Cancers, Vol. 12, Pages 457: Cold Atmospheric Plasma and Gold Quantum Dots Exert Dual Cytotoxicity Mediated by the Cell Receptor-Activated Apoptotic Pathway in Glioblastoma Cells Cancers doi: 10.3390/cancers12020457 Authors: Nagendra Kumar Kaushik Neha Kaushik Rizwan Wahab Pradeep Bhartiya Nguyen Nhat Linh Farheen Khan Abdulaziz A. Al-Khedhairy Eun Ha Choi Brain cancer malignancies represent an immense challenge for research and clinical oncology. Glioblastoma is...
Sun Feb 16, 2020 02:00
Cancers, Vol. 12, Pages 456: An Epitope on EGFR Loading Catastrophic Internalization Serve as a Novel Oncotarget for Hepatocellular Carcinoma Therapy Cancers doi: 10.3390/cancers12020456 Authors: Dianshuai Huang Qingjie Fan Zhiyi Liu Shuqin Zhang Wei Huang Hongrui Li Chongyang Liang Fei Sun The precise role of Epidermal Growth Factor Receptor (EGFR) in Hepatocellular carcinoma (HCC) cells is unknown and EGFR inhibitors have not achieved positive clinical results....
Sun Feb 16, 2020 02:00
Cancers, Vol. 12, Pages 455: Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines Cancers doi: 10.3390/cancers12020455 Authors: Susann Weißbach Sofia Catalina Heredia-Guerrero Stefanie Barnsteiner Lukas Großhans Jochen Bodem Hanna Starz Christian Langer Silke Appenzeller Stefan Knop Torsten Steinbrunn Simone Rost Hermann Einsele Ralf Christian Bargou Andreas Rosenwald Thorsten Stühmer Ellen Leich ...
Sun Feb 16, 2020 02:00
Cancers, Vol. 12, Pages 454: Bioactive Phenolic Compounds in the Modulation of Central and Peripheral Nervous System Cancers: Facts and Misdeeds Cancers doi: 10.3390/cancers12020454 Authors: Lorena Perrone Simone Sampaolo Mariarosa Anna Beatrice Melone Efficacious therapies are not available for the cure of both gliomas and glioneuronal tumors, which represent the most numerous and heterogeneous primary cancers of the central nervous system (CNS), and for neoplasms of the peripheral...
Sat Feb 15, 2020 02:00
Cancers, Vol. 12, Pages 447: Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation Cancers doi: 10.3390/cancers12020447 Authors: Zwergel Fioravanti Stazi Sarno Battistelli Romanelli Nebbioso Mendes Paulo Strippoli Tripodi Pechalrieu Arimondo De Luca Del Bufalo Trisciuoglio Altucci Valente Mai DNA methyltransferases (DNMTs) play a relevant role in epigenetic...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 449: Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma Cancers doi: 10.3390/cancers12020449 Authors: Raimondo Urzì Conigliaro Bosco Parisi Carlisi Siragusa Raimondi Luca Giavaresi Alessandro Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 452: Identification of an Upper Limit of Tumor Burden for Downstaging in Candidates with Hepatocellular Cancer Waiting for Liver Transplantation: A West–East Collaborative Effort Cancers doi: 10.3390/cancers12020452 Authors: Lai Vitale Halazun Iesari Viveiros Bhangui Mennini Wong Uemoto Lin Mittler Ikegami Zhe Zheng Soejima Hoppe-Lotichius Chen Kaido Lo Rossi Soin Finkenstedt Emond...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 451: Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma Cancers doi: 10.3390/cancers12020451 Authors: Schiffmann Loeser Jacob Maus Fuchs Zhao Tharun Essakly Iannos Damanakis Zander Büttner Schröder Bruns Quaas Gebauer Dickkopf-2 (DKK2) has been described as Wnt/beta-catenin pathway antagonist and its expression is mediated by micro RNA-221 (miRNA-221). So far, there...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 448: Impact of Age-Related Genetic Differences on the Therapeutic Outcome of Papillary Thyroid Cancer Cancers doi: 10.3390/cancers12020448 Authors: Seok-Mo Kim Soo Young Kim Cheong Soo Park Hang-Seok Chang Ki Cheong Park The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide. PTC is the most common type of differentiated thyroid cancer and usually shows good prognosis. However, some PTC is driven to advanced stage by epithelial-mesenchymal...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 450: The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease Cancers doi: 10.3390/cancers12020450 Authors: Ferraiuolo Manthey Stanton Triplett Wagner The multidomain protein encoded by the Tumor Susceptibility Gene 101 (TSG101) is ubiquitously expressed and is suggested to function in diverse intracellular processes. In this review, we provide a succinct overview of the main structural features of...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 446: Accelerated Partial Breast Irradiation: Macrophage Polarisation Shift Classification Identifies High-Risk Tumours in Early Hormone Receptor-Positive Breast Cancer Cancers doi: 10.3390/cancers12020446 Authors: Sören Schnellhardt Ramona Erber Maike Büttner-Herold Marie-Charlotte Rosahl Oliver J. Ott Vratislav Strnad Matthias W. Beckmann Lillian King Arndt Hartmann Rainer Fietkau Luitpold Distel Studies have demonstrated correlations...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 453: A ”Clickable” Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT Cancers doi: 10.3390/cancers12020453 Authors: Raghavan Baskin Sharpe Various pathways can repair DNA alkylation by chemotherapeutic agents such as temozolomide (TMZ). The enzyme O6-methylguanine methyltransferase (MGMT) removes O6-methylated DNA adducts, leading to the failure of chemotherapy in resistant glioblastomas. Because of the anti-chemotherapeutic...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 445: Epigenetics of SFRP1: The Dual Roles in Human Cancers Cancers doi: 10.3390/cancers12020445 Authors: Rashidah Baharudin Francis Yew Fu Tieng Learn-Han Lee Nurul Syakima Ab Mutalib Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to the loss of expression in various human cancers, which is mainly attributed by epigenetic inactivation...
Fri Feb 14, 2020 02:00
Cancers, Vol. 12, Pages 444: Novel Breast Cancer Brain Metastasis Patient-Derived Orthotopic Xenograft Model for Preclinical Studies Cancers doi: 10.3390/cancers12020444 Authors: Masanori Oshi Maiko Okano Aparna Maiti Omar M. Rashid Katsuharu Saito Koji Kono Ryusei Matsuyama Itaru Endo Kazuaki Takabe The vast majority of mortality in breast cancer results from distant metastasis. Brain metastases occur in as many as 30% of patients with advanced breast cancer,...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 449: MEG3 Promotes Differentiation of Porcine Satellite Cells by Sponging miR-423-5p to Relieve Inhibiting Effect on SRF Cells doi: 10.3390/cells9020449 Authors: Xiaofang Cheng Long Li Gaoli Shi Lin Chen Chengchi Fang Mengxun Li Changchun Li Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5′-...
Sat Feb 15, 2020 02:00
Cells, Vol. 9, Pages 448: A System Based-Approach to Examine Host Response during Infection with Influenza A Virus Subtype H7N9 in Human and Avian Cells Cells doi: 10.3390/cells9020448 Authors: Biruhalem Taye Hui Chen Dawn Su-Yin Yeo Shirley Gek-Kheng Seah Michelle Su-Yen Wong Richard J Sugrue Boon-Huan Tan Although the influenza A virus H7N9 subtype circulates within several avian species, it can also infect humans with a severe disease outcome. To better understand...
Sat Feb 15, 2020 02:00
Cells, Vol. 9, Pages 447: Interaction of the Anti-Proliferative GPER Inverse Agonist ERα17p with the Breast Cancer Cell Plasma Membrane: From Biophysics to Biology Cells doi: 10.3390/cells9020447 Authors: Michaël Trichet Rosamaria Lappano Mathilde Belnou Lilian Shadai Salazar Vazquez Isabel Alves Delphine Ravault Sandrine Sagan Lucie Khemtemourian Marcello Maggiolini Yves Jacquot The peptide ERα17p, which corresponds to the 295-311 fragment of the...
Sat Feb 15, 2020 02:00
Cells, Vol. 9, Pages 446: A Systematic Review on the Implications of O-linked Glycan Branching and Truncating Enzymes on Cancer Progression and Metastasis Cells doi: 10.3390/cells9020446 Authors: Gupta Leon Rauth Batra Ponnusamy Glycosylation is the most commonly occurring post-translational modifications, and is believed to modify over 50% of all proteins. The process of glycan modification is directed by different glycosyltransferases, depending on the cell in which...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 445: Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2 Cells doi: 10.3390/cells9020445 Authors: Ding Jin Wang Liu Kalds Wang Yang Wang Chen MicroRNAs play key roles during ovary development, with emerging evidence suggesting that miR-202-5p is specifically expressed in female animal gonads. Granulosa cells (GCs) are somatic cells that are closely related to...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 441: Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy Cells doi: 10.3390/cells9020441 Authors: Torrente Bella Tripodi Villa Farini The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2). IGF2/IGF2R interaction influences cell growth, survival, and...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 443: Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity Cells doi: 10.3390/cells9020443 Authors: Pajuelo Reguera Čunátová Vrbacký Pecinová Houštěk Mráček Pecina Cytochrome c oxidase (COX) is regulated through tissue-, development- or environment-controlled expression of subunit isoforms. The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 442: PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma Cells doi: 10.3390/cells9020442 Authors: D’Ambrosio Erriquez Arigoni Capellero Mittica Ghisoni Borella Katsaros Privitera Ribotta Maldi Di Nardo Berrino Venesio Ponzone Vaira Hall Jimenez-Linan Paterson Calogero Brenton Valabrega Di Renzo Olivero Identifying cancer drivers and actionable mutations...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 444: Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia Cells doi: 10.3390/cells9020444 Authors: Butt Stempfle Lister Wolf Kraft Herrmann Viciano Weber Hochhaus Ernst Hoffmann Zernecke Frietsch The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor 4 (CXCR4), and both proteins play a central role in the modulation...
Fri Feb 14, 2020 02:00
Cells, Vol. 9, Pages 440: Impact of JNK and Its Substrates on Dendritic Spine Morphology Cells doi: 10.3390/cells9020440 Authors: Emilia Komulainen Artemis Varidaki Natalia Kulesskaya Hasan Mohammad Christel Sourander Heikki Rauvala Eleanor T. Coffey The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins. JNK1 also phosphorylates dendritic spine proteins,...
Fri Feb 14, 2020 02:00
Clean Technol., Vol. 2, Pages 91-115: Lignocellulosic Biomass Mild Alkaline Fractionation and Resulting Extract Purification Processes: Conditions, Yields, and Purities Clean Technologies doi: 10.3390/cleantechnol2010007 Authors: Oriez Peydecastaing Pontalier Fractionation of lignocellulose is a fundamental step in the valorization of cellulose, hemicelluloses, and lignin to produce various sustainable fuels, materials and chemicals. Strong alkaline fractionation is one of the...
Fri Feb 14, 2020 02:00
Climate, Vol. 8, Pages 33: Preservation of Distemper Painting: Indoor Monitoring Tools for Risk Assessment and Decision Making in Kvernes Stave Church Climate doi: 10.3390/cli8020033 Authors: Olstad Ørnhøi Jernæs de Ferri Freeman Bertolin During the Medieval period, over 1000 stave churches were thought to have been constructed in Norway. However, currently, only 28 of these churches remain and only 19 still have distemper wall paintings. The cultural significance...
Fri Feb 14, 2020 02:00
Dentistry Journal, Vol. 8, Pages 19: Management of a Facilitated Aesthetic Orthodontic Treatment with Clear Aligners and Minimally Invasive Corticotomy Dentistry Journal doi: 10.3390/dj8010019 Authors: Silvia Caruso Atanaz Darvizeh Stefano Zema Roberto Gatto Alessandro Nota Accelerating orthodontic tooth movement has become a topical issue and the corticotomy seems to be the only effective and safe technique reported in the literature. Simultaneously, aesthetic orthodontic...
Sat Feb 15, 2020 02:00
Dentistry Journal, Vol. 8, Pages 18: CD163+ Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study Dentistry Journal doi: 10.3390/dj8010018 Authors: Shigeoka Koma Kodama Nishio Akashi Yokozaki Oral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae....
Fri Feb 14, 2020 02:00
Diagnostics, Vol. 10, Pages 107: Role of pH Value in Clinically Relevant Diagnosis Diagnostics doi: 10.3390/diagnostics10020107 Authors: Kuo Shen Shen Cheng As a highly influential physiological factor, pH may be leveraged as a tool to diagnose physiological state. It may be especially suitable for diagnosing and assessing skin structure and wound status. Multiple innovative and elegant smart wound dressings combined with either pH sensors or drug control-released carriers...
Sun Feb 16, 2020 02:00
Diagnostics, Vol. 10, Pages 106: Accuracy in Referrals to Gynecologic Oncologists Based on Clinical Presentation for Ovarian Mass Diagnostics doi: 10.3390/diagnostics10020106 Authors: Katherine Jane C. Chua Ricky D. Patel Radhika Trivedi Patricia Greenberg Kyle Beiter Thomas Magliaro Ushma Patel Joyce Varughese Ovarian cancer is one of the most lethal gynecological cancers in women due to late diagnosis. Despite technological advancements, experienced physicians...
Sun Feb 16, 2020 02:00
Diagnostics, Vol. 10, Pages 105: Long-Term Follow-up Posthematopoietic Stem Cell Transplantation in a Japanese Patient with Type-VII Mucopolysaccharidosis Diagnostics doi: 10.3390/diagnostics10020105 Authors: Kenji Orii Yasuyuki Suzuki Shunji Tomatsu Tadao Orii Toshiyuki Fukao The effectiveness of hematopoietic stem cell transplantation (HSCT) for type-VII mucopolysaccharidosis (MPS VII, Sly syndrome) remains controversial, although recent studies have shown that it has a...
Sun Feb 16, 2020 02:00
Diagnostics, Vol. 10, Pages 104: Microsatellite Instability and MMR Genes Abnormalities in Canine Mammary Gland Tumors Diagnostics doi: 10.3390/diagnostics10020104 Authors: Khand Yao Hao Wu Kamboh Yang Early diagnosis of mammary gland tumors is a challenging task in animals, especially in unspayed dogs. Hence, this study investigated the role of microsatellite instability (MSI), MMR gene mRNA transcript levels and SNPs of MMR genes in canine mammary gland tumors...
Fri Feb 14, 2020 02:00
Diagnostics, Vol. 10, Pages 103: Breast Cancer Detection—A Synopsis of Conventional Modalities and the Potential Role of Microwave Imaging Diagnostics doi: 10.3390/diagnostics10020103 Authors: Brian M. Moloney Declan O’Loughlin Sami Abd Elwahab Michael J. Kerin Global statistics have demonstrated that breast cancer is the most frequently diagnosed invasive cancer and the leading cause of cancer death among female patients. Survival following a diagnosis of breast cancer is grossly...
Fri Feb 14, 2020 02:00
Diversity, Vol. 12, Pages 75: Structure of Rhodolith Beds and Surrounding Habitats at the Doce River Shelf (Brazil) Diversity doi: 10.3390/d12020075 Authors: Vitória L. Holz Ricardo G. Bahia Cláudia S. Karez Fernanda V. Vieira Fernando C. Moraes Nicholas F. Vale Daniela B. Sudatti Leonardo T. Salgado Rodrigo L. Moura Gilberto M. Amado-Filho Alex C. Bastos The world’s largest rhodolith beds have been reported from the Brazilian continental shelf....
Sat Feb 15, 2020 02:00
EJIHPE, Vol. 10, Pages 441-454: Exploring Issues and Challenges of Leadership among Early Career Doctors in Nigeria Using a Mixed-Method Approach: CHARTING Study European Journal of Investigation in Health, Psychology and Education doi: 10.3390/ejihpe10010033 Authors: Isibor Kanmodi Adebayo Olaopa Igbokwe Adufe Oduyemi Adeniyi Oiwoh Omololu Egbuchulem Kpuduwei Efuntoye Egwu Ogunsuji Grillo Babalola (1) Background: leadership...
Fri Feb 14, 2020 02:00
EJIHPE, Vol. 10, Pages 455-468: Leadership and Conflict Management Style are Associated with the Effectiveness of School Conflict Management in the Region of Epirus, NW Greece European Journal of Investigation in Health, Psychology and Education doi: 10.3390/ejihpe10010034 Authors: Chandolia Anastasiou There are few options available for school managers who wish to effectively tackle school conflicts. The aim of the present work was to assess the issue of school conflict, its sources,...
Fri Feb 14, 2020 02:00
Fermentation, Vol. 6, Pages 27: Optimization of β-galactosidase Production by Batch Cultures of Lactobacillus leichmannii 313 (ATCC 7830™) Fermentation doi: 10.3390/fermentation6010027 Authors: Yongjin Deng Min Xu Dawei Ji Dominic Agyei The endoenzyme β-galactosidase (β-d-galactoside galactohydrolase; EC 3.2.1.23) has been used at industrial scales for the preparation of lactose-free milk and for the conversion of lactose to galacto-oligosaccharides (GOS) prebiotics....
Sat Feb 15, 2020 02:00
Fermentation, Vol. 6, Pages 26: Robotic Cell Printing for Constructing Living Yeast Cell Microarrays in Microfluidic Chips Fermentation doi: 10.3390/fermentation6010026 Authors: Yvanoff Torino Willaert Living cell microarrays in microfluidic chips allow the non-invasive multiplexed molecular analysis of single cells. Here, we developed a simple and affordable perfusion microfluidic chip containing a living yeast cell array composed of a population of cell variants (green fluorescent...
Fri Feb 14, 2020 02:00
Foods, Vol. 9, Pages 205: Unique Distribution of Diacyl-, Alkylacyl-, and Alkenylacyl-Phosphatidylcholine Species Visualized in Pork Chop Tissues by Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging Foods doi: 10.3390/foods9020205 Authors: Hirofumi Enomoto Tomohiro Furukawa Shiro Takeda Hajime Hatta Nobuhiro Zaima Phosphatidylcholine (PC) is the major phospholipid in meat and influences meat qualities, such as healthiness. PC is classified into three groups...
Sun Feb 16, 2020 02:00
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