Nature Communications, Published online: 25 February 2020; doi:10.1038/s41467-020-14911-yDifferent self-healing materials were developed in the past but development of mechanically robust and affordable self-healing materials with high strain and stiffness is challenging. Here the authors develop mechanically robust thermoplastic polyurethane fibers and films capable of autonomous self-healing under ambient conditions.
Tue Feb 25, 2020 02:00
Nature Communications, Published online: 25 February 2020; doi:10.1038/s41467-020-14829-5Familial myeloid malignancies have recently been classified as separate disease entities. Here, using whole-exome sequencing of affected pedigrees - the authors highlight genetic variants associated with these conditions.
Tue Feb 25, 2020 02:00
Nature Communications, Published online: 25 February 2020; doi:10.1038/s41467-020-14935-4Author Correction: Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
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Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Xiao-Ning Wu, Yang Yang, Huan-Huan Zhang, Yu-Sen Zhong, Fang Wu, Bing Yu, Chen-Huan Yu
Tue Feb 25, 2020 13:52
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): François Marceau, Hélène Bachelard, Johanne Bouthillier, Jean-Philippe Fortin, Guillaume Morissette, Marie-Thérèse Bawolak, Xavier Charest-Morin, Lajos Gera
Tue Feb 25, 2020 13:52
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Mikhail A. Shulepko, Maxim L. Bychkov, Olga V. Shlepova, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Tue Feb 25, 2020 13:52
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Haris Saeed, Somaiya Mateen, Shagufta Moin, Abdul Qayyum Khan, Mohammad Owais
Tue Feb 25, 2020 13:52
Related ArticlesTestis transcriptome profiling identified genes involved in spermatogenic arrest of cattleyak. PLoS One. 2020;15(2):e0229503 Authors: Wu S, Mipam T, Xu C, Zhao W, Shah MA, Yi C, Luo H, Cai X, Zhong J Abstract BACKGROUND: Cattleyak are the hybrid offspring between cattle and yak and combine yak hardiness with cattle productivity. Much attempt has been made to examine the mechanisms of male sterility caused by spermatogenic arrest, but...
Tue Feb 25, 2020 14:53
Related ArticlesNovel pyrazolopyrimidine urea derivatives: Synthesis, antiproliferative activity, VEGFR-2 inhibition, and effects on the cell cycle profile. Arch Pharm (Weinheim). 2020 Feb 24;:e1900319 Authors: Kassab AE, El-Dash Y, Gedawy EM Abstract A series of novel diaryl urea pyrazolopyrimidine derivatives was designed and synthesized. All the synthesized compounds were evaluated for cytotoxic activity by the National Cancer Institute. A significant...
Tue Feb 25, 2020 14:53
Related ArticlesDiscovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization. Biochem Biophys Res Commun. 2020 Feb 20;: Authors: Chen L, Fan DM, Tang JW, An T, Li X, Kong LM, Puno PT, Li Y Abstract Microtubules are involved in celluar processes of movement, intracellular trafficking and mitosis, thus microtubule-targeting agents have been widely used in cancer therapy. Herein, we report isopenicin A, a novel meroterpenoid...
Tue Feb 25, 2020 13:51
Related ArticlesAstragaloside IV inhibits cell proliferation in vulvar squamous cell carcinoma through the TGF-β/Smad signaling pathway. Dermatol Ther. 2019 07;32(4):e12802 Authors: Zhao Y, Wang L, Wang Y, Dong S, Yang S, Guan Y, Wu X Abstract OBJECTIVE: To explore the inhibition of the proliferation of vulvar squamous cell carcinoma (VSCC) by astragaloside IV. METHODS: MTT examined the cell proliferation of VSCC. Flow cytometry analyzed cell...
Tue Feb 25, 2020 13:51
Related ArticlesCross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome. Sleep Med. 2020 Feb 04;69:172-178 Authors: Bokov P, Matrot B, Medjahdi N, Boureghda S, Essalhi M, Konofal E, Lecendreux M, Gallego J, Delclaux C Abstract STUDY OBJECTIVES: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA). METHODS: Otherwise healthy children referred...
Tue Feb 25, 2020 15:15
Related ArticlesDaytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea. Sleep Disord. 2020;2020:3029836 Authors: Walker M, Blackwell JN, Stafford P, Patel P, Mazimba S, Mehta N, Cho Y, Mangrum M, Nazarian S, Bilchick K, Kwon Y Abstract Background: Obstructive sleep apnea (OSA) has been linked to sudden cardiac death (SCD). Prolonged QT is a recognized electrocardiographic (ECG) marker of abnormal ventricular repolarization...
Tue Feb 25, 2020 13:50
Related ArticlesApnea events in neonatal age: A case report and literature review. Med Hypotheses. 2019 Oct;131:109296 Authors: Falsaperla R, Vitaliti G, Cimino C, Catanzaro S, Corsello G Abstract BACKGROUND: Among the most common autonomic signs visible in preterm neonates, apnea can represent the first sign of several neurologic and non-neurologic disorders, and seizure is a relatively infrequent cause. Herein authors present a case of neonatal autonomic...
Tue Feb 25, 2020 13:50
Related ArticlesNon-invasive machine learning estimation of effort differentiates sleep-disordered breathing pathology. Physiol Meas. 2019 02 26;40(2):025008 Authors: Hanif U, Schneider LD, Trap L, Leary EB, Moore H, Guilleminault C, Jennum P, Sorensen HBD, Mignot EJM Abstract OBJECTIVE: Obstructive sleep-disordered breathing (SDB) events, unlike central events, are associated with increased respiratory effort. Esophageal pressure (P es) monitoring...
Tue Feb 25, 2020 13:50
Related ArticlesEditor's Perspectives - March 2020. Int J Surg. 2020 Feb 21;: Authors: Lau JWY PMID: 32092451 [PubMed - as supplied by publisher]
Tue Feb 25, 2020 14:45
Publication date: Available online 24 February 2020Source: Allergology InternationalAuthor(s): Naomi Nakamura, Risa Tamagawa-Mineoka, Ayano Maruyama, Mari Nakanishi, Risa Yasuike, Koji Masuda, Hiroshi Matsunaka, Yumi Murakami, Emiko Yokosawa, Norito Katoh
Tue Feb 25, 2020 13:44
Related ArticlesThe efficacy and safety of microvascular decompression for hemifacial spasm: A retrospective analysis of surgical outcomes and complications. Turk Neurosurg. 2019 Sep 25;: Authors: Bekar A, Kuytu T, Türkkan A, Altunyuva O, Eser Ocak P Abstract AIM: Primary hemifacial spasm (HFS) is caused by vascular compression of the facial nerve root entry zone. Microvascular decompression (MVD) is an effective method in patients who are resistant...
Tue Feb 25, 2020 15:41
Related ArticlesChemokine CXCL13 in serum, CSF and blood-CSF barrier function: evidence of compartment restriction. Fluids Barriers CNS. 2020 Feb 24;17(1):7 Authors: Pilz G, Sakic I, Wipfler P, Kraus J, Haschke-Becher E, Hitzl W, Trinka E, Harrer A Abstract BACKGROUND AND PURPOSE: Elevation of the chemokine CXCL13 in CSF frequently occurs during active and acute CNS inflammatory processes and presumably is associated with B cell-related immune activation....
Tue Feb 25, 2020 13:44
Related ArticlesEndonasal transpterygoid approach for lateral sphenoid recess cerebrospinal fluid leaks: Technical aspects. Neurol India. 2019 Jan-Feb;67(1):73 Authors: Balasubramaniam A AbstractPMID: 30860099 [PubMed - indexed for MEDLINE]
Tue Feb 25, 2020 13:44
Related ArticlesEndoscopic transpterygoid repair of cerebrospinal fluid leaks from lateral recess of sphenoid. Neurol India. 2019 Jan-Feb;67(1):71-72 Authors: Jayashankar N AbstractPMID: 30860098 [PubMed - indexed for MEDLINE]
Tue Feb 25, 2020 13:44
The case for using lumbar drainage intraoperatively to help curb the number of iatrogenic CSF leaks.
Related ArticlesThe case for using lumbar drainage intraoperatively to help curb the number of iatrogenic CSF leaks. Neurol India. 2018 Jan-Feb;66(1):51-52 Authors: E Sá MC PMID: 29322958 [PubMed - indexed for MEDLINE]
Tue Feb 25, 2020 13:44
Abstract Background Effective treatment for severe asthma is a significant unmet need. While eosinophilic inflammation caused by Type 2 cytokines is responsive to corticosteroid and biologic therapies, many severe asthmatics exhibit corticosteroid‐unresponsive mixed granulocytic inflammation. Objective Here, we tested the hypothesis that the pro‐allergic cytokine, IL‐13, can drive both corticosteroid‐sensitive and corticosteroid‐resistant responses. Results By integration of in vivo...
Tue Feb 25, 2020 13:42
Related ArticlesLittle Fish, Big Questions: A Collection of Modern Techniques for Mexican Tetra Research. J Vis Exp. 2020 Feb 24;(156): Authors: Riddle MR, Tabin CJ Abstract Articles Discussed: Stahl, B. A. et al. Manipulation of Gene Function in Mexican Cavefish. Journal of Visualized Experiments. (146) (2019). Peuß, R. et al. Gamete Collection and In Vitro Fertilization of Astyanax mexicanus. Journal of Visualized Experiments. (147) (2019). Worsham,...
Tue Feb 25, 2020 15:40
Related ArticlesAssessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation. J Vis Exp. 2020 Feb 07;(156): Authors: Manno FAM, Pan L, Mao Y, Su Y, Manno SHC, Cheng SH, Lau C, Cai Y Abstract The overall goal of this study is to assess the autonomic and behavioral effects of passive motion in rodents using the elevator vertical motion and Ferris-wheel rotation devices. These assays...
Tue Feb 25, 2020 15:40
Related ArticlesDetermining and Controlling External Power Output During Regular Handrim Wheelchair Propulsion. J Vis Exp. 2020 Feb 05;(156): Authors: de Klerk R, Vegter RJK, Leving MT, de Groot S, Veeger DHEJ, van der Woude LHV Abstract The use of a manual wheelchair is critical to 1% of the world's population. Human powered wheeled mobility research has considerably matured, which has led to improved research techniques becoming available over...
Tue Feb 25, 2020 15:40
Related ArticlesDetecting Migration and Infiltration of Neutrophils in Mice. J Vis Exp. 2020 Feb 06;(156): Authors: Lu Q, Yuan K, Li X, Jiang H, Huo G, Jia W, Huang G, Xu A Abstract Neutrophils are a major member of the innate immune system and play pivotal roles in host defense against pathogens and pathologic inflammatory reactions. Neutrophils can be recruited to inflammation sites via the guidance of cytokines and chemokines. Overwhelming infiltration...
Tue Feb 25, 2020 15:40
Related ArticlesDetecting Establishment of Shared Blood Supply in Parabiotic Mice by Caudal Vein Glucose Injection. J Vis Exp. 2020 Feb 06;(156): Authors: Liu X, Bai X, Li M, Li H, Zhang Y, Yang B Abstract Parabiosis is an experimental method for surgically combining two parallel animals along the longitudinal axis of the body. We present a protocol for detecting the successful establishment of blood chimerism in parabionts by a caudal vein injection...
Tue Feb 25, 2020 15:40
Related ArticlesGeneration of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments. J Vis Exp. 2020 Feb 09;(156): Authors: Mazuir E, Dubessy AL, Wallon L, Aigrot MS, Lubetzki C, Sol-Foulon N Abstract In the central nervous system, oligodendrocytes are well-known for their role in axon myelination, that accelerates the propagation of action potentials through saltatory conduction. Moreover, an increasing number of reports...
Tue Feb 25, 2020 15:40
Related ArticlesComparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane. J Vis Exp. 2020 Feb 08;(156): Authors: Ishihara M, Hu J, Zhang X, Choi Y, Wong A, Cano-Ruiz C, Zhao R, Tan P, Tso JL, Wu L Abstract Metastatic clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer. Localized ccRCC has a favorable surgical outcome. However, one third of ccRCC...
Tue Feb 25, 2020 15:40
Related ArticlesUltrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems. J Vis Exp. 2020 Feb 10;(156): Authors: Takaya T, Iwata K Abstract Femtosecond time-resolved stimulated Raman spectroscopy is a promising method of observing the structural dynamics of short-lived transients with near infrared (near-IR) transitions, because it can overcome the low sensitivity of spontaneous Raman spectrometers in the near-IR...
Tue Feb 25, 2020 15:40
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