Publication date: Available online 27 March 2020Source: Journal of Dairy ScienceAuthor(s): Ramon S. Rocha, Ramon Silva, Jonas T. Guimarães, Celso F. Balhtazar, Marcello R. Silveira, Aline A. Martins, Vitória P. Rojas, Juliana S. Graça, Tatiana C. Pimentel, Erick A. Esmerino, Anderson S. Sant'Ana, Daniel Granato, Mônica Q. Freitas, Márcio E. Barros, Márcia C. Silva, Adriano G. Cruz
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Publication date: Available online 27 March 2020Source: Journal of Dairy ScienceAuthor(s): Alice P. Skarbye, Peter T. Thomsen, Mogens A. Krogh, Line Svennesen, Søren Østergaard
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Publication date: Available online 27 March 2020Source: Journal of Dairy ScienceAuthor(s): A.J. Molenaar, P.H. Maclean, M.L. Gilmour, I.G. Draganova, C.W. Symes, J.K. Margerison, C.D. McMahon
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Publication date: Available online 27 March 2020Source: Journal of Dairy ScienceAuthor(s): M. Al-Qaisi, E.J. Mayorga, E.A. Horst, S.K. Kvidera, C.S. McCarthy, M.A. Abeyta, B.M. Goetz, H.A. Ramirez-Ramirez, L.L. Timms, L.H. Baumgard
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Publication date: Available online 27 March 2020Source: Journal of Dairy ScienceAuthor(s): Ishwary P. Acharya, David P. Casper
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Immune checkpoint inhibitors (ICIs) have been extensively investigated as a novel form of cancer therapy against a range of malignancies including urothelial carcinoma [1]. Notably however, they have also been associated with unique toxicities known as immune-related adverse events (irAEs) which may involve any organs, including haematologic systems [2]. The precise mechanisms involved in different irAEs are largely unknown, but they are believed to be associated with aberrant activation of immune...
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Abstract Objective Sleep quality is vital for healthy development in children. Sleep disorders are prevalent and negatively affect sleep quality. Early identification and appropriate intervention can improve children’s health and quality of life. The current reference standard, polysomnography (PSG) has limitations regarding availability, cost, and access and may not replicate normal sleep patterns in the home. Simple, accurate sleep tests,...
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Cancer Immunotherapy has recently emerged as a promising and effective modality to treat different malignancies. Antigenic profiling of cancer tissues and determination of any pre-existing immune responses to ...
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Publication date: Available online 28 March 2020Source: Journal of Controlled ReleaseAuthor(s): Jan Feijen
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Abstract Cybersuicide, or suicide mediated by the internet in various ways, is a growing phenomenon worldwide and one which makes an often private act highly public. This paper provides an exploration of one version of cybersuicide: suicide that is livestreamed on the internet. Through an analysis of three case studies, this paper asks what light anthropological concepts of performance can shed on cybersuicide? It argues that as a public and social act, cybersuicide needs to be...
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Abstract Purpose of Review To appraise the evidence and recommendations from published medical literature about the importance of clinical microbiology laboratory services in the prevention and control of infection in community and in the healthcare setting especially from the Indian perspective. Recent Findings Effective infection prevention and control...
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Publication date: Available online 27 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Marek Trost, Torsten Mundt, Reiner Biffar, Friedhelm Heinemann
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Publication date: Available online 27 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Yinyue Luo, Zhongjun Ma, Zhijuan Tian, Song Wang, Li Chen, Xiaoming Xu
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Publication date: Available online 27 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Lorenzo Alibardi
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Publication date: Available online 27 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): A. Jäger, N. Heim, F.J. Kramer, M. Setiawan, M. Peitz, A. Konermann
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Abstract Soft tissue sarcomas (STSs) are heterogeneous cancers associated with poor prognosis due to high rates of local recurrence and metastasis. The programmed death receptor ligand 1 (PD-L1) is expressed in several cancers. PD-L1 interacts with its receptor, PD-1, on the surface of tumor-infiltrating lymphocytes (TILs), thereby attenuating anti-cancer immune response. Immune checkpoint inhibitors targeting this interaction have been established as effective anti-cancer drugs....
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As the coronavirus disease 2019 (COVID-19) pandemic accelerates, global health care systems have become overwhelmed with potentially infectious patients seeking testing and care. Preventing spread of infection to and from health care workers (HCWs) and patients relies on effective use of personal protective equipment (PPE)—gloves, face masks, air-purifying respirators, goggles, face shields, respirators, and gowns. A critical shortage of all of these is projected to develop or has already developed...
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This case series describes clinical outcomes in 5 Chinese patients with laboratory-confirmed COVID-19, ARDS, and high viral loads despite antiviral treatment who were given human plasma with SARS-CoV-2 antibodies obtained from previously infected and recovered patients.
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In this issue of JAMA, Shen et al report findings from a preliminary study of 5 severely ill patients with coronavirus disease 2019 (COVID-19) who were treated in the Shenzhen Third People's Hospital, China, using plasma from recovered individuals. All patients had severe respiratory failure and were receiving mechanical ventilation; 1 needed extracorporeal membrane oxygenation (ECMO) and 2 had bacterial and/or fungal pneumonia. Four patients without coexisting diseases received convalescent plasma...
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This exploratory analysis of a randomized trial examined the effect of dapagliflozin on a composite of worsening heart failure or cardiovascular death on individuals with heart failure with reduced ejection fraction with and without diabetes.
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This Viewpoint emphasizes the importance of advanced care planning and goals-of-care discussions with older patients and those with chronic disease during the spread of coronavirus disease (COVID-19), given the likelihood these patients could become critically ill and require resuscitation and advanced life support if they became infected with SARS-CoV-2.
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This Viewpoint describes a framework for rationing ventilators during the COVID-19 pandemic should intensive care units find themselves with more patients than they can care for, using a score-based system that incorporates patients’ likelihood of surviving to hospital discharge and beyond and their role in the public health response to the outbreak.
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This randomized trial compares the effects of apabetalone (an inhibitor of bromodomain 2 and extraterminal protein, 2 epigenetic “readers”) vs placebo on major adverse cardiovascular events in patients with acute coronary syndrome (ACS), type 2 diabetes, and low HDL cholesterol level.
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Cells, and hence organisms, have biological memory, recording prior exposures to facilitate future responses. By linking this recall to gene expression, coordinated transcriptional programs are triggered that define normal function and adaptive responses. Efficient, integrated gene expression is essential, as evident with inflammatory responses to infection or tissue repair after injury. Cellular memory may also promote chronic disease states, such as atherosclerosis, with risk factors propagating...
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The profound effects of sodium-glucose transporter 2 (SGLT2) inhibition on the risks of cardiovascular complications in patients with hyperglycemia have provided for rapid and substantive changes to diabetes guidelines from various countries. In this issue of JAMA, Petrie and colleagues report findings from a highly informative exploratory analysis of the most recent large-scale clinical trial of an SGLT2 inhibitor that may suggest the next chapter for this drug class—the transition from a glucose-lowering...
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This JAMA Clinical Guidelines Synopsis summarizes the 2020 Surviving Sepsis Campaign guidelines on the treatment of critically ill adults with coronavirus disease 2019 (COVID-19).
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Guidelines are developed for various reasons, including the emergence of new, potentially practice-changing evidence or a perceived need for guidance in times of uncertainty. The COVID-19 pandemic presents an almost unparalleled example of the latter, prompting the Surviving Sepsis Campaign (SSC) Task Force to rapidly produce Guidelines on the Management of Critically Ill Adults With Coronavirus Disease 2019 (COVID-19). These guidelines are adapted from the well-known 2016 SSC guidelines, and highlights...
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Publication date: Available online 28 March 2020Source: Free Radical Biology and MedicineAuthor(s): Jie Yu, Bingling Zhong, Long Jin, Ying Hou, Nana Ai, Wei Ge, Luoxiang Li, Shuqin Liu, Jin-Jian Lu, Xiuping Chen
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Publication date: Available online 28 March 2020Source: Free Radical Biology and MedicineAuthor(s): Aleksandra Kopacz, Damian Kloska, Henry Jay Forman, Alicja Jozkowicz, Anna Grochot-Przeczek
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Publication date: Available online 27 March 2020Source: Free Radical Biology and MedicineAuthor(s): Ruvanthi N. Kularatne, Chandima Bulumulla, Timothy Catchpole, Alison Takacs, Abigail Christie, Mihaela C. Stefan, Karl G. Csaky
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Publication date: Available online 26 March 2020Source: Free Radical Biology and MedicineAuthor(s): S. Mendes, F. Timóteo-Ferreira, A.I. Soares, A.R. Rodrigues, A.M.N. Silva, S. Silveira, L. Matos, J. Saraiva, L. Guedes-Martins, H. Almeida, E. Silva
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Publication date: Available online 26 March 2020Source: Free Radical Biology and MedicineAuthor(s): Ambra Antonioni, Ivan Dimauro, Cristina Fantini, Rosario Barone, Filippo Macaluso, Valentina Di Felice, Daniela Caporossi
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Publication date: Available online 27 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Michael M. Lindeborg, Pramila Shakya, Bhawani Pradhan, Shiba Kala Rai, Kabita Bhattarai Gurung, Suman Niroula, Badri Rayamajhi, Hema Chaudhary, Bhagwati Gaire, Naina Mahato, Lila Rana, Phana Rokaya, Nilam Shrestha, Renuka Shrestha, Januka Tamang, Hemanta Dhoj Joshi, Pushpa Gaha, Dhana Kumari Khorja, Kiran K. Nakarmi, Carole D. Mitnick
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Publication date: Available online 27 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Kirsten E. Stewart, Ross Bannon, D.B. Mondal, Miles Bannister
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Publication date: Available online 27 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Amber D. Shaffer, Joseph E. Dohar
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Publication date: Available online 27 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Terral Patel, Clarice S. Clemmens, David R. White, Marvella E. Ford, Anne L. Andrews, Phayvanh P. Pecha
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Publication date: Available online 26 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Heather Fenley, Matthew Voorman, James T. Dove, Joseph Scott Greene
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Abstract Currently, the figure of the teacher is a key element to train students in the use of new information and communication technologies (ICT), which will positively influence the entire teaching-learning process. Therefore, it is an indispensable requirement in the initial training of the teacher the development of the digital teaching competence, understanding this construct as the set of knowledge, use and attitudes towards digital technologies. However, in the initial...
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