Cells, Vol. 9, Pages 463: Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair Cells doi: 10.3390/cells9020463 Authors: Moser Basílio Gotzmann Brachner Foisner LAP2-Emerin-MAN1 (LEM) domain-containing proteins represent an abundant group of inner nuclear membrane proteins involved in diverse nuclear functions, but their functional redundancies remain unclear. Here, using the biotinylation-dependent proximity...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 472: The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets Cells doi: 10.3390/cells9020472 Authors: Kumm Pagel Gambaryan Walter Zahedi Smolenski Jurk The cell cycle is controlled by microtubule-associated serine/threonine kinase-like (MASTL), which phosphorylates the cAMP-regulated phosphoproteins 19 (ARPP19) at S62 and 19e/α-endosulfine (ENSA) at S67and converts...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 471: CD38 in Neurodegeneration and Neuroinflammation Cells doi: 10.3390/cells9020471 Authors: Guerreiro Privat Bressac Toulorge Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration and neuroinflammation remains elusive. Yet, CD38 expression increases as a...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 465: The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells Cells doi: 10.3390/cells9020465 Authors: Flinck Hagelund Gorbatenko Severin Pedraz-Cuesta Novak Stock Pedersen Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H+ ATPases (V-ATPases)...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 466: The Histone Code of Senescence Cells doi: 10.3390/cells9020466 Authors: Paluvai Di Giorgio Brancolini Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage. The maintenance of this prolonged condition requires the adaptation of the cells to an unfavorable, demanding...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 467: Dynamic Genome Editing Using In Vivo Synthesized Donor ssDNA in Escherichia coli Cells doi: 10.3390/cells9020467 Authors: Hao Wang Qiao Yin Qiao Qi As a key element of genome editing, donor DNA introduces the desired exogenous sequence while working with other crucial machinery such as CRISPR-Cas or recombinases. However, current methods for the delivery of donor DNA into cells are both inefficient and complicated. Here, we developed a new...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 468: Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia Cells doi: 10.3390/cells9020468 Authors: Meeuwsen de Vries Zoet Franx Fauser Maas Velthuis Appelman Visseren Pasterkamp Hoefer van Rijn den Ruijter de Jager : Introduction: Preeclampsia (PE) represents a hypertensive pregnancy disorder that is associated with increased cardiovascular disease (CVD) risk....
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 462: The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases Cells doi: 10.3390/cells9020462 Authors: Ilan Bank Autoimmune rheumatic diseases (ARDs), affecting ~1–1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs,...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 469: Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway Cells doi: 10.3390/cells9020469 Authors: Majera Skrott Chroma Merchut-Maya Mistrik Bartek Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 470: Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease Cells doi: 10.3390/cells9020470 Authors: Raasakka Kursula Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 464: Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes Cells doi: 10.3390/cells9020464 Authors: Asare-Bediako Noothi Li Calzi Athmanathan Vieira Adu-Agyeiwaah Dupont Jones Wang Chakraborty Levi Nagareddy Grant We sought to delineate the retinal features associated with the high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either a high-fat...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 460: Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets Cells doi: 10.3390/cells9020460 Authors: Fontana Raimondi Marzagalli Di Domizio Limonta Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa;...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 459: TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons Cells doi: 10.3390/cells9020459 Authors: Kepura Braun Dietrich Plant The cation channel subunit TRPC1 is strongly expressed in central neurons including neurons in the CA1 region of the hippocampus where it forms complexes with TRPC4 and TRPC5. To investigate the functional role of TRPC1 in these neurons and in channel function, we compared...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 461: Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development Cells doi: 10.3390/cells9020461 Authors: Ignat Dinescu Hermenean Costache Inflammation has been known to be an important driver of fibrogenesis in the liver and onset of hepatic fibrosis. It starts off as a process meant to protect the liver from further damage, but it can become the main promoter of liver fibrosis. There are many inflammation-related...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 458: Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites Cells doi: 10.3390/cells9020458 Authors: Frey Pucker Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved dinucleotides,...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 457: Role of Angiopoietins in Development of Cancer and Neoplasia Associated with Viral Infection Cells doi: 10.3390/cells9020457 Authors: Xiaolan Yu Fengchun Ye Angiopoietin/tyrosine protein kinase receptor Tie-2 signaling in endothelial cells plays an essential role in angiogenesis and wound healing. Angiopoietin-1 (Ang-1) is crucial for blood vessel maturation while angiopoietin-2 (Ang-2), in collaboration with vascular endothelial growth factor (VEGF), initiates...
Tue Feb 18, 2020 02:00
Children, Vol. 7, Pages 15: The Profile, Health Seeking Behavior, Referral Patterns, and Outcome of Outborn Neonates Admitted to a District and Regional Hospital in the Upper West Region of Ghana: A Cross-Sectional Study Children doi: 10.3390/children7020015 Authors: Edem M. A. Tette Benjamin Demah Nuertey Emmanuel A. Azusong Naa Barnabas Gandau Neonatal mortality is the major contributor to under-five mortality rates in many low and middle income countries. We examined the...
Tue Feb 18, 2020 02:00
Diagnostics, Vol. 10, Pages 110: SD-UNet: Stripping Down U-Net for Segmentation of Biomedical Images on Platforms with Low Computational Budgets Diagnostics doi: 10.3390/diagnostics10020110 Authors: Gadosey Li Adjei Agyekum Zhang Liu Yamak Essaf During image segmentation tasks in computer vision, achieving high accuracy performance while requiring fewer computations and faster inference is a big challenge. This is especially important in medical imaging tasks...
Tue Feb 18, 2020 02:00
Diversity, Vol. 12, Pages 79: A Snap-Shot of Domatial Mite Diversity of Coffea arabica in Comparison to the Adjacent Umtamvuna Forest in South Africa Diversity doi: 10.3390/d12020079 Authors: Situngu Barker Vetter Some plant species possess structures known as leaf domatia, which house mites. The association between domatia-bearing plants and mites has been proposed to be mutualistic, and has been found to be important in species of economic value, such as grapes, cotton, avocado...
Tue Feb 18, 2020 02:00
Diversity, Vol. 12, Pages 78: Green Fluorescence Patterns in Closely Related Symbiotic Species of Zanclea (Hydrozoa, Capitata) Diversity doi: 10.3390/d12020078 Authors: Maggioni Saponari Seveso Galli Schiavo Ostrovsky Montano Green fluorescence is a common phenomenon in marine invertebrates and is caused by green fluorescent proteins. Many hydrozoan species display fluorescence in their polyps and/or medusa stages, and in a few cases patterns of green fluorescence...
Tue Feb 18, 2020 02:00
Diversity, Vol. 12, Pages 77: Biological Invasions 2020 Horizon Diversity doi: 10.3390/d12020077 Authors: Elsa Bonnaud This special issue points to the necessity to continue actively working on biological invasions, as invasive species remain a main and global threat for biodiversity through a global homogenization process. This issue includes six research papers, covering a large range of taxa, studying new invasive processes and proposing innovative management solutions. The way forward...
Tue Feb 18, 2020 02:00
Diversity, Vol. 12, Pages 76: Systematic Review of the Roost-Site Characteristics of North American Forest Bats: Implications for Conservation Diversity doi: 10.3390/d12020076 Authors: Drake Gignoux-Wolfsohn Maslo Continued declines in North American bat populations can be largely attributed to habitat loss, disease, and wind turbines. These declines can be partially mitigated through actions that boost reproductive success; therefore, management aimed at promoting availability...
Tue Feb 18, 2020 02:00
Foods, Vol. 9, Pages 213: Assessment of Water Mobility in Surf Clam and Soy Protein System during Gelation Using LF-NMR Technique Foods doi: 10.3390/foods9020213 Authors: Siqi Wang Rong Lin Shasha Cheng Zhixiang Wang Mingqian Tan Water mobility and distribution of a dual-protein system of surf clam myofibrillar protein (MP) and soy protein (SP) was investigated by the nondestructive low field nuclear magnetic resonance (LF-NMR) technique. Four proton populations were found...
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Foods, Vol. 9, Pages 212: Quantification of Cheese Yield Reduction in Manufacturing Parmigiano Reggiano from Milk with Non-Compliant Somatic Cells Count Foods doi: 10.3390/foods9020212 Authors: Franceschi Faccia Malacarne Formaggioni Summer The mammary gland inflammation process is responsible for an increased number of somatic cells in milk, and transfers into the milk of some blood components; this causes alterations in the chemical composition and physico-chemical...
Tue Feb 18, 2020 02:00
Foods, Vol. 9, Pages 211: Freeze-Drying of Blueberries: Effects of Carbon Dioxide (CO2) Laser Perforation as Skin Pretreatment to Improve Mass Transfer, Primary Drying Time, and Quality Foods doi: 10.3390/foods9020211 Authors: Pablo Munzenmayer Jaime Ulloa Marlene Pinto Cristian Ramirez Pedro Valencia Ricardo Simpson Sergio Almonacid Freeze-dried berry fruits are generally consumed as they are, whole and without peeling or cutting, as the conservation of their original...
Tue Feb 18, 2020 02:00
Foods, Vol. 9, Pages 210: Using Chemometric Analyses for Tracing the Regional Origin of Multifloral Honeys of Montenegro Foods doi: 10.3390/foods9020210 Authors: Vesna Vukašinović-Pešić Nada Blagojević Snežana Brašanac-Vukanović Ana Savić Vladimir Pešić This is the first study of mineral content and basic physicochemical parameters of honeys of Montenegro. We examined honey samples from eight different micro-regions of Montenegro, and the results confirm that, with the exception...
Tue Feb 18, 2020 02:00
Foods, Vol. 9, Pages 209: Sensory Analysis in Assessing the Possibility of Using Ethanol Extracts of Spices to Develop New Meat Products Foods doi: 10.3390/foods9020209 Authors: Krystyna Szymandera-Buszka Katarzyna Waszkowiak Anna Jędrusek-Golińska Marzanna Hęś The food industry has endeavoured to move toward the direction of clean labelling. Therefore, replacing synthetic preservatives with natural plant extracts has gained significant importance. It is necessary to determine...
Tue Feb 18, 2020 02:00
Humanities, Vol. 9, Pages 21: The Open Constructed Public Sphere: Aeschylus’ The Suppliant Women in a Version by David Greig Humanities doi: 10.3390/h9010021 Authors: Rodríguez This article looks at the ‘public’ ‘place’ of drama in Britain at present by offering an analysis of a contemporary version of an ancient Greek play by Aeschylus, entitled The Suppliant Women, written by David Greig, directed by Ramin Gray, and first performed at the Royal...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1319: Investigation of the Interaction Mechanism of Perfluoroalkyl Carboxylic Acids with Human Serum Albumin by Spectroscopic Methods International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041319 Authors: Chen Wang Cai Yuan Wang Zhou Perfluoroalkyl carboxylic acids (PFCAs) are some of the most significant pollutants in human serum, and are reported to be potentially toxic to humans. In this study, the binding...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1318: Assessing Seasonality Variation with Harmonic Regression: Accommodations for Sharp Peaks International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041318 Authors: Ramanathan Thenmozhi George Anandan Veeraraghavan Naumova Jeyaseelan The use of the harmonic regression model is well accepted in the epidemiological and biostatistical communities as a standard procedure to examine seasonal patterns in disease...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1317: Effects of 8-Week Whole-Body Vibration Training on the HbA1c, Quality of Life, Physical Fitness, Body Composition and Foot Health Status in People with T2DM: A Double-Blinded Randomized Controlled Trial International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041317 Authors: Domínguez-Muñoz Villafaina García-Gordillo Hernández-Mocholi Collado-Mateo Adsuar Gusi The aim of this study was to analyze the...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1315: Living with Systematic Lupus Erythematosus: A Profile of Young Female Patients International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041315 Authors: Macejova Madarasova Geckova Husarova Zarikova Kotradyova The aim is to describe a profile of systemic lupus erythematosus (SLE) patient (socio-demographic data, course of disease, health status, and health care utilization, SLE impact on their life, SLE awareness)...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1314: Perceived Facilitators and Barriers to Nigerian Nurses’ Engagement in Health Promoting Behaviors: A Socio-Ecological Model Approach International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041314 Authors: Uchendu Windle Blake Nurses make up the single largest healthcare professional group in the Nigerian healthcare system. As frontline healthcare providers, they promote healthy lifestyles to patients and families. However,...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1316: Correction: Song, C.; Ikei, H.; Park, B.J.; Lee, J.; Kagawa, T.; Miyazaki, Y. Psychological Benefits of Walking through Forest Areas. Int. J. Environ. Res. Public Health 2018, 15, 2804 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041316 Authors: Song Ikei Park Lee Kagawa Miyazaki The authors wish to add the following corrections to their paper published in the International Journal of Environmental...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1312: Molecular Diversity of ESBL-Producing Escherichia coli from Foods of Animal Origin and Human Patients International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041312 Authors: Ángel Alegría Marta Arias-Temprano Isabel Fernández-Natal Jose M. Rodríguez-Calleja María-Luisa García-López Jesús A. Santos Dissemination of enterobacteria that produce extended spectrum β-lactamases (ESBL) throughout the food chain...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1313: Food System Transformation: Integrating a Political–Economy and Social–Ecological Approach to Regime Shifts International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041313 Authors: Laura M. Pereira Scott Drimie Kristi Maciejewski Patrick Bon Tonissen Reinette (Oonsie) Biggs Sustainably achieving the goal of global food security is one of the greatest challenges of the 21st century. The current food system is failing...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1303: A Horticultural Therapy Program Focused on Succulent Cultivation for the Vocational Rehabilitation Training of Individuals with Intellectual Disabilities International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041303 Authors: Joy Lee Park We aimed to develop a horticultural therapy program for the vocational rehabilitation of individuals with intellectual disabilities and examine its effects. Individuals with intellectual...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1308: Evolutionary Characteristics and Trade-Offs’ Development of Social–Ecological Production Landscapes in the Loess Plateau Region from a Resilience Point of View: A Case Study in Mizhi County, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041308 Authors: Zhang Chen Geng Liu Shi Social-ecological production landscape resilience (SELPR) is a significant representation of the continuous supply capacity...
Tue Feb 18, 2020 02:00
IJERPH, Vol. 17, Pages 1301: Socioeconomic Inequalities in Frailty in Hong Kong, China: A 14-Year Longitudinal Cohort Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041301 Authors: Yu Tong Leung Woo The prevalence of frailty varies among socioeconomic groups. However, longitudinal data for the association between subjective social status and frailty is limited. In this study, we examined whether subjective social status was...
Tue Feb 18, 2020 02:00
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