Biology, Vol. 9, Pages 29: Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan Biology doi: 10.3390/biology9020029 Authors: Hering Beller Calulot Snow The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord...
Wed Feb 12, 2020 02:00
Biomedicines, Vol. 8, Pages 31: The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol Biomedicines doi: 10.3390/biomedicines8020031 Authors: Guinobert Blondeau Colicchio Oudrhiri Dieterlen Jeandidier Deschenes Bardot Cotte Ripoche Carde Berthomier M’Kacher A link between telomere shortening and oxidative stress was found in aging people and patients...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 290: Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease Biomolecules doi: 10.3390/biom10020290 Authors: Llorens Villar-Piqué Hermann Schmitz Calero Stehmann Sarros Moda Ferrer Poleggi Pocchiari Catania Klotz O’Regan Brett Heffernan Ladogana Collins Calero Kovacs Zerr Human prion diseases are classified into sporadic, genetic, and acquired...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 284: Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists Biomolecules doi: 10.3390/biom10020284 Authors: Szűcs Stefanucci Dimmito Zádor Pieretti Zengin Vécsei Benyhe Nalli Mollica Kynurenine (kyn) and kynurenic acid (kyna) are well-defined metabolites of tryptophan catabolism collectively known as “kynurenines”, which exert regulatory functions in host-microbiome signaling,...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 287: Investigation of α-Glucosidase Inhibitory Metabolites from Tetracera scandens Leaves by GC–MS Metabolite Profiling and Docking Studies Biomolecules doi: 10.3390/biom10020287 Authors: Nokhala Siddiqui Ahmed Ahamad Bustamam Zakaria Stone leaf (Tetracera scandens) is a Southeast Asian medicinal plant that has been traditionally used for the management of diabetes mellitus. The underlying mechanisms of the antidiabetic activity have not...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 288: Exploration and Characterization of Novel Glycoside Hydrolases from the Whole Genome of Lactobacillus ginsenosidimutans and Enriched Production of Minor Ginsenoside Rg3(S) by a Recombinant Enzymatic Process Biomolecules doi: 10.3390/biom10020288 Authors: Siddiqi Srinivasan Park Im Background: Several studies have reported that ginsenoside Rg3(S) is effective in treating metastatic diseases, obesity, and various cancers, however, its presence...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 281: Auxin-Abscisic Acid Interactions in Plant Growth and Development Biomolecules doi: 10.3390/biom10020281 Authors: Emenecker Strader Plant hormones regulate many aspects of plant growth, development, and response to biotic and abiotic stress. Much research has gone into our understanding of individual plant hormones, focusing primarily on their mechanisms of action and the processes that they regulate. However, recent research has begun to focus on...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 285: Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth Biomolecules doi: 10.3390/biom10020285 Authors: Ehexige Bao Bazarjav Yu Xiao Han Baigude Cutaneous melanoma is the most aggressive skin cancer with notorious drug resistance. Inhibition of immune checkpoint molecules is one of the most promising approaches for cancer therapy. Herein, we show that RNAi...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 286: N-Acetylaspartate Is an Important Brain Osmolyte Biomolecules doi: 10.3390/biom10020286 Authors: Warepam Ahmad Rahman Rahaman Kumari Singh Most of the human diseases related to various proteopathies are confined to the brain, which leads to the development of various forms of neurological disorders. The human brain consists of several osmolytic compounds, such as N-Acetylaspartate (NAA), myo-inositol (mI), glutamate (Glu), glutamine...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 282: Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines Biomolecules doi: 10.3390/biom10020282 Authors: De Bels Tillmans Corazza Bizzari Germonpre Radermacher Orman Balestra Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension....
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 283: Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System Biomolecules doi: 10.3390/biom10020283 Authors: Akimov Kudryavtsev Kryukova Fomina-Ageeva Zakharov Gretskaya Zinchenko Serkov Makhaeva Boltneva Kovaleva Serebryakova Lushchekina Palikov Palikova Dyachenko Kasheverov Tsetlin Bezuglov Cholines acylated...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 289: Endoglin: Beyond the Endothelium Biomolecules doi: 10.3390/biom10020289 Authors: Schoonderwoerd Goumans Hawinkels Keywords: endoglin; CD105 TGF-β; BMP9; ALK-1; TRC105; tumor microenvironment
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 280: Methanol Extract of Dicranopteris linearis Leaves Attenuate Pain via the Modulation of Opioid/NO-Mediated Pathway Biomolecules doi: 10.3390/biom10020280 Authors: Zainul Amiruddin Zakaria Rushduddin Al Jufri Roosli Najihah Hanisah Marmaya Maizatul Hasyima Omar Rusliza Basir Muhammad Nazrul Somchit Dicranopteris linearis leaf has been reported to exert antinociceptive activity. The present study elucidates the possible mechanisms of antinociception...
Wed Feb 12, 2020 02:00
Biomolecules, Vol. 10, Pages 279: Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders Biomolecules doi: 10.3390/biom10020279 Authors: Fernández-Trapero Pérez-Díaz Espejo-Porras de Lago Fernández-Ruiz The phytocannabinoid-based medicine Sativex® is currently marketed for the treatment of spasticity and pain in multiple sclerosis patients and is being investigated for other central and peripheral pathological...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 276: Indoleacetic Acid Levels in Wheat and Rice Seedlings under Oxygen Deficiency and Subsequent Reoxygenation Biomolecules doi: 10.3390/biom10020276 Authors: Yemelyanov Lastochkin Chirkova Lindberg Shishova The lack of oxygen and post-anoxic reactions cause significant alterations of plant growth and metabolism. Plant hormones are active participants in these alterations. This study focuses on auxin–a phytohormone with a wide...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 275: Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ Biomolecules doi: 10.3390/biom10020275 Authors: Ahn Jang Park An Shin Han Noh Adiponectin is an adipocyte-derived cytokine having an insulin-sensitizing activity. During the phenotypic screening of secondary metabolites derived from the marine fungus Aspergillus terreus, a poly cyclin-dependent...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 278: Jasmonate and Ethylene-Regulated Ethylene Response Factor 22 Promotes Lanolin-Induced Anthocyanin Biosynthesis in ‘Zaosu’ Pear (Pyrus bretschneideri Rehd.) Fruit Biomolecules doi: 10.3390/biom10020278 Authors: Wu Liu Zhao Song Wang Yang Zhai Wang Ma Xu Anthocyanin contributes to the coloration of pear fruit and enhances plant defenses. Members of the ethylene response factor (ERF) family play vital roles in hormone...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 277: Accumulation of Anthocyanins through Overexpression of AtPAP1 in Solanum nigrum Lin. (Black Nightshade) Biomolecules doi: 10.3390/biom10020277 Authors: Chhon Jeon Kim Park Black nightshade (Solanum nigrum) belongs to the Solanaceae family and is used as a medicinal herb with health benefits. It has been reported that the black nightshade plant contains various phytochemicals that are associated with antitumor activities. Here we employed...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 270: The Ser290Asn and Thr715Pro Polymorphisms of the SELP Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population ‡ Biomolecules doi: 10.3390/biom10020270 Authors: Herrera-Maya Vargas-Alarcón Pérez-Méndez Posadas-Sánchez Masso Juárez-Cedillo Escobedo Vázquez-Montero Fragoso Recent studies have shown that P-selectin promotes the early formation of...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 273: Comparing Interfacial Trp, Interfacial His and pH Dependence for the Anchoring of Tilted Transmembrane Helical Peptides Biomolecules doi: 10.3390/biom10020273 Authors: Afrose Koeppe II Charged and aromatic amino acid residues, being enriched toward the terminals of membrane-spanning helices in membrane proteins, help to stabilize particular transmembrane orientations. Among them, histidine is aromatic and can be positively charged at low pH. To...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 272: Role of an Aromatic–Aromatic Interaction in the Assembly and Trafficking of the Zebrafish Panx1a Membrane Channel Biomolecules doi: 10.3390/biom10020272 Authors: Timonina Kotova Zoidl Pannexin 1 (Panx1) is a ubiquitously expressed hexameric integral membrane protein known to function as an adenosine triphosphate (ATP) release channel. Panx1 proteins exist in unglycosylated core form (Gly0). They undergo critical post-translational modifications...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 271: Electrophiles Against (Skin) Diseases: More Than Nrf2 Biomolecules doi: 10.3390/biom10020271 Authors: Hennig Fenini Di Filippo Beer The skin represents an indispensable barrier between the organism and the environment and is the first line of defense against exogenous insults. The transcription factor NRF2 is a central regulator of cytoprotection and stress resistance. NRF2 is activated in response to oxidative stress by reactive oxygen...
Tue Feb 11, 2020 02:00
Biomolecules, Vol. 10, Pages 274: Ice Binding Proteins: Diverse Biological Roles and Applications in Different Types of Industry Biomolecules doi: 10.3390/biom10020274 Authors: Białkowska Majewska Olczak Twarda-Clapa More than 80% of Earth’s surface is exposed periodically or continuously to temperatures below 5 °C. Organisms that can live in these areas are called psychrophilic or psychrotolerant. They have evolved many adaptations that allow them to survive...
Tue Feb 11, 2020 02:00
Biosensors, Vol. 10, Pages 11: Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends Biosensors doi: 10.3390/bios10020011 Authors: Andryukov Besednova Romashko Zaporozhets Efimov Infections pose a serious global public health problem and are a major cause of premature mortality worldwide. One of the most challenging objectives faced by modern medicine is timely and accurate laboratory-based diagnostics of infectious...
Wed Feb 12, 2020 02:00
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