Antibiotics, Vol. 9, Pages 89: Staphylococcus aureus Epidemiology in Wildlife: A Systematic ReviewAntibiotics doi: 10.3390/antibiotics9020089Authors: Heaton Gerbig Sensius Patel SmithStaphylococcus aureus is a common bacterial colonizer of humans and a variety of animal species. Many strains have zoonotic potential, moving between humans and animals, including livestock, pets, and wildlife. We examined publications reporting on S. aureus presence in a variety of wildlife species in order to more...
Tue Feb 18, 2020 02:00
Antibiotics, Vol. 9, Pages 90: Metal Complexes, an Untapped Source of Antibiotic Potential?Antibiotics doi: 10.3390/antibiotics9020090Authors: FreiWith the widespread rise of antimicrobial resistance, most traditional sources for new drug compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal complexes have long had only a niche presence in the medicinal chemistry landscape, despite some compounds, such as the anticancer drug cisplatin, having had a profound impact...
Tue Feb 18, 2020 02:00
Antioxidants, Vol. 9, Pages 169: Phenolic and Anthocyanin Compounds and Antioxidant Activity of Tamarillo (Solanum betaceum Cav.) Antioxidants doi: 10.3390/antiox9020169 Authors: Diep Pook Yoo This study examined phenolics and anthocyanins present in Amber, Laird’s Large and Mulligan cultivars of tamarillo that were cultivated in -Whangarei, Northland of New Zealand. Samples were further separated by their tissue types, peel and pulp. Using LC-MS/MS, twelve polyphenols...
Tue Feb 18, 2020 02:00
Antioxidants, Vol. 9, Pages 166: Cytotoxic, Antimicrobial, Antioxidant Properties and Effects on Cell Migration of Phenolic Compounds of Selected Transylvanian Medicinal Plants Antioxidants doi: 10.3390/antiox9020166 Authors: Rita Csepregi Viktória Temesfői Sourav Das Ágnes Alberti Csenge Anna Tóth Róbert Herczeg Nóra Papp Tamás Kőszegi Medicinal plants are widely used in folk medicine but quite often their composition and biological effects are hardly known. Our...
Tue Feb 18, 2020 02:00
Antioxidants, Vol. 9, Pages 167: Cocoa Flavonoids Reduce Inflammation and Oxidative Stress in a Myocardial Ischemia-Reperfusion Experimental Model Antioxidants doi: 10.3390/antiox9020167 Authors: Ahmed Ahmed Rungatscher Linardi Kulsoom Innamorati Meo Gebrie Mani Merigo Guzzo Faggian : Consumption of flavonoid-rich nutraceuticals has been associated with a reduction in coronary events. The present study analyzed the effects of cocoa flavonols...
Tue Feb 18, 2020 02:00
Antioxidants, Vol. 9, Pages 165: Plant Phenolics and Phenolic-Enriched Extracts as Antimicrobial Agents against Food-Contaminating Microorganisms Antioxidants doi: 10.3390/antiox9020165 Authors: Takó Kerekes Zambrano Kotogán Papp Krisch Vágvölgyi Phenolic compounds and extracts with bioactive properties can be obtained from many kinds of plant materials. These natural substances have gained attention in the food research as possible growth inhibitors of foodborne...
Tue Feb 18, 2020 02:00
Antioxidants, Vol. 9, Pages 168: Multidirectional Pharma-Toxicological Study on Harpagophytum procumbens DC. ex Meisn.: An IBD-Focused Investigation Antioxidants doi: 10.3390/antiox9020168 Authors: Recinella Chiavaroli Ronci Menghini Brunetti Leone Tirillini Angelini Covino Venanzoni Zengin Di Simone Ciferri di Giacomo Cataldi Rapino Valerio Orlando Ferrante In the present study, we investigated the water extract...
Tue Feb 18, 2020 02:00
Arts, Vol. 9, Pages 25: De Modo Qualiter Reges Aragonum Coronabuntur. Visual, Material and Textual Evidence during the Middle Ages Arts doi: 10.3390/arts9010025 Authors: Marta Serrano-Coll The aim of this study is to analyze the coronation ceremonies carried out in the Crown of Aragon throughout the Middle Ages. Although the pope granted most Western monarchies the right to hold these ceremonies in their own kingdoms in 1204, our study will address the mechanisms used to appoint kings...
Tue Feb 18, 2020 02:00
Atmosphere, Vol. 11, Pages 210: The Influences of Tropical Volcanic Eruptions with Different Magnitudes on Persistent Droughts over Eastern China Atmosphere doi: 10.3390/atmos11020210 Authors: Chen Ning Liu Liu Sun Yan Liu Qin Xue In this study, the influences on persistent droughts over Eastern China from tropical volcanic eruptions with three categories of magnitudes, i.e., 25 Tg, 50 Tg, and 100 Tg, were investigated through three groups of volcanic...
Tue Feb 18, 2020 02:00
Atmosphere, Vol. 11, Pages 209: Contribution of Satellite-Derived Aerosol Optical Depth PM2.5 Bayesian Concentration Surfaces to Respiratory-Cardiovascular Chronic Disease Hospitalizations in Baltimore, Maryland Atmosphere doi: 10.3390/atmos11020209 Authors: John T. Braggio Eric S. Hall Stephanie A. Weber Amy K. Huff The fine particulate matter baseline (PMB), which includes PM2.5 monitor readings fused with Community Multiscale Air Quality (CMAQ) model predictions, using the...
Tue Feb 18, 2020 02:00
Atmosphere, Vol. 11, Pages 208: The Rise of Climate-Driven Sediment Discharge in the Amazonian River Basin Atmosphere doi: 10.3390/atmos11020208 Authors: Nazzareno Diodato Naziano Filizola Pasquale Borrelli Panos Panagos Gianni Bellocchi The occurrence of hydrological extremes in the Amazon region and the associated sediment loss during rainfall events are key features in the global climate system. Climate extremes alter the sediment and carbon balance but the ecological...
Tue Feb 18, 2020 02:00
Bioengineering, Vol. 7, Pages 17: Recapitulating the Vasculature Using Organ-On-Chip Technology Bioengineering doi: 10.3390/bioengineering7010017 Authors: Andreas M.A.O. Pollet Jaap M.J. den Toonder The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly,...
Tue Feb 18, 2020 02:00
Biology, Vol. 9, Pages 34: Extracellular Traps: An Ancient Weapon of Multiple Kingdoms Biology doi: 10.3390/biology9020034 Authors: Neumann Brogden von Köckritz-Blickwede The discovery, in 2004, of extracellular traps released by neutrophils has extended our understanding of the mode of action of various innate immune cells. This fascinating discovery demonstrated the extracellular trapping and killing of various pathogens by neutrophils. During the last decade, evidence has...
Tue Feb 18, 2020 02:00
Biomedicines, Vol. 8, Pages 35: 5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer Biomedicines doi: 10.3390/biomedicines8020035 Authors: Armentano Curcio Brindisi Mancuso Rago Ziccarelli Frattaruolo Fiorillo Dolce Gabriele Cappello Oxazolidinones are antibiotics that inhibit protein synthesis by binding the...
Tue Feb 18, 2020 02:00
Biomedicines, Vol. 8, Pages 34: Rostral Anterior Cingulate Thickness Predicts the Emotional Psilocybin Experience Biomedicines doi: 10.3390/biomedicines8020034 Authors: Candace R. Lewis Katrin H. Preller B. Blair Braden Cory Riecken Franz X. Vollenweider Psilocybin is the psychoactive compound of mushrooms in the psilocybe species. Psilocybin directly affects a number of serotonin receptors, with highest affinity for the serotonin 2A receptor (5HT-2Ar). Generally, the effects...
Tue Feb 18, 2020 02:00
Biomolecules, Vol. 10, Pages 326: Reduced Local Response to Corticosteroids in Eosinophilic Chronic Rhinosinusitis with Asthma Biomolecules doi: 10.3390/biom10020326 Authors: Kobayashi Kanda Yun Dan Van Suzuki Sawada Asako Iwai Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is recognized as a refractory eosinophilic disorder characterized by both upper and lower airway inflammation. In some severe cases,...
Tue Feb 18, 2020 02:00
Biomolecules, Vol. 10, Pages 327: Characterization of the CRM Gene Family and Elucidating the Function of OsCFM2 in Rice Biomolecules doi: 10.3390/biom10020327 Authors: Zhang Shen Ren Hu Zhu Gao Zhang Guo Zeng Qian The chloroplast RNA splicing and ribosome maturation (CRM) domain-containing proteins regulate the expression of chloroplast or mitochondrial genes that influence plant growth and development. Although 14 CRM domain proteins have previously...
Tue Feb 18, 2020 02:00
Biomolecules, Vol. 10, Pages 325: Current Advances in Allosteric Modulation of Muscarinic Receptors Biomolecules doi: 10.3390/biom10020325 Authors: Jakubik El-Fakahany Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated from the orthosteric binding site for the endogenous neurotransmitter. Allosteric modulators modulate the binding affinity, potency, and efficacy of orthosteric ligands. Muscarinic acetylcholine receptors are prototypical...
Tue Feb 18, 2020 02:00
Biomolecules, Vol. 10, Pages 324: 2α-Hydroxyeudesma-4,11(13)-Dien-8β,12-Olide Isolated from Inula britannica Induces Apoptosis in Diffuse Large B-cell Lymphoma Cells Biomolecules doi: 10.3390/biom10020324 Authors: Jang Lee Shin Yoo 2α-Hydroxyeudesma-4,11(13)-dien-8β,12-olide (HEDO), a eudesmane-type sesquiterpene lactone belonging to large group of plant terpenoids isolated from Inula britannica, displays cytotoxic activity against diffuse large B cell...
Tue Feb 18, 2020 02:00
Biomolecules, Vol. 10, Pages 323: Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors Biomolecules doi: 10.3390/biom10020323 Authors: Zaorska Tomasova Koszelewski Ostaszewski Ufnal Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early clinical studies. For...
Tue Feb 18, 2020 02:00
Biomolecules, Vol. 10, Pages 322: Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast Biomolecules doi: 10.3390/biom10020322 Authors: Pollo-Oliveira Klassen Davis Ciftci Bacusmo Martinelli DeMott Begley Dedon Schaffrath de Crécy-Lagard Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl...
Tue Feb 18, 2020 02:00
Brain Sciences, Vol. 10, Pages 110: Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity Brain Sciences doi: 10.3390/brainsci10020110 Authors: Leonardo Lorente María M. Martín Antonia Pérez-Cejas Agustín F. González-Rivero Pedro Abreu-González Luis Ramos Mónica Argueso Jordi Solé-Violán Juan J. Cáceres Alejandro Jiménez Victor García-Marín Objective: Oxidation is involved in secondary brain injury after traumatic brain injury (TBI)....
Tue Feb 18, 2020 02:00
Brain Sciences, Vol. 10, Pages 109: Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes Brain Sciences doi: 10.3390/brainsci10020109 Authors: Pozhidayeva Farris Goeke Firsick Townsley Guizzetti Ozburn Binge drinking is a dangerous pattern of behavior. We tested whether chronically manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide...
Tue Feb 18, 2020 02:00
Brain Sciences, Vol. 10, Pages 108: Early Screening of the Autism Spectrum Disorders: Validity Properties and Cross-Cultural Generalizability of the First Year Inventory in Italy Brain Sciences doi: 10.3390/brainsci10020108 Authors: Levante Petrocchi Massagli Filograna De Giorgi Lecciso This study examined the cross-cultural generalisability of the First Year Inventory (FYI) on an Italian sample, testing its construct validity, consistency, and structural validity....
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 476: Plasma-activated Ringer’s Lactate Solution Displays a Selective Cytotoxic Effect on Ovarian Cancer Cells Cancers doi: 10.3390/cancers12020476 Authors: Bisag Bucci Coluccelli Girolimetti Laurita De Iaco Perrone Gherardi Marchio Porcelli Colombo Gasparre Epithelial Ovarian Cancer (EOC) is one of the leading causes of cancer-related deaths among women and is characterized by the diffusion of nodules or plaques from...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 477: Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study Cancers doi: 10.3390/cancers12020477 Authors: Cunha Rola Taktak Eleuteri Kalirai Heimann Hussain Bonnett Hill Traynor Jager Marinkovic Luyten Dogrusöz Kilic de Klein Smit van Poppelen Damato Afshar Guthoff Scheef Kakkassery Saakyan Tsygankov Mosci Ligorio...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 470: Transcriptome Analysis Identifies ALCAM Overexpression as a Prognosis Biomarker in Laryngeal Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12020470 Authors: Nicolau-Neto de Souza-Santos Severo Ramundo Valverde Martins Santos Dias de Almeida Simão Ribeiro Pinto Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most incident tumors in the world, especially in developing countries, such as Brazil. Different...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 471: Association of TGF-β1 Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case–Control Studies † Cancers doi: 10.3390/cancers12020471 Authors: Krishna Jana Panda Horne Awasthi Salgia Singhal Reports on the association of TGF-β1 polymorphisms with breast cancer (BC) have been conflicting, inconsistent, inconclusive, and controversial. PubMed, EMBASE, and Google Scholar were used to identify studies on TGF-β1...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 473: Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control Study Cancers doi: 10.3390/cancers12020473 Authors: Tiako Meyo Jouinot Giroux-Leprieur Fabre Wislez Alifano Leroy Boudou-Rouquette Tlemsani Khoudour Arrondeau Thomas-Schoemann Blons Mansuet-Lupo Damotte Vidal Goldwasser Alexandre Blanchet A...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 472: Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12020472 Authors: Kamimura Yokoo Abe Sakai Nagoya Kobayashi Ohtsuka Miura Sakamaki Kamimura Miyamura Nishina Terai Hepatocellular carcinoma (HCC) is a major global malignancy, responsible for >90% of primary liver cancers. Currently available therapeutic options have poor performances due to the highly...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 478: Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy Cancers doi: 10.3390/cancers12020478 Authors: Hiroshi Tazawa Joe Hasei Shuya Yano Shunsuke Kagawa Toshifumi Ozaki Toshiyoshi Fujiwara Adenovirus serotype 5 (Ad5) is widely and frequently used as a virus vector in cancer gene therapy and oncolytic virotherapy. Oncolytic virotherapy is a novel antitumor treatment for inducing lytic cell death in tumor cells...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 475: Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses Cancers doi: 10.3390/cancers12020475 Authors: Patricia Dubot Leonardo Astudillo Nicole Therville Frédérique Sabourdy Jérôme Stirnemann Thierry Levade Nathalie Andrieu-Abadie The roles of ceramide and its catabolites, i.e., sphingosine and sphingosine 1-phosphate, in the development of malignancies and the...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 474: Biological Features and Prognostic Impact of Bone Marrow Infiltration in Patients with Diffuse Large B-Cell Lymphoma Cancers doi: 10.3390/cancers12020474 Authors: Alonso-Álvarez Alcoceba García-Álvarez Blanco Rodríguez Baile Caballero Dávila Vidriales Esteban Arias Díaz Tamayo Caballero Gutiérrez González Martín The biology and clinical impact of bone marrow (BM) infiltration in patients with...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 469: Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids Cancers doi: 10.3390/cancers12020469 Authors: Ali Nowrouzi Mathieu G. Sertorio Mahdi Akbarpour Maximillian Knoll Damir Krunic Matthew Kuhar Christian Schwager Stephan Brons Jürgen Debus Susanne I. Wells James M. Wells Amir Abdollahi Radiation-induced normal...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 468: A Comprehensive Analysis of FUT8 Overexpressing Prostate Cancer Cells Reveals the Role of EGFR in Castration Resistance Cancers doi: 10.3390/cancers12020468 Authors: Naseruddin Höti Tung-Shing Lih Jianbo Pan Yangying Zhou Ganglong Yang Ashely Deng Lijun Chen Mingmimg Dong Ruey-Bing Yang Cheng-Fen Tu Michael C. Haffner Qing Kay Li Hui Zhang The emergence of castration-resistance is one of the major challenges in the management...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 467: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining Cancers doi: 10.3390/cancers12020467 Authors: Schötz Balzer Brandt Ziemann Subtil Rieckmann Köcher Engenhart-Cabillic Dikomey Wittig Arenz The PI3K/Akt/mTOR pathway is frequently altered in human papillomavirus (HPV)-positive...
Tue Feb 18, 2020 02:00
Cancers, Vol. 12, Pages 466: Venetoclax, a BCL-2 Inhibitor, Enhances the Efficacy of Chemotherapeutic Agents in Wild-Type ABCG2-Overexpression-Mediated MDR Cancer Cells Cancers doi: 10.3390/cancers12020466 Authors: Wang Li Teng Lei Ji Cui Zeng Pan Yang Chen Previous studies have shown that small-molecule BCL-2 inhibitors can have a synergistic interaction with ABCG2 substrates in chemotherapy. Venetoclax is a potent and selective BCL-2 inhibitor,...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 473: Metabolic Reprogramming of Host Cells in Response to Enteroviral Infection
Cells, Vol. 9, Pages 473: Metabolic Reprogramming of Host Cells in Response to Enteroviral Infection Cells doi: 10.3390/cells9020473 Authors: Cheng Chien Lai Li Lin Ho Enterovirus 71 (EV71) infection is an endemic disease in Southeast Asia and China. We have previously shown that EV71 virus causes functional changes in mitochondria. It is speculative whether EV71 virus alters the host cell metabolism to its own benefit. Using a metabolomics approach, we demonstrate...
Tue Feb 18, 2020 02:00
Cells, Vol. 9, Pages 474: RNA-Guided Genomic Localization of H2A.L.2 Histone Variant Cells doi: 10.3390/cells9020474 Authors: Hoghoughi Barral Curtet Chuffart Charbonnier Puthier Buchou Rousseaux Khochbin The molecular basis of residual histone retention after the nearly genome-wide histone-to-protamine replacement during late spermatogenesis is a critical and open question. Our previous investigations showed that in postmeiotic male germ cells, the genome-scale...
Tue Feb 18, 2020 02:00
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