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Δευτέρα, 9 Μαρτίου 2020


The characteristics of left atrial diverticula in normal sinüs rhythm patients
Abstract Purpose The purpose of this study was to evaluate the prevalence, location, size and morphological characteristics of left atrial diverticula using electrocardiographically gated multi-detector computed tomography in patients with normal sinus rhythm. Methods Electrocardiographically gated cardiac multi-detector computed tomography...
Surgical and Radiologic Anatomy
07:55
Relationship between appendicitis and diameter of ileocecal lipomatosis and also ileocecal angle
Abstract Purpose One of the most widespread surgical conditions is acute appendicitis in industrialized countries. Nevertheless, diagnosis of borderline cases is mostly troublesome and needs subsequent researches. For this reason, we aimed to investigate new parameters to improve estimation of acute appendicitis. Lymphoid hyperplasia, impacted stool, faecolith, caecal or appendiceal tumors have been accepted as causes of appendicitis...
Surgical and Radiologic Anatomy
07:55
Assessment of clitoral anatomy in human fetuses
Abstract Purpose To determine fetal clitoral dimensions in antenatal period and to provide a contribution to external genital morphology determination in premature infants. Methods Thirty-one formalin fixed female fetuses aged between 18 and 40 weeks (17 fetuses aged 21.53 ± 1.88 weeks in the second trimester and 14 fetuses aged 31.00 ± 4.90 weeks...
Surgical and Radiologic Anatomy
07:55
Distinguishing between HPV-Associated Metastatic Anal Squamous Cell Cancer and HPV-Associated Oropharyngeal Cancer
The histology and immunohistochemistry (IHC) of primary and metastatic diseases from a human papilloma virus- (HPV-) related anal squamous carcinoma (ASCC) would typically demonstrate the same histology as an HPV-related oropharyngeal squamous carcinoma (OPSCC). However, determining whether a site of squamous cell carcinoma represents distant metastatic ASCC versus a metastatic HPV-related metastasis from an OPSCC to a regional lymph node carries profound prognostic and therapeutic implications....
Case Reports in Pathology
03:20
A computational analysis of the effect of supporting organs on predicted vesical pressure in stress urinary incontinence
Abstract Stress urinary incontinence (SUI) or urine leakage from urethra occurs due to an increase in abdominal pressure resulting from stress like a cough or jumping height. SUI is more frequent among post-menopausal women. In the absence of bladder contraction, vesical pressure exceeds urethral pressure leading to urine leakage. The main aim of this study is to utilize fluid-structure interaction techniques to model bladder and urethra computationally under an external pressure...
Latest Results for Medical
02:00
The birth of a bacterial tRNA gene [NEW RESULTS]
While the major function of transfer RNA is conserved across the tree of life, organisms differ in the types and numbers of tRNA genes that they carry. The evolutionary mechanisms behind the emergence of different tRNA gene sets remain largely obscure. Here, we report the rapid and repeated evolution of a tRNA gene set in laboratory populations of the bacterium Pseudomonas fluorescens SBW25. Deletion of the non-essential, single-copy tRNA gene serCGA from SBW25 results in a sub-optimal tRNA gene...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Genetic sex determination and sex-specific lifespan in tetrapods - evidence of a toxic Y effect [NEW RESULTS]
Sex-specific lifespans are ubiquitous across the tree of life and exhibit broad taxonomic patterns that remain a puzzle, such as males living longer than females in birds and vice versa in mammals. The prevailing 'unguarded-X' hypothesis (UXh) explains this by differential expression of recessive mutations in the X/Z chromosome of the heterogametic sex (e.g., females in birds and males in mammals), but has only received indirect support to date. An alternative hypothesis is that the accumulation...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Massive rhizobial genomic variations associated with partner quality in Lotus-Mesorhizobium symbiosis [NEW RESULTS]
In diverse mutualistic relationships, genetic variations in impact on the growth of interacting partners-variations in partner quality-are common, despite the theoretical prediction that selection favoring high-quality partners should eliminate such variations. Here, we investigated how variations in partner quality could be maintained in the nitrogen-fixing mutualism between Lotus japonicus and Mesorhizobium bacteria. We reconstructed de novo assembled full-genome sequences from nine rhizobial symbionts,...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
The evolutionary history of Neandertal and Denisovan Y chromosomes [NEW RESULTS]
Ancient DNA has allowed the study of various aspects of human history in unprecedented detail. However, because the majority of archaic human specimens preserved well enough for genome sequencing have been female, comprehensive studies of Y chromosomes of Denisovans and Neandertals have not yet been possible. Here we present sequences of the first Denisovan Y chromosomes (Denisova 4 and Denisova 8), as well as the Y chromosomes of three late Neandertals (Spy 94a, Mezmaiskaya 2 and El Sidron 1253)....
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Using the Price equation to detect inclusive fitness in class-structured populations [NEW RESULTS]
Inclusive fitness theory has transformed the study of adaptive evolution since 1964, contributing to significant empirical findings. However, its status as a theory has been challenged by the proposals of several alternative frameworks. Those challenges have been countered by analyses that use the Price equation and the regression method. The Price equation is a universal description of evolutionary change, and the partitioning of the Price equation using the regression method immediately yields...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Evolutionary Distance of Gene-Gene Interactions: Estimation under Statistical Uncertainty [NEW RESULTS]
Consider the functional interaction of gene A to an interaction subject X; for instance, it is the gene-gene interaction if X represents for a gene, or gene-tissue interaction (expression status) if X for a tissue. In the simplest case, the status of this A-X interaction is r=1 if they are interacted, or r=0 otherwise. A fundamental problem in molecular evolution is, given two homologous (orthologous or paralogous) genes A and B, to what extent their functional overlapping could be by the means of...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
The coupled dual-oscillator model of wing and haltere motion in flies [NEW RESULTS]
The mechanics of Dipteran thorax is dictated by a network of exoskeletal linkages which, when deformed by flight muscles, generate coordinated wing movements. In Diptera, forewings power flight, whereas hindwings have evolved into specialized halteres which provide rapid mechanosensory feedback for flight stabilization. Although actuated by independent muscles, wing-haltere motion is precisely phase-coordinated at high frequencies. Because wingbeat frequency is a product of wing-thorax resonance,...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Tests of hybridisation in Tetragonula stingless bees using multiple genetic markers. [NEW RESULTS]
Discrepancies in mitochondrial and nuclear genetic data are often interpreted as evidence of hybridisation. We re-examined reports of hybridisation in three cryptic stingless bee species in the genus Tetragonula in South East Queensland, Australia (T. carbonaria, T. davenporti, and T. hockingsi). Previous studies on this group using microsatellites proposed that rare hybrids do occur. In contrast, we find that allele frequencies at neutral regions of the nuclear genome (both microsatellites and random...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Improving the chromosome-level genome assembly of the Siamese fighting fish (Betta splendens) in a university Master's course. [NEW RESULTS]
Background: Ever decreasing costs along with advances in sequencing and library preparation technologies enable even small research groups to generate chromosome-level assemblies today. Here we report the generation of an improved chromosome-level assembly for the Siamese fighting fish (Betta splendens) that was carried out during a practical university Masters course. The Siamese fighting fish is a popular aquarium fish and an emerging model species for research on aggressive behaviour. We updated...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Ecological opportunity as a driving force of radiation events and time-dependent evolutionary rates in papillomaviruses [NEW RESULTS]
Papillomaviruses (PVs) have a wide host range, infecting mammals, birds, turtles, and snakes. The recent discovery of PVs in different fish species allows for a more complete reconstruction of the evolutionary history of the viral family. In this study we combine fossil record estimates and molecular dating to analyze evolutionary events that occurred during PV evolution, as well as to estimate speciation and evolutionary rates. We have used four different data sets to explore and correct for potential...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
A novel allele of ASY3 promotes meiotic stability in autotetraploid Arabidopsis lyrata [NEW RESULTS]
In this study we performed a genotype-phenotype association analysis of meiotic stability in ten autotetraploid Arabidopsis lyrata and A. lyrata/A. arenosa hybrid populations collected from the Wachau region and East Austrian Forealps. The aim was to determine the effect of eight meiosis genes under extreme selection upon adaptation to whole genome duplication. Individual plants were genotyped by high-throughput sequencing of the eight meiosis genes (ASY1, ASY3, PDS5b, PRD3, REC8, SMC3, ZYP1a/b)...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Genetic signatures of evolutionary rescue by a selective sweep [NEW RESULTS]
One of the most useful models in population genetics is that of a selective sweep and the consequent hitch-hiking of linked neutral alleles. While variations on this model typically assume constant population size, many instances of strong selection and rapid adaptation in nature may co-occur with complex demography. Here we extend the hitch-hiking model to evolutionary rescue, where adaptation and demography not only co-occur but are intimately entwined. Our results show how this feedback between...
bioRxiv Subject Collection: Evolutionary Biology
Mon Mar 09, 2020 02:00
Clinicopathological study of organ metastasis in endometrial cancer
Future Oncology, Ahead of Print.
Future Oncology
Mon Mar 09, 2020 13:48
Development, validation and application of a 3D printed model depicting adenoid hypertrophy in comparison to a Nasoendoscopy
The exploration of tridimensional (3D) technology of computational tomography and the development of valid 3D printed models may improve the assessment of adenoid obstruction. The identification of an enlarged...
Head & Face Medicine
Mon Mar 09, 2020 02:00
Predictive value of serum VEGF levels for elderly patients or for patients with poor performance status receiving anti-PD-1 antibody therapy for advanced non-small-cell lung cancer
Abstract The efficacy of immune checkpoint inhibitors (ICIs) in elderly and poor performance status (PS) patients is controversial, because clinical evidence is limited. This study aimed to find a predictive biomarker for the efficacy of anti-programmed cell death 1 (PD-1) antibodies in these patient populations. We retrospectively reviewed medical records of advanced non-small-cell lung cancer (NSCLC) patients who were ≥ 75 years of age or classified as PS 2 and received anti-PD-1...
Anti-VEGF/VEGFR therapy,,
02:00
ESTIMATE algorithm is not appropriate for inferring tumor purity and stromal and immune cell admixture in hematopoietic or stromal tumors
Cancer Immunology, Immunotherapy
Mon Mar 09, 2020 02:00
Significant association between tumor mutational burden and immune-related adverse events during immune checkpoint inhibition therapies
Abstract More than 2000 immuno-oncology agents are being tested or are in use as a result of the cancer immunotherapy revolution. Manipulation of co-inhibitory receptors has achieved tumor eradication in a minority of patients, but widespread immune-related adverse events (irAEs) compromised tolerance to healthy self-tissues in the majority. We have proposed that a major mechanism of irAEs is similar to a graft-versus-malignancy effect of graft-versus-host disease. To verify our...
Cancer Immunology, Immunotherapy
Mon Mar 09, 2020 02:00
Predictors of dental erosions in patients evaluated with upper digestive endoscopy: a cross-sectional study
Abstract The most studied medical condition related with dental erosions is gastroesophageal reflux disease (GERD). The aim of this study was to assess other predictors of dental erosions besides GERD in outpatients referred for upper digestive endoscopy. In a cross-sectional study, we prospectively evaluated 235 patients who underwent upper digestive endoscopy. Patients were interviewed and examined by a trained dentist before the endoscopies, addressing dental health as well...
Odontology
02:00
Antibiotics in the clinical pipeline in October 2019
The Journal of Antibiotics - Issue - nature.com science feeds
02:00
Deciphering colistin heteroresistance in <i>Acinetobacter baumannii</i> clinical isolates from Wenzhou, China
The Journal of Antibiotics - Issue - nature.com science feeds
Mon Mar 09, 2020 02:00
Deciphering colistin heteroresistance in <i>Acinetobacter baumannii</i> clinical isolates from Wenzhou, China
The Journal of Antibiotics, Published online: 09 March 2020; doi:10.1038/s41429-020-0289-2Deciphering colistin heteroresistance in Acinetobacter baumannii clinical isolates from Wenzhou, China
The Journal of Antibiotics - Issue - nature.com science feeds
Mon Mar 09, 2020 02:00
Improvement of the novel inhibitor for <i>Mycobacterium</i> enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening
The Journal of Antibiotics, Published online: 09 March 2020; doi:10.1038/s41429-020-0293-6Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening
The Journal of Antibiotics - Issue - nature.com science feeds
Mon Mar 09, 2020 02:00
Improvement of the novel inhibitor for <i>Mycobacterium</i> enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening
The Journal of Antibiotics - Issue - nature.com science feeds
Mon Mar 09, 2020 02:00
Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus <i>Clonostachys compactiuscula</i> FKR-0021
The Journal of Antibiotics - Issue - nature.com science feeds
Fri Mar 06, 2020 02:00
Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography
Clinical Ophthalmology
04:11
Plume Sign in the Deturgescence of Macular Cysts – A Novel OCT Finding
Clinical Ophthalmology
04:09
Multi-Center Prospective Study of Restrictive Post-Operative Antibiotic Treatment of Children with Complicated Appendicitis
Surgical Infections, Ahead of Print.
Surgical Infections
Wed Mar 04, 2020 10:00
Outcomes in Pediatric Transsphenoidal Pituitary Surgery Stratified by the Use of Image Guidance: An Analysis of the Kids' Inpatient Database from 1997 to 2016
J Neurol Surg BDOI: 10.1055/s-0040-1701602 Background To evaluate the utilization of image guidance technology for pediatric transsphenoidal pituitary resection (TSPR) and analyze the complication rates, length of stay (LOS), and total cost for such surgeries as function of time and utilization of image guidance. Methods The Healthcare Cost and Utilization Project Kids' Inpatient Database (KID) was queried for all cases of TSPR between 1997 and 2016. Factors extracted included...
Journal of Neurological Surgery Part B: Skull Base
Mon Mar 09, 2020 01:00
Indications and Safety of the Zygomatic Osteotomy in Middle Cranial Fossa Surgery: A Retrospective Cohort Review
J Neurol Surg BDOI: 10.1055/s-0040-1705166Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text
Journal of Neurological Surgery Part B: Skull Base
Mon Mar 09, 2020 01:00
Design and Development of a Growing Pneumatic Soft Robot
Soft Robotics, Ahead of Print.
Soft Robotics
Wed Mar 04, 2020 10:00
The Medial Subcoronoid Process Region as a Novel Source of Bone Grafts in Orthognathic Surgery and Genioplasty
Background: Since 2012, the authors have adopted the medial subcoronoid process bone interpositional grafting in OGS and genioplasty procedures. The purpose of this study was to present the technical details and clinical outcomes of this alternative bone interpositional grafting for LeFort I and chin osteotomies. Methods: Consecutive patients (n = 50) who underwent single-splint bimaxillary OGS with or without genioplasty and received medial subcoronoid bone interpositional grafting were...
Craniofacial Surgery - Current Issue
Sun Mar 01, 2020 02:00
The History and Innovations of Plastic Surgery in China
No abstract available
Craniofacial Surgery - Current Issue
Sun Mar 01, 2020 02:00
Temporal Muscle Flap as a Treatment of an Extensive Cleft Palate in an Adult Patient
For the management of cleft palate, the surgical approach has been suggested at an early stage even in childhood, varying in the number of interventions. Once the interventions are not performed at appropriate times, such as sequences that may accompany specific psychological, functional, and aesthetic effects. Since it has been indicated, temporal muscle flap is a technique with satisfactory results for a resolution of extensive clef palate in adult patients. The purpose of this paper is reporting...
Craniofacial Surgery - Current Issue
Sun Mar 01, 2020 02:00

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