Antioxidants, Vol. 9, Pages 163: Biopotential of Bersama abyssinica Fresen Stem Bark Extracts: UHPLC Profiles, Antioxidant, Enzyme Inhibitory, and Antiproliferative Propensities Antioxidants doi: 10.3390/antiox9020163 Authors: Sinan Chiavaroli Orlando Bene Zengin Cziáky Jekő Mahomoodally Picot-Allain Menghini Recinella Brunetti Leone Ciferri Simone Ferrante In this study, ethyl acetate, methanol, and water extracts of Bersama...
Mon Feb 17, 2020 02:00
Antioxidants, Vol. 9, Pages 164: Digestive Stability and Bioaccessibility of Antioxidants in Prickly Pear Fruits from the Canary Islands: Healthy Foods and Ingredients Antioxidants doi: 10.3390/antiox9020164 Authors: Gómez-Maqueo Antunes-Ricardo Welti-Chanes Cano Although prickly pear fruits have become an important part of the Canary diet, their native varieties are yet to be characterized in terms of betalains and phenolic compounds. To exert potential health benefits,...
Mon Feb 17, 2020 02:00
Antioxidants, Vol. 9, Pages 162: Transcriptomic Analysis Reveals Cu/Zn SODs Acting as Hub Genes of SODs in Hylocereus undatus Induced by Trypsin during Storage Antioxidants doi: 10.3390/antiox9020162 Authors: Pang Li Liu Cai Li Li It has been revealed by us that superoxide scavenging is a new activity of trypsin. In this study, the synergistic mechanisms of trypsin and superoxide dismutases (SODs) were evaluated in Hylocereus undatus (pitaya). Trypsin significantly...
Mon Feb 17, 2020 02:00
Antioxidants, Vol. 9, Pages 161: CsCYT75B1, a Citrus CYTOCHROME P450 Gene, Is Involved in Accumulation of Antioxidant Flavonoids and Induces Drought Tolerance in Transgenic Arabidopsis Antioxidants doi: 10.3390/antiox9020161 Authors: Muhammad Junaid Rao Yuantao Xu Xiaomei Tang Yue Huang Jihong Liu Xiuxin Deng Qiang Xu CYTOCHROME P450s genes are a large gene family in the plant kingdom. Our earlier transcriptome data revealed that a CYTOCHROME P450 gene of Citrus sinensis...
Mon Feb 17, 2020 02:00
Beverages, Vol. 6, Pages 10: Nutrient Addition to Low pH Base Wines (L. cv. Riesling) during Yeast Acclimatization for Sparkling Wine: Its Influence on Yeast Cell Growth, Sugar Consumption and Nitrogen Usage Beverages doi: 10.3390/beverages6010010 Authors: Belinda Kemp Jessy Plante Debra L. Inglis In traditional method sparkling wine production, to carry out a successful second alcoholic fermentation, yeast are acclimatized to stressful base wine conditions. Base wines typically...
Mon Feb 17, 2020 02:00
Biology, Vol. 9, Pages 33: From One Ejaculate to Another: Transference of Sperm Traits via Seminal Plasma Supplementation in the Ram Biology doi: 10.3390/biology9020033 Authors: Christine Green Jessica P. Rickard Simon P. de Graaf Angela J. Crean Males can adjust sperm motility instantaneously in response to the perceived risk of sperm competition. The speed of this response suggests that sperm motility is regulated by changes in seminal plasma rather than changes in the sperm...
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Biology, Vol. 9, Pages 32: Morphological Features of the Anther Development in Tomato Plants with Non-Specific Male Sterility Biology doi: 10.3390/biology9020032 Authors: Inna A. Chaban Neonila V. Kononenko Alexander A. Gulevich Liliya R. Bogoutdinova Marat R. Khaliluev Ekaterina N. Baranova The study was devoted to morphological and cytoembryological analysis of disorders in the anther and pollen development of transgenic tomato plants with a normal and abnormal phenotype,...
Mon Feb 17, 2020 02:00
Biology, Vol. 9, Pages 30: Genome-Scale Metabolic Reconstruction and in Silico Perturbation Analysis of the Polar Diatom Fragilariopsis cylindrus Predicts High Metabolic Robustness Biology doi: 10.3390/biology9020030 Authors: Michel Lavoie Blanche Saint-Béat Jan Strauss Sébastien Guérin Antoine Allard Simon V. Hardy Angela Falciatore Johann Lavaud Diatoms are major primary producers in polar environments where they can actively grow under extremely variable conditions....
Mon Feb 17, 2020 02:00
Biology, Vol. 9, Pages 31: CXCR4 Antagonists as Stem Cell Mobilizers and Therapy Sensitizers for Acute Myeloid Leukemia and Glioblastoma? Biology doi: 10.3390/biology9020031 Authors: Vashendriya V.V. Hira Cornelis J.F. Van Noorden Remco J. Molenaar Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs),...
Mon Feb 17, 2020 02:00
Biomimetics, Vol. 5, Pages 7: The Impact of a Flexible Stern on Canoe Boat Maneuverability and Speed
Biomimetics, Vol. 5, Pages 7: The Impact of a Flexible Stern on Canoe Boat Maneuverability and Speed Biomimetics doi: 10.3390/biomimetics5010007 Authors: Anna Theresia Stadler Martin Schönauer Roozbeh Aslani Werner Baumgartner Tillmann Philippi Paddle boats like canoes and kayaks draw a sinusoidal path when a linear movement is intended. The reason for this behavior is that each paddle stroke induces a lateral movement of the boat. In this study, we sought to reduce the so-called...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 321: The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity Biomolecules doi: 10.3390/biom10020321 Authors: Gewehr Teixeira Santos Biondo Gozzo Cordibello Eichler Reckziegel Oliveira Dos Santos Camara Castoldi Barreto-Chaves Dale Senger Lima Seelaender Inada Akamine Castro Rodrigues Neto Ferro Thimet oligopeptidase (EC 3.4.24.15;...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 319: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis Biomolecules doi: 10.3390/biom10020319 Authors: Maifata Hod Zakaria Ghani Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 320: Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology Biomolecules doi: 10.3390/biom10020320 Authors: Kasai Shimizu Tatara Mimura Itoh Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various electrophilic compounds...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 316: Progress in the Use of Antisense Oligonucleotides for Vaccine Improvement Biomolecules doi: 10.3390/biom10020316 Authors: Batista-Duharte Sendra Herrero Téllez-Martínez Carlos Aliño : Antisense oligonucleotides (ASOs) are synthetically prepared short single-stranded deoxynucleotide sequences that have been validated as therapeutic agents and as a valuable tool in molecular driving biology. ASOs can block the expression of specific...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 317: Generation and Characterization of a CRISPR/Cas9 -Induced 3-mst Deficient Zebrafish Biomolecules doi: 10.3390/biom10020317 Authors: Katsouda Peleli Asimakopoulou Papapetropoulos Beis 3-mercaptopyruvate sulfurtransferase (3-MST) is an enzyme capable of synthesizing hydrogen sulfide (H2S) and polysulfides. In spite of its ubiquitous presence in mammalian cells, very few studies have investigated its contribution to homeostasis and disease...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 315: Fatty Acid Content and Composition of the Yakutian Horses and Their Main Food Source: Living in Extreme Winter Conditions Biomolecules doi: 10.3390/biom10020315 Authors: Petrov Dudareva Nokhsorov Stoyanov Makhutova : For the first time, seasonal changes in the content of total lipids (TLs) and phospholipids (PLs) were studied in fodder plants growing in Central Yakutia—a perennial cereal, smooth brome (Bromopsis inermis L.),...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 318: Kernel Differential Subgraph Analysis to Reveal the Key Period Affecting Glioblastoma Biomolecules doi: 10.3390/biom10020318 Authors: Xie Sun Feng Yang Wang Wen Nie Glioblastoma (GBM) is a fast-growing type of malignant primary brain tumor. To explore the mechanisms in GBM, complex biological networks are used to reveal crucial changes among different biological states, which reflect on the development of living organisms. It...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 314: Regulation of Adipsin Expression by Endoplasmic Reticulum Stress in Adipocytes Biomolecules doi: 10.3390/biom10020314 Authors: Ka-Young Ryu Eon Ju Jeon Jaechan Leem Jae-Hyung Park Hochan Cho Adpsin is an adipokine that stimulates insulin secretion from β-cells and improves glucose tolerance. Its expression has been found to be markedly reduced in obese animals. However, it remains unclear what factors lead to downregulation of adipsin...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 313: Brain Cytoplasmic RNAs in Neurons: From Biosynthesis to Function Biomolecules doi: 10.3390/biom10020313 Authors: Younghoon Lee Hee-Seung Lee Meehyein Kim Heegwon Shin Flexibility in signal transmission is essential for high-level brain function. This flexibility is achieved through strict spatial and temporal control of gene expression in neurons. Given the key regulatory roles of a variety of noncoding RNAs (ncRNAs) in neurons, studying neuron-specific...
Mon Feb 17, 2020 02:00
Biomolecules, Vol. 10, Pages 312: The Role of Retinoic Acid in Establishing the Early Limb Bud Biomolecules doi: 10.3390/biom10020312 Authors: Feneck Logan Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and specifically on the role of RA in establishing the domain of cells that will go on to form...
Mon Feb 17, 2020 02:00
Brain Sciences, Vol. 10, Pages 107: CDKL5 Deficiency Disorder—A Complex Epileptic Encephalopathy Brain Sciences doi: 10.3390/brainsci10020107 Authors: Martyna Jakimiec Justyna Paprocka Robert Śmigiel CDKL5 deficiency disorder (CDD) is a complex of clinical symptoms resulting from the presence of non-functional CDKL5 protein, i.e., serine-threonine kinase (previously referred to as STK9), or its complete absence. The clinical picture is characterized by epileptic seizures (that...
Mon Feb 17, 2020 02:00
Brain Sciences, Vol. 10, Pages 106: The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding Brain Sciences doi: 10.3390/brainsci10020106 Authors: Ch’ng Walker McCarthy Le Thomas Gibbons Udawela Kusljic Dean Gogos Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 459: CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma Cancers doi: 10.3390/cancers12020459 Authors: Chia-Chia Chao Chiang-Wen Lee Tsung-Ming Chang Po-Chun Chen Ju-Fang Liu Osteosarcoma, the most common of all bone malignancies, has a high likelihood of lung metastasis. Up until now, the molecular mechanisms involved in osteosarcomas with lung metastases are not clearly understood. Recent observations have shown that the chemokine...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 465: Loss of CDKN1A mRNA and Protein Expression Are Independent Predictors of Poor Outcome in Chromophobe Renal Cell Carcinoma Patients Cancers doi: 10.3390/cancers12020465 Authors: Ohashi Angori Batavia Rupp Ajioka Schraml Moch Chromophobe renal cell carcinoma (chRCC) patients have good prognosis. Only 5%–10% patients die of metastatic disease after tumorectomy, but tumor progression cannot be predicted by histopathological...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 464: Melanoma-Derived Exosomal miR-125b-5p Educates Tumor Associated Macrophages (TAMs) by Targeting Lysosomal Acid Lipase A (LIPA) Cancers doi: 10.3390/cancers12020464 Authors: Dennis Gerloff Jana Lützkendorf Rose K.C. Moritz Tom Wersig Karsten Mäder Lutz P. Müller Cord Sunderkötter Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment, promoting tumor initiation, growth, progression, metastasis,...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 461: Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis Cancers doi: 10.3390/cancers12020461 Authors: Decmann Perge Turai Patócs Igaz Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 463: Changes in Functional Outcome and Quality of Life in Soft Tissue Sarcoma Patients within the First Year after Surgery: A Prospective Observational Study Cancers doi: 10.3390/cancers12020463 Authors: Saebye Amidi Keller Andersen Baad-Hansen Soft tissue sarcoma (STS) patients undergoing surgery may experience reduced functional outcome (FO) and quality of life (QoL) compared to the general population. The aim of this study was to evaluate the...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 462: Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer Cancers doi: 10.3390/cancers12020462 Authors: Huang Chiang Chen Chen Hu Yang Ke Chao Programmed cell death-1 (PD-1) has demonstrated impressive clinical outcomes in several malignancies, but its therapeutic efficacy in the majority of colorectal cancers is still low. Therefore, methods to improve its therapeutic efficacy in colorectal...
Mon Feb 17, 2020 02:00
Cancers, Vol. 12, Pages 460: Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth Cancers doi: 10.3390/cancers12020460 Authors: Bruce M. Boman Arthur Guetter Ryan M. Boman Olaf A. Runquist The goal of our study was to measure the kinetics of human colorectal cancer (CRC) development in order to identify aberrant mechanisms in tissue dynamics and processes that contribute to colon tumorigenesis. The kinetics of tumor development were...
Mon Feb 17, 2020 02:00
Cells, Vol. 9, Pages 456: α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin Cells doi: 10.3390/cells9020456 Authors: Ute A. Schwinghammer Magda M. Melkonyan Lilit Hunanyan Roman Tremmel Ralf Weiskirchen Erawan Borkham-Kamphorst Elke Schaeffeler Torgom Seferyan Wolfgang Mikulits Konstantin Yenkoyan Matthias Schwab Lusine Danielyan The noradrenergic system is proposed to play a prominent role in the pathogenesis of liver...
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Cells, Vol. 9, Pages 453: Extracellular Vesicles Derived from Induced Pluripotent Stem Cells Promote Renoprotection in Acute Kidney Injury Model Cells doi: 10.3390/cells9020453 Authors: Collino Lopes Tapparo Tortelote Kasai-Brunswick Lopes Almeida Skovronova Wendt Miranda Bussolati Vieyra Lindoso Induced pluripotent stem cells (iPSC) have been the focus of several studies due to their wide range of application, including in cellular therapy....
Mon Feb 17, 2020 02:00
Cells, Vol. 9, Pages 454: TRPC Channels in Cardiac Plasticity Cells doi: 10.3390/cells9020454 Authors: Numaga-Tomita Nishida The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively. In physiological conditions, these structural changes of the heart are reversible. However, chronic stresses such as hypertension...
Mon Feb 17, 2020 02:00
Cells, Vol. 9, Pages 455: Esophageal Cancer Development: Crucial Clues Arising from the Extracellular Matrix Cells doi: 10.3390/cells9020455 Authors: Antonio Palumbo Nathalia Meireles Da Costa Bruno Pontes Felipe Leite de Oliveira Matheus Lohan Codeço Luis Felipe Ribeiro Pinto Luiz Eurico Nasciutti In the last years, the extracellular matrix (ECM) has been reported as playing a relevant role in esophageal cancer (EC) development, with this compartment being related...
Mon Feb 17, 2020 02:00
Cells, Vol. 9, Pages 452: Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver Cells doi: 10.3390/cells9020452 Authors: Buniatian Weiskirchen Weiss Schwinghammer Fritz Seferyan Proksch Glaser Lourhmati Buadze Borkham-Kamphorst Gaunitz Gleiter Lang Schaeffeler Tremmel Cynis Frey II Gebhardt Friedman Mikulits Schwab * The function and regulation of amyloid-beta (Aβ) in healthy...
Mon Feb 17, 2020 02:00
Cells, Vol. 9, Pages 451: The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats Cells doi: 10.3390/cells9020451 Authors: Jiménez-González Marín-Royo Jurado-López Bartolomé Romero-Miranda Luaces Islas Nieto Martínez-Martínez Cachofeiro The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac alterations associated with obesity. Male Wistar...
Mon Feb 17, 2020 02:00
Cells, Vol. 9, Pages 450: Correction: Zhou, P., et al. Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy. Cells, 2019, 8, 213 Cells doi: 10.3390/cells9020450 Authors: Zhou Xie Meng Zhai Dong Zhang Sun Sun The authors wish to make the following corrections to this paper [...]
Mon Feb 17, 2020 02:00
Children, Vol. 7, Pages 14: Harnessing T Cells to Target Pediatric Acute Myeloid Leukemia: CARs, BiTEs, and Beyond Children doi: 10.3390/children7020014 Authors: Rebecca Epperly Stephen Gottschalk Mireya Paulina Velasquez Outcomes for pediatric patients with acute myeloid leukemia (AML) remain poor, highlighting the need for improved targeted therapies. Building on the success of CD19-directed immune therapy for acute lymphocytic leukemia (ALL), efforts are ongoing to develop similar...
Mon Feb 17, 2020 02:00
Diagnostics, Vol. 10, Pages 108: Long-Term Outcomes of Early Enzyme Replacement Therapy for Mucopolysaccharidosis IV: Clinical Case Studies of Two Siblings Diagnostics doi: 10.3390/diagnostics10020108 Authors: Barak Anikster Sarouk Stern Eisenstein Yissar Sherr-Lurie Raas-Rothschild Guttman Enzyme replacement therapy (ERT) is one of the available therapies for mucopolysaccharidosis (MPS). This study presents a follow-up of two siblings with MPS IVA (Morquio...
Mon Feb 17, 2020 02:00
Diagnostics, Vol. 10, Pages 109: Combination of Two Rapid Ophthalmic Test Kits for Improved Diagnosis in Cases of Severe Binocular Conjunctivitis Diagnostics doi: 10.3390/diagnostics10020109 Authors: Asako Kodama Fumitaka Kobayashi Hao Yung Yang Kazumi Fukagawa Hiroyuki Yazu Hiroshi Fujishima Introduction: Diagnosis of conjunctivitis can be sometimes difficult, especially in cases of severe conjunctivitis and those involving both eyes. In this study, we performed commercial...
Mon Feb 17, 2020 02:00
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