Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Aortic aneurysms in children are rare and when present are usually caused by a connective tissue disorder. In this article, we present a case of multiple aortic aneurysms in an adolescent with a novel finding of a gene variation that is associated with aortic disease.
Thu Feb 27, 2020 08:45
Abstract Objective The aim of this study was to determine how the removal of nonimpacted third molars (N‐M3s) affects the periodontal status of neighboring second molars (M2s). Subjects and Methods The periodontal condition of M2s for which the neighboring N‐M3s were removed (more than 6 months previously) and those with intact N‐M3s was analyzed in a cross‐sectional observation study. In an additional case series, periodontal changes in M2s in response to adjacent N‐M3 removal were observed...
Thu Feb 27, 2020 17:15
Abstract Objectives 1) To compare levels of pro‐ and anti‐inflammatory mediators in saliva and gingival crevicular fluid (GCF) in children with and without congenital heart defects (CHD), and to test if a systemic component exists in CHD children by controlling for gingivitis and plaque scores. 2) To correlate the levels of pro‐ and anti‐inflammatory mediators in GCF and saliva with plaque bacterial composition among CHD cases and controls. Materials and Methods Whole un‐stimulated saliva...
Thu Feb 27, 2020 17:15
Abstract Background Oral cancer patients can benefit from dental implant placement. Traditionally implants are placed after completing oncologic treatment (secondary implant placement). Implant placement during ablative surgery (primary placement) in oral cancer patients seems beneficial in terms of early start of oral rehabilitation and limiting additional surgical interventions. Guidelines on the ideal timing of implant placement in oral cancer patients are missing. Objective To perform...
Thu Feb 27, 2020 17:15
Abstract Background The establishment of adaptive immune responses to neoplasms involves not only the tumour tissue but also the peripheral blood. We aimed to conduct a preliminary exploration to understand the immune response of T lymphocytes of peripheral blood mononuclear cells (PBMC‐Ts) in oral squamous cell carcinoma (OSCC). Methods A total of 103 blood samples from OSCC patients and 18 blood samples from healthy donors were analysed by flow cytometry. Results Compared to those...
Thu Feb 27, 2020 17:15
Abstract Local anaesthetics (LA) are commonly used into daily clinical practice for many operational procedures (in both primary care and dentistry and across all hospital specializations). The literature reports few and controversial data on the prevalence of IgE‐mediated allergic reactions to LA, as adverse reactions are common and may simulate a hypersensitivity reaction. The real incidence of allergic reactions to LAs is reported to be < 1% (Berkun et al., 2003, Gall et al., 1996, Giovannitti...
Thu Feb 27, 2020 17:15
Publication date: Available online 26 February 2020Source: Acta HistochemicaAuthor(s): Fengyan Gong, Wei Chai, Junwei Wang, Huiyan Cheng, Yuee Shi, Lifeng Cui, Guifeng Jia
Thu Feb 27, 2020 17:13
Abstract Anti‐tumour necrosis factor (TNF) drugs are often prescribed for the treatment of rheumatoid arthritis (RA) and other immune‐mediated inflammatory diseases. While this treatment has been shown to be effective in many patients, up to 40% of patients do not achieve disease control. Drug concentration in plasma may be a factor affecting the observed variability in therapeutic response. This study aimed to identify the plasma concentrations of the anti‐TNF certolizumab pegol (CZP) associated...
Thu Feb 27, 2020 17:11
Abstract Asians as a group comprise of over 60% the world’s population. There is an incredible amount of diversity in Asian and admixed populations that has not been studied in a pharmacogenetic context. The known pharmacogenetic differences in Asians subgroups generally represent previously known variants that are present at much lower or higher frequencies in Asians compared to other populations. This review aims to summarize the main drugs and known genes that appear to have differences in their...
Thu Feb 27, 2020 17:11
Abstract Hydrazinocurcumin (HZC), a synthetic derivative of curcumin (CUR), has been documented to show anti‐cancer potential in impeding tumor growth in several cancers, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms remain to be unclear. This study aimed to explore the function and underlying mechanisms of HZC on HCC cells, which may involve the p38 MAPK pathway. HZC was first purified and identified. HepG2 cells were then subjected to treatment with HZC...
Thu Feb 27, 2020 17:11
Abstract Polymorphisms in drug transporters, like the ATP‐binding cassette (ABC) and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug response in African patients. This review aims to provide a comprehensive summary and analysis of the frequencies and distributions in African populations of ABC and SLC variants that affect drug pharmacokinetics (PK) and pharmacodynamics (PD). Of polymorphisms evaluated in African populations, SLCO1B1 rs4149056 and SLC22A6 rs1158626...
Thu Feb 27, 2020 17:11
The lymphovenous valve of the thoracic duct (TD), seen from the venous side, and using microcomputed tomography. Our study demonstrated the morphology of this valve in humans, which historically has received little attention. Interest in the TD and the lymphovenous junction (LVJ) is growing as the lymphatic system is understood to play a key role in the promotion of systemic inflammation and organ dysfunction during acute and critical illness. This has implicated the terminal TD and LVJ as locations...
Thu Feb 27, 2020 16:59
The plantar aponeurosis is commonly assumed to be an adaptation to bipedal walking in humans that evolved in concert with the longitudinal arch. However, there is still considerable uncertainty about the comparative anatomy of plantar aponeurosis in non‐human primates, which has undermined attempts to test adaptive hypotheses about this structure. In this study, we review and score descriptions of plantar aponeurosis anatomy in 40 primate species and apply new comparative phylogenetic methods to...
Thu Feb 27, 2020 16:59
Thu Feb 27, 2020 16:56
Publication date: Available online 26 February 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): L. Santini, V. Favier, F. Benoudiba, G. Garcia, R. Abgral, S. Zerdoud, G. Russ, A. Bozec, S. Tronche, S. Pondaven, R. Garrel, E. de Monès
Thu Feb 27, 2020 16:51
Abstract There have been several studies on the role of the monocyte chemotactic protein‐1 / C‐C chemokine receptor type 2 (CCR2) signaling pathway in fibrotic diseases, which identified the blockade of this pathway as a potential therapeutic target for treating fibrosis. We examined the efficacy of CCR2 antagonist (RS‐504393) in a mouse model of scleroderma induced by bleomycin. RS‐504393 was administered via intradermal injection 6 hours prior to bleomycin injection, in the same sites. Histopathological...
Thu Feb 27, 2020 16:49
Publication date: Available online 27 February 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Michael Blumer, Maximilian Eberhard Wagner, Martin Rücker, Martin Lanzer, Harald Essig, Thomas Gander
Thu Feb 27, 2020 16:45
Publication date: Available online 26 February 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): M. Franklin Dolwick, Daili Diaz, Danielle L. Freburg-Hoffmeister, Charles G. Widmer
Thu Feb 27, 2020 16:45
Publication date: Available online 27 February 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nikolaus E. Wolter, Aimee A. Kennedy, Michael J. Rutter, Clyde Matava, Osami Honjo, Priscila L. Chiu, Evan J. Propst
Thu Feb 27, 2020 16:41
Publication date: Available online 27 February 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Tang Ru, Mao Song, Ye Haibo, Zhang Weitian
Thu Feb 27, 2020 16:41
Publication date: Available online 26 February 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Kimberly Mae C. Ong, Adovich S. Rivera, Abner L. Chan, Charlotte M. Chiong
Thu Feb 27, 2020 16:41
170 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/02/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Feb 27, 2020 16:39
170 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/02/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Feb 27, 2020 14:36
3312 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/02/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Feb 27, 2020 16:27
3312 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/02/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Feb 27, 2020 14:22
Publication date: Available online 26 February 2020Source: Pathology - Research and PracticeAuthor(s): Yu Wang, Yingren Zhao, Xu Zhang, Aiyun Zhang, Juan Ma
Thu Feb 27, 2020 16:27
Publication date: Available online 26 February 2020Source: Pathology - Research and PracticeAuthor(s): Fang Deng, Yaguang Weng, Xian Li, Teng Wang, Mengtian Fan, Qiong Shi
Thu Feb 27, 2020 16:27
Publication date: Available online 26 February 2020Source: Pathology - Research and PracticeAuthor(s): Guangrong Dai, Yue Tan, Jingjing Liu, Beibei Yuan, Qinglian Song, Jiaming Liu, Shuixiang He
Thu Feb 27, 2020 16:27
Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression...
Thu Feb 27, 2020 16:24
Abstract Aim To report the activity of the Otorhinolaryngology Research Society (ORS) from its’ founding in 1978 until dissolution in 2017. Method Data was obtained, (Minutes of Council Meetings, and Correspondence) from the Societies web site (now closed and archived), and relevant documents and e‐mails that pervious secretaries and treasurers of ORS and The British Society of Academics in Otolaryngology (BSAO) had available. The secretarial documents of the ORS, the first 20 years had...
Thu Feb 27, 2020 16:23
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