This study aimed to develop a novel biscuit by supplementing cladode flour (CF) into whole-wheat flour (WWF) at different proportions 0, 25, 50, 75, and 100%. Proximate analysis revealed that CF had a high amount of ash (11.9%) and dietary fiber (41.04%). Major minerals determined by ICP-MS were calcium (4.47 g/100 g); potassium (1.25 g/100 g); magnesium (1.46 g/100 g); and trace elements such as zinc (1.77 mg/100 g), copper (0.95 mg/100 g), and selenium (148.5 μg/100 g). The analysis of total phenolics,...
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Background. Solitary fibrous tumor (SFT) is a rare variant of soft tissue sarcoma (STS). Materials and Methods. We reviewed SFT patients (pts) treated at our institution between 12/1990 and 09/2017. Results. We identified 94 pts with a median follow-up (mFU) of 4.7 years (range: 0.1–21.53). Primary sites were the chest (33%), abdomen (21.3%), brain (12.8%), and extremities (9.6%); 6.4% of pts presented with synchronous metastasis. Median overall survival (mOS) from the first diagnosis was 56.0 months...
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Aim. To investigate prognostic factors in pediatric and young adult patients with localized osteosarcoma that could predict the development of subsequent pulmonary metastases and lead to an ability to risk-stratify therapy. We performed a systematic review of the literature published since January 1990 to establish common evidence-based prognostic factors. Methods. PubMed and Embase searches (Jan 1990–Aug 2018) were performed. Two reviewers independently selected papers for patients with localized...
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Background and Objectives. Methadone is commonly used in chronic pain, but it is not frequently used as an intraoperative analgesic. Several randomized studies have compared intraoperative methadone to morphine regarding postsurgical analgesia, but they have generated conflicting results. The aim of this investigation was to compare the analgesic efficacy of intraoperative methadone to morphine in patients undergoing surgical procedures. Methods. We performed a quantitative systematic review of randomized...
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Background. The purpose of this study was to investigate if the addition of liposome bupivacaine (LB) to an interscalene block (ISB) had an effect on the number of patients with surgical- or block-related complications. Methods. This was a single-center retrospective chart view performed by identifying patients who received an ISB from January 1, 2014, through April 26, 2018, at the University of Minnesota. 1,518 patients were identified who received an ISB (LB = 784, nonliposomal bupivacaine = 734)....
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Antiplatelet therapy is the mainstay of treatment and secondary prevention of cardiovascular disease (CVD), including acute coronary syndrome (ACS), transient ischemic attack (TIA) or minor stroke, and peripheral artery disease (PAD). The P2Y12 inhibitors, of which clopidogrel was the first, play an integral role in antiplatelet therapy and therefore in the treatment and secondary prevention of CVD. This review discusses the available evidence concerning antiplatelet therapy in patients with CVD,...
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Hirudiniasis is a condition caused by infestation by leeches. Despite the annoyance, clinical signs, and associated lesions caused by leeches in both humans and animals, the extent of the problem in Tanzania is not well elucidated. Individual animals and people become infested when they drink, bath, or walk through contaminated water sources. Leech infestations are more common in rural areas where water is scarce especially during the dry season. In this report, clinical cases of hirudiniasis in...
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This paper investigates the problem of quantized dissipative observer-based output feedback control of Markovian descriptor jump systems with unavailable states, appearing networked-induced delay. The descriptor systems are presented as Markovian jump systems which give a more realistic presentation for a variety of nonlinear dynamical systems than conventional state-space representation. To accomplish the objective, a uniform framework is employed to design the delayed Markov observer-based controller...
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Sine Cosine Algorithm (SCA) has been proved to be superior to some existing traditional optimization algorithms owing to its unique optimization principle. However, there are still disadvantages such as low solution accuracy and poor global search ability. Aiming at the shortcomings of the sine cosine algorithm, a multigroup multistrategy SCA algorithm (MMSCA) is proposed in this paper. The algorithm executes multiple populations in parallel, and each population executes a different optimization...
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Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong. Different thrombotic risk scores for patients with essential thrombocythemia have been proposed, but only one of them (the IPSET-t scoring system) takes into account the classical cardiovascular risk factors as one of the scoring items. Currently, in clinical practice, the presence of cardiovascular risk factors in patients with diagnosis...
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Consumption of junk food among adolescents has been recognized as a serious health problem in the world. Therefore, this study aims to assess the effectiveness of an educational intervention program (interactive lecture) based on the theory of planned behavior (TPB) for reducing junk food consumption among school adolescents in Birgunj Metropolitan City, Nepal. A structured questionnaire was deployed for collecting the data from four government schools. Pretest and Posttest group study design and...
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The lack of online sensors for Mooney viscosity measurement has posed significant challenges for enabling efficient monitoring, control, and optimization of industrial rubber mixing process. To obtain real-time and accurate estimations of Mooney viscosity, a novel soft sensor method, referred to as multimodal perturbation- (MP-) based ensemble just-in-time learning Gaussian process regression (MP-EJITGPR), is proposed by exploiting ensemble JIT learning. This method employs perturbations on similarity...
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Recently, algebraic characterization of multiagent controllability through its topology has been widely concerned by the systems and control community. The controllability of leader-follower networked multiagent systems under the framework of generic linear dynamics is firstly discussed via λ-matrix. Some new algebra-theoretic necessary and/or sufficient conditions of the controllability for generic linear multiagent systems are established. Moreover, the controllable conditions for multiagent networks...
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Multimodal anesthesia, which combines general and epidural anesthesia, is used in surgical cases in which a large or painful incision is anticipated. However, both epidural blocks and opioid-based analgesia have limitations in application. Here, we present a case of supra-infraumbilical laparotomy in a patient whose history of neurostimulator use and marked scoliosis discouraged the placement of an epidural catheter and whose prior adverse response to opioids prohibited their use. The intraoperative...
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Anesthesiologists should supply proper sedation and high-quality awakening in awake craniotomy anesthesia. At our institution, we perform an asleep-awake-asleep technique for awake craniotomy anesthesia by using short-acting anesthetic drugs, such as propofol and remifentanil. However, elderly patients do not wake adequately in our normal protocol and hence are unable to complete the required neurological tasks. In this case series, we present the anesthetic management of three elderly patients with...
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Actinomycetes are Gram-positive, facultative anaerobic fungus-like filamentous bacteria which remain on the top of the natural antibiotic producers. Due to the climatic and geographical diversity of Nepal, a wide range of microorganisms with potent source of antimicrobials are available. The objective of this study was to isolate, identify, and screen the potential antimicrobial-producing actinomycetes from soils covering different altitude range of Nepal. Forty-one isolates of actinomycetes were...
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The study and accurate prediction of the movement of overburden rock mass and surface subsidence are crucial for a safe production in metal mines. This study investigates the relationship between the movement laws of overlaying strata and the time space of a mined-out volume using Rock Failure Process Analysis (RFPA) System. Furthermore, the movement, deformation, and failure laws of overlaying strata are examined in different positions when a goaf volume is certain and the failure behavior of the...
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Retroperitoneal abscesses are uncommon conditions with occult and insidious presentations. There is often a lack of abdominal signs and ultrasound findings, causing a delay in diagnosis and definitive treatment, leading to poor patient outcomes. We report a case of right-sided retroperitoneal abscess of a 28-year-old female patient with diabetes mellitus. Prior to admission, the patient reported a vague 2 weeks history of right-sided back and abdominal pain and dysuria. She presented to our medical...
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This is a case of a two-year-old boy with a ganglion arising from the sternoclavicular joint. Ganglia are rare in the pediatric population, with less than 2% occurring under the age of 2 years old. Additionally, sternoclavicular joint ganglia are also exceedingly rare. The case illustrates the importance of keeping ganglion within the differential diagnosis for palpable subcutaneous masses, even in young children, especially when they are seen to connect to the joint.
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The magnetic field is the most common element in the universe, and high static magnetic field (HiSMF) has been reported to act as an inhibited factor for osteoclasts differentiation. Although many studies have indicated the negative role of HiSMF on osteoclastogenesis of RANKL-induced RAW264.7 cells, the molecular mechanism is still elusive. In this study, the HiSMF-retarded cycle and weakened differentiation of RAW264.7 cells was identified. Through RNA-seq analysis, RANKL-induced RAW264.7 cells...
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Protein homeostasis or proteostasis is an essential balance of cellular protein levels mediated through an extensive network of biochemical pathways that regulate different steps of the protein quality control, from the synthesis to the degradation. All proteins in a cell continuously turn over, contributing to development, differentiation, and aging. Due to the multiple interactions and connections of proteostasis pathways, exposure to stress conditions may cause various types of protein damage,...
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Enhanced licensed-assisted access (eLAA) is an operational mode that allows the use of unlicensed band to support long-term evolution (LTE) service via carrier aggregation technology. The extension of additional bandwidth is beneficial to meet the demands of the growing mobile traffic. In the uplink eLAA, which is prone to unexpected interference from WiFi access points, resource scheduling by the base station, and then performing a listen before talk (LBT) mechanism by the users can seriously affect...
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A set of six new 4-pyridinio-1,4-dihydropyridine (1,4-DHP) compounds has been synthesized. The calcium channel modulating activity of these compounds was evaluated in an aorta vascular smooth muscle cell line (A7R5), in an isolated rat aortic ring model, and in human neuroblastoma cell lines (SH-SY5Y). The antagonistic effect of these 1,4-DHP was tested by modulating the impact of carbachol-dependent mobilization of intracellular Ca2+ in SH-SY5Y cells. The intracellular free Ca2+ concentration was...
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Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and decreased mtDNA copy number. Current wisdom indicates that mtDNA is susceptible to damage by mitochondrial reactive oxygen species (mtROS). This review presents the cellular and molecular mechanisms of cardiac aging, including autophagy, chronic...
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Background. Previous studies have demonstrated that lncRNAs play functional roles in regulating cancer cell proliferation, invasion, and apoptosis. Recent studies confirmed that lncRNA 00312 has important biological functions in lung and colorectal cancer. However, the role of lncRNA 00312 in renal cell carcinoma (RCC) remains unclear. Our aim was to explore the function of lncRNA 00312 in RCC and its potential molecular mechanism. Methods. RCC cell lines A498 and ACHN were used as in vitro models...
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Background. Alzheimer’s disease (AD) is a neurodegenerative disorder and characterized by the cognitive impairments. It is essential to identify potential gene biomarkers for AD pathology. Methods. DNA methylation expression data of patients with AD were downloaded from the Gene Expression Omnibus (GEO) database. Differentially methylated sites were identified. The functional annotation analysis of corresponding genes in the differentially methylated sites was performed. The optimal diagnostic gene...
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Purpose. The purpose of this study was to compare the relative safety and efficacy of different types of phosphodiesterase type 5 inhibitors (PDE5-Is) with tamsulosin for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostate hyperplasia (BPH) (BPH-LUTS) with or without erectile dysfunction (ED). Methods. We use the Stata version 13.0 to conduct the network meta-analysis (NMA) with a random effects model of the Bayesian framework. The International Prostate Symptom Score...
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Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization,...
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The black box model of a dynamic system usually consists of just input and output. There is no correlation or coupling between the input and output. This paper proposes a self-coupling black box model method to realize the coupling between its input and output by introducing “virtual variables” to the black box model of a dynamic system considering the advantages of artificial neural network (ANN) in the system. The ANN is used for black box modeling. The modeling process of the self-coupling black...
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The accurate recognition of road condition is one of the important factors that influence vehicle safety performance. This paper comes up with an original mathematical method of an interval recognition algorithm of the pavement surface condition based on Lagrange interpolation. The ordinate of the peak point is solved by the Lagrange interpolation method, and the pavement surface condition is deduced by the interval identification algorithm. The simulation results from six typical roads and the varied...
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This paper investigates a single-period principal-agent model with moral hazard. In the model, we implement bonus tax for the agent and analyze the effect of loss aversion by comparing with the results by Dietl et al. (2013). The existence and uniqueness of the optimal contracting problem are proved. Through an example, concrete illustrations of how loss aversion affects the compensation package are given. It is shown that although the agent’s efforts reduce, the fixed salary and marginal bonus paid...
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In order to solve the precision and stability control problems of nonlinear uncertain systems applied in machining systems, in this paper, a robust adaptive fuzzy control technique based on Dynamic Surface Control (DSC) method is proposed for the generalized single-input single-output (SISO) uncertain nonlinear system. A first-order low-pass filter is introduced in each step of the traditional robust control method to overcome the “calculation expansion” problem, and Takagi–Sugeno (T-S) fuzzy logic...
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Background and Aims. Left-sided portal hypertension (LSPH) is a rare type of portal hypertension, which occurs due to obstruction, stenosis, or thrombosis within the splenic vein. Pancreatic diseases are the most common etiology of LSPH. This study is aimed at reporting our experiences and discussing the presentation, management, and prognosis of LSPH secondary to pancreatic diseases. Patients and Methods. We retrospectively reviewed five patients who were diagnosed with LSPH secondary to pancreatic...
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Background and Aims. Helicobacter pylori is a common infectious bacterium mostly found in gastroduodenal diseases. The increased prevalence of clarithromycin-resistant H. pylori strains is a major challenge in the successful treatment of infections caused by this organism. The present study is aimed at detecting the clarithromycin resistance pattern of H. pylori strains isolated from gastric biopsies and evaluating point mutations of the 23S rRNA gene. Patients and methods. In the present descriptive...
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In this paper, the whale optimization algorithm (WOA) is applied to the inverse scattering of an imperfect conductor with corners. The WOA is a new metaheuristic optimization algorithm. It mimics the hunting behavior of humpback whales. The inspiration results from the fact that a whale recognizes the location of a prey (i.e., optimal solution) by swimming around the prey within a shrinking circle and along a spiral-shaped path simultaneously. Initially, the inverse scattering is first transformed...
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In order to more accurately analyze the fatigue reliability of motor hanger for high-speed train and reduce the influence of uncertain factors, a Bayesian statistical method is introduced to propose a novel fatigue reliability analysis method based on Bayesian updating and subset simulation. First, considering the influence of various uncertain parameters on the first principal stress (FPS) of motor hanger, the ANSYS parametric design language (APDL) is used to establish the parametric model. The...
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MicroRNAs (miRNAs) of the miR-30 family are closely linked with tumor metastasis and play key roles in the complex malignant phenotypes of cancers by targeting many tumor-related genes. Deregulated expression of miR-30 family members has been commonly observed in breast cancer. However, associations between the genetic variants in the regulatory region of miR-30 family and the risk of breast cancer are still limited, especially in the Chinese Han population. In the present study, we conducted a case-control...
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Background. Circulating microRNA-122 (miR-122) has been recognized as a marker of hepatocellular carcinoma (HCC). The current meta-analysis was performed to quantitatively evaluate the diagnostic performance of circulating miR-122 for HCC. Methods. Related studies that evaluated the diagnostic performance of circulating miR-122 determined from pathophysiological examination for HCC were obtained by systematic searches of the PubMed and Embase databases. A randomized fixed effects model was applied...
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Introduction and Objectives. Celiac disease (CD) is a complex autoimmune disorder occurring in genetically susceptible individuals. There is limited data on the impact of gluten-free diet (GFD) on the risk of developing cardiovascular diseases. Hereby, we present our study regarding the impact of treatment with GFD on the biochemical risk factors of atherosclerosis. Material and Methods. 277 patients with CD from 7 Polish clinics were enrolled in the study (210 children treated for at least 5 years...
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