IJMS, Vol. 21, Pages 1324: Blood Metabolite Signatures of Metabolic Syndrome in Two Cross-Cultural Older Adult Cohorts International Journal of Molecular Sciences doi: 10.3390/ijms21041324 Authors: Uma V. Mahajan Vijay R. Varma Chiung-Wei Huang Yang An Toshiko Tanaka Luigi Ferrucci Toru Takebayashi Sei Harada Miho Iida Cristina Legido-Quigley Madhav Thambisetty Metabolic syndrome (MetS) affects an increasing number of older adults worldwide. Cross-cultural...
Sun Feb 16, 2020 02:00
IJMS, Vol. 21, Pages 1322: The Floral Repressor GmFLC-like is Involved in Regulating Flowering Time Mediated by Low Temperature in Soybean International Journal of Molecular Sciences doi: 10.3390/ijms21041322 Authors: Lyu Cai Li Suo Yi Zhang Nian Soybean is an important crop that is grown worldwide. Flowering time is a critical agricultural trait determining successful reproduction and yields. For plants, light and temperature are important environmental factors...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1323: Overexpression of Grapevine VvIAA18 Gene Enhanced Salt Tolerance in Tobacco International Journal of Molecular Sciences doi: 10.3390/ijms21041323 Authors: Wei Li Changxi Dang Yuxiu Ye Zunxin Wang Baolai Hu Fan Zhang Yang Zhang Xingzhi Qian Jiabin Shi Yanyun Guo Qing Zhou Tailin Wang Xinhong Chen Feibing Wang In plants, auxin/indoleacetic acid (Aux/IAA) proteins are transcriptional regulators that regulate developmental...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1321: A Wheat WRKY Transcription Factor TaWRKY46 Enhances Tolerance to Osmotic Stress in transgenic Arabidopsis Plants International Journal of Molecular Sciences doi: 10.3390/ijms21041321 Authors: Xiaorui Li Yan Tang Chunju Zhou Lixin Zhang Jinyin Lv WRKY transcription factors play central roles in developmental processes and stress responses of wheat. Most WRKY proteins of the same group (Group III) have a similar function in abiotic stress responses...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1318: Encoding Information into Polyethylene Glycol Using an Alcohol-Isocyanate “Click” Reaction International Journal of Molecular Sciences doi: 10.3390/ijms21041318 Authors: Lajos Nagy Ákos Kuki Tibor Nagy Bence Vadkerti Zoltán Erdélyi Levente Kárpáti Miklós Zsuga Sándor Kéki In this article, the capability of encoding information using a homologous series of monodisperse monomethoxypolyethylene glycols (mPEG), with a number of ethylene oxide...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1319: Role of microRNAs in the Regulation of Dendritic Cell Generation and Function International Journal of Molecular Sciences doi: 10.3390/ijms21041319 Authors: Viviana Scalavino Marina Liso Grazia Serino Dendritic cells (DCs) are antigen-presenting cells with a key role in immune responses. They act as a link between the innate and adaptive systems and they can induce and maintain immunologic tolerance. DCs are subdivided into conventional and plasmacytoid...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1313: In Vivo and In Vitro Mechanical Loading of Mouse Achilles Tendons and Tenocytes—A Pilot Study International Journal of Molecular Sciences doi: 10.3390/ijms21041313 Authors: Viviane Fleischhacker Franka Klatte-Schulz Susann Minkwitz Aysha Schmock Maximilian Rummler Anne Seliger Bettina M. Willie Britt Wildemann Mechanical force is a key factor for the maintenance, adaptation, and function of tendons. Investigating the impact of mechanical...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1320: Overexpression of the High-Affinity Nitrate Transporter OsNRT2.3b Driven by Different Promoters in Barley Improves Yield and Nutrient Uptake Balance International Journal of Molecular Sciences doi: 10.3390/ijms21041320 Authors: Bingbing Luo Man Xu Limei Zhao Peng Xie Yi Chen Wendy Harwood Guohua Xu Xiaorong Fan Anthony J. Miller Improving nitrogen use efficiency (NUE) is very important for crops throughout the world. Rice mainly utilizes...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1316: High-Density Lipoprotein (HDL) Inhibits Serum Amyloid A (SAA)-Induced Vascular and Renal Dysfunctions in Apolipoprotein E-Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms21041316 Authors: Xiaoping Cai Gulfam Ahmad Farjaneh Hossain Yuyang Liu XiaoSuo Wang Joanne Dennis Ben Freedman Paul K. Witting Serum amyloid A (SAA) promotes endothelial inflammation and dysfunction that is associated with cardiovascular disease...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1317: Doxorubicin Inhibits Phosphatidylserine Decarboxylase and Modifies Mitochondrial Membrane Composition in HeLa Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041317 Authors: Nadège Bellance Fabienne Furt Su Melser Claude Lalou Didier Thoraval Lilly Maneta-Peyret Didier Lacombe Patrick Moreau Rodrigue Rossignol Doxorubicin (DXR) is a drug widely used in chemotherapy. Its mode of action is based on its intercalation...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1314: The Role of Th17-Related Cytokines in Atopic Dermatitis International Journal of Molecular Sciences doi: 10.3390/ijms21041314 Authors: Makoto Sugaya T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and psoriasis. IL-17 and related cytokines are therapeutic targets of these diseases. In atopic dermatitis (AD), Th2...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1315: IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection International Journal of Molecular Sciences doi: 10.3390/ijms21041315 Authors: Shanshan Zhao Dai Shi Chen Su Wen Jiang Chao Zhang Ting Liang Guihua Hou Non-invasively monitoring allogeneic graft rejection with a specific marker is of great importance for prognosis of patients. Recently, data revealed that IL-27Rα was up-regulated in alloreactive CD4+ T cells and participated...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1312: Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules International Journal of Molecular Sciences doi: 10.3390/ijms21041312 Authors: Sara S. Rinne Tianqi Xu Charles Dahlsson Leitao Stefan Ståhl John Löfblom Anna Orlova Vladimir Tolmachev Anzhelika Vorobyeva Human epidermal growth factor receptor type 3 (HER3) is an emerging therapeutic target in several malignancies. To...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1311: Role of Mycoplasma Chaperone DnaK in Cellular Transformation International Journal of Molecular Sciences doi: 10.3390/ijms21041311 Authors: Francesca Benedetti Fiorenza Cocchi Olga S. Latinovic Sabrina Curreli Selvi Krishnan Arshi Munawwar Robert C. Gallo Davide Zella Studies of the human microbiome have elucidated an array of complex interactions between prokaryotes and their hosts. However, precise bacterial pathogen–cancer...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1310: Heterogeneous Network Model to Identify Potential Associations Between Plasmodium vivax and Human Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21041310 Authors: Apichat Suratanee Kitiporn Plaimas Integration of multiple sources and data levels provides a great insight into the complex associations between human and malaria systems. In this study, a meta-analysis framework was developed based on a heterogeneous network model for integrating...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1308: Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence International Journal of Molecular Sciences doi: 10.3390/ijms21041308 Authors: Razmik Mirzayans David Murray A major challenge in treating cancer is posed by intratumor heterogeneity, with different sub-populations of cancer cells within the same tumor exhibiting therapy resistance through different biological processes....
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1307: Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/β-catenin Signaling in Human Oral Mucosa Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041307 Authors: Rita Arroyo Sonia López Enrique Romo Gonzalo Montoya Lía Hoz Claudia Pedraza Yonathan Garfias Higinio Arzate Human cementum protein 1 (CEMP1) is known to induce cementoblast and osteoblast differentiation and...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1309: Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041309 Authors: Olga Egorova Heather HC Lau Kate McGraphery Yi Sheng Dysfunction of the tumor suppressor p53 occurs in most human cancers. Mdm2 and MdmX are homologous proteins from the Mdm (Murine Double Minute) protein family, which play a...
Sat Feb 15, 2020 02:00
IJMS, Vol. 21, Pages 1305: Differential Secretion of Angiopoietic Factors and Expression of MicroRNA in Umbilical Cord Blood from Healthy Appropriate-For-Gestational-Age Preterm and Term Newborns—in Search of Biomarkers of Angiogenesis-Related Processes in Preterm Birth International Journal of Molecular Sciences doi: 10.3390/ijms21041305 Authors: Gródecka-Szwajkiewicz Ulańczyk Zagrodnik Łuczkowska Rogińska Kawa Stecewicz Safranow Machaliński Objectives:...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1306: Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing International Journal of Molecular Sciences doi: 10.3390/ijms21041306 Authors: Loubna Mazini Luc Rochette Brahim Admou Said Amal Gabriel Malka Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal sheets (dermal sheet cells),...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1304: Genomics-Enabled Analysis of Puroindoline b2 Genes Identifies New Alleles in Wheat and Related Triticeae Species International Journal of Molecular Sciences doi: 10.3390/ijms21041304 Authors: Xiaoyan Li Yin Li Xiaofen Yu Fusheng Sun Guangxiao Yang Guangyuan He Kernel hardness is a key trait of wheat seeds, largely controlled by two tightly linked genes Puroindoline a and b (Pina and Pinb). Genes homologous to Pinb, namely Pinb2, have been studied....
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1294: Correction: Wang, YT., et al. Selenite Reduction and the Biogenesis of Selenium Nanoparticles by Alcaligenes faecalis Se03 Isolated from the Gut of Monochamus alternatus (Coleoptera: Cerambycidae). Int. J. Mol. Sci. 2018, 19, 2799 International Journal of Molecular Sciences doi: 10.3390/ijms21041294 Authors: Wang Shu Zhou Fan Wang Chen Li Ma Ni Hou Zhao Li Huang Wu The authors wish to make the following corrections...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1293: Characterization of the OFP Gene Family and its Putative Involvement of Tuberous Root Shape in Radish International Journal of Molecular Sciences doi: 10.3390/ijms21041293 Authors: Wang Wang Hao Sun Zhang The shape of the tuberous root, a very important quality trait, varies dramatically among radish cultivars. Ovate family proteins (OFPs) are plant-specific proteins that regulate multiple aspects of plant growth and development. To investigate...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1295: Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms21041295 Authors: Remiszewski Jarocka-Karpowicz Biernacki Jastrząb Schlicker Toczek Harasim-Symbor Pędzińska-Betiuk Malinowska We investigated the...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1296: Secondhand Smoke Induces Liver Steatosis through Deregulation of Genes Involved in Hepatic Lipid Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms21041296 Authors: Tommasi Yoon Besaratinia We investigated the role of secondhand smoke (SHS) exposure, independently of diet, in the development of chronic liver disease. Standard diet-fed mice were exposed to SHS (5 h/day, 5 days/week for 4 months). Genome-wide gene expression analysis,...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1297: Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis International Journal of Molecular Sciences doi: 10.3390/ijms21041297 Authors: Tonini Colardo Colella Di Bartolomeo Berardinelli Caretti Pallottini Segatto The homeostatic control of lipid metabolism is essential for many fundamental physiological processes. A deep understanding of its regulatory...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1298: C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21041298 Authors: Kim Seo Kim Yoo Lee Min Lee Hwangbo Apoptosis pathways in cells are classified into two pathways: the extrinsic pathway, mediated by binding of the ligand to a death receptor and the intrinsic pathway, mediated by mitochondria....
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1299: Comparative Analysis of Structural Variations Due to Genome Shuffling of Bacillus Subtilis VS15 for Improved Cellulase Production International Journal of Molecular Sciences doi: 10.3390/ijms21041299 Authors: Ega Drendel Petrovski Egidi Franks Muddada Cellulose is one of the most abundant and renewable biomass products used for the production of bioethanol. Cellulose can be efficiently hydrolyzed by Bacillus subtilis VS15, a strain isolate...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1300: Comparative Analysis of the Effect of Inorganic and Organic Chemicals with Silver Nanoparticles on Soybean under Flooding Stress International Journal of Molecular Sciences doi: 10.3390/ijms21041300 Authors: Hashimoto Mustafa Nishiuchi Komatsu Extensive utilization of silver nanoparticles (NPs) in agricultural products results in their interaction with other chemicals in the environment. To study the combined effects of silver NPs with nicotinic...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1301: Chemoradiotherapy Increases Intratumor Heterogeneity of HPSE Expression in the Relapsed Glioblastoma Tumors International Journal of Molecular Sciences doi: 10.3390/ijms21041301 Authors: Suhovskih Kazanskaya Volkov Tsidulko Aidagulova Grigorieva Adjuvant chemoradiotherapy is a standard treatment option for glioblastoma multiforme (GBM). Despite intensive care, recurrent tumors developed during the first year are fatal for the patients....
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1292: Comprehensive Transcriptomic Analysis of Auxin Responses in Submerged Rice Coleoptile Growth International Journal of Molecular Sciences doi: 10.3390/ijms21041292 Authors: Wu Yang Cultivating rice in wet or water direct seeding systems is simple and time and labor efficient. Rice (Oryza sativa) seeds are a unique cereal that can germinate not only when submerged, but also in anoxic conditions. Many complicated hormone signals interact in submerged seed...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1303: The Oviductal Extracellular Vesicles’ RNA Cargo Regulates the Bovine Embryonic Transcriptome International Journal of Molecular Sciences doi: 10.3390/ijms21041303 Authors: Bauersachs Mermillod Almiñana Oviductal extracellular vesicles (oEVs) are emerging as key players in the gamete/embryo–oviduct interactions that contribute to successful pregnancy. Various positive effects of oEVs on gametes and early embryos have been found in vitro. To...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1302: Microtubule-Mediated NLRP3 Inflammasome Activation Is Independent of Microtubule-Associated Innate Immune Factor GEF-H1 in Murine Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms21041302 Authors: Lai Hsu Lee Chiang Inflammasomes are intracellular multiple protein complexes that mount innate immune responses to tissue damage and invading pathogens. Their excessive activation is crucial in the development and pathogenesis...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1291: Waterpipe Tobacco Smoke Inhalation Triggers Thrombogenicity, Cardiac Inflammation and Oxidative Stress in Mice: Effects of Flavouring International Journal of Molecular Sciences doi: 10.3390/ijms21041291 Authors: Abderrahim Nemmar Suhail Al-Salam Sumaya Beegam Priya Yuvaraju Nur Elena Zaaba Javed Yasin Badreldin H. Ali The consumption of water-pipe smoking (WPS) has been promoted by the use of flavoured tobacco. However, little is known about...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1289: Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology International Journal of Molecular Sciences doi: 10.3390/ijms21041289 Authors: Amit Koren-Iton Shiran Salomon-Zimri Alex Smolar Efrat Shavit-Stein Amir Dori Joab Chapman Daniel M. Michaelson Apolipoprotein E (APOE) ε4 gene allele and type 2 diabetes mellitus (T2DM) are prime risk factors for Alzheimer’s disease (AD). Despite evidence linking T2DM and...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1285: Atomistic Insights of Calmodulin Gating of Complete Ion Channels International Journal of Molecular Sciences doi: 10.3390/ijms21041285 Authors: Eider Núñez Arantza Muguruza-Montero Alvaro Villarroel Intracellular calcium is essential for many physiological processes, from neuronal signaling and exocytosis to muscle contraction and bone formation. Ca2+ signaling from the extracellular medium depends both on membrane potential, especially controlled by...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1288: Cbx2, a PcG Family Gene, Plays a Regulatory Role in Medaka Gonadal Development International Journal of Molecular Sciences doi: 10.3390/ijms21041288 Authors: Qinghe Chao Fengfeng Shen Yidong Xue Jikui Wu Junling Zhang Chromobox homolog 2 (CBX2), a key member of the polycomb group (PcG) family, is essential for gonadal development in mammals. A functional deficiency or genetic mutation in cbx2 can lead to sex reversal in mice and humans. However,...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1290: Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21041290 Authors: Jennifer S. Winn Zachary Hasse Michael Slifker Jianming Pei Sebastian M. Arisi-Fernandez Jacqueline N. Talarchek Elias Obeid Donald A. Baldwin Yulan Gong Eric Ross Massimo Cristofanilli R. Katherine Alpaugh Sandra V. Fernandez We...
Fri Feb 14, 2020 02:00
IJMS, Vol. 21, Pages 1286: PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder International Journal of Molecular Sciences doi: 10.3390/ijms21041286 Authors: Dayita Biswas Whitney Cary Jan A. Nolta Protein Phosphatase 2 Regulatory Subunit B′ Delta (PPP2R5D)-related intellectual disability (ID) and neurodevelopmental delay results from germline de novo mutations...
Fri Feb 14, 2020 02:00
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