Antibiotics, Vol. 9, Pages 92: A Rapid Fluorescence-Based Microplate Assay to Investigate the Interaction of Membrane Active Antimicrobial Peptides with Whole Gram-Positive BacteriaAntibiotics doi: 10.3390/antibiotics9020092Authors: Boix-Lemonche Lekka SkerlavajBackground: Membrane-active antimicrobial peptides (AMPs) are interesting candidates for the development of novel antimicrobials. Although their effects were extensively investigated in model membrane systems, interactions of AMPs with living...
Wed Feb 19, 2020 02:00
Antibiotics, Vol. 9, Pages 91: Marine Actinobacteria: Screening for Predation Leads to the Discovery of Potential New Drugs against Multidrug-Resistant BacteriaAntibiotics doi: 10.3390/antibiotics9020091Authors:Manar IbrahimiWassila KorichiMohamed HafidiLaurent LemeeYedir OuhdouchSouad LoqmanPredatory bacteria constitute a heterogeneous group of prokaryotes able to lyse and feed on the cellular constituents of other bacteria in conditions of nutrient scarcity. In this study, we describe the isolation...
Wed Feb 19, 2020 02:00
Antioxidants, Vol. 9, Pages 171: NADPH Oxidase 2 Mediates Myocardial Oxygen Wasting in Obesity Antioxidants doi: 10.3390/antiox9020171 Authors: Hafstad Hansen Lund Santos Boardman Shah Aasum Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO2) and impaired cardiac efficiency. Although the pathophysiology of this...
Wed Feb 19, 2020 02:00
Antioxidants, Vol. 9, Pages 170: Long-Term Adverse Effects of Oxidative Stress on Rat Epididymis and Spermatozoa Antioxidants doi: 10.3390/antiox9020170 Authors: Pei You Wu Eleonora Scarlata Cristian O’Flaherty Oxidative stress is a common culprit of several conditions associated with male fertility. High levels of reactive oxygen species (ROS) promote impairment of sperm quality mainly by decreasing motility and increasing the levels of DNA oxidation. Oxidative stress is a common...
Wed Feb 19, 2020 02:00
Atmosphere, Vol. 11, Pages 212: Evaluation of the Performance of Low-Cost Air Quality Sensors at a High Mountain Station with Complex Meteorological Conditions Atmosphere doi: 10.3390/atmos11020212 Authors: Li Zhu Zhao Chen Jiang Shan Liu Mu Yin Wu Zhang Si Wang Wang Xue Low-cost sensors have become an increasingly important supplement to air quality monitoring networks at the ground level, yet their performances have not been...
Wed Feb 19, 2020 02:00
Atmosphere, Vol. 11, Pages 211: Characterization of the Gaseous and Odour Emissions from the Composting of Conventional Sewage Sludge Atmosphere doi: 10.3390/atmos11020211 Authors: Daniel González Nagore Guerra Joan Colón David Gabriel Sergio Ponsá Antoni Sánchez Many different alternatives exist to manage and treat sewage sludge, all with the common drawback of causing environmental and odour impacts. The main objective of this work is to present a full inventory of the...
Wed Feb 19, 2020 02:00
Biology, Vol. 9, Pages 35: Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity Biology doi: 10.3390/biology9020035 Authors: Liu Krump Herlyn You Merkel cell carcinoma (MCC) is a highly lethal skin cancer. MCC tumors rapidly develop resistance to the chemotherapies tested to date. While PD-1/PD-L1 immune checkpoint blockade has demonstrated success in MCC treatment, a significant portion of MCC patients are nonresponsive. Therefore,...
Wed Feb 19, 2020 02:00
Biomedicines, Vol. 8, Pages 36: The Co-Expression of Programmed Death-Ligand 1 (PD-L1) in Untreated EGFR-Mutated Metastatic Lung Adenocarcinoma Biomedicines doi: 10.3390/biomedicines8020036 Authors: Ping-Chih Hsu Chih-Wei Wang Scott Chih-Hsi Kuo Shu-Min Lin Yu-Lun Lo Allen Chung-Cheng Huang Li-Chung Chiu Cheng-Ta Yang Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) is the standard first-line therapy for metastatic lung adenocarcinoma harboring...
Wed Feb 19, 2020 02:00
Biomedicines, Vol. 8, Pages 37: Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7 Biomedicines doi: 10.3390/biomedicines8020037 Authors: Yin Deuis Dekan Jin Alewood King Herzig Vetter Spider venom is a novel source of disulfide-rich peptides with potent and selective activity at voltage-gated sodium channels (NaV). Here, we describe the discovery of μ-theraphotoxin-Pme1a and μ/δ-theraphotoxin-Pme2a,...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 338: Acorus gramineusand and Euodia ruticarpa Steam Distilled Essential Oils Exert Anti-Inflammatory Effects Through Decreasing Th1/Th2 and Pro-/Anti-Inflammatory Cytokine Secretion Ratios In Vitro Biomolecules doi: 10.3390/biom10020338 Authors: Tzu-He Yeh Jin-Yuarn Lin To clarify the effects of steam distilled essential oils (SDEO) from herbs used in traditional Chinese medicine on immune functions, two potential herbs, Acorus gramineusand (AG) and Euodia...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 336: Cinnamomum verum Bark Extract Mediated Green Synthesis of ZnO Nanoparticles and Their Antibacterial Potentiality Biomolecules doi: 10.3390/biom10020336 Authors: Ansari Murali Prasad Alzohairy Almatroudi Alomary Udayashankar Singh Asiri Ashwini Gowtham Kalegowda Amruthesh Lakshmeesha Niranjana Cinnamomum verum plant extract mediated propellant chemistry route was used for the green synthesis of...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 335: The Challenge of Disease-Modifying Therapies in Parkinson’s Disease: Role of CSF Biomarkers Biomolecules doi: 10.3390/biom10020335 Authors: Paolini Paoletti Gaetani Parnetti The development of disease modifying strategies in Parkinson’s disease (PD) largely depends on the ability to identify suitable populations after accurate diagnostic work-up. Therefore, patient molecular profiling and disease subtyping are mandatory. Thus far,...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 337: Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment Biomolecules doi: 10.3390/biom10020337 Authors: Zarrer Haider Smit Taipaleenmäki Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 332: Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis Biomolecules doi: 10.3390/biom10020332 Authors: Zieba Chen Lee Bae Skeletal development is a complex process which requires the tight regulation of gene activation and suppression in response to local signaling pathways. Among these pathways, Notch signaling is implicated in governing cell fate determination, proliferation, differentiation and apoptosis of skeletal cells-osteoblasts,...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 333: Characterization of a Novel Mannose-Binding Lectin with Antiviral Activities from Red Alga, Grateloupia chiangii Biomolecules doi: 10.3390/biom10020333 Authors: Hwang Han Jeon Cho Kim Lee Han Lectins have the ability to bind specific carbohydrates and they have potential applications as medical and pharmacological agents. The unique structure and usefulness of red algal lectin have been reported, but these lectins are limited...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 331: Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity Biomolecules doi: 10.3390/biom10020331 Authors: Gerard Kian-Meng Goh A. Keith Dunker James A. Foster Vladimir N. Uversky The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 334: Anti-Infectives Restore ORKAMBI® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa Biomolecules doi: 10.3390/biom10020334 Authors: Onofrio Laselva Tracy A. Stone Christine E. Bear Charles M. Deber Chronic infection and inflammation are the primary causes of declining lung function in Cystic Fibrosis (CF) patients. ORKAMBI® (Lumacaftor-Ivacaftor) is an approved combination...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 328: Seasonal and Antioxidant Evaluation of Essential Oil from Eugenia uniflora L., Curzerene-Rich, Thermally Produced in Situ Biomolecules doi: 10.3390/biom10020328 Authors: Jamile S. da Costa Adenilson S. Barroso Rosa Helena V. Mourão Joyce Kelly R. da Silva José Guilherme S. Maia Pablo Luis B. Figueiredo The essential oil of Eugenia uniflora has been attributed anti-depressive, antinociceptive, antileishmanial, larvicidal, antioxidant, antibacterial,...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 329: Effects of Cannabis Use on the Protein and Lipid Profile of Olfactory Neuroepithelium Cells from Schizophrenia Patients Studied by Synchrotron-Based FTIR Spectroscopy Biomolecules doi: 10.3390/biom10020329 Authors: Sergi Saladrigas-Manjón Tanja Dučić Liliana Galindo Cristina Fernández-Avilés Víctor Pérez Rafael de la Torre Patricia Robledo Schizophrenia (SCZ) is a neurodevelopmental disorder with a high genetic component, but the presence...
Wed Feb 19, 2020 02:00
Biomolecules, Vol. 10, Pages 330: NAD+ Metabolism and Regulation: Lessons from Yeast Biomolecules doi: 10.3390/biom10020330 Authors: Croft Venkatakrishnan Lin Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite involved in various cellular processes. The cellular NAD+ pool is maintained by three biosynthesis pathways, which are largely conserved from bacteria to human. NAD+ metabolism is an emerging therapeutic target for several human disorders including diabetes,...
Wed Feb 19, 2020 02:00
Biosensors, Vol. 10, Pages 14: Attack Graph Modeling for Implantable Pacemaker Biosensors doi: 10.3390/bios10020014 Authors: Mariam Ibrahim Ahmad Alsheikh Aseel Matar Remote health monitoring systems are used to audit implantable medical devices or patients’ health in a non-clinical setting. These systems are prone to cyberattacks exploiting their critical vulnerabilities. Thus, threatening patients’ health and confidentiality. In this paper, a pacemaker automatic remote monitoring...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 490: Stiffer Matrix Accelerates Migration of Hepatocellular Carcinoma Cells through Enhanced Aerobic Glycolysis Via the MAPK-YAP Signaling Cancers doi: 10.3390/cancers12020490 Authors: Liu Luo Deng Ju Song Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells are two fundamental mediators of tumor progression, including hepatocellular carcinoma (HCC). Yet, the correlation between ECM stiffness and excessive...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 489: Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation Cancers doi: 10.3390/cancers12020489 Authors: Huang Chen Chen Wu Lin Syk is a non-receptor tyrosine kinase involved in the signalling of immunoreceptors and growth factor receptors. Previously, we reported that Syk mediates epidermal growth factor receptor (EGFR) signalling and plays a negative role...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 488: Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells Cancers doi: 10.3390/cancers12020488 Authors: Grazia Carbotti Andrea Petretto Elisabeth Naschberger Michael Stürzl Stefania Martini Maria Cristina Mingari Gilberto Filaci Silvano Ferrini Marina Fabbi We showed that IL-27 shares several effects with IFN-γ in human cancer cells. To identify novel extracellular mediators, potentially...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 480: P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer Cancers doi: 10.3390/cancers12020480 Authors: Baker Abba Garcia-Mata Kazanietz The GTPase Rac1 is a well-established master regulator of cell motility and invasiveness contributing to cancer metastasis. Dysregulation of the Rac1 signaling pathway, resulting in elevated motile and invasive potential, has been reported in multiple cancers. However, there are limited studies...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 484: Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues Cancers doi: 10.3390/cancers12020484 Authors: Ismail Fiehn Elfert Helal Salama El-Said The major risk factors for hepatocellular carcinoma (HCC) are hepatitis C and B viral infections that proceed to Chronic Liver Disease (CLD). Yet, the early diagnosis and treatment of HCC are challenging because the pathogenesis...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 482: Current Advances in the Treatment of BRAF-Mutant Melanoma Cancers doi: 10.3390/cancers12020482 Authors: Hima Yacoub Mishra White Long Alanazi Garrett Melanoma is the most lethal form of skin cancer. Melanoma is usually curable with surgery if detected early, however, treatment options for patients with metastatic melanoma are limited and the five-year survival rate for metastatic melanoma had been 15–20% before the...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 483: Nerve Sparing Radical Hysterectomy: Short-Term Oncologic, Surgical, and Functional Outcomes Cancers doi: 10.3390/cancers12020483 Authors: Muallem Armbrust Neymeyer Miranda Muallem There is an obvious prevalence of disparity in opinions concerning the technique of nerve-sparing radical hysterectomy and its application, despite agreement on the need to spare the pelvic autonomic nerve system during such a radical operation. Understanding the...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 481: Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma: A Review of the Current Status of Literature Cancers doi: 10.3390/cancers12020481 Authors: Hull Li Bartholomeusz Hsieh Allen Bezak Pancreatic ductal adenocarcinoma (PDAC) has long been associated with lowαα survival rates. A lack of accurate diagnostic tests and limited treatment options contribute to the poor prognosis of PDAC. Radioimmunotherapy using α-...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 485: Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis Cancers doi: 10.3390/cancers12020485 Authors: Kobayashi Katayama Irajizad Vykoukal Fahrmann Kundnani Yu Cai Hsiao Yang Lu Celestino Long Do Lu Ladd Urban Bast Jr Hanash Harnessing the immune response to tumor antigens in the form of autoantibodies, which occurs early during tumor development,...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 487: Circulating Tumor Cells and Metabolic Parameters in NSCLC Patients Treated with Checkpoint Inhibitors Cancers doi: 10.3390/cancers12020487 Authors: Angelo Castello Francesco Giuseppe Carbone Sabrina Rossi Simona Monterisi Davide Federico Luca Toschi Egesta Lopci Circulating tumor cells (CTC) count and characterization have been associated with poor prognosis in recent studies. Our aim was to examine CTC count and its association with metabolic...
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 479: ARH1 in Health and Disease Cancers doi: 10.3390/cancers12020479 Authors: Hiroko Ishiwata-Endo Jiro Kato Linda A. Stevens Joel Moss Arginine-specific mono-adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD)+-dependent, reversible post-translational modification involving the transfer of an ADP-ribose from NAD+ by bacterial toxins and eukaryotic ADP-ribosyltransferases (ARTs) to arginine on an acceptor protein or peptide....
Wed Feb 19, 2020 02:00
Cancers, Vol. 12, Pages 486: Imaging of Monoclonal Gammapathy of Undetermined Significance and Smoldering Multiple Myeloma Cancers doi: 10.3390/cancers12020486 Authors: Bastien Jamet Clément Bailly Thomas Carlier Cyrille Touzeau Anne-Victoire Michaud Mickael Bourgeois Philippe Moreau Caroline Bodet-Milin Françoise Kraeber-Bodere Multiple myeloma (MM) is always preceded by an initial monoclonal gammopathy of undetermined significance (MGUS) that then develops into...
Wed Feb 19, 2020 02:00
Cells, Vol. 9, Pages 483: Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway Cells doi: 10.3390/cells9020483 Authors: Haake Neehus Buchegger Kühnel Blank Philipp Oleaga-Quintas Schulz Grimley Goethe Jonigk Kalinke Boisson-Dupuis Casanova Bustamante Lachmann Interferon γ (IFN-γ) was shown to be a macrophage activating factor already in 1984. Consistently, inborn errors...
Wed Feb 19, 2020 02:00
Cells, Vol. 9, Pages 475: The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review Cells doi: 10.3390/cells9020475 Authors: Yuki Ishikawa Chikashi Terao Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent proliferation of synovial tissues, which eventually leads to cartilage and bone destruction without effective treatments. Anti-citrullinated cyclic peptide/protein antibody (ACPA) and rheumatoid factor...
Wed Feb 19, 2020 02:00
Cells, Vol. 9, Pages 481: The VDAC1-based R-Tf-D-LP4 Peptide as a Potential Treatment for Diabetes Mellitus Cells doi: 10.3390/cells9020481 Authors: Pittala Levy De Kumar Pandey Melnikov Hyman Shoshan-Barmatz Diabetes mellitus is a metabolic disorder approaching epidemic proportions. Non-alcoholic fatty liver disease (NAFLD) regularly coexists with metabolic disorders, including type 2 diabetes, obesity, and cardiovascular disease. Recently, we demonstrated that...
Wed Feb 19, 2020 02:00
Cells, Vol. 9, Pages 478: Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging Cells doi: 10.3390/cells9020478 Authors: Serreli Deiana The olive-oil-centered Mediterranean diet has been associated with extended life expectancy and a reduction in the risk of age-related degenerative diseases. Extra virgin olive oil (EVOO) itself has been proposed to promote a “successful aging”, being able to...
Wed Feb 19, 2020 02:00
Cells, Vol. 9, Pages 480: Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy Cells doi: 10.3390/cells9020480 Authors: Plava Cihova Burikova Bohac Adamkov Drahosova Rusnakova Pindak Karaba Simo Mego Danisovic Kucerova Miklikova During cancer progression, breast tumor cells interact with adjacent adipose tissue, which has been shown to be engaged in cancer aggressiveness....
Wed Feb 19, 2020 02:00
Cells, Vol. 9, Pages 479: The Role of miR-21 in Osteoblasts–Osteoclasts Coupling In Vitro Cells doi: 10.3390/cells9020479 Authors: Smieszek Marcinkowska Pielok Sikora Valihrach Marycz MiR-21 is being gradually more and more recognized as a molecule regulating bone tissue homeostasis. However, its function is not fully understood due to the dual role of miR-21 on bone-forming and bone-resorbing cells. In this study, we investigated the impact of miR-21 inhibition...
Wed Feb 19, 2020 02:00
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