In this paper, we investigate pattern dynamics with multivariable by using the method of matrix analysis and obtain a condition under which the system loses stability and Turing bifurcation occurs. In addition, we also derive the amplitude equation with multivariable. This is an effective tool to investigate multivariate pattern dynamics. The example and simulation used in this paper validate our theoretical results. The method presented is a novel approach to the investigation of specific real systems...
The paper presents the results of a study that attempts to investigate the impact of foreign direct investment (FDI) on energy intensity by constructing panel regression model and panel smooth transition regression (PSTR) model. Based on panel data from 1990 to 2014, this study contributes to conduct the impact of FDI on energy intensity from the perspective of emerging country, including BRICS and non-BRICS countries, and investigates the channels of influence of FDI on energy intensity. Besides...
Objective. Influenza virus poses a major threat to human health and has serious morbidity and mortality which commonly occurs in high-risk populations. Pharynx and larynx of the upper respiratory tract mucosa is the first defense line against influenza virus infection. However, the ability of the pharynx and larynx organ to eliminate the influenza pathogen is still not clear under different host conditions. Methods. In this study, a mouse model of kidney yang deficiency syndrome (KYDS) was used to...
Miombo woodlands are major vegetation type covering about 93% of the forest land of Mainland Tanzania. It forms an integral part of the rural landscape in Tanzania and plays a crucial role in providing a wide range of goods and services including carbon sequestration. However, the sustainability of forest resources is mostly affected by the magnitude of its utilization. There should be a balance between the forest growth and removals. Nevertheless, the magnitude of removed volume and carbon in the...
Background. Rising hypertension prevalence, coupled with increasing overweight and obesity rates, has been observed in Yi people. Moreover, the growing blood pressure level among Yi people was mostly attributable to the continuous increase of body mass index (BMI). However, little is known about the trend of association between them. Methods. Consequently, we investigated the impact of overweight/obesity on hypertension over three periods (1996, 2007-2008, 2015) using data from Yi Migrant Study (n = 8749)....
Four LnMnO3+δ (Ln = La, Pr, Sm, and Gd) perovskites were synthesized and characterized by powder XRD. It was shown that the perovskite lattice became more and more distorted when lowering the size of the A-site cation. The manganite-based perovskites were evaluated for the ability to electrochemically reduce oxygen and nitric oxide in the temperature range of 200 to 400°C. At the lowest temperature, the electrodes were better at reducing nitric oxide than oxygen. At higher temperatures, the activity...
Electromechanical delay (EMD) is the time interval between local myocyte depolarization and the onset of myofiber shortening. Previously, researchers measured EMD during sinus rhythm and ectopic pacing in normal and heart failure conditions. However, to our knowledge, there are no reports regarding EMD during another type of rhythms or arrhythmia. The goal of this study was to quantify EMD during sinus rhythm, tachycardia, and ventricular fibrillation conditions. We hypothesized that EMD under sinus...
Background. Proximal femoral nail antirotation-2 (PFNA-2) has been widely used to treat intertrochanteric fractures with varied outcomes in the previous studies. The entry point of the nail plays an important role in achieving acceptable reduction, stable fixation, and avoiding implant related complications. This study was proposed to determine the optimal greater trochanteric entry point for PFNA-2 in unstable intertrochanteric femur fractures. Methods. We conducted an observational study on 40...
This study proposes a novel approach to study the mechanism of mining and dynamic changes in surface subsidence and geological hazard-prone regions caused by shallow, thick coal seam mining in gully areas. This approach combines field observation, three-dimensional modeling, numerical simulation, and theoretical analysis based on the conditions of the Chuancao Gedan coal mine. The in situ stress field of coalbeds is influenced by the gully terrain. Shear stress becomes concentrated on the surface,...
Opinion natural reversals are important and common phenomena in network management. It is a naturally emerging process of opinions characterized by interactions between individuals and the evolution of attitudes themselves. To explore the underlying mechanism of this social phenomenon and to reveal its dynamic traits, we propose here a novel model which takes the effects of natural reversal parameter and opinion interaction on the individual’s view choice behavior into account based on the Hegselmann...
Deep learning-based visual odometry systems have shown promising performance compared with geometric-based visual odometry systems. In this paper, we propose a new framework of deep neural network, named Deep Siamese convolutional neural network (DSCNN), and design a DL-based monocular VO relying on DSCNN. The proposed DSCNN-VO not only considers positive order information of image sequence but also focuses on the reverse order information. It employs supervised data-driven training without relying...
In this paper, event-triggered leader-following consensus of general linear multiagent systems under both fixed topology and switching topologies is studied. First, centralised and decentralised event-triggered control strategies based on neighbors’ state estimation are proposed under fixed topology, in which the controller is only updated at the time of triggering. Obviously, compared with the continuous time control algorithms, the event-triggered control strategies can reduce the communication...
Oral fosfomycin is approved in Canada for the treatment of acute uncomplicated cystitis. Several studies have reported “off label” use of oral fosfomycin in the treatment of patients with complicated lower urinary tract infection (cLUTI). This review summarizes the available literature describing the use of oral fosfomycin in the treatment of patients with cLUTI. Collectively, these studies support the use of a regimen of 3 grams of oral fosfomycin administered once every 48 or 72 hours for a total...
Prediction of DNA-binding proteins (DBPs) has become a popular research topic in protein science due to its crucial role in all aspects of biological activities. Even though considerable efforts have been devoted to developing powerful computational methods to solve this problem, it is still a challenging task in the field of bioinformatics. A hidden Markov model (HMM) profile has been proved to provide important clues for improving the prediction performance of DBPs. In this paper, we propose a...
A 60-year-old woman was diagnosed with isolated mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa and treated with two years of weekly rituximab for eight doses followed by rituximab maintenance. After nearly two years of maintenance therapy, she developed a tender, indurated mass on the left neck. Biopsy results were consistent with primary cutaneous classical Hodgkin lymphoma (PCCHL).
The image-to-image translation method aims to learn inter-domain mappings from paired/unpaired data. Although this technique has been widely used for visual predication tasks—such as classification and image segmentation—and achieved great results, we still failed to perform flexible translations when attempting to learn different mappings, especially for images containing multiple instances. To tackle this problem, we propose a generative framework DAGAN (Domain-aware Generative Adversarial etwork)...
The brain is a complex and dynamic system, consisting of interacting sets and the temporal evolution of these sets. Electroencephalogram (EEG) recordings of brain activity play a vital role to decode the cognitive process of human beings in learning research and application areas. In the real world, people react to stimuli differently, and the duration of brain activities varies between individuals. Therefore, the length of EEG recordings in trials gathered in the experiment is variable. However,...
Plaque psoriasis is the most common type of psoriasis that manifests as red scaly patches with white scales affecting body areas including scalp, elbows, knees, trunk, and buttocks. Although many treatment options are available including novel biologics, no cure is available. Mesenchymal stem cells (MSCs) have been safely used to treat a variety of human diseases. Allogeneic MSCs possess unique characteristics including hypoimmunogenicity, immunomodulatory, and anti-inflammatory properties, and they...
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory disorder with multiple phenotypes. The syndrome has identifiable radiologic characteristics that are the most important when making a diagnosis. X-rays of cases diagnosed with SAPHO syndrome reveal sclerotic lesions or mixed lytic and sclerotic lesions. Pure osteolytic lesions in SAPHO syndrome are rare, and to the best of our knowledge, no study has reported the radiologic change of purely osteolytic...
Aim. To analyse the target of Rhizoma Curcumae in nasopharyngeal carcinoma by using pharmacological techniques and to explore the associated molecular mechanism. Methods. The targets of nasopharyngeal carcinoma were retrieved from the GeneCards database. At the same time, the drug therapeutic targets of Rhizoma Curcumae were obtained from the TCMSP and SymMap databases. The data were imported into the STRING database and Cytoscape 3.7.1 to construct a network of “Chinese medicine component-target-disease”...
In this study, we construct a mixture of bivariate inverse Weibull distribution. We assumed that the parameters of two marginals have Bernoulli distributions. Several properties of the proposed model are obtained, such as probability marginal density function, probability marginal cumulative function, the product moment, the moment of the two variables x and y, the joint moment-generating function, and the correlation between x and y. The real dataset has been analyzed. We observed that the mixture...
Two fixed-point theorems for -admissible mappings satisfying contractive inequality of integral type with -distance in complete metric spaces are proved. Our results extend and improve a few existing results in the literature. As applications, we use the fixed-point theorems obtained in this paper to establish solvability of nonlinear integral equations. Examples are included.
Increasing energy cost has driven the food canning industries to optimize their energy consumption in order to produce safe and shelf-stable foods efficiently. In the mushroom canning industry, energy efficiency is very critical to improve product (price) competitiveness. This research aimed at demonstrating total steam consumption to achieve the same sterility level (-value) of canned mushroom by using different combinations of times and temperatures of retorting. Agaricus bisporus in brine contained...
Objectives. Clarithromycin is recommended as the core agent for treating M. abscessus infections, which usually calls for at least one year of treatment course, facilitating the development of resistance. This study aimed to identify the underlying mechanism of in vivo development of clarithromycin resistance in M. abscessus clinical isolates. Methods. M. abscessus isolates from patients with lung infections during long-term antibiotic therapy were longitudinally collected and sequenced. PFGE DNA...
Traditional fuzzy neural network has certain drawbacks such as long computation time, slow convergence rate, and premature convergence. To overcome these disadvantages, an improved quantum-behaved particle swarm optimization algorithm is proposed as the learning algorithm. In this algorithm, a new chaotic search is introduced, and benchmark function experiments prove it outperforms the other five existing algorithms. Finally, the proposed algorithm is presented as the learning algorithm for Takagi–Sugeno...
Background. Kawasaki disease (KD) is an inflammatory vasculitis and is the most common cause of acquired childhood heart disease in developed countries. Current treatment with intravenous immunoglobulin (IVIG) is often ineffective in patients with delayed or refractory disease. We present a case of combination anticytokine therapy in an infant with delayed and refractory KD. Case Presentation. A 3-month-old infant presented with refractory KD with giant aneurysms after a delayed diagnosis of one...
Introduction. Complaints relating to patient care are known to correlate with surgical complication rates and malpractice lawsuits. In a continually evolving health service and on-going financial pressures, identifying current complaint themes could drive future improvements in healthcare delivery. Objective. The aim of this paper is to review and analyse complaints received by the ENT department of two large teaching hospitals in London in order to determine current trends and mitigate future challenges....
Relevance vector machine (RVM) is a Bayesian sparse kernel method for regression in statistical learning theory, which can avoid principal limitations of the support vector machine (SVM) and result in faster performance on test data while maintaining comparable generalization error. In this paper, we develop a logic framework of the evidence function approximation associated with RVM based on Taylor expansion instead of traditional technology called “completing the square.” While constructing the...
House price is affected by households’ expectation of future house price trend and volatility, where the expected volatility of housing capital return, indicated by variance, is defined as the housing market risk. Theoretically, risk element cannot be directly inserted in the standard housing models because most of the models are built on the underlying assumption of certainty. Extending the life-cycle model to a two-asset expected utility case with uncertainty, we show house price is affected by...
Thymus atlanticus, an endemic plant of Morocco, is traditionally used as a liniment or a drink to treat various diseases. However, there are few available scientific data regarding its biological effects. In this connection, the present study aimed to investigate the hypolipidemic and antioxidant effects of aqueous extract and polyphenol fraction of Thymus atlanticus in Syrian golden hamsters treated with Triton WR-1339 (triton, 20 mg/100 g body weight). The hamsters orally received the extracts...
Background. The conversion from a nonshockable rhythm (asystole or pulseless electrical activity (PEA)) to a shockable rhythm (pulseless ventricular tachycardia or ventricular fibrillation) may be associated with better out-of-hospital cardiac arrest (OHCA) outcomes. There are insufficient data on the prognostic significance of such conversions by initial heart rhythm and different rhythm conversion time. Methods. Among 24,849 adult OHCA patients of presumed cardiac etiology with initial asystole...
Background. Immunosuppressants such as cyclophosphamide (CTX) have been employed to treat a wide array of autoimmune diseases. The most unfavourable side effects of these drugs are their suppression on the antimicrobial immunity and increasing the risk of infection. As a promising substitution/adjunct, mesenchymal stem cells (MSCs) are currently being tested in several clinical trials. However, their influence on the recipients’ antimicrobial immunity remains unclear. Methods. In this study, C57BL/6...
The active engine mount (AEM) provides an effective solution to improve the acoustic and vibration comfort of a car. The same AEM can be installed for different engines and different vehicle bodies and attenuates the engine vibration, which is one of the most pressing challenges. To study this problem, this paper develops a mathematical model of a secondary path between the input voltage and output force of the AEM on the engine side considering the frequency-dependent characteristic of the stiffness,...
In this paper, the existence and uniqueness results of the generalization nonlinear fractional integro-differential equations with nonseparated type integral boundary conditions are investigated. A natural formula of solutions is derived and some new existence and uniqueness results are obtained under some conditions for this class of problems by using standard fixed point theorems and Leray–Schauder degree theory, which extend and supplement some known results. Some examples are discussed for the...
We show the existence of positive solutions for a singular superlinear fourth-order equation with nonlinear boundary conditions. where λ > 0 is a small positive parameter, is continuous, superlinear at ∞, and is allowed to be singular at 0, and h: [0, 1] ⟶ [0, ∞) is continuous. Our approach is based on the fixed-point result of Krasnoselskii type in a Banach space.
Background. Personalised medicine in oncology needs standardised immunological assays. Flow cytometry (FCM) methods represent an essential tool for immunomonitoring, and their harmonisation is crucial to obtain comparable data in multicentre clinical trials. The objective of this study was to design a harmonisation workflow able to address the most effective issues contributing to intra- and interoperator variabilities in a multicentre project. Methods. The Italian National Institute of Health (Istituto...
Objectives. To prepare the conductive MWCNT (multiwall carbon nanotube)-agarose scaffolds with multi-microchannel for neuron growth under electrical stimulation. Methods. The scaffolds were produced by gradient freeze and lyophilization methods. The synthesized materials were characterized by SEM and near-infrared spectroscopy, and their microstructure, swelling-deswelling, conductivity, biocompatibility, and shape memory behavior were measured. A three-dimensional culture model by implanting cells...
Normal cellular physiology and biochemical processes require undamaged RNA molecules. However, RNAs are frequently subjected to oxidative damage. Overproduction of reactive oxygen species (ROS) leads to RNA oxidation and disturbs redox (oxidation-reduction reaction) homeostasis. When oxidation damage affects RNA carrying protein-coding information, this may result in the synthesis of aberrant proteins as well as a lower efficiency of translation. Both of these, as well as imbalanced redox homeostasis,...
According to the results of the physical model tests, the failure plane of an anaclinal layered rock slope was a linear-type plane at an angle above the plane normal to the discontinuities, and the failure mode of rock strata was bending tension. However, the shear failure occurred near the slope toe, the effects of the cohesion of the discontinuities on the stability of the slope, and the contribution of tangential force to cross-section axial force were neglected in such studies. Moreover, none...
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