Molecules, Vol. 25, Pages 1542: Genetic Polymorphism of GSTP-1 Affects Cyclophosphamide Treatment of Autoimmune Diseases Molecules doi: 10.3390/molecules25071542 Authors: Péter Hajdinák Melinda Szabó Emese Kiss Lili Veress Lívius Wunderlich András Szarka Cyclophosphamide is one of the most potent and reliable anti-cancer and immunosuppressive drugs. In our study, 33 individuals with different autoimmune diseases were treated with cyclophosphamide according to standard...
Sat Mar 28, 2020 02:00
Molecules, Vol. 25, Pages 1543: Antibacterial Prodrugs to Overcome Bacterial Resistance Molecules doi: 10.3390/molecules25071543 Authors: Buthaina Jubeh Zeinab Breijyeh Rafik Karaman Bacterial resistance to present antibiotics is emerging at a high pace that makes the development of new treatments a must. At the same time, the development of novel antibiotics for resistant bacteria is a slow-paced process. Amid the massive need for new drug treatments to combat resistance, time...
Sat Mar 28, 2020 02:00
Molecules, Vol. 25, Pages 1541: Structure and Properties of Biodegradable Poly (Xylitol Sebacate-Co-Butylene Sebacate) Copolyester Molecules doi: 10.3390/molecules25071541 Authors: Marta Piątek-Hnat Kuba Bomba Jakub Pęksiński In this work, a bio-based copolyester with good mechanical properties was synthesized and characterized in terms of structure, main properties and biodegradability Determining the chemical structure of such materials is important to understand their behavior...
Sat Mar 28, 2020 02:00
Molecules, Vol. 25, Pages 1540: Outlier Profiles of Atomic Structures Derived from X-ray Crystallography and from Cryo-Electron Microscopy Molecules doi: 10.3390/molecules25071540 Authors: Lin Chen Jing He Background: As more protein atomic structures are determined from cryo-electron microscopy (cryo-EM) density maps, validation of such structures is an important task. Methods: We applied a histogram-based outlier score (HBOS) to six sets of cryo-EM atomic structures and five sets...
Sat Mar 28, 2020 02:00
Molecules, Vol. 25, Pages 1539: New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers Molecules doi: 10.3390/molecules25071539 Authors: Cornelia Vasile Daniela Pamfil Elena Stoleru Mihaela Baican New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids,...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1537: Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources Molecules doi: 10.3390/molecules25071537 Authors: Solano Direct sun exposure is one of the most aggressive factors for human skin. Sun radiation contains a range of the electromagnetic spectrum including UV light. In addition to the stratospheric ozone layer filtering the most harmful UVC, human skin contains a photoprotective pigment...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1536: A DyP-Type Peroxidase of Pleurotus sapidus with Alkene Cleaving Activity Molecules doi: 10.3390/molecules25071536 Authors: Nina-Katharina Krahe Ralf G. Berger Franziska Ersoy Alkene cleavage is a possibility to generate aldehydes with olfactory properties for the fragrance and flavor industry. A dye-decolorizing peroxidase (DyP) of the basidiomycete Pleurotus sapidus (PsaPOX) cleaved the aryl alkene trans-anethole. The PsaPOX was semi-purified from...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1538: Formulation and Optimization of Nanoemulsions using the Natural Surfactant Saponin from Quillaja Bark Molecules doi: 10.3390/molecules25071538 Authors: Schreiner Santamaria-Echart Ribeiro Peres Dias Pinho Barreiro Replacing synthetic surfactants by natural alternatives when formulating nanoemulsions has gained attention as a sustainable approach. In this context, nanoemulsions based on sweet almond oil and stabilized by saponin...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1535: Acorn Isotopic Composition: A New Promising Tool for Authenticity Maps of Montado’s High-Value Food Products Molecules doi: 10.3390/molecules25071535 Authors: Carla Alegria Cristina Antunes Manuela Giovanetti Marta Abreu Cristina Máguas It is often overlooked that even food production is linked to the ecology of plants and animals. Living organisms respond to environmental short- and long-term variability: acknowledging this may help in the...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1534: Glycosylated-Chitosan Derivatives: A Systematic Review Molecules doi: 10.3390/molecules25071534 Authors: Pasquale Sacco Michela Cok Francesca Scognamiglio Chiara Pizzolitto Federica Vecchies Andrea Marfoglia Eleonora Marsich Ivan Donati Chitosan derivatives, and more specifically, glycosylated derivatives, are nowadays attracting much attention within the scientific community due to the fact that this set of engineered polysaccharides...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1532: Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators Molecules doi: 10.3390/molecules25071532 Authors: Fernández-Dueñas Qian Argerich Amaral Risseeuw Van Calenbergh Ciruela In recent years, new drug discovery approaches based on novel pharmacological concepts have emerged. Allosteric modulators, for example, target receptors at sites other than...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1533: Novel Approach to Automated Flow Titration for the Determination of Fe(III) Molecules doi: 10.3390/molecules25071533 Authors: Kozak Paluch Kozak Duracz Wieczorek Kościelniak A novel approach to automated flow titration with spectrophotometric detection for the determination of Fe(III) is presented. The approach is based on the possibility of strict and simultaneous control of the flow rates of sample and titrant streams over time....
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1529: Lysophosphatidic Acid Inhibits Simvastatin-Induced Myocytoxicity by Activating LPA Receptor/PKC Pathway Molecules doi: 10.3390/molecules25071529 Authors: Kyung-Jong Won Yu-Jin Goh Sung-Hee Hwang Statins such as simvastatin have many side effects, including muscle damage, which is known to be the most frequent undesirable side effect. Lysophosphatidic acid (LPA), a kind of biolipid, has diverse cellular activities, including cell proliferation, survival,...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1531: Catalytic Effect of Hydrogen Bond on Oxhydryl Dehydrogenation in Methanol Steam Reforming on Ni(111) Molecules doi: 10.3390/molecules25071531 Authors: Changming Ke Zijing Lin Dehydrogenation of H3COH and H2O are key steps of methanol steam reforming on transition metal surfaces. Oxhydryl dehydrogenation reactions of HxCOH (x = 0–3) and OH on Ni (111) were investigated by DFT calculations with the OptB88-vdW functional. The transition states...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1530: Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and their Potential Against Parasitic Infections Molecules doi: 10.3390/molecules25071530 Authors: Casertano Menna Fattorusso Basilico Parapini Persico Imperatore Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1527: An Efficient Metal-Free Oxidative Esterification and Amination of Benzyl C–H Bond Molecules doi: 10.3390/molecules25071527 Authors: Saiwen Liu Ru Chen Guowen He Jin Zhang An esterification and amination of benzylic C–H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidative coupling...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1525: Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.) Molecules doi: 10.3390/molecules25071525 Authors: Jaqueline Moraes Bazioli Jonas Henrique Costa Larissa Shiozawa Ana Lúcia Tasca Gois Ruiz Mary Ann Foglio João Ernesto de Carvalho The research of natural products has allowed for the discovery of biologically relevant compounds inspired by plant secondary metabolites, which contributes to the development...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1528: Are Alkynyl Spacers in Ancillary Ligands in Heteroleptic Bis(diimine)copper(I) Dyes Beneficial for Dye Performance in Dye-Sensitized Solar Cells? Molecules doi: 10.3390/molecules25071528 Authors: Guglielmo Risi Mariia Becker Catherine E. Housecroft Edwin C. Constable The syntheses of 4,4′-bis(4-dimethylaminophenyl)-6,6′-dimethyl-2,2′-bipyridine (1), 4,4′-bis(4-dimethylaminophenylethynyl)-6,6′-dimethyl-2,2′-bipyridine...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1519: Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches Molecules doi: 10.3390/molecules25071519 Authors: Razvan Stefan Boiangiu Ion Brinza Monica Hancianu Ilkay Erdogan Orhan Gokcen Eren Elife Gündüz Halis Ertas Lucian Hritcu Oana Cioanca The present study investigated the capability of an essential oil mix (MO: 1% and 3%)...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1526: Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides Molecules doi: 10.3390/molecules25071526 Authors: Katherine Seley-Radtke For decades, nucleosides and nucleotides have formed the cornerstone of antiviral, antiparasitic and anticancer therapeutics and have been used as tools in exploring nucleic acid structure and function [...]
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1524: The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties Molecules doi: 10.3390/molecules25071524 Authors: Georg Aichinger Falk-Bach Lichtenberger Tamara N. Steinhauer Inken Flörkemeier Giorgia Del Favero Bernd Clement Doris Marko The benzo[c]phenanthridine P8-D6 was recently found to suppress the catalytic activity of both human topoisomerase (Topo) I and...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1521: Combined Pre- and Posttreatment of Paraoxon Exposure Molecules doi: 10.3390/molecules25071521 Authors: Lorke Nurulain Hasan Kuča Petroianu Aims: Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory. Experimental data indicate that superior therapeutic results can be obtained when reversible cholinesterase...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1520: Synthesis and Characterization of Silica-Coated Oxyhydroxide Aluminum/Doped Polymer Nanocomposites: A Comparative Study and Its Application as a Sorbent Molecules doi: 10.3390/molecules25071520 Authors: Ahmed Hussein Ragab Al-Radadi The present investigation is a comparison study of two nanocomposites: Nano-silica-coated oxyhydroxide aluminum (SiO2–AlOOH; SCB) and nano-silica-coated oxyhydroxide aluminum doped with polyaniline (SiO2–AlOOH–PANI;...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1523: Full Parametric Study of the Influence of Ionomer Content, Catalyst Loading and Catalyst Type on Oxygen and Ion Transport in PEM Fuel Cell Catalyst Layers Molecules doi: 10.3390/molecules25071523 Authors: Robert Alink Rajveer Singh Patrick Schneider Kläre Christmann Johannes Schall Roman Keding Nada Zamel To advance the technology of polymer electrolyte membrane fuel cells, material development is at the forefront of research. This is...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1518: N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—The Synthesis and Biological Evaluation of Enantiomers Molecules doi: 10.3390/molecules25071518 Authors: Martin Juhás Lucie Kučerová Ondřej Horáček Ondřej Janďourek Vladimír Kubíček Klára Konečná Radim Kučera Pavel Bárta Jiří Janoušek Pavla Paterová Jiří Kuneš Martin Doležal Jan Zitko Tuberculosis is an infectious disease caused by Mycobacterium...
Fri Mar 27, 2020 02:00
Molecules, Vol. 25, Pages 1522: Disordered Residues and Patterns in the Protein Data Bank Molecules doi: 10.3390/molecules25071522 Authors: Mikhail Yu. Lobanov Ilya V. Likhachev Oxana V. Galzitskaya We created a new library of disordered patterns and disordered residues in the Protein Data Bank (PDB). To obtain such datasets, we clustered the PDB and obtained the groups of chains with different identities and marked disordered residues. We elaborated a new procedure for finding...
Fri Mar 27, 2020 02:00
Nanomaterials, Vol. 10, Pages 640: Polyelectrolyte Based Sensors as Key to Achieve Quantitative Electronic Tongues: Detection of Triclosan on Aqueous Environmental Matrices Nanomaterials doi: 10.3390/nano10040640 Authors: Cátia Magro Paulo Zagalo João Pereira-da-Silva Eduardo Pires Mateus Alexandra Branco Ribeiro Paulo Ribeiro Maria Raposo Triclosan (TCS) is a bacteriostatic used in household items that promotes antimicrobial resistance and endocrine disruption effects...
Sun Mar 29, 2020 02:00
Nanomaterials, Vol. 10, Pages 638: Synthesis of Biogenic Silver Nanoparticles (AgCl-NPs) Using a Pulicaria vulgaris Gaertn. Aerial Part Extract and Their Application as Antibacterial, Antifungal and Antioxidant Agents Nanomaterials doi: 10.3390/nano10040638 Authors: Majid Sharifi-Rad Pawel Pohl In this study, very simple and fast one-step synthesis of biogenic silver chloride nanoparticles (AgCl-NPs) using a Pulicaria vulgaris Gaertn. aerial part extract from an aqueous solution of...
Sun Mar 29, 2020 02:00
Nanomaterials, Vol. 10, Pages 639: Nanoarchitectonics of Nanoporous Carbon Materials in Supercapacitors Applications Nanomaterials doi: 10.3390/nano10040639 Authors: Rekha Goswami Shrestha Subrata Maji Lok Kumar Shrestha Katsuhiko Ariga High surface area and large pore volume carbon materials having hierarchical nanoporous structure are required in high performance supercapacitors. Such nanoporous carbon materials can be fabricated from organic precursors with high carbon content,...
Sun Mar 29, 2020 02:00
Nanomaterials, Vol. 10, Pages 636: Morphological, Optical, and Electrical Properties of p-type Nickel Oxide Thin Films by Nonvacuum Deposition Nanomaterials doi: 10.3390/nano10040636 Authors: Chien-Chen Diao Chun-Yuan Huang Cheng-Fu Yang Chia-Ching Wu In this study, a p-type 2 at% lithium-doped nickel oxide (abbreviation L2NiO) solution was prepared using Ni(NO3)2·6H2O, and LiNO3·L2NiO thin films were deposited using an atomizer by spraying the L2NiO solution...
Sun Mar 29, 2020 02:00
Nanomaterials, Vol. 10, Pages 635: Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid Nanomaterials doi: 10.3390/nano10040635 Authors: Catenacci Marrubini Sorrenti Rossi Sandri Ferrari Fagnani Valentino Bonferoni Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core–shell"...
Sun Mar 29, 2020 02:00
Nanomaterials, Vol. 10, Pages 637: Dose Enhancement for the Flattening-Filter-Free and Flattening-Filter Photon Beams in Nanoparticle-Enhanced Radiotherapy: A Monte Carlo Phantom Study Nanomaterials doi: 10.3390/nano10040637 Authors: Stefano Martelli James C L Chow Monte Carlo simulations were used to predict the dose enhancement ratio (DER) using the flattening-filter-free (FFF) and flattening-filter (FF) photon beams in prostate nanoparticle-enhanced radiotherapy, with multiple...
Sun Mar 29, 2020 02:00
Nanomaterials, Vol. 10, Pages 634: Anisotropy of Mechanical Properties of Pinctada margaritifera Mollusk Shell Nanomaterials doi: 10.3390/nano10040634 Authors: Martyna Strąg Łukasz Maj Magdalena Bieda Paweł Petrzak Anna Jarzębska Jürgen Gluch Emre Topal Kristina Kutukova André Clausner Wieland Heyn Katarzyna Berent Kinga Nalepka Ehrenfried Zschech Antonio G. Checa Krzysztof Sztwiertnia The mechanical properties such as compressive strength and...
Sat Mar 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 633: Invisible Silver Nanomesh Skin Electrode via Mechanical Press Welding Nanomaterials doi: 10.3390/nano10040633 Authors: Ji Soo Oh Jong Sik Oh Geun Young Yeom Silver nanowire (AgNW) has been studied as an important material for next-generation wearable devices due to its high flexibility, high electrical conductivity and high optical transmittance. However, the inherently high surface roughness of AgNWs and low adhesion to the substrate still need...
Sat Mar 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 631: TiO2 Passivation Layer on ZnO Hollow Microspheres for Quantum Dots Sensitized Solar Cells with Improved Light Harvesting and Electron Collection Nanomaterials doi: 10.3390/nano10040631 Authors: Zhen Li Libo Yu Hao Wang Huiwen Yang Huan Ma Light harvesting and electron recombination are essential factors that influence photovoltaic performance of quantum dots sensitized solar cells (QDSSCs). ZnO hollow microspheres (HMS) as architectures...
Sat Mar 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 630: Piezoelectric BiFeO3 Thin Films: Optimization of MOCVD Process on Si Nanomaterials doi: 10.3390/nano10040630 Authors: Quentin Micard Guglielmo Guido Condorelli Graziella Malandrino This paper presents a simple and optimized metal organic chemical vapor deposition (MOCVD) protocol for the deposition of perovskite BiFeO3 films on silicon-based substrates, in order to move toward the next generation of lead-free hybrid energy harvesters. A bi-metal...
Sat Mar 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 632: Ultrasound-Assisted Hydrazine Reduction Method for the Preparation of Nickel Nanoparticles, Physicochemical Characterization and Catalytic Application in Suzuki-Miyaura Cross-Coupling Reaction Nanomaterials doi: 10.3390/nano10040632 Authors: Ádám Szabados Varga Papp Musza Kónya Kukovecz Sipos Pálinkó In the experimental work leading to this contribution, the parameters of the ultrasound treatment (temperature, output...
Sat Mar 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 628: Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment Nanomaterials doi: 10.3390/nano10040628 Authors: João P. F. Carvalho Ana C. Q. Silva Verónica Bastos Helena Oliveira Ricardo J. B. Pinto Armando J. D. Silvestre Carla Vilela Carmen S. R. Freire Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning...
Sat Mar 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 629: K vs. Na Effects on the Self-Assembly of Guanosine 5’-Monophosphate: A Solution SAXS Structural Study++ Nanomaterials doi: 10.3390/nano10040629 Authors: Enrico Junior Baldassarri Maria Grazia Ortore Francesco Spinozzi Adam Round Claudio Ferrero Paolo Mariani The hierarchical process of guanosine (G) self-assembly, leading in aqueous solution and in the presence of metal cations to the formation of G-quadruplexes, represents an intriguing...
Sat Mar 28, 2020 02:00
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