IJMS, Vol. 21, Pages 1397: Integrated Metabolomic and Transcriptomic Analysis to Characterize Cutin Biosynthesis between Low- and High-Cutin Genotypes of Capsicum chinense Jacq International Journal of Molecular Sciences doi: 10.3390/ijms21041397 Authors: Purushothaman Natarajan Tolulope Abodunrin Akinmoju Padma Nimmakayala Carlos Lopez-Ortiz Marleny Garcia-Lozano Benjamin J. Thompson John Stommel Umesh K. Reddy Habanero peppers constantly face biotic and abiotic...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1395: Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21041395 Authors: Ilias Thomas Alex M. Dickens Jussi P. Posti Mehrbod Mohammadian Christian Ledig Riikka S. K. Takala Tuulia Hyötyläinen Olli Tenovuo Matej Orešič Recent evidence suggests that patients with traumatic brain injuries (TBIs) have...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1392: Impact of Pituitary Autoimmunity and Genetic Disorders on Growth Hormone Deficiency in Children and Adults International Journal of Molecular Sciences doi: 10.3390/ijms21041392 Authors: Giuseppe Bellastella Maria Ida Maiorino Miriam Longo Paolo Cirillo Lorenzo Scappaticcio Maria Teresa Vietri Antonio Bellastella Katherine Esposito Annamaria De Bellis Growth hormone (GH), mostly through its peripheral mediator, the insulin-like growth...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1391: P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21041391 Authors: Alexandre Mansour Christilla Bachelot-Loza Nicolas Nesseler Pascale Gaussem Isabelle Gouin-Thibault The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted to the primary and secondary...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1393: New Insights into the Role of Glutathione in the Mechanism of Fever International Journal of Molecular Sciences doi: 10.3390/ijms21041393 Authors: Sylwia Wrotek Justyna Sobocińska Henryk M. Kozłowski Małgorzata Pawlikowska Tomasz Jędrzejewski Artur Dzialuk Glutathione is one of the most important and potent antioxidants. The development of pharmacological compounds that can either increase or decrease glutathione concentrations has allowed investigation...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1374: OmixLitMiner: A Bioinformatics Tool for Prioritizing Biological Leads from ‘Omics Data Using Literature Retrieval and Data Mining International Journal of Molecular Sciences doi: 10.3390/ijms21041374 Authors: Pascal Steffen Jemma Wu Shubhang Hariharan Hannah Voss Vijay Raghunath Mark P. Molloy Hartmut Schlüter Proteomics and genomics discovery experiments generate increasingly large result tables, necessitating more researcher time to convert...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1387: Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041387 Authors: Jingqiu Wang Dong-Hua Yang Yuqi Yang Jing-Quan Wang Chao-Yun Cai Zi-Ning Lei Qiu-Xu Teng Zhuo-Xun Wu Linguo Zhao Zhe-Sheng Chen The overexpressing ABCB1 transporter is one of the key factors leading to multidrug resistance (MDR). Thus, many ABCB1 inhibitors...
Wed Feb 19, 2020 02:00
IJMS, Vol. 21, Pages 1390: Effect of Low Temperature on Chlorophyll Biosynthesis and Chloroplast Biogenesis of Rice Seedlings during Greening International Journal of Molecular Sciences doi: 10.3390/ijms21041390 Authors: Zhao Han Ding Huang Liao Chen Feng Zhou Zhang Chen Yuan Yuan Rice (Oryza sativa L.) frequently suffers in late spring from severe damage due to cold spells, which causes the block of chlorophyll biosynthesis during early...
Wed Feb 19, 2020 02:00
IJNS, Vol. 6, Pages 12: Introducing and Expanding Newborn Screening in the MENA Region International Journal of Neonatal Screening doi: 10.3390/ijns6010012 Authors: Skrinska Khneisser Schielen Loeber This special edition of the International Journal of Neonatal Screening includes the presentations ofthe fourth Meeting of the Middle East North Africa (MENA) Region of the International Society forNeonatal Screening (ISNS) held in Limassol, Cyprus, March 8–11, 2020...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 569: Correction: Association between Gait Deviation Index and Physical Function in Children with Bilateral Spastic Cerebral Palsy: A Cross-Sectional Study. J. Clin. Med. 2020, 9, 28 Journal of Clinical Medicine doi: 10.3390/jcm9020569 Authors: Tadashi Ito Koji Noritake Hiroshi Sugiura Yasunari Kamiya Hidehito Tomita Yuji Ito Hideshi Sugiura Nobuhiko Ochi Yuji Yoshihashi The authors wish to make the following corrections to this paper [...]
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 572: Application of Artificial Intelligence Techniques to Predict Survival in Kidney Transplantation: A Review Journal of Clinical Medicine doi: 10.3390/jcm9020572 Authors: Díez-Sanmartín Sarasa Cabezuelo A key issue in the field of kidney transplants is the analysis of transplant recipients’ survival. By means of the information obtained from transplant patients, it is possible to analyse in which cases a transplant has a higher likelihood of success...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 570: Genetic Components of 25-Hydroxyvitamin D Increase in Three Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9020570 Authors: Trummer Schweighofer Haudum Trummer Pilz Theiler-Schwetz Keppel Grübler Pieber Renner Obermayer-Pietsch Lerchbaum The 25-Hydroxyvitamin D (25[OH)D) serum concentration depends on vitamin D intake, endogenous vitamin D production and genetic factors. The latter have been...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 571: Risk Assessment of Novel Coronavirus COVID-19 Outbreaks Outside China Journal of Clinical Medicine doi: 10.3390/jcm9020571 Authors: Péter Boldog Tamás Tekeli Zsolt Vizi Attila Dénes Ferenc A. Bartha Gergely Röst We developed a computational tool to assess the risks of novel coronavirus outbreaks outside of China. We estimate the dependence of the risk of a major outbreak in a country from imported cases on key parameters such as: (i) the evolution...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 567: TIPS Modification in the Management of Shunt-Induced Hepatic Encephalopathy: Analysis of Predictive Factors and Outcome with Shunt Modification Journal of Clinical Medicine doi: 10.3390/jcm9020567 Authors: Schindler Seifert Masthoff Riegel Köhler Wilms Schmidt Heinzow Wildgruber Purpose: To evaluate predictive parameters for the development of Hepatic Encephalopathy (HE) after Transjugular Intrahepatic Portosystemic Shunt (TIPS)...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 565: New First Line Treatment Options of Clear Cell Renal Cell Cancer Patients with PD-1 or PD-L1 Immune-Checkpoint Inhibitor-Based Combination Therapies Journal of Clinical Medicine doi: 10.3390/jcm9020565 Authors: Marc-Oliver Grimm Katharina Leucht Viktor Grünwald Susan Foller In metastatic renal cell carcinoma (mRCC) the PD-1 immune-checkpoint inhibitor (ICI) Nivolumab became a standard second line treatment option in 2015 based on a significant improvement...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 566: Aromatase Inhibitors and Risk of Arthritis and Carpal Tunnel Syndrome among Taiwanese Women with Breast Cancer: A Nationwide Claims Data Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020566 Authors: Chien Kao Yang Kwoh Chalasani Wilson Lo-Ciganic Tamoxifen or aromatase inhibitor (AI) therapy may prevent breast cancer recurrence, however, adverse effects may lead to treatment discontinuation. Evidence regarding the occurrence of AI-associated...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 568: Effect of Radial Extracorporeal Shock Wave Therapy on Pain Intensity, Functional Efficiency, and Postural Control Parameters in Patients with Chronic Low Back Pain: A Randomized Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm9020568 Authors: Walewicz Taradaj Dobrzyński Sopel Kowal Ptaszkowski Dymarek Low back pain (LBP) is the leading cause of disability worldwide, placing a significant economic burden on healthcare systems....
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 562: Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study Journal of Clinical Medicine doi: 10.3390/jcm9020562 Authors: Pegon Rochette Rouel Pereira Doré Isfan Grèze Merlin Kanold Duché Background: Leukemia is the most common cancer in pediatrics, with many late effects such as higher risk of dyslipidemia, insulin resistance, obesity, and metabolic syndrome. The objective of this work was to...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 563: The Effect of Viral Clearance Achieved by Direct-Acting Antiviral Agents on Hepatitis C Virus Positive Patients with Type 2 Diabetes Mellitus: A Word of Caution after the Initial Enthusiasm Journal of Clinical Medicine doi: 10.3390/jcm9020563 Authors: Davide Giuseppe Ribaldone Marco Sacco Giorgio Maria Saracco The causal link between chronic hepatitis C and glycometabolic alterations has been confirmed by much biochemical, clinical, and epidemiological research...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 564: Intraoperative Oxygen Delivery and Acute Kidney Injury after Liver Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9020564 Authors: Kim Lee Yoon Lee Suh Although intraoperative hemodynamic variables were reported to be associated with acute kidney injury (AKI) after liver transplantation, the time-dependent association between intraoperative oxygen delivery and AKI has not yet been evaluated. We reviewed 676 cases of liver transplantation....
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 560: Leptin as a Key Player in Insulin Resistance of Liver Cirrhosis? A Cross-Sectional Study in Liver Transplant Candidates Journal of Clinical Medicine doi: 10.3390/jcm9020560 Authors: Iva Košuta Anna Mrzljak Branko Kolarić Marijana Vučić Lovrenčić Insulin resistance is associated with increased risk of death and liver transplantation in the cirrhotic population, independent of disease aetiology. However, factors accounting for insulin resistance in the...
Wed Feb 19, 2020 02:00
JCM, Vol. 9, Pages 561: Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: An Immunological Perspective Journal of Clinical Medicine doi: 10.3390/jcm9020561 Authors: Koudstaal Boomars Kool Pulmonary hypertension (PH) is a debilitating progressive disease characterized by increased pulmonary arterial pressures, leading to right ventricular (RV) failure, heart failure and, eventually, death. Based on the underlying conditions, PH patients can be...
Wed Feb 19, 2020 02:00
Medicina, Vol. 56, Pages 85: Bedside Sonographic Duplex Technique as a Monitoring Tool in Patients after Decompressive Craniectomy: A Single Centre Experience Medicina doi: 10.3390/medicina56020085 Authors: Bendella Spreer Hartmann Igressa Maegele Lefering Nakamura Background and objectives: Bedside sonographic duplex technique (SDT) may be used as an adjunct to cranial computed tomography (CCT) to monitor brain-injured patients after decompressive craniectomy...
Wed Feb 19, 2020 02:00
Medicina, Vol. 56, Pages 84: Comparison of Lateral Abdominal Musculature Activation during Expiration with an Expiratory Flow Control Device Versus the Abdominal Drawing-in Maneuver in Healthy Women: A Cross-Sectional Observational Pilot Study Medicina doi: 10.3390/medicina56020084 Authors: Vanesa Abuín-Porras Paula Maldonado-Tello Mónica de la Cueva-Reguera David Rodríguez-Sanz César Calvo-Lobo Daniel López-López Emmanuel Navarro-Flores Carlos Romero-Morales Background...
Wed Feb 19, 2020 02:00
Metabolites, Vol. 10, Pages 75: LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum Metabolites doi: 10.3390/metabo10020075 Authors: Samah O. Alshehri Rania T. Malatani Hanin A. Bogari Ahmad O. Noor Amany K. Ibrahim Sameh S. Elhady Reda F. A. Abdelhameed Chemical investigation of the ethyl acetate extract of Penicillium chrysogenum strain S003, a fungus isolated from Red Sea deep sediment, led to the isolation of a cerebroside molecular...
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Metabolites, Vol. 10, Pages 74: Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems Metabolites doi: 10.3390/metabo10020074 Authors: Røst Brekke Thorfinnsdottir Kumar Fuchino Eide Langørgen Bartosova Kristiansen Bruheim Absolute quantification of intracellular metabolite pools is a prerequisite for modeling and in-depth biological interpretation of metabolomics data. It is the final step...
Wed Feb 19, 2020 02:00
Microorganisms, Vol. 8, Pages 283: Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus Microorganisms doi: 10.3390/microorganisms8020283 Authors: Licht Nuss Volk Konzer Beckstette Berghoff Klug Photosynthetic bacteria have to deal with the risk of photooxidative stress that occurs in presence of light and oxygen due to the photosensitizing activity of (bacterio-) chlorophylls....
Wed Feb 19, 2020 02:00
Microorganisms, Vol. 8, Pages 284: Degradation Potential of the Nonylphenol Monooxygenase of Sphingomonas sp. NP5 for Bisphenols and Their Structural Analogs Microorganisms doi: 10.3390/microorganisms8020284 Authors: Takeo Akizuki Kawasaki Negoro The nonylphenol-degrading bacterium Sphingomonas sp. strain NP5 has a very unique monooxygenase that can attack a wide range of 4-alkylphenols with a branched side chain. Due to the structural similarity, it can also attack bisphenolic...
Wed Feb 19, 2020 02:00
Microorganisms, Vol. 8, Pages 282: Development of a Lyophilization Process for Campylobacter Bacteriophage Storage and Transport Microorganisms doi: 10.3390/microorganisms8020282 Authors: Liang Carrigy Kariuki Muturi Onsare Nagel Vehring Connerton Connerton Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to phage use, notably titer stability and...
Wed Feb 19, 2020 02:00
Microorganisms, Vol. 8, Pages 285: The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance Microorganisms doi: 10.3390/microorganisms8020285 Authors: Martyna Mroczyńska Ewelina Kurzyk Magdalena Śliwka-Kaszyńska Urszula Nawrot Marta Adamik Anna Brillowska-Dąbrowska Triazoles are the only compounds used as antibiotics in both medicine and agriculture. The presence of triazoles in the environment can contribute...
Wed Feb 19, 2020 02:00
Microorganisms, Vol. 8, Pages 281: Evaluation of Potential Probiotics Bacillus subtilis WB60, Pediococcus pentosaceus, and Lactococcus lactis on Growth Performance, Immune Response, Gut Histology and Immune-Related Genes in Whiteleg Shrimp, Litopenaeus vannamei Microorganisms doi: 10.3390/microorganisms8020281 Authors: Seonghun Won Ali Hamidoghli Wonsuk Choi Jinho Bae Won Je Jang Seunghan Lee Sungchul C. Bai An eight-week feeding trial was conducted to evaluate the...
Wed Feb 19, 2020 02:00
Microorganisms, Vol. 8, Pages 280: Antimicrobial Peptides: Virulence and Resistance Modulation in Gram-Negative Bacteria Microorganisms doi: 10.3390/microorganisms8020280 Authors: Marylise Duperthuy Growing resistance to antibiotics is one of the biggest threats to human health. One of the possibilities to overcome this resistance is to use and develop alternative molecules such as antimicrobial peptides (AMPs). However, an increasing number of studies have shown that bacterial resistance...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 942: Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections Molecules doi: 10.3390/molecules25040942 Authors: Serban Viral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately 90 drugs approved for the treatment of human viral infections. As resistance toward...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 941: Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation Molecules doi: 10.3390/molecules25040941 Authors: Leu Wang Wu Huang Jiang Hsu Chen Epidermal growth factor receptor (EGFR) is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC), which is the major type of lung cancer. The EGFR tyrosine kinase inhibitors (TKIs) are the approved treatment for patients harboring...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 939: Electrochemical Properties and Structure of Multi-Ferrocenyl Phosphorus Thioesters Molecules doi: 10.3390/molecules25040939 Authors: Shekurov Khrizanforov Gerasimova Yamaleeva Ivshin Lakomkina Bezkishko Kononov Sinyashin Budnikova Kataeva Miluykov The reaction of triferrocenylthiophosphite with elemental sulfur leads to triferrocenyltetrathiophosphate. The molecule of tetrathiophosphate adopts propeller-like...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 940: The Effect of Formulation of Curcuminoids on Their Metabolism by Human Colonic Microbiota Molecules doi: 10.3390/molecules25040940 Authors: Bresciani Favari Calani Francinelli Riva Petrangolini Allegrini Mena Del Rio Turmeric (Curcuma longa L.) is the only edible plant recognized as a dietary source of curcuminoids, among which curcumin, demethoxycurcumin (DMC) and bis-demethoxycurcumin (Bis-DMC) are the most representative...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 938: Large-Scale Virtual Screening Against the MET Kinase Domain Identifies a New Putative Inhibitor Type Molecules doi: 10.3390/molecules25040938 Authors: Emmanuel Bresso Alessandro Furlan Philippe Noel Vincent Leroux Flavio Maina Rosanna Dono Bernard Maigret By using an ensemble-docking strategy, we undertook a large-scale virtual screening campaign in order to identify new putative hits against the MET kinase target. Following a large molecular...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 935: Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition Molecules doi: 10.3390/molecules25040935 Authors: Cavalloro Russo Vasile Pignataro Torretta Donini Semrau Storici Rossi Rapetti Brullo Parisini Bruno Collina Alzheimer’s disease is the most common type of dementia, affecting millions of people worldwide. One of its main consequences is...
Wed Feb 19, 2020 02:00
Molecules, Vol. 25, Pages 937: Synthesis of New C-3 Substituted Kynurenic Acid Derivatives Molecules doi: 10.3390/molecules25040937 Authors: Lőrinczi Csámpai Fülöp Szatmári The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as morpholine, piperidine, or N-methylpiperazine and aldehydes...
Wed Feb 19, 2020 02:00
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