IJMS, Vol. 21, Pages 1219: Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21041219 Authors: Choi Doss Kim Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and low-molecular weight isoforms. Numerous studies have demonstrated its insulin-sensitizing, anti-atherogenic,...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1223: Oxathiapiprolin, a Novel Chemical Inducer Activates the Plant Disease Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21041223 Authors: Peng Wang Liu Liang Zhao Li Liu Xia Oxathiapiprolin was developed as a specific plant pathogenic oomycete inhibitor, previously shown to have highly curative and protective activities against the pepper Phytophthora blight disease under field and greenhouse tests. Therefore,...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1217: Shockwave Therapy Combined with Autologous Adipose-Derived Mesenchymal Stem Cells Is Better than with Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells on Knee Osteoarthritis International Journal of Molecular Sciences doi: 10.3390/ijms21041217 Authors: Chieh-Cheng Hsu Jai-Hong Cheng Ching-Jen Wang Jih-Yang Ko Shan-Ling Hsu Tsai-Chin Hsu Extracorporeal shockwave therapy (ESWT) and mesenchymal stem cells (MSCs) have been reported...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1224: Differential Signaling Profiles of MC4R Mutations with Three Different Ligands International Journal of Molecular Sciences doi: 10.3390/ijms21041224 Authors: Sarah Paisdzior Ioanna Maria Dimitriou Paul Curtis Schöpe Paolo Annibale Patrick Scheerer Heiko Krude Martin J. Lohse Heike Biebermann Peter Kühnen The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin–melanocortin...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1218: Disruption of Bone Zinc Metabolism during Postnatal Development of Rats after Early Life Exposure to Cadmium International Journal of Molecular Sciences doi: 10.3390/ijms21041218 Authors: Boughammoura Ben Mimouna Chemek Ostertag Cohen-Solal Messaoudi This current study was conducted to investigate whether bone tissue impairment induced by early life exposure to cadmium (Cd) during postnatal development could result from disruption to zinc...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1221: Challenges in the Diagnosis and Management of Bacterial Lung Infections in Solid Organ Recipients: A Narrative Review International Journal of Molecular Sciences doi: 10.3390/ijms21041221 Authors: Carugati Morlacchi Peri Alagna Rossetti Bandera Gori Blasi Working Group Respiratory infections pose a significant threat to the success of solid organ transplantation, and the diagnosis and management of these infections are challenging....
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1220: Dynamic Changes in pStat3 are Involved in Meiotic Spindle Assembly in Mouse Oocytes International Journal of Molecular Sciences doi: 10.3390/ijms21041220 Authors: Haraguchi Ikeda Akagi Hirao The signal transducer and activator of transcription 3 (Stat3) is activated upon phosphorylation at Y705 (pStat3) and serves the dual function of signal transduction and transcription activation. Our previous study suggested that pStat3 is functional during...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1214: Mathematical Model of ATM Activation and Chromatin Relaxation by Ionizing Radiation International Journal of Molecular Sciences doi: 10.3390/ijms21041214 Authors: Li Cucinotta We propose a comprehensive mathematical model to study the dynamics of ionizing radiation induced Ataxia-telangiectasia mutated (ATM) activation that consists of ATM activation through dual mechanisms: the initiative activation pathway triggered by the DNA damage-induced local chromatin...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1215: PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation International Journal of Molecular Sciences doi: 10.3390/ijms21041215 Authors: Irrera Bitto Vaccaro Mannino Squadrito Pallio Arcoraci Minutoli Ieni Lentini Altavilla Squadrito Nuclear factor-κB (NF-κB) plays a central role in psoriasis and canonical...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1216: Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21041216 Authors: Begum Reddy Yakoub Belli Davies Di Pietro Sport-related traumatic brain injury (TBI) elicits a multifaceted inflammatory response leading to brain injury and morbidity. This response could be a predictive tool for the progression of TBI and to stratify...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1213: Syntaxin 1: A Novel Robust Immunophenotypic Marker of Neuroendocrine Tumors International Journal of Molecular Sciences doi: 10.3390/ijms21041213 Authors: Kővári Turkevi-Nagy Báthori Fekete Krenács Considering the specific clinical management of neuroendocrine (NE) neoplasms (NENs), immunohistochemistry (IHC) is required to confirm their diagnosis. Nowadays, synaptophysin (SYP), chromogranin A (CHGA), and CD56 are the most frequently used NE...
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1212: Amino Acids Transport and Metabolism 2.0 International Journal of Molecular Sciences doi: 10.3390/ijms21041212 Authors: Scalise Indiveri This editorial aims to summarize the 19 scientific papers that contributed to this Special Issue.
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1211: Molecular Approach to Cutaneous Squamous Cell Carcinoma: From Pathways to Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21041211 Authors: Palazzo Morasso Pincelli Cutaneous squamous cell carcinoma (cSCC) represents the second most frequent skin cancer,recently showing a rapid increase in incidence worldwide, with around >1 million cases/year in theUnited States and 2500 deaths [1] [...]
Wed Feb 12, 2020 02:00
IJMS, Vol. 21, Pages 1209: Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21041209 Authors: Czabanka Petrilli Elvers-Hornung Bieback Albert Imhof Vajkoczy Vinci : The homing of Endothelial Progenitor Cells (EPCs) to tumor angiogenic sites has been described as a multistep process, involving adhesion,...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1208: Molecular Mechanisms Involved in the Impairment of Boar Sperm Motility by Peroxynitrite-Induced Nitrosative Stress International Journal of Molecular Sciences doi: 10.3390/ijms21041208 Authors: Serrano Garrido Céspedes González-Fernández García-Marín Bragado Excessive levels of reactive nitrogen species (RNS) produce nitrosative stress. Among RNS is peroxynitrite, a highly reactive free radical generated when nitric oxide reacts with superoxide...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1210: Calmodulin and Calmodulin Binding Proteins in Dictyostelium: A Primer International Journal of Molecular Sciences doi: 10.3390/ijms21041210 Authors: O’Day Taylor Myre Dictyostelium discoideum is gaining increasing attention as a model organism for the study of calcium binding and calmodulin function in basic biological events as well as human diseases. After a short overview of calcium-binding proteins, the structure of Dictyostelium calmodulin and...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1206: In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21041206 Authors: Siculella Giannotti Testini Gnoni Damiano Non-alcoholic fatty liver disease (NAFLD) is a chronic disease in which excessive amount of lipids is accumulated as droplets in hepatocytes. Recently, cumulative...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1205: The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel International Journal of Molecular Sciences doi: 10.3390/ijms21041205 Authors: Langan Recke Bokor-Billmann Billmann Kahle Zillikens The development of next generation sequencing, coupled with advances in bio-informatics, has provided new insights into the role of the cutaneous microbiome in the pathophysiology of a range of inflammatory...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1203: Early Programming of Adult Systemic Essential Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms21041203 Authors: Verónica Guarner-Lans Abril Ramírez-Higuera María Esther Rubio-Ruiz Vicente Castrejón-Téllez María Elena Soto Israel Pérez-Torres Cardiovascular diseases are being included in the study of developmental origins of health and disease (DOHaD) and essential systemic hypertension has also been added to this field....
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1204: Underestimated Aspect of Mucopolysaccharidosis Pathogenesis: Global Changes in Cellular Processes Revealed by Transcriptomic Studies International Journal of Molecular Sciences doi: 10.3390/ijms21041204 Authors: Gaffke Pierzynowska Podlacha Hoinkis Rintz Brokowska Cyske Wegrzyn Mucopolysaccharidoses (MPS), a group of inherited metabolic disorders caused by deficiency in enzymes involved in degradation of glycosaminoglycans (GAGs),...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1202: Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson’s Disease and Its Substrate-Involved Mouse Experimental Models International Journal of Molecular Sciences doi: 10.3390/ijms21041202 Authors: Torii Kasai Yoshida Yasumoto Shimizu Parkinson’s disease (PD) is a common neurodegenerative disorder. Recent identification of genes linked to familial forms of PD has revealed that post-translational...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1207: Conversion of Glycosylated Platycoside E to Deapiose-Xylosylated Platycodin D by Cytolase PCL5 International Journal of Molecular Sciences doi: 10.3390/ijms21041207 Authors: Shin Kim Woo Oh Kim Platycosides, the saponins abundant in Platycodi radix (the root of Platycodon grandiflorum), have diverse pharmacological activities and have been used as food supplements. Since deglycosylated saponins exhibit higher biological activity than glycosylated...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1186: T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21041186 Authors: Banfi Diani Pigatto Reali Fibromyalgia is one of the most important “rheumatic” disorders, after osteoarthritis. The etiology of the disease is still not clear. At the moment, the most defined pathological mechanism is the alteration of central pain pathways, and...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1201: Protective Effect of L-Hexaguluroic Acid Hexasodium Salt on UVA-Induced Photo-Aging in HaCaT Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041201 Authors: Li Bai Qin Shao Liu Zhang Yan Yu Hao This study aimed to show the α-L-Hexaguluroic acid hexasodium salt (G6) protective effect against UVA-induced photoaging of human keratinocyte cells. We found that G6 localized to the mitochondria and improved...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1199: Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21041199 Authors: Sridharan Basu The mechanistic target of rapamycin (mTOR) is a master regulator of protein translation, metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 is frequently deregulated in many cancers, including breast cancer, and is an important target for...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1197: Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21041197 Authors: Yap Pruthi Seers Belobrov McCullough Celentano Extracellular vesicles (EVs) are secreted from most cell types and utilized in a complex network of near and distant cell-to-cell communication. Insight into this complex nanoscopic interaction in...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1198: Overexpression of a Malus baccata NAC Transcription Factor Gene MbNAC25 Increases Cold and Salinity Tolerance in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21041198 Authors: Han Du Zhou Wang Li Han Xu Yang NAC (no apical meristem (NAM), Arabidopsis thaliana transcription activation factor (ATAF1/2) and cup shaped cotyledon (CUC2)) transcription factors play crucial roles in plant development and stress...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1196: Assessment of Nuclear and Mitochondrial DNA, Expression of Mitochondria-Related Genes in Different Brain Regions in Rats after Whole-Body X-ray Irradiation International Journal of Molecular Sciences doi: 10.3390/ijms21041196 Authors: Serazhutdin Abdullaev Nina Gubina Tatiana Bulanova Azhub Gaziev Studies of molecular changes occurred in various brain regions after whole-body irradiation showed a significant increase in terms of the importance in gaining...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1195: Metabolomics to Improve the Diagnostic Efficiency of Inborn Errors of Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms21041195 Authors: Mordaunt Cox Fuller Early diagnosis of inborn errors of metabolism (IEM)—a large group of congenital disorders—is critical, given that many respond well to targeted therapy. Newborn screening programs successfully capture a proportion of patients enabling early recognition...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1200: Comparative Proteomics Profiling Illuminates the Fruitlet Abscission Mechanism of Sweet Cherry as Induced by Embryo Abortion International Journal of Molecular Sciences doi: 10.3390/ijms21041200 Authors: Qiu Wen Yang Tian Qiao Hong Wen Sweet cherry (Prunus avium L.) is a delicious nutrient-rich fruit widely cultivated in countries such as China, America, Chile, and Italy. However, the yield often drops severely due to the frequently-abnormal...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1194: Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities International Journal of Molecular Sciences doi: 10.3390/ijms21041194 Authors: Lee Epidermal barrier integrity could be influenced by various factors involved in epidermal cell differentiation and proliferation, cell–cell adhesion, and skin lipids. Dysfunction of this barrier can cause skin disorders, including eczema. Inversely, eczema can also damage the epidermal barrier....
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1192: Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology International Journal of Molecular Sciences doi: 10.3390/ijms21041192 Authors: Ameri Schiattarella Crotti Torchio Bertero Rodolico Forte Di Mauro Paolillo Chimenti Torella Catalucci Sciarretta Basso Indolfi Perrino Despite...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1191: The Role of Brassinosteroids in Controlling Plant Height in Poaceae: A Genetic Perspective International Journal of Molecular Sciences doi: 10.3390/ijms21041191 Authors: Castorina Consonni The most consistent phenotype of the brassinosteroid (BR)-related mutants is the dwarf habit. This observation has been reported in every species in which BR action has been studied through a mutational approach. On this basis, a significant role has been attributed...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1193: MiRNAs and LncRNAs: Dual Roles in TGF-β Signaling-Regulated Metastasis in Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21041193 Authors: Lai Li Tang Chen Zhang Xiong Lung cancer is one of the most malignant cancers around the world, with high morbidity and mortality. Metastasis is the leading cause of lung cancer deaths and treatment failure. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs), two groups of...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1190: Accurate Diels-Alder Energies and Endo Selectivity in Ionic Liquids Using the OPLS-VSIL Force Field International Journal of Molecular Sciences doi: 10.3390/ijms21041190 Authors: Velez Doherty Acevedo Our recently developed optimized potentials for liquid simulations-virtual site ionic liquid (OPLS-VSIL) force field has been shown to provide accurate bulk phase properties and local ion-ion interactions for a wide variety of imidazolium-based ionic...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1188: Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models International Journal of Molecular Sciences doi: 10.3390/ijms21041188 Authors: Tomita Fu Wang Cakir Cho Britton Sun Hellström Talukdar Smith The aim of the current study was to investigate the impact of long-acting fibroblast growth factor 21 (FGF21) on retinal vascular leakage utilizing machine learning and to clarify the mechanism underlying...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1189: Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3 International Journal of Molecular Sciences doi: 10.3390/ijms21041189 Authors: Zhu Yao Duan Xu Cheng Gao Li Yang Liu Yuan Silicosis is a chronic occupational lung disease caused by long-term inhalation ofcrystalline silica particulates. We created a rat...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1187: Urinary NMR Profiling in Pediatric Acute Kidney Injury—A Pilot Study International Journal of Molecular Sciences doi: 10.3390/ijms21041187 Authors: Muhle-Goll Eisenmann Luy Kölker Tönshoff Fichtner Westhoff Acute kidney injury (AKI) in critically ill children and adults is associated with significant short- and long-term morbidity and mortality. As serum creatinine- and urine output-based definitions of AKI have relevant limitations,...
Tue Feb 11, 2020 02:00
IJMS, Vol. 21, Pages 1183: The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host International Journal of Molecular Sciences doi: 10.3390/ijms21041183 Authors: Lodge Cowburn Li Condliffe Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the release of neutrophil extracellular...
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