IJMS, Vol. 21, Pages 1354: Expression and In Vitro Function of Anti-Breast Cancer Llama-Based Single Domain Antibody VHH Expressed in Tobacco Plants International Journal of Molecular Sciences doi: 10.3390/ijms21041354 Authors: Se Ra Park Jeong-Hwan Lee Kibum Kim Taek Min Kim Seung Ho Lee Young-Kug Choo Kyung Soo Kim Kisung Ko Overexpression of human epidermal growth factor receptor type 2 (HER2) is considered as a prognostic factor of breast cancer, which is positively...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1348: Mutual Regulation of RNA Silencing and the IFN Response as an Antiviral Defense System in Mammalian Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041348 Authors: Takahashi Ui-Tei RNA silencing is a posttranscriptional gene silencing mechanism directed by endogenous small non-coding RNAs called microRNAs (miRNAs). By contrast, the type-I interferon (IFN) response is an innate immune response induced by exogenous RNAs, such as viral...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1347: Ethyl Acetate Fraction of Aqueous Extract of Lentinula edodes Inhibits Osteoclastogenesis by Suppressing NFATc1 Expression International Journal of Molecular Sciences doi: 10.3390/ijms21041347 Authors: Lee Lee Lee Lee Jeong Lim Hyun Yi Kim Bone tissue is continuously remodeled by the coordinated action of osteoclasts and osteoblasts. Nuclear factor-activated T cells c1 (NFATc1) is a well-known transcription factor for osteoclastogenesis...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1349: EMT Transcription Factors Are Involved in the Altered Cell Adhesion under Simulated Microgravity Effect or Overloading by Regulation of E-cadherin International Journal of Molecular Sciences doi: 10.3390/ijms21041349 Authors: Shi Li Cao Diao Zhang Yue Wei In order to study the effect of stress changes on cell adhesion, HUVEC, and MCF-7 cells were treated with simulated microgravity effect (SMG) and overloading (OL). Methods: Rotating...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1345: Inheritance and Molecular Characterization of a Novel Mutated AHAS Gene Responsible for the Resistance of AHAS-Inhibiting Herbicides in Rapeseed (Brassica napus L.) International Journal of Molecular Sciences doi: 10.3390/ijms21041345 Authors: Huang Lv Sun Wang Guo Qu Hu The use of herbicides is an effective and economic way to control weeds, but their availability for rapeseed is limited due to the shortage of herbicide-resistant cultivars...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1334: Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms21041334 Authors: Katarzyna A. Roszkowska Slawomir Gizinski Maria Sady Zdzislaw Gajewski Maciej B. Olszewski Forty years of research has proven beyond any doubt that p53 is a key regulator of many aspects of cellular physiology. It is best known for its tumor suppressor function, but it is also a regulator of processes...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1344: Genetic Dissection of Seed Dormancy using Chromosome Segment Substitution Lines in Rice (Oryza sativa L.) International Journal of Molecular Sciences doi: 10.3390/ijms21041344 Authors: Yuan Wang Zhang He Yu Timing of germination determines whether a new plant life cycle can be initiated; therefore, appropriate dormancy and rapid germination under diverse environmental conditions are the most important features for a seed. However, the genetic...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1343: Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity International Journal of Molecular Sciences doi: 10.3390/ijms21041343 Authors: Zhu Pedersen Ahmed Abdolalizadeh Grell Berg Thulstrup Franzyk Edvinsson Sams Sheykhzade Hansen : Human α-calcitonin gene-related peptide (h-α-CGRP) is a highly potent vasodilator peptide that belongs to the family of calcitonin...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1346: p53-Related Transcription Targets of TAp73 in Cancer Cells—Bona Fide or Distorted Reality? International Journal of Molecular Sciences doi: 10.3390/ijms21041346 Authors: Wang Teo Sabapathy Identification of p73 as a structural homolog of p53 fueled early studies aimed at determining if it was capable of performing p53-like functions. This led to a conundrum as p73 was discovered to be hardly mutated in cancers, and yet, TAp73, the full-length form,...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1342: Genomic Prediction for Grain Yield and Yield-Related Traits in Chinese Winter Wheat International Journal of Molecular Sciences doi: 10.3390/ijms21041342 Authors: Ali Zhang Rasheed Wang Zhang Genomic selection (GS) is a strategy to predict the genetic merits of individuals using genome-wide markers. However, GS prediction accuracy is affected by many factors, including missing rate and minor allele frequency (MAF) of genotypic data, GS models,...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1337: Combined Analysis of the Metabolome and Transcriptome Identified Candidate Genes Involved in Phenolic Acid Biosynthesis in the Leaves of Cyclocarya paliurus International Journal of Molecular Sciences doi: 10.3390/ijms21041337 Authors: Lin Li Lu Lu Li To assess changes of metabolite content and regulation mechanism of the phenolic acid biosynthesis pathway at different developmental stages of leaves, this study performed a combined metabolome...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1341: The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain International Journal of Molecular Sciences doi: 10.3390/ijms21041341 Authors: Jaewoo Hong Yurim Kim Sudhirkumar Yanpallewar P. Charles Lin Vav1 is a Rho/Rac (Ras-related C3 botulinum toxin substrate) guanine nucleotide exchange factor expressed in hematopoietic and endothelial cells that are involved in a wide range of cellular...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1340: Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21041340 Authors: Nishimura Hata Takahata Murakami Nakamura Ohkawa Ruengsinpinya : Osteoarthritis and rheumatoid arthritis are common cartilage and joint diseases that globally affect more than 200 million and 20 million people, respectively. Several transcription factors have been...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1338: Phytotoxicity, Bioaccumulation, and Degradation of Nonylphenol in Different Microalgal Species without Bacterial Influences International Journal of Molecular Sciences doi: 10.3390/ijms21041338 Authors: Ning He Zhiwei Liu Xian Sun Shuangyao Wang Weijie Liu Dong Sun Shunshan Duan Nonylphenol (NP) is a contaminant that has negative impacts on aquatic organisms. To investigate its phytotoxicity, bioaccumulation, and degradation in algae without...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1339: Structural Changes and Astrocyte Response of the Lateral Geniculate Nucleus in a Ferret Model of Ocular Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms21041339 Authors: Fujishiro Honjo Kawasaki Asaoka Yamagishi Aihara We investigated structural changes and astrocyte responses of the lateral geniculate nucleus (LGN) in a ferret model of ocular hypertension (OH). In 10 ferrets, OH was induced via the injection of...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1335: Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes International Journal of Molecular Sciences doi: 10.3390/ijms21041335 Authors: Lambert Ashi Srour Delpy Saulière The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can act with dominant-negative or gain-of-function effects. To...
Mon Feb 17, 2020 02:00
IJMS, Vol. 21, Pages 1336: Direct Interaction between Calmodulin and the Grb7 RA-PH Domain International Journal of Molecular Sciences doi: 10.3390/ijms21041336 Authors: Watson Wilce Grb7 is a signalling adapter protein that engages activated receptor tyrosine kinases at cellular membranes to effect downstream pathways of cell migration, proliferation and survival. Grb7’s cellular location was shown to be regulated by the small calcium binding protein calmodulin (CaM)....
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 549: Biomarkers in Community-Acquired Pneumonia (Cardiac and Non-Cardiac) Journal of Clinical Medicine doi: 10.3390/jcm9020549 Authors: Raúl Méndez Irene Aldás Rosario Menéndez Community-acquired pneumonia (CAP) remains the first cause of morbidity and mortality worldwide due to infection. Several aspects such as severity and host response are related to its clinical course and outcome. Beyond the acute implications that the infection provokes in the host, pneumonia...
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JCM, Vol. 9, Pages 548: Dysfunction of Salivary Glands, Disturbances in Salivary Antioxidants and Increased Oxidative Damage in Saliva of Overweight and Obese Adolescents Journal of Clinical Medicine doi: 10.3390/jcm9020548 Authors: Zalewska Kossakowska Taranta-Janusz Zięba Fejfer Salamonowicz Kostecka-Sochoń Wasilewska Maciejczyk Obesity is inseparably connected with oxidative stress. This process may disturb the functioning of the oral cavity, although...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 547: Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD? Journal of Clinical Medicine doi: 10.3390/jcm9020547 Authors: Aksan Tugal Hein Boettger Caicedo-Zea Diehl Schumann Armbruster Stein Evidence gained from recent studies has generated increasing interest in the role of vitamin D in extraskeletal functions such as inflammation...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 546: Treatment with CPAP in Elderly Patients with Obstructive Sleep Apnoea Journal of Clinical Medicine doi: 10.3390/jcm9020546 Authors: Posadas Oscullo Zaldívar Garcia-Ortega Gómez-Olivas Monteagudo Martínez-García The population pyramid is changing as a result of the ever-increasing life expectancy, which makes it crucial to acquire an in-depth understanding of the diseases that most often affect the elderly. Obstructive sleep apnoea (OSA)...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 545: Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy: From Disease towards Asymptomatic Carriers of Pathogenic Variants Journal of Clinical Medicine doi: 10.3390/jcm9020545 Authors: Rob W. Roudijk Laurens P. Bosman Jeroen F. van der Heijden Jacques M. T. de Bakker Richard N. W. Hauer J. Peter van Tintelen Folkert W. Asselbergs Anneline S. J. M. te Riele Peter Loh Fragmented QRS complexes (fQRS) are common in patients...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 543: Clarithromycin Versus Metronidazole in First-Line Helicobacter Pylori Triple Eradication Therapy Based on Resistance to Antimicrobial Agents: Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020543 Authors: Masaki Murata Mitsushige Sugimoto Hitomi Mizuno Takeshi Kanno Kiichi Satoh Background: International treatment guidelines for Helicobacter pylori infection recommend a proton pump inhibitor (PPI)/amoxicillin/clarithromycin (CAM) regimen...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 542: Progress in Microneedle-Mediated Protein Delivery Journal of Clinical Medicine doi: 10.3390/jcm9020542 Authors: Jamaledin Di Natale Onesto Taraghdari Zare Makvandi Vecchione Netti The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 544: Modulation of SERCA in Patients with Persistent Atrial Fibrillation Treated by Epicardial Thoracoscopic Ablation: The CAMAF Study Journal of Clinical Medicine doi: 10.3390/jcm9020544 Authors: Sardu Santulli Guerra Trotta Santamaria Sacra Testa Ducceschi Gatta Amico Sasso Paolisso Marfella Objectives: To evaluate atrial fibrillation (AF) recurrence and Sarcoplasmic Endoplasmic Reticulum Calcium ATPase (SERCA) levels...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 540: Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020540 Authors: Flor de Liz Pérez-Losada Albert Estrugo-Devesa Lissett Castellanos-Cosano Juan José Segura-Egea José López-López Eugenio Velasco-Ortega Objective: Investigate if there is an association between apical periodontitis and diabetes mellitus. Material and methods: A bibliographic search was performed on...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 541: TLR2 Expression on Select Lymphocyte Subsets as a New Marker in Glomerulonephritis Journal of Clinical Medicine doi: 10.3390/jcm9020541 Authors: Mertowski Grywalska Gosik Smarz-Widelska Hymos Dworacki Niedźwiedzka-Rystwej Drop Roliński Załuska Toll-like receptor (TLR) signaling may be involved in autoimmune kidney disorders and has been implicated in proliferative and non-proliferative glomerulonephritis (PGN and NPGN). In...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 539: Diagnosis of Inherited Platelet Disorders on a Blood Smear Journal of Clinical Medicine doi: 10.3390/jcm9020539 Authors: Carlo Zaninetti Andreas Greinacher Inherited platelet disorders (IPDs) are rare diseases featured by low platelet count and defective platelet function. Patients have variable bleeding diathesis and sometimes additional features that can be congenital or acquired. Identification of an IPD is desirable to avoid misdiagnosis of immune thrombocytopenia...
Mon Feb 17, 2020 02:00
JCM, Vol. 9, Pages 538: Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data Journal of Clinical Medicine doi: 10.3390/jcm9020538 Authors: Natalie M. Linton Tetsuro Kobayashi Yichi Yang Katsuma Hayashi Andrei R. Akhmetzhanov Sung-mok Jung Baoyin Yuan Ryo Kinoshita Hiroshi Nishiura The geographic spread of 2019 novel coronavirus (COVID-19) infections...
Mon Feb 17, 2020 02:00
JFMK, Vol. 5, Pages 15: Effect of progressive fatigue on session RPE Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010015 Authors: Fusco Sustercich Edgerton Cortis Jaime Mikat Porcari Foster Rating of perceived exertion (RPE) and session RPE (sRPE) are reliable tools for predicting exercise intensity and are alternatives to more technological and physiological measurements, such as blood lactate (HLa) concentration, oxygen consumption...
Mon Feb 17, 2020 02:00
JFMK, Vol. 5, Pages 14: Joint Mobility Protection during the Developmental Age among Free Climbing Practitioners: A Pilot Study Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010014 Authors: Ludovica Gasbarro Elvira Padua Virginia Tancredi Giuseppe Annino Michela Montorsi Grazia Maugeri Agata Grazia D’Amico Sport-climbing popularity increased intensely over the past years. Particularly, children’s and adolescents’ interest therein...
Mon Feb 17, 2020 02:00
Medicina, Vol. 56, Pages 82: Cortical Bone Trajectory Instrumentation with Vertebroplasty for Osteoporotic Thoracolumbar Compression Fracture Medicina doi: 10.3390/medicina56020082 Authors: Hsu Lin Chuang Lee Chen Chu Cho Chen Background: Osteoporotic spinal fractures commonly occur in elderly patients with low bone mineral density. In these cases, percutaneous vertebroplasty or percutaneous kyphoplasty can provide significant pain relief and improve mobility....
Mon Feb 17, 2020 02:00
Medicina, Vol. 56, Pages 81: Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer Medicina doi: 10.3390/medicina56020081 Authors: Stumbrytė-Kaminskienė Gudlevičienė Dabkevičienė Mackevičienė Background and objectives: Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck tumors. The molecular mechanism of LSCC remains unclear. The aim of this study was to evaluate the prevalence of Human papillomavirus (HPV) and single nucleotide polymorphisms...
Mon Feb 17, 2020 02:00
Metabolites, Vol. 10, Pages 73: Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities Metabolites doi: 10.3390/metabo10020073 Authors: Alburae Mohammed Alorfi JamanTurki Asfour Alarif Abdel-Lateff The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites. The published classes of natural...
Mon Feb 17, 2020 02:00
Metabolites, Vol. 10, Pages 72: Metabolomics in Psychiatric Disorders: What We Learn from Animal Models Metabolites doi: 10.3390/metabo10020072 Authors: Humer Probst Pieh Biomarkers are a recent research target within biological factors of psychiatric disorders. There is growing evidence for deriving biomarkers within psychiatric disorders in serum or urine samples in humans, however, few studies have investigated this differentiation in brain or cerebral fluid samples in psychiatric...
Mon Feb 17, 2020 02:00
Microorganisms, Vol. 8, Pages 267: Abstracts of the International Conference and Expo on Microbiology. Barcelona, Spain November 18–19, 2019. Hotel Novotel Barcelona Sant Joan Despi Microorganisms doi: 10.3390/microorganisms8020267 Authors: Irene Frank International Conference and Expo on Microbiology (Microbiology 2019) organized by Coalesce Research Group was held on November 18–19, 2019 at Hotel Novotel Barcelona Sant Joan Despi, Barcelona, Spain. The conference highlighted...
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Microorganisms, Vol. 8, Pages 273: Erratum: Inglis, G.D., et al. Tetracycline Resistant Campylobacter jejuni Subtypes Emanating from Beef Cattle Administered Non-Therapeutic Chlortetracycline Are Longitudinally Transmitted within the Production Continuum but Are Not Detected in Ground Beef. Microorganisms 2020, 8, 23 Microorganisms doi: 10.3390/microorganisms8020273 Authors: G. Douglas Inglis Jenny F. Gusse Kathaleen E. House Tara G. Shelton Eduardo N. Taboada The authors...
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Microorganisms, Vol. 8, Pages 271: Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis Microorganisms doi: 10.3390/microorganisms8020271 Authors: Lin Zhang Wu Xie Qiao Zhao Monensin, produced by Streptomyces cinnamonensis, is a polyether ionophore antibiotic widely used as a coccidiostat and a growth-promoting agent in agricultural industry. In this study, cyclic AMP receptor protein (Crp), the global transcription factor for regulation...
Mon Feb 17, 2020 02:00
Microorganisms, Vol. 8, Pages 272: Disinfection of Ready-to-Eat Lettuce Using Polyhexamethylene Guanidine Hydrochloride Microorganisms doi: 10.3390/microorganisms8020272 Authors: Wang Yu Dong As a novel and safe sanitizer, polyhexamethylene guanidine hydrochloride (PHMG) has been used to inhibit the spoilage of agricultural products caused by fungi. However, little is known about its antibacterial effects on vegetables. In this study, we evaluated the disinfection efficacy of...
Mon Feb 17, 2020 02:00
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