Results from 46 patients given treatments that target specific molecular changes in tumour cells suggest that these therapies could help patients with pancreatic cancer whose tumours harbour those changes survive an extra year.
10:07
Break The Rules For More Productivity Getting the most out of your day is a personal thing. Do you impose impossible and unenjoyable scheduling on yourself? It might be time to forget the rules. Frankly, your friends, family, and society don't always know what is best for you. Why go to the gym at 5 AM if that doesn’t work for you? Is checking your email the first the morning a bad thing? What if you like getting it out of the way first thing? You will be happier and more productive when you schedule...
10:00
Defining Healthy Relationships The quality of your life is a direct result of your relationships. Whether it's a personal, professional, or business relationship. There are three ways to play the relationship game. There is only one way to win. 1) All relationships begin with two independent individuals. If you remain independent, you will never connect. 2) Some relationships become co-dependent. Developing this kind of relationship means losing individuality. Isn't that what attracted you in the...
10:00
IJMS, Vol. 21, Pages 1691: The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21051691 Authors: Zhou Zhi Yu Xu The stem cells of neurogenesis and carcinogenesis share many properties, including proliferative rate, an extensive replicative potential, the potential to generate different cell types of a given tissue, and an ability to independently...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1690: Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21051690 Authors: Masahiro Kamata Yayoi Tada Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients’ quality of life enormously. It has been recognized not only as a skin disease but as a systemic disease,...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1689: N-terminal Backbone Pairing Shifts in CCL5-12AAA14 Dimer Interface: Structural Significance of the FAY Sequence International Journal of Molecular Sciences doi: 10.3390/ijms21051689 Authors: Jin-Ye Li Yi-Chen Chen Yi-Zong Lee Chun-Hsiang Huang Shih-Che Sue CC-type chemokine ligand 5 (CCL5) has been known to regulate immune responses by mediating the chemotaxis of leukocytes. Depending on the environment, CCL5 forms different orders of oligomers...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1692: Remote Ischemic Preconditioning Induces Cardioprotective Autophagy and Signals through the IL-6-Dependent JAK-STAT Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21051692 Authors: Muntasir Billah Anisyah Ridiandries Usaid K Allahwala Harshini Mudaliar Anthony Dona Stephen Hunyor Levon M. Khachigian Ravinay Bhindi Autophagy is a cellular process by which mammalian cells degrade and assist in recycling damaged...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1688: S-Nitroso-Proteome Revealed in Stomatal Guard Cell Response to Flg22 International Journal of Molecular Sciences doi: 10.3390/ijms21051688 Authors: Sheldon R. Lawrence Meghan Gaitens Qijie Guan Craig Dufresne Sixue Chen Nitric oxide (NO) plays an important role in stomata closure induced by environmental stimuli including pathogens. During pathogen challenge, nitric oxide (NO) acts as a second messenger in guard cell signaling networks...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1687: Brugada Syndrome: Oligogenic or Mendelian Disease? International Journal of Molecular Sciences doi: 10.3390/ijms21051687 Authors: Michelle M. Monasky Emanuele Micaglio Giuseppe Ciconte Carlo Pappone Brugada syndrome (BrS) is diagnosed by a coved-type ST-segment elevation in the right precordial leads on the electrocardiogram (ECG), and it is associated with an increased risk of sudden cardiac death (SCD) compared to the general population. Although...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1686: Transcriptomics and Proteomics Reveal the Cellulose and Pectin Metabolic Processes in the Tension Wood (Non-G-Layer) of Catalpa bungei International Journal of Molecular Sciences doi: 10.3390/ijms21051686 Authors: Xiao Yi Ling Wang Zhao Lu Qu Kong Ma Wang : Catalpa bungei is an economically important tree with high-quality wood and highly valuable to the study of wood formation. In this work, the xylem microstructure of...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1683: Structural and Functional Characterization of New SsoPox Variant Points to the Dimer Interface as a Driver for the Increase in Promiscuous Paraoxonase Activity International Journal of Molecular Sciences doi: 10.3390/ijms21051683 Authors: Suzumoto Dim Roviello Worek Sussman Manco Increasing attention is more and more directed toward the thermostable Phosphotriesterase-Like-Lactonase (PLL) family of enzymes, for the efficient and reliable...
Sun Mar 01, 2020 02:00
IJMS, Vol. 21, Pages 1685: Study of Inheritance and Linkage of Virulence Genes in a Selfing Population of a Pakistani Dominant Race of Puccinia striiformis f. sp. tritici International Journal of Molecular Sciences doi: 10.3390/ijms21051685 Authors: Mehmood Sajid Husnain Zhao Huang Kang Wheat stripe rust is a severe threat of almost all wheat-growing regions in the world. Being an obligate biotrophic fungus, Puccinia striiformis f. sp. tritici (PST) produces new...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1681: Spatial and Pregnancy-Related Changes in the Protein, Amino Acid, and Carbohydrate Composition of Bovine Oviduct Fluid International Journal of Molecular Sciences doi: 10.3390/ijms21051681 Authors: Rodríguez-Alonso Maillo Acuña López-Úbeda Torrecillas Simintiras Sturmey Avilés Lonergan Rizos Knowledge of how the biochemical composition of the bovine oviduct is altered due to the oviduct anatomy or the presence of an embryo...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1682: Somatostatin Analogs in Clinical Practice: a Review International Journal of Molecular Sciences doi: 10.3390/ijms21051682 Authors: Gomes-Porras Cárdenas-Salas Álvarez-Escolá Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1680: Genome-Wide Identification of Metal Tolerance Protein Genes in Populus trichocarpa and Their Roles in Response to Various Heavy Metal Stresses International Journal of Molecular Sciences doi: 10.3390/ijms21051680 Authors: Yongfeng Gao Fengming Yang Jikai Liu Wang Xie Lin Zhang Zihao Chen Zhuoxi Peng Yongbin Ou Yinan Yao Metal tolerance proteins (MTPs) are plant divalent cation transporters that play important roles in plant metal tolerance...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1684: Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21051684 Authors: Sereno Akhoundi Sayehmri Mirzaei Holzmuller Lejon Waleckx Unicellular eukaryotes of the Trypanosomatidae family include human and animal pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the diseases...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1679: Butyrate Decreases ICAM-1 Expression in Human Oral Squamous Cell Carcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051679 Authors: Gabriel Leonardo Magrin Francesca Di Di Summa Franz-Josef Strauss Layla Panahipour Michael Mildner Magalhães Benfatti Magalhães Benfatti Reinhard Gruber Short-chain fatty acids (SCFA) are bacterial metabolites that can be found in periodontal pockets. The expression of adhesion molecules...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1678: Combined Effect of Light and Nutrients on the Micromorphology of the White rot Fungus Cerrena Unicolor International Journal of Molecular Sciences doi: 10.3390/ijms21051678 Authors: Anna Pawlik Magdalena Jaszek Dawid Stefaniuk Urszula Świderska-Burek Andrzej Mazur Jerzy Wielbo Piotr Koper Kamil Żebracki Grzegorz Janusz Light influences developmental pathways in fungi. Recent transcriptomic and biochemical analyses have demonstrated that...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1677: Functional Cyclization of Eukaryotic mRNAs International Journal of Molecular Sciences doi: 10.3390/ijms21051677 Authors: Olga M. Alekhina Ilya M. Terenin Sergey E. Dmitriev Konstantin S. Vassilenko The closed-loop model of eukaryotic translation states that mRNA is circularized by a chain of the cap-eIF4E-eIF4G-poly(A)-binding protein (PABP)-poly(A) interactions that brings 5′ and 3′ ends together. This circularization...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1676: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule International Journal of Molecular Sciences doi: 10.3390/ijms21051676 Authors: James Elste Dominik Kaltenbach Vraj R. Patel Max T. Nguyen Harsh Sharthiya Ritesh Tandon Satish K. Mehta Michael V. Volin Michele Fornaro Vaibhav Tiwari Umesh R. Desai Human cytomegalovirus (HCMV) infections are wide-spread among the general...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1675: Genetic Identification and Transcriptome Analysis of Lintless and Fuzzless Traits in Gossypium arboreum L International Journal of Molecular Sciences doi: 10.3390/ijms21051675 Authors: Liu Moncuquet Zhu Stiller Zhang Wilson Cotton fibres, as single cells arising from the seed coat, can be classified as lint and fuzz according to their final length. Gossypium arboreum is a cultivated diploid cotton species and a potential donor of the A...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1674: The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation International Journal of Molecular Sciences doi: 10.3390/ijms21051674 Authors: Ahyayauch de la Arada Masserini Arrondo Goñi Alonso The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1672: Differential Inhibitory Actions of Multitargeted Tyrosine Kinase Inhibitors on Different Ionic Current Types in Cardiomyocytes International Journal of Molecular Sciences doi: 10.3390/ijms21051672 Authors: Wei-Ting Chang Ping-Yen Liu Kaisen Lee Yin-Hsun Feng Sheng-Nan Wu Lapatinib (LAP) and sorafenib (SOR) are multitargeted tyrosine kinase inhibitors (TKIs) with antineoplastic properties. In clinical observations, LAP and SOR may contribute...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1671: Circulating Tumor Cells in Early and Advanced Breast Cancer; Biology and Prognostic Value International Journal of Molecular Sciences doi: 10.3390/ijms21051671 Authors: Fabisiewicz Szostakowska-Rodzos Zaczek Grzybowska Breast cancer metastasis is the leading cause of cancer deaths in women and is difficult to combat due to the long periods in which disseminated cells retain a potential to be re-activated and start the relapse. Assessing the number...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1673: The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21051673 Authors: Renaude Kroemer Loyon Binda Borg Guittaut Hervouet Peixoto Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor RORγt and the production of IL-17. Epigenetic modifications such as post-translational...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1669: A Survey of Antimicrobial Resistance Determinants in Category A Select Agents, Exempt Strains, and Near-Neighbor Species International Journal of Molecular Sciences doi: 10.3390/ijms21051669 Authors: Taitt Leski Chen Berk Dorsey Gregory Sozhamannan Frey Dutt Vora A dramatic increase in global antimicrobial resistance (AMR) has been well documented. Of particular concern is the dearth of information regarding the spectrum...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1670: Application of Thin-Layer Chromatography-Flame Ionization Detection (TLC-FID) to Total Lipid Quantitation in Mycolic-Acid Synthesizing Rhodococcus and Williamsia Species International Journal of Molecular Sciences doi: 10.3390/ijms21051670 Authors: Nahar Baker Nichols Bowman Britz In addition to cell membrane phospholipids, Actinobacteria in the order Corynebacteriales possess a waxy cell envelope containing mycolic acids (MA). In optimized...
Sat Feb 29, 2020 02:00
IJMS, Vol. 21, Pages 1663: Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium International Journal of Molecular Sciences doi: 10.3390/ijms21051663 Authors: Enders Heider Ludwig Kuerten Calcium ions are vital for maintaining the physiological and biochemical processes inside cells. The central nervous system (CNS) is particularly dependent on calcium homeostasis and its dysregulation has been associated with several neurodegenerative disorders including...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1664: EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues International Journal of Molecular Sciences doi: 10.3390/ijms21051664 Authors: Havis Duprez Although the transcription factor EGR1 is known as NGF1-A, TIS8, Krox24, zif/268, and ZENK, it still has many fewer names than biological functions. A broad range of signals induce Egr1 gene expression via numerous regulatory elements identified in...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1666: Contributions of DNA Damage to Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21051666 Authors: Xiaozeng Lin Anil Kapoor Yan Gu Mathilda Jing Chow Jingyi Peng Kuncheng Zhao Damu Tang Alzheimer’s disease (AD) is the most common type of neurodegenerative disease. Its typical pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Mutations...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1665: Design, Synthesis, and Biological Evaluation of Two Series of Novel A-Ring Fused Steroidal Pyrazines as Potential Anticancer Agents International Journal of Molecular Sciences doi: 10.3390/ijms21051665 Authors: Shijun Wang Xiaorong Yuan Hao Qian Na Li Junru Wang Background: Increasingly, different heterocyclic systems have been introduced into the steroid nucleus to significantly enhance the antitumor activities of steroid molecules. However, in...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1667: Altered Growth and Envelope Properties of Polylysogens Containing Bacteriophage Lambda N−cI− Prophages International Journal of Molecular Sciences doi: 10.3390/ijms21051667 Authors: Barik Mandal The bacterial virus lambda (λ) is a temperate bacteriophage that can lysogenize host Escherichia coli (E. coli) cells. Lysogeny requires λ repressor, the cI gene product, which shuts off transcription of the phage genome. The λ...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1662: Into the Seed: Auxin Controls Seed Development and Grain Yield International Journal of Molecular Sciences doi: 10.3390/ijms21051662 Authors: Jinshan Cao Guoji Li Dejie Qu Xia Li Youning Wang Seed development, which involves mainly the embryo, endosperm and integuments, is regulated by different signaling pathways, leading to various changes in seed size or seed weight. Therefore, uncovering the genetic and molecular mechanisms of seed development...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1656: Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375) International Journal of Molecular Sciences doi: 10.3390/ijms21051656 Authors: Mohammed O. Altonsy Anutosh Ganguly Matthias Amrein Philip Surmanowicz Shu Shun Li Gilles J. Lauzon P. Régine Mydlarski Microtubules (MTs), microfilaments, and intermediate filaments, the main constituents of...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1657: Erythropoietin-Induced Changes in Bone and Bone Marrow in Mouse Models of Diet-Induced Obesity International Journal of Molecular Sciences doi: 10.3390/ijms21051657 Authors: Sukanya Suresh Josue Caban Alvarez Soumyadeep Dey Constance Tom Noguchi Obesity remodels bone and increases bone marrow adipocytes (BMAT), which negatively regulate hematopoiesis and bone. Reduced BMAT could restore altered hematopoiesis and bone features. We analyzed the potential...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1659: The ArathEULS3 Lectin Ends up in Stress Granules and Can Follow an Unconventional Route for Secretion International Journal of Molecular Sciences doi: 10.3390/ijms21051659 Authors: Malgorzata Dubiel Tibo De De Coninck Vinicius Jose Silva Osterne Isabel Verbeke Daniël Van Van Damme Guy Smagghe Els J. M. Van Van Damme Stress granules are cytoplasmic compartments, which serve as mRNA storage units during stress, therefore regulating translation....
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1658: Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist? International Journal of Molecular Sciences doi: 10.3390/ijms21051658 Authors: Caterina Vivaldi Silvia Catanese Valentina Massa Irene Pecora Francesca Salani Stefano Santi Monica Lencioni Enrico Vasile Alfredo Falcone Lorenzo Fornaro Esophageal cancer remains a challenging disease due to limited treatment options and poor prognosis....
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1660: METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export International Journal of Molecular Sciences doi: 10.3390/ijms21051660 Authors: Li Cai Meng Feng Xu Osteoclast differentiation and function are crucial for maintaining bone homeostasis and preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification that has recently been shown to be important in regulating cell...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1661: Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin International Journal of Molecular Sciences doi: 10.3390/ijms21051661 Authors: Anamarija Mojzeš Marko Tomljanović Lidija Milković Renata Novak Kujundžić Ana Čipak Gašparović Koraljka Gall Trošelj In order to support uncontrolled proliferation, cancer cells need to adapt to increased energetic and biosynthetic requirements. One such adjustment is aerobic glycolysis or the Warburg...
Fri Feb 28, 2020 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου