A new study looks at the incidence of asthma among children and adults by evaluating age at onset and the role of childhood allergies.BMC Pulmonary Medicine (Source: Medscape Today Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Clinicians can help lead the way in COVID-19 preparedness by fighting pandemic denial in themselves and being frank with their patients, an expert in risk communication said.Medscape Medical News (Source: Medscape Allergy Headlines)
BOSTON (CBS) – As concerns about the spread of the novel coronavirus mount, many people are left wondering if there’s anything they can do. And no, the answer is not to get your hands on a face mask. Face masks are useful when worn by people who are already sick to prevent the spread of germs, but not very helpful for healthy people trying to avoid getting sick. So forget the face masks and focus on the basics. Read: Answers To Your Coronavirus Questions According to the U.S. Department of Homeland...
Parents of children with food allergies should acknowledge their kids'anxiety, as well as their own, a group of allergy experts advises.Reuters Health Information (Source: Medscape Allergy Headlines)
Two Chinese nurses on the frontlines of the coronavirus outbreak in the city of Wuhan made an unusual global appeal for help in a letter published by a prestigious British medical journal.Reuters Health Information (Source: Medscape Allergy Headlines)
Secretory immunoglobulin A (sIgA) represents the immune system’s first line of defense against mucosal pathogens. IgAs are transported across the epithelium, as dimers and higher-order polymers, by the polymeric immunoglobulin receptor (pIgR). Upon reaching the luminal side, sIgAs mediate host protection and pathogen neutralization. In recent years, an increasing amount of attention has been given to IgA as a novel therapeutic antibody. However, despite extensive studies, sIgA structures have remained...
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We report a cryo–electron microscopy structure of the Fc region of human IgM in complex with the J-chain and pIgR ectodomain. The IgM-Fc pentamer is formed asymmetrically, resembling a hexagon with a missing triangle. The tailpieces of IgM-Fc pack into an amyloid-like structure to stabilize the pentamer. The J-chain caps the tailpiece assembly and bridges the interaction between IgM-Fc and the polymeric immunoglobulin receptor, which undergoes a large conformational change to engage the IgM-J complex....
(Source: ScienceNOW)
We report a first-in-human phase 1 clinical trial to test the safety and feasibility of multiplex CRISPR-Cas9 editing to engineer T cells in three patients with refractory cancer. Two genes encoding the endogenous T cell receptor (TCR) chains, TCRα (TRAC) and TCRβ (TRBC), were deleted in T cells to reduce TCR mispairing and to enhance the expression of a synthetic, cancer-specific TCR transgene (NY-ESO-1). Removal of a third gene encoding programmed cell death protein 1 (PD-1; PDCD1), was performed...
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Animals, Vol. 10, Pages 390: Nutrient Intake, Excretion and Use Efficiency of Grazing Lactating Herds on Commercial Dairy Farms Animals doi: 10.3390/ani10030390 Authors: Aarons Gourley Powell Estimating excreted nutrients is important for farm nutrient management, but seldom occurs on commercial grazing system farms due to difficulties in quantifying pasture intake. Nitrogen (N), phosphorus (P), potassium (K), sulphur (S), calcium (Ca) and magnesium (Mg) intake, excretion and...
Marine Drugs, Vol. 18, Pages 142: Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria Marine Drugs doi: 10.3390/md18030142 Authors: Lever Brkljača Kraft Urban Marine macroalgae occurring in the south eastern region of Victoria, Australia, consistingof Port Phillip Bay and the heads entering the bay, is the focus of this review. This area is home toapproximately 200 different species of macroalgae,...
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“The American dream is not a sprint, or even a marathon, but a relay. Our families don’t always cross the finish line in the span of one generation. But each generation passes on to the next the fruits of their labor.” Julian Castro, Former 2020 Presidential Candidate and 16th United States Secretary of Housing and […]
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Abstract Background and Objectives To examine the effect of conditional survival on 5‐year cancer‐specific survival (CSS) probability after radical nephroureterectomy (RNU) in a contemporary cohort of patients with non‐metastatic urothelial carcinoma of the upper urinary tract (UTUC). Methods Within the Surveillance, Epidemiology and End Results database (2004‐2015), 6826 patients were identified. Conditional 5‐year CSS estimates were assessed after event‐free follow‐up duration. Multivariable...
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Hear from Dr Lucy Wynter as well as staff and students about their experiences with CBL at Sydney Medical School.
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Abstract Background As reported by the World Health Organization, a novel coronavirus (2019-nCoV) was identified as the causative virus of Wuhan pneumonia of unknown etiology by Chinese authorities on 7 January, 2020. The virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by International Committee on Taxonomy of Viruses on 11 February, 2020. This study aimed to develop a mathematical model for calculating...
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Kavitha Venkatnarayan, Uma Maheswari Krishnaswamy, Uma Devaraj, Priya RamachandranLung India 2020 37(2):167-168
Manoj Kumar Goel, Ajay Kumar, Gargi MaitraLung India 2020 37(2):183-185
Bharat Bhushan Sharma, Sheetu Singh, Krishna Kumar Sharma, KP Suraj, Tariq Mahmood, Kumar Utsav Samaria, Surya Kant, Nishtha Singh, Tejraj Singh, Aradhna Singh, Rajeev Gupta, Parvaiz A Koul, Sundeep Salvi, Virendra Singh, SWORD Study Group Lung India 2020 37(2):100-106 Background: Respiratory disorders are important contributors to disease burden across the world. The aim is to assess the proportionate burden of types of respiratory diseases and their seasonal patterns in India we are performing...
Meetakshi Gupta, Naveen Mummudi, Ritesh Mhatre, Jai Prakash AgarwalLung India 2020 37(2):177-179
Vikas Marwah, C D S Katoch, Kunal Kumar, Kamal Pathak, Saikat Bhattacharjee, Prashant JindamwarLung India 2020 37(2):107-113 Background: Bronchoscopic device closure plays a significant role in the nonsurgical management of bronchopleural fistulae (BPF). Herein, we describe our 10-year experience in the management of postoperative BPF using various device closure modalities. This is the largest series of bronchoscopic device closure of BPF being reported from India. Materials and Methods: This...
Nurhayat Yakut, Eda Kepenekli Kadayifci, Ela Erdem Eralp, Yasemin GokdemirLung India 2020 37(2):161-163 Allergic bronchopulmonary aspergillosis (ABPA) is recognized as a rare, progressive, allergic disorder in patients with cystic fibrosis (CF) and asthma. Treatment of ABPA mainly includes systemic corticosteroids (CSs) and antifungal agents. Here, we report posaconazole treatment in a 9-year-old male child with ABPA and also review the literature on antifungal management of ABPA. The child with...
Ajmal Khan, Zia Hashim, Mansi Gupta, Hira Lal, Aarti Agarwal, Alok NathLung India 2020 37(2):114-119 Background: Central airway obstruction (CAO) is a significant cause of morbidity and mortality in patients with thoracic malignancies. In this prospective study, we describe the role of rigid bronchoscopy (RB) in the multimodality management of CAO. Methods: Prospective description of different rigid bronchoscopic techniques used for CAO between July 2016 and July 2019. Results: A total of 152 procedures...
Joseph Thomas Kathayanatt, Shaji Palangadan, Ratish Radhakrishnan, Jayakumar ThanathLung India 2020 37(2):174-175
Gholamreza HeydariLung India 2020 37(2):120-125 Background: Perfect implementation of the six priority policies advocated by the MPOWER package is the most important challenge for member states (MS) to reach tobacco control goals. Methods: A validated checklist set according to the WHO Report on the Global Tobacco Epidemic was filled out five times based on biannual reports from 2011 to 2019 for 22 MS in the Eastern Mediterranean Region. It contained ten topics including smoking prevalence and...
Vivek Agarwal, Ujjwal GorsiLung India 2020 37(2):181-181
Soedarsono Soedarsono, Kana Wulung Arie Ichida Prinasetyo, Mayfanny Tanzilia, Jusak NugrahaLung India 2020 37(2):126-129 Background and Objectives: Tuberculosis (TB) continues to be a public health crisis with an estimated 10 million people developing TB disease in 2017. Adenosine deaminase (ADA) level in serum and pleural fluid as a biomarker may be used to diagnose pulmonary TB (PTB), but it is not always easy to obtain those samples at the end of treatment. This study was conducted to analyze...
Valliappan Muthu, Kuruswamy Thurai Prasad, Ritesh AgarwalLung India 2020 37(2):97-99
Amit Dhamija, Saurabh Goyal, Abhinav Guliani, Reena Raveendran, Arup Kumar BasuLung India 2020 37(2):130-133 Background: Drug resistance in tuberculosis (TB) is a major public health problem. It is easy to assess for drug resistance in pulmonary samples, but the resistance pattern of TB in the mediastinal nodes has not been studied. The aim of this study is to assess the incidence of multidrug resistance in tubercular mediastinal adenopathy with the help of endobronchial ultrasound (EBUS)-guided...
Shagun Jyotin Shah, Chandrahas T Deshmukh, Jane J E David, Moushmi M HosalkarLung India 2020 37(2):164-166 Hemoptysis is a rare but distressing complaint in children. Pulmonary venous atresia (PVA) is a rare cause of recurrent hemoptysis in children. We report a 3-year-old boy with recurrent hemoptysis for 2 years. The child had tachycardia, tachypnea, tender hepatomegaly, and left-sided decreased air entry with crepitations. Coagulation and Koch's workup was negative. X-ray of the chest showed...
Sandip Ganguly, Bivas Biswas, Sayanika Bhattacharjee, Joydeep Ghosh, Sumit Mukhopadhyay, Divya Midha, Deepak DabkaraLung India 2020 37(2):134-139 Background and Objectives: Small cell lung cancer (SCLC) constitutes 14%–20% of all lung cancers. Clinical data on SCLC are scarce in literature. To report clinical features and treatment outcome of SCLC treated at our center. Materials and Methods: This is a single institutional data review of SCLC patients treated between June 2011 and December 2018....
Sujeet Rajan, Nithya J Gogtay, Mahanjit Konwar, Urmila Mukund ThatteLung India 2020 37(2):169-173 The Global Initiative for Asthma (GINA) recently released their updated Global Strategy for Asthma Management and Prevention Guide (2019). The pocket guide for practicing clinicians states that “the 2019 GINA strategy report represents the most important change in asthma management in 30 years.” An important recommendation is the change in treatment strategy for the management of mild asthma where...
Rachid Marouf, Sara Zerrouki, Ihsan Alloubi, Brahim HousniLung India 2020 37(2):140-144 Background: The accidental aspiration of foreign bodies (FBs) is a rare occurrence in adults. However, inhalation of scarf pin is a phenomenon more and more common in the context of Muslim nations. The aim of our study was to describe the characteristics of this particular FB and illustrate the circumstances and consequences of inhalation. Methods: This retrospective study involved patients with a history of...
Valliappan Muthu, Sahajal Dhooria, Inderpaul Singh Sehgal, Kuruswamy Thurai Prasad, Ritesh AgarwalLung India 2020 37(2):176-177
Manish Kumar, Bhupesh Guleria, Shivashankar Swamy, Sneha SoniLung India 2020 37(2):145-150 Objectives: The aim of this study is to evaluate the incidence of programmed cell death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) cases and its correlation with gene mutation and clinicopathological parameters. Methods: Samples from NSCLCs patients were studied for PD-L1 expression through immunohistochemistry (IHC) using Rabbit anti-human PDL-1/CD274 Monoclonal Antibody. Genetic mutations...
Antony Terance Benjamin, Ram Ganesh, Jagdish Chinnappa, Ilin Kinimi, Jane LucasLung India 2020 37(2):179-180
Shruti Singh, Sara Z Khan, Dilbagh Singh, Sameer Verma, Arunabh TalwarLung India 2020 37(2):151-157 Overnight pulse oximetry (OPO) has proven to be an effective and beneficial technique to determine the cardiorespiratory status of patients in both the inpatient and outpatient settings. It is a cheap, safe, reliable, simple, and accurate method of patient monitoring as compared to the expensive and labor-intensive method of multichannel polysomnography for detecting sleep-disordered breathing. It...
Bijay Pattnaik, PB Sryma, Saurabh Mittal, Karan MadanLung India 2020 37(2):182-183
Justin Panthappattu, Vidhu Sharma, Sameer Verma, Arunabh TalwarLung India 2020 37(2):158-160 In clinical practice, the presence of wheezing generally indicates an airway disease. In rare circumstances, adjacent mediastinal structures may compress the tracheobronchial tree leading to obstructive physiology. Compression of the tracheobronchial region by an enlarged pulmonary artery (PA) is exceedingly rare. We present here a case of pulmonary hypertension, where the enlarged PA resulted in obstructive...
Bronchopleural fistula secondary to bronchoalveolar lavage-induced pneumothorax: A rare complication
Shalendra Singh, Shreyas Kate, Saurabh Sud, Deepak DwivediLung India 2020 37(2):185-186
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Manav I Bhalla, Kennedy M Wirtz, Eric S Fair, Daniel J BucklanWorld Journal of Nuclear Medicine 2020 19(1):78-81 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) has shown superiority over111Indium-octreotide scanning for the detection of phosphaturic mesenchymal tumors (PMTs). We report a case of tumor-induced osteomalacia resulting from PMT which, although initially clinically suspected, was not localized on octreotide scintigraphy performed several years prior. Subsequent...
Boon Mathew, Nilendu C Purandare, Ameya Puranik, Sneha Shah, Archi Agrawal, CS Pramesh, George Karimundackal, Sabita Jiwnani, Venkatesh RangarajanWorld Journal of Nuclear Medicine 2020 19(1):8-14 18F-fluorodeoxyglucose positron emission tomography-computed tomography-derived metabolic parameters can play a role in prognostication. We investigated the prognostic value of various metabolic parameters such as maximum standardized uptake value (SUVmax), mean SUV (SUVmean), whole-body metabolic tumor...
Courtney Lawhn-Heath, Robert R Flavell, Eunice Y Chuang, Chienying LiuWorld Journal of Nuclear Medicine 2020 19(1):61-64 Elevated thyroid stimulating hormone (TSH) is required when preparing for radioactive iodine therapy in patients with differentiated thyroid cancer. Recombinant human TSH (rhTSH: Thyrogen; Genzyme Corporation, Cambridge, MA) avoids hypothyroidism and has been commonly used in place of thyroid hormone withdrawal (THW) in this process. We describe a 31-year-old woman with sclerosing...
Majid Assadi, Samira Rezaei, Esmail Jafari, Seyed Javad Rekabpour, Mohammad Reza Ravanbod, Farshad Zohrabi, AbdulLatif Amini, Saeid Keshmiri, Habibollah Dadgar, Hojjat AhmadzadehfarWorld Journal of Nuclear Medicine 2020 19(1):15-20 In recent years, lutetium-177 (177Lu)-labeled prostate-specific membrane antigen (PSMA)-617 has become a promising new therapeutic agent in patients with metastatic castration-resistant prostate cancer (mCRPC). In this study, we report on an early experience of177Lu-PSMA...
Ismet Sarikaya, Prem N Sharma, Ali Sarikaya, Abdelhamid H ElgazzarWorld Journal of Nuclear Medicine 2020 19(1):1-7 Oral glucose and intravenous insulin (G/I) loading protocols are commonly used in18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) cardiac viability studies. Although the amount of insulin to be given per blood glucose range has been well described in guidelines, the amount of glucose to be given is not detailed well. In this retrospective study, we aimed to assess if...
Maimoona Siddique, Aamna Hassan, Muhammad Khalid Nawaz, Humayun Bashir, Muhammad Zulqarnain ChaudhryWorld Journal of Nuclear Medicine 2020 19(1):21-27 To compare the detection efficacy of radionuclide lymphoscintigraphy (LS) versus patent blue dye (PBD) technique for hidden sentinel lymph node (SLN) in breast cancer patients and to determine which modality is better for SLN detection. One hundred and thirty-four early stage breast cancer female patients with clinically negative axilla who underwent...
Sakditad Saowapa, Wichana Chamroonrat, Ronnarat Suvikapakornkul, Chutintorn SriphrapradangWorld Journal of Nuclear Medicine 2020 19(1):69-71 Nuclear scintigraphy is functional imaging and can be combined with anatomical imaging to improve diagnostic yield. Detection of parathyroid lesion by technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) can facilitate an appropriate operative approach in a patients with primary hyperparathyroidism. Tc-99m MIBI is concentrated in highly cellular or metabolically...
Muge Tamam, Ercan Uyanik, Nurcan Edís, Mehmet Mulazimoglu, Tevfik OzpacaciWorld Journal of Nuclear Medicine 2020 19(1):28-35 Differentiated thyroid cancer (DTC) is rare in children, but it still remains the most common endocrine malignancy in children. The aim of this study was to analyze treatment response to radioactive iodine (RAI) therapy, clinical outcomes, recurrences, survival analysis, and long-term follow-up. We retrospectively reviewed the medical records of 43 pediatric patients (≤17...
Robert Matthews, Michael Joseph Salerno, Paul Vaska, Halley HindmanWorld Journal of Nuclear Medicine 2020 19(1):85-88 Positron emission tomography-magnetic resonance (PET-MR) hybrid imaging is a relatively new imaging modality combining the superb MR contrast capabilities among different soft-tissue structures with the high sensitivity of PET functional imaging. With the development of any new technology, a variety of limitations will be encountered including the introduction of new types of artifacts....
K Kamakshi, Arvind Krishnamurthy, V Karthik, Preetha Vinodkumar, R Krishna Kumar, KM LakshmipathyWorld Journal of Nuclear Medicine 2020 19(1):36-40 With the increasing use of18F-fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET-CT) scans in oncology, the finding of thyroid incidentalomas, also popularly described as PET-associated incidental neoplasms (PAINs) of the thyroid gland is not unusual. The18F-FDG PET-CT scans of all patients who underwent imaging for indications...
Scott A Fleming, Andrew M KeenanWorld Journal of Nuclear Medicine 2020 19(1):59-60 Radiolabeled red blood cell (RBC) scintigraphy is a common study to detect and localize gastrointestinal hemorrhage. There are many potential entities that may result in false-positive RBC scintigraphy. Here, we present a case of enlarged feeding vessels of omental carcinomatosis which scintigraphically might be mistaken as intraluminal bowel activity and thus active hemorrhage. This case highlights the importance...
Saud A Alenezi, Shorouk F Dannoon, Naheel S Alnafisi, Saqr M Asa'ad, Medhat M Osman, Abdelhamid H ElgazzarWorld Journal of Nuclear Medicine 2020 19(1):41-46 The aim of this study is to investigate the relationship between brown adipose tissue (BAT) activation and myocardial fluorine-18-fluorodeoxyglucose ([18F] FDG) uptake in terms of intensity and patterns. The patients were divided into two groups as follows: BAT and control groups. The BAT group consists of 34 cases that showed BAT uptake. The...
Colin Raymond Young, Mallini Harigopal, Darko PucarWorld Journal of Nuclear Medicine 2020 19(1):65-68 Cancer in the dermis of the breast has a poor prognosis. The breast dermis can become malignantly involved primarily in inflammatory breast cancer, through the direct extension of locally advanced breast cancer, or metastatically from an underlying breast mass or a distant primary malignancy (e.g., gastric adenocarcinoma). Breast dermal metastases have the shortest median survival among them. Breast...
Nosheen Fatima, Maseeh Uz Zaman, Areeba Zaman, Unaiza Zaman, Sidra Zaman, Rabia TahseenWorld Journal of Nuclear Medicine 2020 19(1):47-51 Carcinoma of unknown primary (CUP) is defined as biopsy proven tumor metastases that remains unidentified after a thorough diagnostic evaluation. The purpose of this study was to find the detection efficiency of18F-flourodeoxyglucose positron emission tomography/computed tomography (18FDG PET/CT) in patients with CUP. This prospective study was conducted at PET/CT...
Tanyaluck Thientunyakit, Thonnapong Thongpraparn, Tossaporn Siriprapa, Juri G GelovaniWorld Journal of Nuclear Medicine 2020 19(1):72-77 We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [18F]-2'-fluoro-2'-deoxy-D-glucose ([18F]-FDG) and [18F]-fluorocholine ([18F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [18F]-FDG and [18F]-FCH...
Dharmalingam Anitha, Pawar U Shwetal, Shetye S Suruchi, Ghorpade K MangalaWorld Journal of Nuclear Medicine 2020 19(1):52-55 Complicated Meckel's diverticulum (MD) in pediatric age group may not present with classic symptoms or signs. The routine modalities of investigations for the detection of MD are ultrasonography (US), computerized tomography, and air enema. However, these may miss the diagnosis in cases of atypical patterns of presentation. In such situations, the radionuclide Meckel scan...
Shelvin Kumar Vadi, Anish Bhattacharya, Ashwani Sood, Bhagwant Rai MittalWorld Journal of Nuclear Medicine 2020 19(1):82-84 99mTc-ethylenedicysteine (99mTc-EC) diuretic renal scintigraphy is an established, safe, and noninvasive study to evaluate relative renal function and drainage. We present a known case of bilateral renal stone disease who presented with acute urinary obstruction detected intraprocedurally on99mTc-EC diuretic renography. He was managed subsequently with emergency double J stenting....
Abderrahim Doudouh, Salah Nabih Oueriagli, Omar Ait Sahel, Yassir BenameurWorld Journal of Nuclear Medicine 2020 19(1):56-58 Scalp metastasis from a primary visceral malignancy is an uncommon clinical entity. Here, we report a case of scalp metastases from lung cancer seen on fluorodeoxyglucose positron-emission tomography-computed tomography.
Alex Cheen Hoe Khoo, Yew Teik CheongWorld Journal of Nuclear Medicine 2020 19(1):89-91 Renal cell carcinomas (RCCs) commonly metastasize to the lungs and bones and rarely to the parathyroid, maxillary sinus, and adrenals. It is indeed very rare to have these all these metastases occurring simultaneously in an individual. We share a case of 67-year-old woman provisionally treated for parathyroid carcinoma but subsequently found to actually have metastatic RCC to the left maxillary sinus, parathyroid,...
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