IJMS, Vol. 21, Pages 1270: Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology International Journal of Molecular Sciences doi: 10.3390/ijms21041270 Authors: Fioravanti Pirtoli Giordano Dotta MicroRNAs (miRNA), are short regulatory RNA molecules that regulate gene expression by binding specific sequences within target messenger RNA (mRNA) [...]
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1271: Dynamic Behavior of p53 Driven by Delay and a Microrna-34a-Mediated Feedback Loop International Journal of Molecular Sciences doi: 10.3390/ijms21041271 Authors: Gao Liu Yan The tumor suppressor protein p53 is a critical hub in the comprehensive transcriptional network that inhibits the growth of cells after acute stress stimulation. In this paper, an integrated model of the p53 signaling pathway in response to DNA damage is proposed and the p53 stability...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1267: CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21041267 Authors: Wang Zhang Liu Peng Ren Huang Liu Wang Cadherin epidermal growth factor (EGF) laminin G (LAG) seven-pass G-type receptor 1 (CELSR1) is a member of a special subgroup of adhesion G protein-coupled receptors. Although Celsr1 has been reported to be a...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1266: Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21041266 Authors: Ferrín Guerrero Amado Rodríguez-Perálvarez De la Mata Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and occurs mainly in patients with liver cirrhosis. The mammalian target of rapamycin (mTOR) signaling pathway is involved in many hallmarks of cancer including cell growth,...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1250: Healthy Effects of Plant Polyphenols: Molecular Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21041250 Authors: Leri Scuto Ontario Calabrese Calabrese Bucciantini Stefani The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective,...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1248: NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility International Journal of Molecular Sciences doi: 10.3390/ijms21041248 Authors: Hu Xing Fu Yang Ren Wang Li Li Zhang NCAPG is a subunit of condensin I that plays a crucial role in chromatin condensation during mitosis. NCAPG has been demonstrated to be associated with farm animal growth traits. However, its role in regulating...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1269: Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21041269 Authors: Bu Nie Quinn Wang Cortical spreading depression (CSD) is a propagating wave of depolarization followed by depression of cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) channel opening, which may eventually cause...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1254: Identifying the Translatome of Mouse NEBD-Stage Oocytes via SSP-Profiling; A Novel Polysome Fractionation Method International Journal of Molecular Sciences doi: 10.3390/ijms21041254 Authors: Masek del Llano Gahurova Kubelka Susor Roucova Lin Bruce Pospisek Meiotic maturation of oocyte relies on pre-synthesised maternal mRNA, the translation of which is highly coordinated in space and time. Here, we provide a detailed polysome...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1252: Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity International Journal of Molecular Sciences doi: 10.3390/ijms21041252 Authors: Lee Ohara Shinoda Hayashi Kubo Sugawara Asano Soma Kanno Ando Koyama Kimura Sakanashi Iinuma Iwata : The mechanical head-withdrawal threshold (MHWT) was significantly reduced following inferior alveolar nerve transection...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1251: Genome-Wide Profiling and Phylogenetic Analysis of the SWEET Sugar Transporter Gene Family in Walnut and Their Lack of Responsiveness to Xanthomonas arboricola pv. juglandis Infection International Journal of Molecular Sciences doi: 10.3390/ijms21041251 Authors: Shijiao Jiang Bipin Balan Renata de A. B. Assis Cintia H. D. Sagawa Xueqin Wan Shan Han Le Wang Lanlan Zhang Paulo A. Zaini Sriema L. Walawage Aaron Jacobson Steven H. Lee...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1249: Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS) International Journal of Molecular Sciences doi: 10.3390/ijms21041249 Authors: Roberts Varma Huang An Oommen Tanaka Ferrucci Elango Takebayashi Harada Iida Thambisetty Rapid lifestyle and dietary changes...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1256: The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy International Journal of Molecular Sciences doi: 10.3390/ijms21041256 Authors: Jiang Liu Ying Nie Muhammad Chaudhry Fang Bai Justin Chuang Komal Sodhi Joseph I. Shapiro In recent years, Na/K-ATPase signaling has been implicated in different physiological and pathophysiological conditions, including cardiac hypertrophy and uremic cardiomyopathy. Cardiotonic steroids (CTS), specific...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1255: RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity International Journal of Molecular Sciences doi: 10.3390/ijms21041255 Authors: Kim Kim Mostafa Park Choi Kim Choi Scrapie infection, which converts cellular prion protein (PrPC) into the pathological and infectious isoform (PrPSc), leads to neuronal cell death, glial cell activation and PrPSc accumulation. Previous studies reported that PrPC regulates RhoA/Rho-associated...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1247: Immunoglobulin Abnormalities in Gaucher Disease: an Analysis of 278 Patients Included in the French Gaucher Disease Registry International Journal of Molecular Sciences doi: 10.3390/ijms21041247 Authors: Yann Nguyen Jérôme Stirnemann Florent Lautredoux Bérengère Cador Monia Bengherbia Karima Yousfi Dalil Hamroun Leonardo Astudillo Thierry Billette de Villemeur Anaïs Brassier Fabrice Camou Florence Dalbies Dries Dobbelaere Francis...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1246: Exploring the Photodynamic Properties of Two Antiproliferative Benzodiazopyrrole Derivatives International Journal of Molecular Sciences doi: 10.3390/ijms21041246 Authors: Concetta Imperatore Mohammadhassan Valadan Luciana Tartaglione Marco Persico Anna Ramunno Marialuisa Menna Marcello Casertano Carmela Dell’Aversano Manjot Singh Maria Luisa d’Aulisio Garigliota Francesco Bajardi Elena Morelli Caterina Fattorusso Carlo Altucci...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1245: Transcriptomic Analysis of Ficus carica Peels with a Focus on the Key Genes for Anthocyanin Biosynthesis International Journal of Molecular Sciences doi: 10.3390/ijms21041245 Authors: Jing Li Yuyan An Liangju Wang Fig (Ficus carica L.), a deciduous fruit tree of the Moraceae, provides ingredients for human health such as anthocyanins. However, little information is available on its molecular structure. In this study, the fig peels in the yellow (Y) and...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1243: Identification and Molecular Characterization of a Pellino Protein in Kuruma Prawn (Marsupenaeus Japonicus) in Response to White Spot Syndrome Virus and Vibrio Parahaemolyticus Infection International Journal of Molecular Sciences doi: 10.3390/ijms21041243 Authors: Heqian Zhang Wenzhi Cheng Jinbin Zheng Panpan Wang Qinghui Liu Zhen Li Tianyi Shi Yijian Zhou Yong Mao Xiangyong Yu Kuruma prawn, Marsupenaeus japonicus, has the third...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1242: Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies International Journal of Molecular Sciences doi: 10.3390/ijms21041242 Authors: Elena Conte Elena Bresciani Laura Rizzi Ornella Cappellari Annamaria De Luca Antonio Torsello Antonella Liantonio Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1244: X-ray Diffraction Studies on the Structural Origin of Dynamic Tension Recovery Following Ramp-Shaped Releases in High-Ca Rigor Muscle Fibers International Journal of Molecular Sciences doi: 10.3390/ijms21041244 Authors: Haruo Sugi Maki Yamaguchi Tetsuo Ohno Hiroshi Okuyama Naoto Yagi It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1241: Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21041241 Authors: Fionán Donohoe Michael Wilkinson Eva Baxter Donal J. Brennan Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review,...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1240: Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge International Journal of Molecular Sciences doi: 10.3390/ijms21041240 Authors: Bisera Stepanovska Antonia I. Lange Stephanie Schwalm Josef Pfeilschifter Sina M. Coldewey Andrea Huwiler Sphingosine 1-phosphate (S1P) is a key bioactive lipid that regulates a myriad of physiological and pathophysiological processes,...
Thu Feb 13, 2020 02:00
IJMS, Vol. 21, Pages 1239: IL-33/IL-31 Axis in Osteoporosis International Journal of Molecular Sciences doi: 10.3390/ijms21041239 Authors: Massimo De Martinis Maria Maddalena Sirufo Mariano Suppa Lia Ginaldi The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis...
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 515: Effect of rhTSH on Lipids Journal of Clinical Medicine doi: 10.3390/jcm9020515 Authors: Alessandro P. Delitala Angelo Scuteri Margherita Maioli Gavino Casu Pierluigi Merella Giuseppe Fanciulli Background: Subclinical hypothyroidism is associated with increased blood lipid levels. However, the exact role of thyrotropin (TSH) alone is not clear. In order to clarify this point, we analysed the acute effect of recombinant human TSH (rhTSH) administration...
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JCM, Vol. 9, Pages 513: Comprehensive Assessment of Orofacial Health and Disease Related Parameters in Adolescents with Juvenile Idiopathic Arthritis—A Cross-Sectional Study Journal of Clinical Medicine doi: 10.3390/jcm9020513 Authors: Merle Hoffmann Schmickler Rühlmann Challakh Haak Schmalz Ziebolz Background: The aim of this cross-sectional study was to investigate oral health and functional status of adolescents with juvenile idiopathic arthritis (JIA)...
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 512: Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue Journal of Clinical Medicine doi: 10.3390/jcm9020512 Authors: Catalano-Iniesta Sánchez Robledo Iglesias-Osma Galán Albiñana Carrero Blanco Carretero-Hernández Carretero García-Barrado The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the...
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 510: Intraocular Inflammation Control and Changes in Retinal and Choroidal Architecture in Refractory Non-Infectious Uveitis Patients after Adalimumab Therapy Journal of Clinical Medicine doi: 10.3390/jcm9020510 Authors: Vittorio Pirani Paolo Pelliccioni Serena De Turris Alessandro Rosati Alessandro Franceschi Pierangelo Pasanisi Rosaria Gesuita Michele Nicolai Cesare Mariotti Background: Non-infectious uveitis represents a leading cause of...
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 511: High Plasma Branched-Chain Amino Acids Are Associated with Higher Risk of Post-Transplant Diabetes Mellitus in Renal Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm9020511 Authors: Maryse C. J. Osté Jose L. Flores-Guerrero Eke G. Gruppen Lyanne M. Kieneker Margery A. Connelly James D. Otvos Robin P. F. Dullaart Stephan J. L. Bakker Post-transplant diabetes mellitus (PTDM) is a serious complication in renal transplant recipients....
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 509: Multidisciplinary Group Education for Gestational Diabetes Mellitus: A Prospective Observational Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9020509 Authors: Caro Minschart Kelly Amuli Anouk Delameillieure Peggy Calewaert Chantal Mathieu Katrien Benhalima The value of diabetes education, focusing on lifestyle measures, in women with gestational diabetes mellitus (GDM) is acknowledged, but requires intensive education and input of resources...
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 508: Staphylococcus Aureus Bacteriuria as a Predictor of In-Hospital Mortality in Patients with Staphylococcus Aureus Bacteremia. Results of a Retrospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9020508 Authors: Tobias Siegfried Kramer Beate Schlosser Désirée Gruhl Michael Behnke Frank Schwab Petra Gastmeier Rasmus Leistner Staphylococcus aureus bloodstream infection (SA-BSI) is an infection with increasing morbidity and mortality....
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 507: The Surgical Benefit of Hysterolaparoscopy in Endometriosis-Related Infertility: A Single Centre Retrospective Study with a Minimum 2-Year Follow-Up Journal of Clinical Medicine doi: 10.3390/jcm9020507 Authors: Atombosoba Adokiye Ekine István Fülöp István Tekse Árpád Rúcz Sara Jeges Ágnes Koppán Miklós Koppán Aim: This study examined the fertility performance of women after combined hysterolaparoscopic surgical management of endometriosis. Design:...
Thu Feb 13, 2020 02:00
JCM, Vol. 9, Pages 506: High Electrode Impedance Values in Pediatric Cochlear Implant Recipients May Imply Insufficient Auditory and Language Skills Development Journal of Clinical Medicine doi: 10.3390/jcm9020506 Authors: Faris F. Brkic Sekib Umihanic Alen Harcinovic Lejla Piric Fuad Brkic Background: Measurements of electrode impedance values are routinely performed after cochlear implantation. The primary objective of the study was to determine if pediatric, prelingually...
Thu Feb 13, 2020 02:00
JFMK, Vol. 5, Pages 12: Perceived Well-Being and Quality of Life in People with Typical and Atypical Development: The Role of Sports Practice Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010012 Authors: Ingrassia Mazza Totaro Benedetto Sports and physical activity are recognized as a source of psycho-physical well-being. Therefore, practicing sports can improve the perception of the quality of life (QoL). The study investigated in adults with atypical...
Thu Feb 13, 2020 02:00
JoF, Vol. 6, Pages 24: Cysteine Dioxygenase Enzyme Activity and Gene Expression in the Dimorphic Pathogenic Fungus Histoplasma capsulatum Is in both the Mold and Yeast Morphotypes and Exhibits Substantial Strain Variation Journal of Fungi doi: 10.3390/jof6010024 Authors: Melissa A. Adams Glenmore Shearer In the dimorphism (mold/yeast) Histoplasma capsulatum (Hc) literature are reports that yeast (the so-called pathogenic form) uniquely expresses a cysteine dioxygenase (CDO, approx....
Thu Feb 13, 2020 02:00
Life, Vol. 10, Pages 17: Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols Life doi: 10.3390/life10020017 Authors: Adèle Dramé-Maigné Anton S. Zadorin Iaroslava Golovkova Yannick Rondelez High-throughput, in vitro approaches for the evolution of enzymes rely on a random micro-encapsulation to link phenotypes to genotypes, followed by screening or selection steps. In order to optimise these approaches, or compare one to another, one needs a measure...
Thu Feb 13, 2020 02:00
Medical Sciences, Vol. 8, Pages 13: 25th International Symposium on Infections in the Critically Ill Patient Medical Sciences doi: 10.3390/medsci8010013 Authors: Artigas Carlet Ferrer Niederman Torres This 25th International Symposium on Infections in the Critically Ill Patient aims to reviewcurrent concepts, technology and present advances in infections in critically ill patient [...]
Thu Feb 13, 2020 02:00
Medical Sciences, Vol. 8, Pages 12: Cholecalciferol Inhibits Cell Growth and Induces Apoptosis in the CaSki Cell Line Medical Sciences doi: 10.3390/medsci8010012 Authors: Sachin Bhoora Yuvelia Pather Sumari Marais Rivak Punchoo Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. Experimental cultures were incubated...
Thu Feb 13, 2020 02:00
Medicina, Vol. 56, Pages 74: Vegetarian Diets along with Regular Exercise: Impact on High-Density Lipoprotein Cholesterol Levels among Taiwanese Adults Medicina doi: 10.3390/medicina56020074 Authors: Chang Lee Nfor Chen Lu Ho Lung Chou Liaw Background and objectives: High-density lipoprotein cholesterol (HDL-C) is important for improving risk estimates of atherosclerotic cardiovascular disease. We investigated the effect of omnivore and diverse vegetarian...
Thu Feb 13, 2020 02:00
Medicina, Vol. 56, Pages 75: Sinus Augmentation with Simultaneous, Non-Submerged, Implant Placement Using a Minimally Invasive Hydraulic Technique Medicina doi: 10.3390/medicina56020075 Authors: Chaushu Chaushu Better Naishlos Kolerman Aragoneses Calvo-Guirado Nissan Background and objectives: To evaluate whether sinus augmentation, using a minimally invasive implant device, via a non-submerged surgical approach, might negatively influence the outcome. Materials...
Thu Feb 13, 2020 02:00
Metabolites, Vol. 10, Pages 67: Lipidomic Analysis of Cells and Extracellular Vesicles from High- and Low-Metastatic Triple-Negative Breast Cancer Metabolites doi: 10.3390/metabo10020067 Authors: Nishida-Aoki Izumi Takeda Takahashi Ochiya Bamba Extracellular vesicles (EVs) are lipid bilayer nanovesicles secreted from almost all cells including cancer. Cancer-derived EVs contribute to cancer progression and malignancy via educating the surrounding normal cells. In...
Thu Feb 13, 2020 02:00
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