Biomolecules, Vol. 10, Pages 512: The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra) Biomolecules doi: 10.3390/biom10040512 Authors: Plácido Bueno Barbosa Moreira Dias Cabral Albuquerque Bessa Freitas Kuckelhaus Lima Batagin-Neto Brand Relvas Leite Eaton Amphibian skin is a multifunctional organ that plays key roles in defense, breathing,...
Fri Mar 27, 2020 02:00
Biomolecules, Vol. 10, Pages 511: Octominin Inhibits LPS-Induced Chemokine and Pro-inflammatory Cytokine Secretion from RAW 264.7 Macrophages via Blocking TLRs/NF-κB Signal Transduction Biomolecules doi: 10.3390/biom10040511 Authors: Sanjeewa Nagahawatta Yang Oh Jayawardena Jeon De Zoysa Whang Ryu Inflammation is a well-organized innate immune response that plays an important role during the pathogen attacks and mechanical injuries. The Toll-like receptors...
Fri Mar 27, 2020 02:00
Biomolecules, Vol. 10, Pages 510: An Extract of Transgenic Senna obtusifolia L. Hairy Roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line Biomolecules doi: 10.3390/biom10040510 Authors: Kowalczyk Sitarek Toma Picot Wielanek Skała Śliwiński Many biologically-active plant-derived compounds have therapeutic or chemopreventive effects. The use of plant in vitro cultures in conjunction with...
Fri Mar 27, 2020 02:00
Biomolecules, Vol. 10, Pages 509: The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II Biomolecules doi: 10.3390/biom10040509 Authors: Steffen Glöckner Khang Ngo Björn Wagner Andreas Heine Gerhard Klebe The fluorination of lead-like compounds is a common tool in medicinal chemistry to alter molecular properties in various ways and with different goals. We herein present a detailed study...
Fri Mar 27, 2020 02:00
Biomolecules, Vol. 10, Pages 508: Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI Biomolecules doi: 10.3390/biom10040508 Authors: Yonghyo Kim Yutaka Sugihara Tae Young Kim Sung Min Cho Jin Young Kim Ju Yeon Lee Jong Shin Yoo Doona Song Gyoonhee Han Melinda Rezeli Charlotte Welinder Roger Appelqvist György Marko-Varga Ho Jeong Kwon Although natural products are an important source...
Fri Mar 27, 2020 02:00
Biomolecules, Vol. 10, Pages 506: A Novel Sweetpotato WRKY Transcription Factor, IbWRKY2, Positively Regulates Drought and Salt Tolerance in Transgenic Arabidopsis Biomolecules doi: 10.3390/biom10040506 Authors: Zhu Zhou Zhai He Zhao Liu WRKYs play important roles in plant growth, defense regulation, and stress response. However, the mechanisms through which WRKYs are involved in drought and salt tolerance have been rarely characterized in sweetpotato [Ipomoea batatas...
Fri Mar 27, 2020 02:00
Biomolecules, Vol. 10, Pages 507: Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression Biomolecules doi: 10.3390/biom10040507 Authors: Andrei E. Siniavin Maria A. Streltsova Denis S. Kudryavtsev Irina V. Shelukhina Yuri N. Utkin Victor I. Tsetlin Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial...
Fri Mar 27, 2020 02:00
Biosensors, Vol. 10, Pages 30: Graphene Oxide Nanoribbons in Chitosan for Simultaneous Electrochemical Detection of Guanine, Adenine, Thymine and Cytosine Biosensors doi: 10.3390/bios10040030 Authors: Zhou Li Noroozifar Kerman Herein, graphene oxide nanoribbons (GONRs) were obtained from the oxidative unzipping of multi-walled carbon nanotubes. Covalent coupling reaction of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS)...
Fri Mar 27, 2020 02:00
Brain Sciences, Vol. 10, Pages 200: Transcriptomic Analysis Reveals Abnormal Expression of Prion Disease Gene Pathway in Brains from Patients with Autism Spectrum Disorders Brain Sciences doi: 10.3390/brainsci10040200 Authors: Salvo Danilo Lombardo Giuseppe Battaglia Maria Cristina Petralia Katia Mangano Maria Sofia Basile Valeria Bruno Paolo Fagone Rita Bella Ferdinando Nicoletti Eugenio Cavalli The role of infections in the pathogenesis of autism spectrum...
Sun Mar 29, 2020 02:00
Brain Sciences, Vol. 10, Pages 199: EEG Theta Power Activity Reflects Workload among Army Combat Drivers: An Experimental Study Brain Sciences doi: 10.3390/brainsci10040199 Authors: Carolina Diaz-Piedra María Victoria Sebastián Leandro L. Di Stasi We aimed to evaluate the effects of mental workload variations, as a function of the road environment, on the brain activity of army drivers performing combat and non-combat scenarios in a light multirole vehicle dynamic simulator. Forty-one...
Sat Mar 28, 2020 02:00
Brain Sciences, Vol. 10, Pages 198: Cognition, The Menstrual Cycle, and Premenstrual Disorders: A Review Brain Sciences doi: 10.3390/brainsci10040198 Authors: Le Thomas Gurvich Sex hormones, such as estrogens, progesterone, and testosterone, have a significant influence on brain, behavior, and cognitive functioning. The menstrual cycle has been a convenient model to examine how subtle fluctuations of these hormones can relate to emotional and cognitive functioning. The aim of...
Fri Mar 27, 2020 02:00
Brain Sciences, Vol. 10, Pages 197: Comparison of Aneurysm Patency and Mural Inflammation in an Arterial Rabbit Sidewall and Bifurcation Aneurysm Model under Consideration of Different Wall Conditions Brain Sciences doi: 10.3390/brainsci10040197 Authors: Basil Erwin Grüter Stefan Wanderer Fabio Strange Sivani Sivanrupan Michael von Gunten Hans Rudolf Widmer Daniel Coluccia Lukas Andereggen Javier Fandino Serge Marbacher Background: Biological processes that...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 824: Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes Cancers doi: 10.3390/cancers12040824 Authors: Raghvendra Vishwakarma Kirk J. McManus Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately associated with cancer development and progression. The presence, extent, and level of CIN has...
Sun Mar 29, 2020 02:00
Cancers, Vol. 12, Pages 823: The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and their Clinical Implications Cancers doi: 10.3390/cancers12040823 Authors: Devis Pascut Muhammad Yogi Pratama Niem V.T. Vo Rina Masadah Claudio Tiribelli The communication between hepatocellular carcinoma (HCC) cells and their microenvironment is an essential mechanism supporting or preventing tumor development and progression....
Sun Mar 29, 2020 02:00
Cancers, Vol. 12, Pages 822: Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy Cancers doi: 10.3390/cancers12040822 Authors: Saleh Bloukh Carpenter Alwohoush Bakeer Darwish Azab Gewirtz For the past two decades, cellular senescence has been recognized as a central component of the tumor cell response to chemotherapy and radiation. Traditionally, this form of senescence, termed Therapy-Induced Senescence (TIS), was linked to extensive nuclear damage...
Sun Mar 29, 2020 02:00
Cancers, Vol. 12, Pages 820: Frequent FOXA1-Activating Mutations in Extramammary Paget’s Disease Cancers doi: 10.3390/cancers12040820 Authors: Takuya Takeichi Yusuke Okuno Takaaki Matsumoto Nobuyuki Tsunoda Kyogo Suzuki Kana Tanahashi Michihiro Kono Toyone Kikumori Yoshinao Muro Masashi Akiyama Extramammary Paget’s disease (EMPD) is a neoplastic skin disease of indeterminate origin with an unknown genetic cause. We performed a comprehensive genetic...
Sun Mar 29, 2020 02:00
Cancers, Vol. 12, Pages 821: Metastatic Heterogeneity of Breast Cancer: Companion and Theranostic Approach in Nuclear Medicine Cancers doi: 10.3390/cancers12040821 Authors: Christopher Montemagno Gilles Pagès Breast cancer is the most common malignancy in women throughout the world. Metastatic dissemination to vital organs is the leading cause of breast cancer-related deaths. The treatment of metastases is mainly based on the primary tumor characteristics. However, breast cancer metastases...
Sun Mar 29, 2020 02:00
Cancers, Vol. 12, Pages 819: Early Triple Negative Breast Cancer: Conventional Treatment and Emerging Therapeutic Landscapes Cancers doi: 10.3390/cancers12040819 Authors: Anna Diana Francesca Carlino Elisena Franzese Olga Oikonomidou Carmen Criscitiello Ferdinando De Vita Fortunato Ciardiello Michele Orditura Triple negative breast cancers (TNBCs) are characterized by worse prognosis, higher propensity to earlier metastases, and shorter survival after recurrence...
Sun Mar 29, 2020 02:00
Cancers, Vol. 12, Pages 818: Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer Cancers doi: 10.3390/cancers12040818 Authors: Martins Oliveira Cavadas Pinto Cardoso Castro Sousa Pinto Silva Adão Loureiro Pedro Reis Pereira Oliveira Costa In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk....
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 817: NK and NKT Cell-Mediated Immune Surveillance against Hematological Malignancies Cancers doi: 10.3390/cancers12040817 Authors: Shimizu Iyoda Yamasaki Kadowaki Tojo Fujii Recent cancer treatment modalities have been intensively focused on immunotherapy. The success of chimeric antigen receptor T cell therapy for treatment of refractory B cell acute lymphoblastic leukemia has pushed forward research on hematological malignancies. Among the...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 816: Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively Cancers doi: 10.3390/cancers12040816 Authors: Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong Gastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including Helicobacter pylori (H. pylori)...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 813: Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme Cancers doi: 10.3390/cancers12040813 Authors: Vagiannis Novotna Skarka Kammerer Küpper Chen Guo Staud Hofman Ensartinib (X-396) is a promising tyrosine kinase inhibitor currently undergoing advanced clinical evaluation for the treatment of non-small cell lung cancer. In...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 814: External Validation of an MRI-Derived Radiomics Model to Predict Biochemical Recurrence after Surgery for High-Risk Prostate Cancer Cancers doi: 10.3390/cancers12040814 Authors: Vincent Bourbonne Georges Fournier Martin Vallières François Lucia Laurent Doucet Valentin Tissot Gilles Cuvelier Stephane Hue Henri Le Penn Du Luc Perdriel Nicolas Bertrand Frederic Staroz Dimitris Visvikis Olivier Pradier Mathieu Hatt Ulrike...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 815: Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and Polyps Cancers doi: 10.3390/cancers12040815 Authors: Egle Rebane-Klemm Laura Truu Leenu Reinsalu Marju Puurand Igor Shevchuk Vladimir Chekulayev Natalja Timohhina Kersti Tepp Jelena Bogovskaja Vladimir Afanasjev Külliki Suurmaa Vahur Valvere Tuuli Kaambre This study aimed to characterize the ATP-synthesis by oxidative phosphorylation in colorectal...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 812: Personalized Medicine—Current and Emerging Predictive and Prognostic Biomarkers in Colorectal Cancer Cancers doi: 10.3390/cancers12040812 Authors: Christine Koulis Raymond Yap Rebekah Engel Thierry Jardé Simon Wilkins Gemma Solon Jeremy D. Shapiro Helen Abud Paul McMurrick Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and is heterogeneous both morphologically and molecularly. In an era of personalized...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 811: An Organotypic Microcosm for the Pancreatic Tumor Microenvironment Cancers doi: 10.3390/cancers12040811 Authors: Miranda Lin Mei Gao Prakash K. Pandalai Michael J. Cavnar Joseph Kim Pancreatic duct adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths in the next few years. Unfortunately, the development of novel therapies for PDAC has been challenged by a uniquely complex tumor microenvironment. The development...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 810: Liposomal TLR9 Agonist Combined with TLR2 Agonist-Fused Antigen Can Modulate Tumor Microenvironment through Dendritic Cells Cancers doi: 10.3390/cancers12040810 Authors: Kuan-Yin Shen Hsin-Yu Liu Wan-Lun Yan Chiao-Chieh Wu Ming-Hui Lee Chih-Hsing Leng Shih-Jen Liu Dendritic cells (DCs) are antigen-presenting cells involved in T cell activation and differentiation to regulate immune responses. Lipoimmunogens can be developed as pharmaceutical...
Sat Mar 28, 2020 02:00
Cancers, Vol. 12, Pages 809: Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus Cancers doi: 10.3390/cancers12040809 Authors: Umma Habiba Elora Hossain Aya Yanagawa-Matsuda Abu Faem Mohammad Almas Chowdhury Masumi Tsuda Asad-uz- Zaman Shinya Tanaka Fumihiro Higashino The combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 808: Outcomes According to MSKCC Risk Score with Focus on the Intermediate-Risk Group in Metastatic Renal Cell Carcinoma Patients Treated with First-Line Sunitinib: A Retrospective Analysis of 2390 Patients Cancers doi: 10.3390/cancers12040808 Authors: Ondrej Fiala Jindrich Finek Alexandr Poprach Bohuslav Melichar Jindrich Kopecký Milada Zemanova Katerina Kopeckova Tomas Mlcoch Tomas Dolezal Lenka Capkova Tomas Buchler Background:...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 806: Are Synapse-Like Structures a Possible Way for Crosstalk of Cancer with Its Microenvironment? Cancers doi: 10.3390/cancers12040806 Authors: Irina V Alekseenko Igor P Chernov Sergei V Kostrov Eugene D Sverdlov The failure of therapies directed at targets within cancer cells highlight the necessity for a paradigm change in cancer therapy. The attention of researchers has shifted towards the disruption of cancer cell interactions with the tumor microenvironment....
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 807: The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas Cancers doi: 10.3390/cancers12040807 Authors: Simone Serafini Cosimo Sperti Alessandra Rosalba Brazzale Diego Cecchin Pietro Zucchetta Elisa Sefora Pierobon Alberto Ponzoni Michele Valmasoni Lucia Moletta Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas represent a heterogeneous group of tumors,...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 804: Hyperprogression Under Immune Checkpoint-Based Immunotherapy—Current Understanding, The Role of PD-1/PD-L1 Tumour-Intrinsic Signalling, Future Directions and a Potential Large Animal Model Cancers doi: 10.3390/cancers12040804 Authors: Kocikowski Dziubek Parys Immune evasion is a major challenge for the development of successful cancer treatments. One of the known mechanisms is the expression of immune checkpoints (ICs)—proteins regulating...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 805: Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities Cancers doi: 10.3390/cancers12040805 Authors: Alessandro Allegra Caterina Musolino Alessandro Tonacci Giovanni Pioggia Sebastiano Gangemi The human microbiota is made up of the fungi, bacteria, protozoa and viruses cohabiting within the human body. An altered microbiota can provoke diseases such as cancer. The mechanisms by which a modified...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 801: Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells Cancers doi: 10.3390/cancers12040801 Authors: Peris-Torres Plaza-Calonge López-Domínguez Domínguez-García Barrientos-Durán Carmona-Sáez Rodríguez-Manzaneque Extracellular matrix remodeling within the tumor microenvironment has been recognized as a relevant dynamic framework...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 802: ER and PI3K Pathway Activity in Primary ER Positive Breast Cancer Is Associated with Progression-Free Survival of Metastatic Patients under First-Line Tamoxifen Cancers doi: 10.3390/cancers12040802 Authors: Sieuwerts Inda Smid van Ooijen van de Stolpe Martens Verhaegh : Estrogen receptor positive (ER+) breast cancer patients are eligible for hormonal treatment, but only around half respond. A test with higher specificity for prediction...
Fri Mar 27, 2020 02:00
Cancers, Vol. 12, Pages 803: Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1β in Human Immune Cells Cancers doi: 10.3390/cancers12040803 Authors: Suneesh Kumar Pachathundikandi Nicole Blaser Heiko Bruns Steffen Backert Helicobacter pylori persistently colonizes the human stomach, and is associated with inflammation-induced gastric cancer. Bacterial crosstalk with the host immune system produces various inflammatory...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 825: The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation Cells doi: 10.3390/cells9040825 Authors: Hicham Mahboubi Ossama Moujaber Mohamed Kodiha Ursula Stochaj The co-chaperone HspBP1 interacts with members of the hsp70 family, but also provides chaperone-independent functions. We report here novel biological properties of HspBP1 that are relevant to the formation of cytoplasmic stress granules (SGs). SG assembly...
Sun Mar 29, 2020 02:00
Cells, Vol. 9, Pages 824: Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia Cells doi: 10.3390/cells9040824 Authors: Wang de Vries Sol van Oeveren-Rietdijk de Boer van Zonneveld Quax Rabelink van den Berg We recently reported that loss of hyaluronan (HA) from the endothelial glycocalyx leads to loss of vessel stability in specific microcirculatory vascular beds. Here we hypothesized...
Sun Mar 29, 2020 02:00
Cells, Vol. 9, Pages 823: Decreased Metabolic Flexibility in Skeletal Muscle of Rat Fed with a High-Fat Diet Is Recovered by Individual CLA Isomer Supplementation via Converging Protective Mechanisms Cells doi: 10.3390/cells9040823 Authors: Trinchese Cavaliere Cimmino Catapano Carta Pirozzi Murru Lama Meli Bergamo Banni Mollica Energy balance, mitochondrial dysfunction, obesity, and insulin resistance are disrupted by metabolic inflexibility...
Sun Mar 29, 2020 02:00
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