly more aggressive clinical course. Significance of tumor budding has mainly been examined in the...
Wed Feb 26, 2020 00:00
Ziad El-Zaatari, Mukul K DivatiaIndian Journal of Pathology and Microbiology 2020 63(5):7-17 Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant syndrome wherein affected individuals are at risk for the development of cutaneous leiomyomas, early-onset multiple uterine leiomyomas, and an aggressive subtype of renal cell cancer. HLRCC is caused by germline mutations in the fumarate hydratase (FH) gene, which inactivates the enzyme and alters the function of the tricarboxylic...
Wed Feb 26, 2020 00:00
Abhilash Deo, Souvik Mukherjee, Bharat Rekhi, Pritha RayIndian Journal of Pathology and Microbiology 2020 63(5):64-69 In spite of the advent of many high throughput technologies, tumor tissue biomarkers are still the gold standard for diagnosis and prognosis of different malignancies including epithelial ovarian cancer (EOC). EOC is a heterogeneous disease comprised of five major subtypes which show distinct clinicopathological features and therapy response. Acquirement of chemoresistance toward...
Wed Feb 26, 2020 00:00
Gowri Garudadri, B Vishal Rao, Challa Sundaram, Daphne Fonseca, S Sudha Murthy, Rakesh Sharma, T Subramanyeshwar RaoIndian Journal of Pathology and Microbiology 2020 63(5):18-24 Context: The diagnosis of prostatic adenocarcinoma on histopathology depends on architectural and cytomorphological features supported by immunohistochemistry (IHC). Though all the prostate markers show excellent specificity, the sensitivity and percentage positivity vary. Aims: In this study, we aim to study the expression...
Wed Feb 26, 2020 00:00
Anup K Boler, Sana Akhtar, Arghya Bandyopadhyay, Shreosee RoyIndian Journal of Pathology and Microbiology 2020 63(5):91-93 Dedifferentiated endometrioid carcinoma or dedifferentiated endometrioid adenocarcinoma (DEAC) is defined by the presence of undifferentiated carcinoma with endometrioid carcinoma. Undifferentiated component can be misinterpreted as solid component of high-grade endometrioid carcinoma or sarcomatous component of malignant mixed mullerian tumor. We present two cases of DEAC....
Wed Feb 26, 2020 00:00
Yelda Dere, Özgür Ilhan Çelik, Serkan Yasar Çelik, Sümeyye Ekmekçi, Gözde Evcim, Fatma Pehlivan, Anıl Ağalar, Hasan Deliktaş, Nil ÇulhacıIndian Journal of Pathology and Microbiology 2020 63(5):25-29 Objective: Gleason scoring is the grading system which strongly predicts the prognosis of prostate cancer. However, even being one of the most commonly used systems, the presence of different interobserver agreement rates push the uropathologists update the definitons of the Gleason patterns. In this...
Wed Feb 26, 2020 00:00
Owain Blackwood, Rahul DebIndian Journal of Pathology and Microbiology 2020 63(5):105-112 The multidisciplinary team approach has been employed internationally for decades, as an attempt to bring collaborative decision-making and concentrate clinical experience from multiple specialties on single patient cases in a systematic fashion. Adoption is not yet worldwide, but is increasing. The role of the histopathologist is central, providing vital information and context to clinical diagnosis and...
Wed Feb 26, 2020 00:00
Kinjal N Bera, Shakti K Yadav, Om Prakash, Sompal Singh, Namrata SarinIndian Journal of Pathology and Microbiology 2020 63(5):30-33 Context: The roles of estrogen and progesterone in human prostate carcinogenesis have been only recently recognized. Aims: This study was conducted to evaluate the expressions of esterone receptor-beta (ER-β), progesterone receptor (PR), and Ki-67 in benign and malignant lesions of the prostate. Settings and Design: The study was conducted at a tertiary care hospital....
Wed Feb 26, 2020 00:00
Atena Azami, Seyed Hamid Madani, Sedigheh Khazaei, Babak Izadi, Elahe Saleh, Soraya SajadimajdIndian Journal of Pathology and Microbiology 2020 63(5):129-133 Introduction: Breast cancer is the most common cancer in women. Owning to the prominent role of biomarkers in molecular classification of breast cancer in recent years, evaluation of estrogen receptor (ER), progesterone receptor (PR), and Her2/neu seems to be required for prognosis and treatment of patients. Material and Methods: One-hundred...
Wed Feb 26, 2020 00:00
Dorian I Dikov, Maria S Koleva, Jean-Francois Boivin, Tomo Lisner, Veselin T Belovezhdov, Victoria SarafianIndian Journal of Pathology and Microbiology 2020 63(5):34-40 Background: Recently, we publish two case reports about association of nonspecific granulomatous prostatitis (NSGP) and eosinophilic metaplasia (EM) in benign prostatic epithelium. There is no investigation of large series of this association in medical literature. Aim of the current study is to investigate the frequency of association...
Wed Feb 26, 2020 00:00
Ranjan AgrawalIndian Journal of Pathology and Microbiology 2020 63(5):1-2
Wed Feb 26, 2020 00:00
Junying Wang, Lin ZhongIndian Journal of Pathology and Microbiology 2020 63(5):41-43 Paraganglioma is a rare neuroendocrine tumor arising from undifferentiated cells of the primitive neural crest. We report a case of renal paraganglioma in a 67-year-old patient. Computed tomography demonstrated a solid mass in the middle and lower pole of the right kidney. Sonography revealed an enlarged right kidney with an irregular shape but distinct border. Renal cell carcinoma was diagnosed provisionally;...
Wed Feb 26, 2020 00:00
Bharat RekhiIndian Journal of Pathology and Microbiology 2020 63(5):70-80 Over the years, immunohistochemistry has emerged as a powerful tool for a more precise diagnosis of certain tumors in gynecologic oncopathology and resolving certain diagnostic dilemmas with significant treatment implications. Certain specific immunohistochemical (IHC) markers have been useful in the more correct identification of rare tumors, characterized by specific molecular signatures. Immunohistochemistry has also...
Wed Feb 26, 2020 00:00
Ilke Onur Kazaz, Safak Ersoz, Fatih Colak, Ahmet Serdar Teoman, Seher Nazli Kazaz, Ersagun Karaguzel, Omer KutluIndian Journal of Pathology and Microbiology 2020 63(5):44-46 Primary renal angiosarcomas (AS) are uncommon tumors with poor prognosis. Aetiology is unknown but some unproven risk factors have been described. It is difficult to discriminate these masses from renal cell carcinomas or other renal masses with imaging modalities. Immunohistochemistry plays an important role in the diagnosis....
Wed Feb 26, 2020 00:00
Azam Begum Heena, Gnana KumariIndian Journal of Pathology and Microbiology 2020 63(5):87-90 Background: Abnormal placentations such as placenta accreta, placenta increta and placenta percreta are important causes of hemorrhage after delivery causing maternal morbidity and mortality. Risk factors for abnormal placentation are prior caesarean section, placenta previa and pre-eclampsia. There is a need for reliable antenatal diagnosis for these serious conditions. If these pregnancies can be identified,...
Wed Feb 26, 2020 00:00
Smita Mary Matthai, Anjali Mohapatra, Neelaveni Duhli, Vinoi G David, Santosh VarugheseIndian Journal of Pathology and Microbiology 2020 63(5):47-49 Collagenofibrotic glomerulopathy (CFG) is a rare idiopathic kidney disease characterized by abnormal deposition of atypical Type III collagen fibers in the glomerulus causing subendothelial and mesangial expansion, manifesting as progressive renal dysfunction accompanied by proteinuria. The majority of CFG cases reported in literature are from Japan...
Wed Feb 26, 2020 00:00
Dongni Liang, Lei Li, Yanmei He, Wei JiangIndian Journal of Pathology and Microbiology 2020 63(5):94-97 Primary uterine angiosarcoma is a very rare malignant tumor in the female genital tract and only 23 cases have been previously reported in the literature. It is often clinically misrecognized as another disease due to its low incidence. In this report, we present a new case of a 78-year-old woman diagnosed on histopathologic observation and immunohistochemical staining. Additionally, available...
Wed Feb 26, 2020 00:00
Xiaorong Zhang, Jiali Hu, Xiao Xu, Lin ChengIndian Journal of Pathology and Microbiology 2020 63(5):50-52 Malignant phyllodes tumor of the prostate is a very rare entity. Here, we describe a 51-year-old patient with a malignant phyllodes tumor of the prostate with a poor prognosis and normal prostate-specific antigen levels. Digital rectal examination revealed a hard, nodular mass in the prostate, and magnetic resonance imaging exhibited a cystic mass measuring 8.7 cm × 7.0 cm × 6.7 cm. Immunohistochemical...
Wed Feb 26, 2020 00:00
Xu Nan, Li Lei, Yang JianpingIndian Journal of Pathology and Microbiology 2020 63(5):102-104
Wed Feb 26, 2020 00:00
Svitlana Y Bachurska, Petar A Antonov, Ivan Y Dechev, Antonio Lopez-BeltranIndian Journal of Pathology and Microbiology 2020 63(5):53-55 Paratesticular tumours are relatively rare and mostly of the mesenchymal origin. Due to its rarity, general surgical pathologists might have limited experience on the diagnostic entities and relevant differential diagnoses related to mesenchymal paratesticular tumours. This may likely cause diagnostic difficulties in a daily pathology practice. Paratesticular...
Wed Feb 26, 2020 00:00
Varuna Mallya, Vishal Singh, Navpreet Kaur, Priyanka Yadav, Shramana Mandal, Nita Khurana, Pawanindra LalIndian Journal of Pathology and Microbiology 2020 63(5):113-116 Aims and Objectives: We examined the prognostic value of Tumor stroma ratio (TSR) in breast tumor core biopsy (TCB) specimen to determine response to neoadjuvant therapy (NAT) prior to modified radical mastectomy (MRM). Methods: This was a retrospective analysis of patients with breast cancer who underwent TCB before NAT between...
Wed Feb 26, 2020 00:00
Muzaffer I Tosun, Cumhur S Topal, Cagatay TosunIndian Journal of Pathology and Microbiology 2020 63(5):56-58
Wed Feb 26, 2020 00:00
Nadia Gheni, David WestenbergIndian Journal of Pathology and Microbiology 2020 63(5):123-128 Human epidermal growth factor receptor HER2/neu status is an important prognostic factor for breast cancer as it is crucial in stimulating growth and cellular motility. Overexpression of HER2/neu is observed in 10%−35% of the human breast cancer and is associated with prognosis and response to treatment. The magnitude of amplification must be determined to facilitate better prognosis and personalized...
Wed Feb 26, 2020 00:00
Meenakshi Rao, Gautam R Choudhary, Taruna Yadav, Aasma NalwaIndian Journal of Pathology and Microbiology 2020 63(5):59-60
Wed Feb 26, 2020 00:00
Zeba Nisar, Jaydeep N Pol, Rakhi V Jagdale, Madhura D Phadke, Girish A KadkolIndian Journal of Pathology and Microbiology 2020 63(5):134-140Aims: To explore clinical, histopathological and immunohistochemistry (IHC) features of mammary analogue secretory carcinoma (MASC) with systematic literature review. Settings and Design: Hospital based cross-sectional study. Subjects and Methods: The data of all cases of MASC diagnosed over a period of 1 year i.e., from July 2017 to July 2018 were retrieved....
Wed Feb 26, 2020 00:00
Diya Das, Chhanda Datta, Uttara Chatterjee, Dilip Kumar PalIndian Journal of Pathology and Microbiology 2020 63(5):61-63
Wed Feb 26, 2020 00:00
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