Brain Sciences, Vol. 10, Pages 97: Factors Moderating the Association Between Cannabis Use and Psychosis Risk: A Systematic Review Brain Sciences doi: 10.3390/brainsci10020097 Authors: van der Steur Batalla Bossong Increasing evidence indicates a relationship between cannabis use and psychosis risk. Specific factors, such as determinants of cannabis use or the genetic profile of cannabis users, appear to moderate this association. The present systematic review presents a detailed...
Wed Feb 12, 2020 02:00
Brain Sciences, Vol. 10, Pages 98: Understanding Exercise Adherence: The Predictability of Past Experience and Motivational Determinants Brain Sciences doi: 10.3390/brainsci10020098 Authors: Rodrigues Teixeira Neiva Cid Monteiro Background: An unresolved debate lingers over the effect of past behavior on motivational patterns and future behavior stability in the exercise context. Theorists argue that past behavior has a residual effect on future behavior; however, empirical...
Wed Feb 12, 2020 02:00
Brain Sciences, Vol. 10, Pages 96: Cerebellar Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Pilot Study Brain Sciences doi: 10.3390/brainsci10020096 Authors: Workman Fietsam Uc Rudroff People with Parkinson’s disease (PwPD) often experience gait and balance problems that substantially impact their quality of life. Pharmacological, surgical, and rehabilitative treatments have limited effectiveness and many PwPD continue to experience...
Tue Feb 11, 2020 02:00
Brain Sciences, Vol. 10, Pages 95: Dorsal Root Ganglion Stimulation Modulates Cortical Gamma Activity in the Cognitive Dimension of Chronic Pain Brain Sciences doi: 10.3390/brainsci10020095 Authors: Parker Huang Raghu FitzGerald Green Aziz A cognitive task, the n-back task, was used to interrogate the cognitive dimension of pain in patients with implanted dorsal root ganglion stimulators (DRGS). Magnetoencephalography (MEG) signals from thirteen patients with implanted...
Tue Feb 11, 2020 02:00
Cancers, Vol. 12, Pages 428: The Impact of Cand1 in Prostate Cancer Cancers doi: 10.3390/cancers12020428 Authors: Eigentler Tymoszuk Zwick Schmitz Pircher Kocher Schlicker Lesche Schäfer Theurl Klocker Heidegger Evidence has accumulated asserting the importance of cullin-RING (really interesting new gene) ubiquitin ligases (CRLs) and their regulator Cullin-associated neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8)...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 421: Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression Cancers doi: 10.3390/cancers12020421 Authors: Chen Tseng Chen Al Haq Hwang Hsu Reactive oxygen species (ROS) produced during intracellular metabolism or triggered by extrinsic factors can promote neoplastic transformation and malignant microenvironment that mediate tumor development. Oligo-Fucoidan is a sulfated polysaccharide isolated from the brown seaweed....
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 426: Emerging Roles of ALK in Immunity and Insights for Immunotherapy Cancers doi: 10.3390/cancers12020426 Authors: Wang Lui Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 423: Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer? Cancers doi: 10.3390/cancers12020423 Authors: Hińcza Kowalik Pałyga Walczyk Gąsior-Perczak Mikina Trybek Szymonek Gadawska-Juszczyk Zajkowska Suligowska Kuchareczko Krawczyk Kopczyński Chrapek Góźdź Kowalska Thyroid cancer (TC) is the most common cancer of the endocrine...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 424: Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients Cancers doi: 10.3390/cancers12020424 Authors: Horio Morishita Mizuno Uchino Hanamura Espinoza Morishima Kodera Onizuka Kashiwase Fukuda Doki Miyamura Mori Nakao Takami Heme oxygenase-1 (HO-1), an intracellular enzyme that catalyzes the degradation of heme into biliverdin,...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 425: Calcium Delivery by Electroporation Induces In Vitro Cell Death through Mitochondrial Dysfunction without DNA Damages Cancers doi: 10.3390/cancers12020425 Authors: Gibot Montigny Baaziz Fourquaux Audebert Rols Adolescent cancer survivors present increased risks of developing secondary malignancies due to cancer therapy. Electrochemotherapy is a promising anti-cancer approach that potentiates the cytotoxic effect of drugs by application...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 427: Bench to Bedside: Animal Models of Radiation Induced Musculoskeletal Toxicity Cancers doi: 10.3390/cancers12020427 Authors: Farris Helis Hughes LeCompte Borg Nieto Munley Willey Ionizing radiation is a critical aspect of current cancer therapy. While classically mature bone was thought to be relatively radio-resistant, more recent data have shown this to not be the case. Radiation therapy (RT)-induced bone loss leading to fracture...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 422: MAL2-Induced Actin-Based Protrusion Formation is Anti-Oncogenic in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12020422 Authors: Lopez-Coral del Vecchio Chahine Kallakury Tuma Recent studies report that the polarity gene myelin and lymphocyte protein 2 (MAL2), is overexpressed in multiple human carcinomas largely at the transcript level. Because chromosome 8q24 amplification (where MAL2 resides) is associated with hepatocellular-...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 430: BRAF Exon 15 Mutations in Papillary Carcinoma and Adjacent Thyroid Parenchyma: A Search for the Early Molecular Events Associated with Tumor Development Cancers doi: 10.3390/cancers12020430 Authors: Acquaviva de Biase Diquigiovanni Argento De Leo Bonora Rhoden Pession Tallini BRAF exon 15 mutations are the most common molecular alterations found in papillary thyroid carcinoma (PTC). To date, there is no information regarding...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 429: ABCG2 Overexpression Contributes to Pevonedistat Resistance Cancers doi: 10.3390/cancers12020429 Authors: Kathawala Espitia Jones Islam Gupta Zhang Chen Carew Nawrocki MLN4924 (pevonedistat) is a first-in-class NEDD8-activating enzyme (NAE) inhibitor in clinical trials for the treatment of solid tumors and hematologic malignancies. Despite the promising activity of MLN4924 observed in early trials, drug resistance has been...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 419: Patient Derived Models to Study Head and Neck Cancer Radiation Response
Cancers, Vol. 12, Pages 419: Patient Derived Models to Study Head and Neck Cancer Radiation Response Cancers doi: 10.3390/cancers12020419 Authors: Pippa F. Cosper Lindsey Abel Yong-Syu Lee Cristina Paz Saakshi Kaushik Kwangok P. Nickel Roxana Alexandridis Jacob G. Scott Justine Y. Bruce Randall J. Kimple Patient-derived model systems are important tools for studying novel anti-cancer therapies. Patient-derived xenografts (PDXs) have gained favor over the last...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 420: Deletion of Von Hippel–Lindau Interferes with Hyper Osmolality Induced Gene Expression and Induces an Unfavorable Gene Expression Pattern Cancers doi: 10.3390/cancers12020420 Authors: Alexander Groß Dmitry Chernyakov Lisa Gallwitz Nicola Bornkessel Bayram Edemir Loss of von Hippel–Lindau (VHL) protein function can be found in more than 90% of patients with clear cell renal carcinoma (ccRCC). Mice lacking Vhl function in the kidneys have...
Wed Feb 12, 2020 02:00
Cancers, Vol. 12, Pages 417: Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy Cancers doi: 10.3390/cancers12020417 Authors: Wong Berstad Fremstedal Berg Patzke Sørensen Peng Selbo Weyergang Lysosomal accumulation of sunitinib has been suggested as an underlying mechanism of resistance. Here, we investigated if photochemical internalization (PCI), a technology for cytosolic release of drugs entrapped...
Tue Feb 11, 2020 02:00
Cancers, Vol. 12, Pages 418: Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer Cancers doi: 10.3390/cancers12020418 Authors: Sulma I. Mohammed Sagar Utturkar Maxwell Lee Howard H. Yang Zhibin Cui Nadia Atallah Lanman GuangJun Zhang Xavier E. Ramos Cardona Suresh K. Mittal Margaret A. Miller The mechanisms that drive ductal carcinoma in situ (DCIS) progression to invasive cancer are not clear. Studying DCIS progression in humans is challenging...
Tue Feb 11, 2020 02:00
Cancers, Vol. 12, Pages 415: Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity Cancers doi: 10.3390/cancers12020415 Authors: Schlaak SenthilKumar Boerma Bergom Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably...
Tue Feb 11, 2020 02:00
Cancers, Vol. 12, Pages 414: Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer Cancers doi: 10.3390/cancers12020414 Authors: De Pasquale Crocoli Caldaro Rinelli Spinelli Francalanci Cozza Inserra Miele Background: Colorectal carcinoma (CRC) is very rare in the pediatric and adolescent age range and clinical management is performed according to adult protocols. We report, for the first time in the literature, a case of a...
Tue Feb 11, 2020 02:00
Cancers, Vol. 12, Pages 416: Colorectal Cancer Research: Basic, Preclinical, and Clinical Approaches
Cancers, Vol. 12, Pages 416: Colorectal Cancer Research: Basic, Preclinical, and Clinical Approaches Cancers doi: 10.3390/cancers12020416 Authors: Beaulieu Colorectal cancer remains one of the deadliest cancers worldwide. It has become evident that further efforts in colorectal cancer research are required, from providing a better understanding of the cellular and molecular mechanisms leading to colorectal neoplasm initiation and progression from adenoma to metastasis, to generating...
Tue Feb 11, 2020 02:00
Cancers, Vol. 12, Pages 413: MAIT Cells Come to the Rescue in Cancer Immunotherapy? Cancers doi: 10.3390/cancers12020413 Authors: Lukasik Elewaut Venken Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells. Invariant T cells are characterized by T cell receptors recognizing a limited range of non-peptide antigens,...
Tue Feb 11, 2020 02:00
Cells, Vol. 9, Pages 432: Mitochondrial Calcium Regulation of Redox Signaling in Cancer Cells doi: 10.3390/cells9020432 Authors: Delierneux Kouba Shanmughapriya Potier-Cartereau Trebak Hempel Calcium (Ca2+) uptake into the mitochondria shapes cellular Ca2+ signals and acts as a key effector for ATP generation. In addition, mitochondria-derived reactive oxygen species (mROS), produced as a consequence of ATP synthesis at the electron transport chain (ETC), modulate...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 431: The Phenotype and Functional Activity of Mesenchymal Stromal Cells in Pediatric Patients with Non-Malignant Hematological Diseases Cells doi: 10.3390/cells9020431 Authors: Kuci Jordan Wehner Sörensen Jarisch Salzmann-Manrique Pfeffermann Klingebiel Bader Kuҫi As the biology of mesenchymal stromal cells (MSCs) in patients with non-malignant hematological diseases (NMHD) is poorly understood, in the current study we performed...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 426: SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy Cells doi: 10.3390/cells9020426 Authors: Pires Da Silva Monceaux Guilbert Gressette Piquereau Novotova Ventura-Clapier Garnier Lemaire Many recent studies have demonstrated the involvement of endoplasmic reticulum (ER) stress in the development of cardiac diseases and have suggested that modulation of ER stress response could be...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 420: Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and Regeneration Cells doi: 10.3390/cells9020420 Authors: Messina Luce Hussein Dubart-Kupperschmitt The liver is a very complex organ that ensures numerous functions; it is thus susceptible to multiple types of damage and dysfunction. Since 1983, orthotopic liver transplantation (OLT) has been considered the only medical solution available to patients when most...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 419: Inflammation-Modulating Hydrogels for Osteoarthritis Cartilage Tissue Engineering Cells doi: 10.3390/cells9020419 Authors: Koh Jin Kim Hwang Osteoarthritis (OA) is the most common form of the joint disease associated with age, obesity, and traumatic injury. It is a disabling degenerative disease that affects synovial joints and leads to cartilage deterioration. Despite the prevalence of this disease, the understanding of OA pathophysiology is still...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 421: Asbestos and Intrahepatic Cholangiocarcinoma Cells doi: 10.3390/cells9020421 Authors: Brandi Tavolari The link between asbestos exposure and the onset of thoracic malignancies is well established. However epidemiological studies have provided evidences that asbestos may be also involved in the development of gastrointestinal tumors, including intrahepatic cholangiocarcinoma (ICC). In line with this observation, asbestos fibers have been detected in the...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 428: Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance Cells doi: 10.3390/cells9020428 Authors: Dudas Ladanyi Ingruber Steinbichler Riechelmann Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell invasion, and therapy resistance. EMT is regulated by transcription factors such as the protein products of the SNAI gene family, which inhibits the expression of epithelial genes....
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 422: Purity Determines the Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells Cells doi: 10.3390/cells9020422 Authors: Forteza-Genestra Antich-Rosselló Calvo Gayà Monjo Ramis Extracellular vesicles (EVs) have been recently identified as vital components of cell-based therapies based on the observation that conditioned media from cultured stromal cells reproduce some of the beneficial effects of intact cells. In order to obtain...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 425: Association Between Microsatellite Instability Status and Peri-Operative Release of Circulating Tumour Cells in Colorectal Cancer Cells doi: 10.3390/cells9020425 Authors: Toh Lim MacKenzie de Souza Bokey Chapuis Spring Microsatellite instability (MSI) in colorectal cancer (CRC) is a marker of immunogenicity and is associated with an increased abundance of tumour infiltrating lymphocytes (TILs). In this subgroup of colorectal cancer,...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 423: Intravenous Administration of Allogenic Cell-Derived Microvesicles of Healthy Origins Defend Against Atherosclerotic Cardiovascular Disease Development by a Direct Action on Endothelial Progenitor Cells Cells doi: 10.3390/cells9020423 Authors: Alexandru Andrei Safciuc Dragan Balahura Badila Georgescu Atherosclerosis and cardiovascular disease development is the outcome of intermediate processes where endothelial dysfunction and vascular...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 427: Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II Cells doi: 10.3390/cells9020427 Authors: Kaiser Krüger Eiselt Bechler Kniemeyer Huber Schmidt Paracrine interactions between malignant estrogen receptor positive (ER+) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs. In breast cancer, mainly the cAMP-responsive...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 424: Clustered DNA Damage: Electronic Properties and Their Influence on Charge Transfer. 7,8-Dihydro-8-Oxo-2′-Deoxyguaosine Versus 5′,8-Cyclo-2′-Deoxyadenosines: A Theoretical Approach Cells doi: 10.3390/cells9020424 Authors: Karwowski Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron–sulfur glycosylases (MutyH), which...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 429: Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance Cells doi: 10.3390/cells9020429 Authors: Mendoza-Reinoso Baek Kurutz Rubin Koh McCauley Roca The clearance of apoptotic cells by macrophages (efferocytosis) is crucial to maintain normal tissue homeostasis; however, efferocytosis of cancer cells frequently results in inflammation and immunosuppression. Recently, we demonstrated that efferocytosis of...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 430: Increase in Leptin and PPAR-γ Gene Expression in Lipedema Adipocytes Differentiated in vitro from Adipose-Derived Stem Cells Cells doi: 10.3390/cells9020430 Authors: Al-Ghadban Diaz Singer Mert Bunnell Lipedema is a painful loose connective tissue disorder characterized by a bilaterally symmetrical fat deposition in the lower extremities. The goal of this study was to characterize the adipose-derived stem cells (ASCs) of healthy and lipedema...
Wed Feb 12, 2020 02:00
Cells, Vol. 9, Pages 417: Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma Cells doi: 10.3390/cells9020417 Authors: Monti Consoli Vescovi Bugatti Vermi The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has significantly improved the survival of MM patients. Notably,...
Tue Feb 11, 2020 02:00
Cells, Vol. 9, Pages 416: c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells Cells doi: 10.3390/cells9020416 Authors: Strassheim Karoor Nijmeh Weston Lapel Schaack Sullivan Dempsey Stenmark Gerasimovskaya Angiogenic vasa vasorum (VV) expansion plays an essential role in the pathogenesis of hypoxia-induced pulmonary hypertension (PH), a cardiovascular...
Tue Feb 11, 2020 02:00
Cells, Vol. 9, Pages 415: miRNAs as Key Players in the Management of Cutaneous Melanoma Cells doi: 10.3390/cells9020415 Authors: Lorusso De Summa Pinto Danza Tommasi The number of treatment options for melanoma patients has grown in the past few years, leading to considerable improvements in both overall and progression-free survival. Targeted therapies and immune checkpoint inhibitors have opened a new era in the management of melanoma patients. Despite the clinical...
Tue Feb 11, 2020 02:00
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