Tumor growth is supported by oncogene-driven metabolic activities that allow cancer cells to take up nutrients, build macromolecules, and proliferate. A long-standing goal of cancer research has been to deprive tumors of the nutrients that supply the anabolic metabolism that promotes their growth.…
Thu Feb 27, 2020 02:00
Abstract Purpose We aimed to assess the role of radiologists, cardiologists, and other medical and non-medical figures in cardiac magnetic resonance imaging (MRI) research in the last 34 years, focusing on first and last authorship, number of published studies, and journal impact factors (IF). Methods Articles in the field of cardiac MRI were...
Thu Feb 27, 2020 02:00
Abstract Background Giant cell tumor (GCT) is a nonmalignant neoplasm composed of multinucleated giant and mononuclear stromal cells. This study aimed to compare imaging findings of GCT pre- and post-denosumab treatment, including lesion size, percentage of signal intensity/density change, and time of initial objective tumor response. This will have a great impact on selection of most appropriate imaging technique...
Thu Feb 27, 2020 02:00
Oxygen-sensing pathways orchestrate phenotypic adjustments from the cellular to the whole-body level, allowing function and survival under a variety of conditions. The hypoxic response is exquisitely sensitive and dynamic, with relatively small changes in oxygen availability initiating…
Thu Feb 27, 2020 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00274
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05753
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00036
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05657
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05519
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00144
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05130
Thu Feb 27, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00728
Thu Feb 27, 2020 07:00
Matrix metalloproteinases (MMPs) are a large family of ubiquitously expressed zinc-dependent enzymes with proteolitic activities. They are expressed in physiological situations and pathological conditions involving inflammatory processes including epithelial to mesenchymal transition (EMT), neuronal injury, and cancer. There is also evidence that MMPs regulate inflammation in tumor microenvironment, which plays an important role in healing tissue processes. Looking at both inflammatory and neuronal...
Thu Feb 27, 2020 15:35
Chronic kidney disease (CKD) causes anemia by renal damage. In CKD, the kidney is submitted to hypoxia, persistent inflammation, leading to fibrosis and permanent loss of renal function. Human recombinant erythropoietin (rEPO) has been widely used to treat CKD-associated anemia and is known to possess organ-protective properties that are independent from its well-established hematopoietic effects. Nonhematopoietic effects of EPO are mediated by an alternative receptor that is proposed to consist...
Thu Feb 27, 2020 13:05
An Atlantic spotted mackerel with its skeleton stained for analysis. (© AMNH/J. Sparks/)For February, we’re focusing on the body parts that shape us, oxygenate us, and power us as we take long walks on the beach. Bony bonafide bones. These skeletal building blocks inspire curiosity and spark fear in different folks—we hope our stories, covering everything from surgeries and supplements to good old-fashioned boning, will only do the first. Once you’ve thoroughly blasted your mind with bone facts,...
01:46
Chill out with some cold brew. (Matt Hoffman via Unsplash/)Getting your caffeine fix in warm weather can be complicated. Hot coffee or tea is unappealing when you’re already sweating, and a trip to the cafe for something cold is exhausting if you haven’t already had a cup. Though cold-brew coffee may carry an air of mystery, it is easier than ever to make at home. Doing so will save you time, money, and the mental energy of having to figure out where your next cold-brew is coming from. Have it to...
01:05
Sound machines for better sleep. (Gregory Pappas via Unsplash/)A diffuse sound containing literally every audible frequency at an equal intensity, white noise is a nondescript hiss that’s fantastic for discreetly drowning out random background noise and keeping your conversations private. Its noise-cancelling properties are well known for being an effective sleep and study aid, and its qualities are found in numerous naturally-occurring sounds like rain storms and the crashing of ocean waves. If...
00:58
Suck it up and keep your house clean. (Amazon/)If you live in a smaller apartment or dorm room or simply don’t have enough storage space, a full-sized vacuum isn’t a total necessity. There are some powerful handheld vacuums currently on the market that are just as effective as their bigger counterparts and in some cases more versatile. These smaller handheld vacs, known commonly as “dust busters,” are also great for cleaning cars and reaching the top of shelves or fan-blades where dust tends to go...
00:55
This is not a drill. Wait, actually, these are all drills. (El Alce Web via Unsplash /)We’ve all toiled over a box of pre-packed furniture pieces with nothing more than a screwdriver and sore, sweaty hands. Life doesn’t have to be like that, though—a power drill is a super accessible must-have for any functional modern home. If you hang pictures on drywall, you’ll need a drill to make a safe and clean pilot hole. Ever tried to make one with a screwdriver? It doesn’t work. Putting up curtains? You...
00:53
They've adapted a little too well to human habits. (DepositPhoto/)As anyone who has ever had a boardwalk pizza slice snatched from their hand can attest, gulls are a bit of a menace when it comes to food. These birds thrive in human-created areas, where they find lots of things to mooch off us. A new study from researchers at the University of Exeter demonstrated that—at least for the herring gulls of Falmouth and Penzance, two towns in South West England—human touch may be the key to identifying...
Thu Feb 27, 2020 23:08
It's bigger than a plant. (Stan Horaczek /)Venture into the stereo department of any brick-and-mortar department store and it feels like entering a time warp. So many of the systems seem stuck where they were decades ago, with neon lights that glow and flash from behind oversized buttons and dials. Exaggerated grills and tubes promise mega bass in all caps. They shout “PARTY” louder than an obnoxious teenager in an ‘80s movie.The new Ultimate Ears Hyperboom speaker is built for the same party rocking,...
Thu Feb 27, 2020 23:05
Space rocks much smaller than our moon might occasionally get stuck in our cosmic backyard. (Deposit Photos/)For the last two and a half years, the Earth may have had two moons. There’s the obvious one that raises the tides and can often be seen during the day, and now researchers have identified a candidate for a second. The “mini-moon,” as some are calling it, is a couch-sized speck roughly 10 trillion times dimmer than its more famous counterpart. And astronomers found the satellite just in time,...
00:07
The 708-pound bluefin tuna outweighs the previous Virginia state record by a whopping 102 pounds. (Photos by The Confluence Group/Buzz Hayes/)This story originally featured on Field & Stream.Editor’s Note: Unsustainable fishing practices have depleted Atlantic bluefin tuna around the world, so much that the US tightly regulates harvest of the endangered species. Given that Jake Hiles’s catch falls within the federal limits, and that he didn’t take the meat to the market, we decided to share the...
Thu Feb 27, 2020 19:44
In the absence of a federal mandate, some local governments and institutions are stepping up. (Unsplash/Pixabay/DepositPhotos/)In 2018, the United Nations’ Intergovernmental Panel on Climate Change set a deadline: Snuff greenhouse gas emissions 45 percent by 2030 to keep warming from creeping past 1.5 degrees Celsius, the threshold beyond which lie the worst consequences of an overheated planet. Technologically, the scientists pointed out, we have the tools to make such a drastic clamp-down happen,...
Thu Feb 27, 2020 18:33
The tail on this experimental Bell craft consists of four electric fans. (Bell /)Watch a helicopter fly, and the big spinning top rotor hogs the spotlight. After all, that’s the main mechanism that allows a whirlybird to defy gravity and soar through the air as the pilot commands.But there’s a key supporting actor on nearly all helicopters: the smaller tail rotor. It plays a crucial role as an anti-torque device—it prevents the helicopter from spinning around in circles in response to the movement...
Thu Feb 27, 2020 17:27
An x-ray of a patient with melorheostosis (NIH Image Gallery/)For February, we’re focusing on the body parts that shape us, oxygenate us, and power us as we take long walks on the beach. Bony bonafide bones. These skeletal building blocks inspire curiosity and spark fear in different folks—we hope our stories, covering everything from surgeries and supplements to good old-fashioned boning, will only do the first. Once you’ve thoroughly blasted your mind with bone facts, check out our previous themed...
Thu Feb 27, 2020 15:00
Horm Metab ResDOI: 10.1055/a-1116-2173Androgens play a pivotal role in non-reproductive organs such as the kidney, heart, liver, and pancreas. As androgen receptors are expressed in pancreatic and liver cells, excess testosterone can result in hypersecretion of insulin and fetuin-A, a protein produced in the liver. The expression of fetuin-A, a natural inhibitor of tyrosine kinase activity in muscle and liver, leads to insulin resistance. In addition, insulin and fetuin-A levels are thought to be...
Thu Feb 27, 2020 01:00
Horm Metab ResDOI: 10.1055/a-1110-7251Neuroendocrine neoplasms (NENs) are rare tumours that arise mainly in the gastrointestinal or pulmonary system. Most NENs are well-differentiated and may obtain prolonged survival besides the presence of metastatic disease; however, a subset (poorly differentiated NENs) may display a truly aggressive behaviour exhibiting a poor prognosis. The recently developed...
Thu Feb 27, 2020 01:00
DRW (Diagnostics for the Real World), a company with headquarters in San Jose, California, and Cambridge, United Kingdom, has developed the SAMBA II, a point-of-care diagnostic device for the detection of infectious diseases, including HIV and HCV, for use in low-resource and/or remote regions. The system employs nucleic acid amplification to detect viral RNA or DNA in whole blood or plasma samples. The technology involves easy-to-use test cartridges, containing all the required consumables...
01:14
FUJIFILM is introducing a new technology that is capable of automatically detecting suspected polyps in real-time during colonoscopy exams. Called CAD EYE, the technology consists of hardware and software components that are compatible with the company’s ELUXEO 7000 endoscopy system. CAD EYE relies on FUJIFILM’s REiLI, an AI platform developed for medical applications. It can perform complex segmentation of 2D and 3D images, spot lesions, and is compatible with various imaging...
00:39
A variety of congenital cardiac abnormalities require the placement of prosthetic heart valves in very young children. As the hearts grow, the valves have to be replaced through repeated surgeries. A team of researchers from Harvard and Boston Children’s Hospital have now developed an artificial valve that can be expanded, via a minimally invasive transcatheter procedure, to compensate for the growing lumen within which it sits. Such adjustment procedures are a lot easier on the patients and...
Thu Feb 27, 2020 21:07
When imaging tissues microscopically, pathology labs have to stain the samples to see the cellular shapes and structures within. This is not trivial and requires expertise, time, and related costs. Infrared light has the capability to help visualize biomedical samples without staining, but the wavelengths of such light make it incompatible with optical microscopes and require samples to be prepared in a special way. Now, researchers at the University of Illinois at Urbana-Champaign...
Thu Feb 27, 2020 19:03
Abstract The cognitive processes involved in humor comprehension were analyzed by directly comparing the time course of brain activity associated with the perception of slapstick humor and that associated with the comprehension of humor requiring theory of mind (ToM). Four different comic strips (strips containing humorous scenes that required ToM, non-ToM humorous strips, non-humorous semantically coherent strips and non-humorous semantically incoherent strips) were presented...
Thu Feb 27, 2020 02:00
Abstract Recent research has shown that systematic postural adjustments occur during periods of manual motor imagery (MI), but the timing (anticipatory or reactive) and directionality (against or in the direction of arm extension) of these postural motions relative to individual manual actions or imagery are not well understood. This study analyzed the anteroposterior hip and head motion of healthy young and older participants, while they imagined bilateral arm raises under self-initiated...
Thu Feb 27, 2020 02:00
Metal hypersensitivity reactions in the setting of joint arthroplasties is a poorly understood phenomenon and often challenging to diagnose. This treatment conundrum is exemplified by TS, a 65-year-old male with a history of severe osteoarthritis who underwent a right total knee arthroplasty 14 months ago. He presents with complaints of pain, swelling, delayed wound healing, and intermittent skin rashes around the right knee. He was unable to reach the expected physical rehab goals following his...
Thu Feb 27, 2020 02:00
It was a pleasure to see so many SUNTA members at our business meeting in Vancouver, where we recognized SUNTA members’ research, and discussed initiatives in 2019 that will continue in 2020. Board transitions We welcomed three new members to the board, as follows: Rudolf Gaudio (secretary), Christina Schwenkel (1st year councilor) and Claire Panetta (student councilor). Many thanks to outgoing board members Ahmed Kanna (councilor), Faedah Totah (secretary), and Camille Frazier (student councilor)....
00:00
Henry Gray, an anatomist and surgeon at St George’s Hospital Medical School in London, first published his book on human anatomy in 1858. He died of smallpox 3 years later at the age of 34,1 but his legacy lives on over one and a half century later with the publication of the first edition of Gray’s Surgical Anatomy, written by a team of authors led by Professor Peter Brennan, an Oral & Maxillofacial Surgeon.
Thu Feb 27, 2020 02:00
It is increasingly being recognised that human factors can contribute to error in complex safety systems. Healthcare, however, has a long way to go before the promotion of training in, and awareness of, human factors will catch up with other high-risk organisations. A critical component that is deemed essential both for improving clinical performance and reducing medical error is situational awareness (SA). This is dynamic and can reduce quickly or be lost entirely, particularly when the workload...
Thu Feb 27, 2020 02:00
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