Rhabdomyosarcoma (RMS) encompasses a heterogenous collection of tumors in which new groups have recently been identified that improved the World Health Organization (WHO) classification. While performing RNA-sequencing in our routine practice, we identified 3 cases of well-differentiated RMS harboring new fusion genes. We also analyzed these tumors through array-comparative genomic hybridization. Clinically, these tumors were deep paraspinal tumors, occurring in neo-nat and young children. The patients...
Mon Mar 16, 2020 02:00
Common variable immunodeficiency (CVID) has a heterogenous clinical presentation and can be challenging to diagnose. Distinct histologic changes have been linked with CVID in several organ systems, which can help identify the correct diagnosis. In this study we review a cohort of hepatic CVID biopsies, to better define the spectrum of histologic and biochemical alterations. We reviewed 26 liver biopsies from 24 patients with CVID, obtained at 4 institutions between 2010 and 2019. Histologic slides...
Mon Mar 16, 2020 02:00
Related ArticlesCorrection: Assessment of staffing needs for physicians and nurses at Upazila health complexes in Bangladesh using WHO workload indicators of staffing need (WISN) method. BMJ Open. 2020 Mar 16;10(3):e035183corr1 Authors: PMID: 32179565 [PubMed - in process]
Wed Mar 18, 2020 14:54
Related ArticlesCorrection: Effectiveness of internet-delivered cognitive behavioural therapy in reducing sickness absence among young employees with depressive symptoms: study protocol for a large-scale pragmatic randomised controlled trial. BMJ Open. 2020 Mar 16;10(3):e032119corr1 Authors: PMID: 32179564 [PubMed - in process]
Wed Mar 18, 2020 14:54
Related ArticlesIs dual use of nicotine products and cigarettes associated with smoking reduction and cessation behaviours? A prospective study in England. BMJ Open. 2020 Mar 15;10(3):e036055 Authors: Jackson SE, Farrow E, Brown J, Shahab L Abstract OBJECTIVES: To investigate associations of dual use of e-cigarettes and cigarettes with subsequent quitting activity (smoking reduction, quit attempts and use of evidence-based cessation aids). To overcome...
Wed Mar 18, 2020 14:54
Related ArticlesEffect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial. BMJ Open. 2020 Mar 15;10(3):e035108 Authors: Lamb KL, Lynn A, Russell J, Barker ME Abstract INTRODUCTION: Gout is a painful form of inflammatory arthritis associated with several comorbidities, particularly cardiovascular disease. Cherries, which are rich in anti-inflammatory and antioxidative bioactive compounds, are proposed to be efficacious...
Wed Mar 18, 2020 14:54
Related ArticlesHow do trainee doctors learn about research? Content analysis of Australian specialist colleges' intended research curricula. BMJ Open. 2020 Mar 15;10(3):e034962 Authors: Stehlik P, Noble C, Brandenburg C, Fawzy P, Narouz I, Henry D, Glasziou P Abstract OBJECTIVES: Patients do better in research-intense environments. The importance of research is reflected in the accreditation requirements of Australian clinical specialist colleges. The...
Wed Mar 18, 2020 14:54
Related ArticlesPediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-disordered breathing. BMJ Open. 2020 Mar 15;10(3):e033889 Authors: Wang R, Bakker JP, Chervin RD, Garetz SL, Hassan F, Ishman SL, Mitchell RB, Morrical MG, Naqvi SK, Radcliffe J, Riggan EI, Rosen CL, Ross K, Rueschman M, Tapia IE, Taylor HG, Zopf DA, Redline S Abstract...
Wed Mar 18, 2020 14:54
Related ArticlesHas working-age morbidity been declining? Changes over time in survey measures of general health, chronic diseases, symptoms and biomarkers in England 1994-2014. BMJ Open. 2020 Mar 15;10(3):e032378 Authors: Geiger BB Abstract OBJECTIVES: As life expectancy has increased in high-income countries, there has been a global debate about whether additional years of life are free from ill-health/disability. However, little attention has been...
Wed Mar 18, 2020 14:54
Related ArticlesA Case Involving Massive Insulin Overdose: Direct and Indirect Conditions Requiring Extended Management of Serum Potassium. Am J Case Rep. 2020 Mar 17;21:e920078 Authors: Miyakuni Y, Nakajima M, Kaszynski RH, Tarui T, Goto H, Yamaguchi Y Abstract BACKGROUND Insulin lowers not only blood glucose levels but also serum potassium levels by driving potassium into the cells. Hypokalemia can occur during aggressive treatment of hypoglycemia...
Wed Mar 18, 2020 14:59
Related ArticlesSingle versus multiple port laparoscopic left lateral sectionectomy for hepatocellular carcinoma: a retrospective comparative study. Int J Surg. 2020 Mar 13;: Authors: Wang JC, Pan Y, Chen J, Hu D, Tuoheti Y, Zhou Z, Xu L, Chen J, Chen M, Zhang Y Abstract BACKGROUND: Single port laparoscopic hepatectomy has been applied in some surgeries. We aimed to describe our experience with single port laparoscopic left lateral sectionectomy...
Wed Mar 18, 2020 14:52
Related ArticlesC1 Transverse Process Resection for Management of Jugular Stenosis. Oper Neurosurg (Hagerstown). 2020 Mar 17;: Authors: Fritch C, Voronovich Z, Carlson AP Abstract BACKGROUND AND IMPORTANCE: Idiopathic intracranial hypertension, also known as pseudotumor cerebri, often presents with severe headache and associated vision loss. Venous outflow obstruction has been noted as a prominent etiologic factor in many cases, and previous anatomic...
Wed Mar 18, 2020 14:53
Related ArticlesTrans-nasal Trans-sphenoidal Endoscopic Resection of Spindle Cell Oncocytoma of Adenohypophysis: The First Case Report in a Child and a Review of Literature. Asian J Neurosurg. 2020 Jan-Mar;15(1):210-213 Authors: Samadian M, Mousavinejad SA, Khoshsirat S, Dehghan M, Sharifi G, Ebrahimzadeh K, Rezaei O Abstract Spindle cell oncocytoma (SCO) is a rare tumor of adenohypophysis, arising from the sellar region. So far, about 35 cases of SCO...
Wed Mar 18, 2020 14:53
Related ArticlesSpontaneous Cerebral Spinal Fluid Rhinorrhea with Meningocele Secondary to Congenital Foramen Rotundum Defect: A Case Report and Review of Literature. Asian J Neurosurg. 2020 Jan-Mar;15(1):187-189 Authors: Scott KW, Tavanaiepour D, Tavanaiepour K, Halawi A, Rao D, Rahmathulla G Abstract Spontaneous cerebrospinal fluid (CSF) rhinorrhea is a rare occurrence. We present a case of spontaneous CSF rhinorrhea in a 57-year-old patient secondary...
Wed Mar 18, 2020 14:53
Related ArticlesTranspalpebral Approach for Microsurgical Removal of Tuberculum Sellae Meningiomas. Asian J Neurosurg. 2020 Jan-Mar;15(1):98-106 Authors: Dzhindzhikhadze RS, Dreval ON, Lazarev VA, Polyakov AV, Kambiev RL, Salyamova EI Abstract Background: The evolution of skull base approaches associated with individualization of surgical corridor and minimizing the collateral damage. Achieving the radical removal of tumor and preserving the neurological...
Wed Mar 18, 2020 14:53
Related ArticlesIntraoperative Use of Microscope-Integrated Flow 800 - A Valuable Tool in Surgical Management of Anterior Communicating Artery Aneurysm: Our Institutional Experience. Asian J Neurosurg. 2020 Jan-Mar;15(1):26-30 Authors: Chavan VS, Yamada Y, Chandratej K, Gowtham D, Riccardo S, Firuz S, Yoko K Abstract Background: Flow 800 is microscope-integrated analytical visualization tool which analyses the indocyanine green (ICG) video sequence and...
Wed Mar 18, 2020 14:53
Related ArticlesEndoscopic Endonasal Transsphenoidal Approach for Resection of Tuberculum Sella and Planum Sphenoidale Meningiomas: A Snapshot of Our Institutional Experience. Asian J Neurosurg. 2020 Jan-Mar;15(1):22-25 Authors: Salek MAA, Faisal MH, Manik MAH, Choudhury AU, Chowdhury RU, Islam MA Abstract Introduction: Meningiomas of the tuberculum sellae and planum sphenoidale represent a subgroup of anterior skull base tumors that comprise approximately...
Wed Mar 18, 2020 14:53
Related ArticlesCombining Stereoscopic Video and Virtual Reality Simulation to Maximize Education in Lateral Skull Base Surgery. Otolaryngol Head Neck Surg. 2020 Mar 17;:194599820907866 Authors: Barber SR, Jain S, Mooney MA, Almefty KK, Lawton MT, Son YJ, Stevens SM Abstract Mastery of lateral skull base (LSB) surgery requires thorough knowledge of complex, 3-dimensional (3D) microanatomy and techniques. While supervised operation under binocular microscopy...
Wed Mar 18, 2020 14:53
Related ArticlesThe atlas of StW 573 and the late emergence of human-like head mobility and brain metabolism. Sci Rep. 2020 Mar 16;10(1):4285 Authors: Beaudet A, Clarke RJ, Heaton JL, Pickering TR, Carlson KJ, Crompton RH, Jashashvili T, Bruxelles L, Jakata K, Bam L, Van Hoorebeke L, Kuman K, Stratford D Abstract Functional morphology of the atlas reflects multiple aspects of an organism's biology. More specifically, its shape indicates patterns of head...
Wed Mar 18, 2020 14:53
Related ArticlesDEVELOPING A GUIDELINE FOR NEUROTRAUMA IN NIGERIA. World Neurosurg. 2020 Mar 13;: Authors: Emejulu JK, Malomo A, Oremakinde A, Onyia C, Nwaribe E, Ekweogwu O, Oseni A, Opara O, Iroegbu-Emeruem L, Otorkpa E, Komolafe E, Bankole O, Shehu B Abstract BACKGROUND: The Nigerian Academy of Neurological Surgeons in 2019 resolved to standardize the practice of Neurosurgery in Nigeria. It set up Committees to standardize the various aspects of neurosurgery...
Wed Mar 18, 2020 14:53
Related ArticlesCranial Base Manifestations of Granulomatosis with Polyangiitis. Otolaryngol Head Neck Surg. 2020 Mar 17;:194599820912025 Authors: Kiessling PT, Marinelli JP, Peters PA, DeLone DR, Lane JI, Koster MJ, Carlson ML Abstract OBJECTIVE: Although granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) is classically characterized by systemic disease involving the kidneys and airway, approximately 10% of patients who have it present...
Wed Mar 18, 2020 14:53
Related Articles4-PBA enhances autophagy by inhibiting endoplasmic reticulum stress in recombinant human beta nerve growth factor induced PC12 cells after mechanical injury via PI3K/AKT/mTOR signaling pathway. World Neurosurg. 2020 Mar 13;: Authors: Wang Z, Zheng S, Gu Y, Zhou L, Lin B, Liu W Abstract OBJECTIVE: To investigate mechanism of endoplasmic reticulum (ER) stress-mediated autophagy in spinal cord injury (SCI). METHODS: An in vitro...
Wed Mar 18, 2020 15:56
Related ArticlesThe Historical Evolution of Intracranial Pressure Monitoring. World Neurosurg. 2020 Mar 13;: Authors: Sonig A, Jumah F, Raju B, Patel NV, Gupta G, Nanda A Abstract Intracranial pressure (ICP) monitoring has become an important tool in neurocritical care. Despite being used in ICUs all over the world, many are unfamiliar with its origins and the people and events that shaped the development of this technique. Herein, we provide a comprehensive...
Wed Mar 18, 2020 15:56
Related ArticlesWoven Endobridge (WEB) Device as a Re-Treatment Strategy after Unsuccessful Surgical Clipping. World Neurosurg. 2020 Mar 13;: Authors: Booth TC, Parra-Farinas C, deSouza RM, Kandasamy N, Bhattacharya J, Rangi P, Downer J Abstract BACKGROUND: Surgical clipping of intracranial aneurysms is typically robust and durable. However, residual aneurysmal components may be seen after clipping. Furthermore, there may be occasional aneurysmal recurrence....
Wed Mar 18, 2020 15:56
Related ArticlesOxygen embolism and pneumocephalus after hydrogen peroxide application during minimally invasive transforaminal lumbar interbody fusion surgery: A case report and literature review. World Neurosurg. 2020 Mar 13;: Authors: Zou P, Yang JS, Wang XF, Wei JM, Guo H, Zhang B, Zhang F, Chu L, Hao DJ, Zhao YT Abstract BACKGROUND: Hydrogen peroxide (H2O2) solution is commonly used to irrigate wounds because of its hemostatic and antiseptic properties....
Wed Mar 18, 2020 15:56
Related ArticlesClinical Analysis of Patients with Ipsilateral Coexistence of Hemifacial Spasm and Trigeminal Neuralgia. World Neurosurg. 2020 Mar 13;: Authors: Liu J, Zhu C, Liu R, Liu B, Zhou J, Fan C, Jiao F, Wang D, Wu G, Jiang Y Abstract OBJECTIVE: To analyze the clinical data of patients with ipsilateral coexistence of hemifacial spasm (HFS) and trigeminal neuralgia (TN) and their treatment by microvascular decompression (MVD). METHODS:...
Wed Mar 18, 2020 15:56
Related ArticlesGiant Malignant Peripheral Nerve Sheath Tumor of the Scalp: Case Report and Review of the Literature. World Neurosurg. 2020 Mar 13;: Authors: Farinha NC, Belo D, Freitas H, Coiteiro D Abstract BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are rare nervous system tumors, that rarely appear on the scalp. About half of the scalp MPNSTs described in the literature have reached giant dimensions at the time of diagnosis. The...
Wed Mar 18, 2020 15:56
Related ArticlesInguinal Extrusion of a Ventriculoperitoneal Shunt: A Case Report. World Neurosurg. 2020 Mar 13;: Authors: Mazza J, Brandel MG, Steinberg JA, U HS Abstract BACKGROUND: Complications of ventriculoperitoneal (VP) shunts include migration into various anatomic compartments, and even extrusion through tissue layers. CASE REPORT: A 31-year-old female patient with a VP shunt presented with distal shunt tubing extruding through the...
Wed Mar 18, 2020 15:56
Related ArticlesReduction versus In-situ fusion for Adult High-Grade Spondylolisthesis: A Systematic Review and Meta-analysis. World Neurosurg. 2020 Mar 13;: Authors: Lak AM, Abunimer AM, Devi S, Chawla S, Aydin L, Tafel I, Smith TR, Mekary RA, Zaidi HA Abstract BACKGROUND: Surgical management of high-grade spondylolisthesis remains controversial. Both reduction and in-situ fusion are available options, but it remains unclear which approach provides...
Wed Mar 18, 2020 15:56
Related ArticlesAttitudes of Patients and Their Relatives Towards Artificial Intelligence in Neurosurgery. World Neurosurg. 2020 Mar 13;: Authors: Palmisciano P, Jamjoom AA, Taylor D, Stoyanov D, Marcus HJ Abstract BACKGROUND: Artificial Intelligence (AI) may favorably support surgeons but may result in concern among patients and their relatives. OBJECTIVE: To evaluate attitudes of patients and their relatives towards the use of AI in neurosurgery....
Wed Mar 18, 2020 15:56
Related ArticlesPost-esophagectomy Symptomatic Dunbar Syndrome: A rare diagnosis of abdominal pain after surgery. Int J Surg Case Rep. 2020 Mar 07;68:198-202 Authors: Takeda FR, Darce GFB, Sobrado LF, de Faria LL, Tustumi F, Sallum RAA, de Souza Rocha M, Ribeiro U, Cecconello I Abstract INTRODUCTION: Dunbar syndrome is a rare anatomical abnormality characterized by the extrinsic compression of the celiac trunk by the median arcuate ligament (MAL). Though...
Wed Mar 18, 2020 14:44
Related ArticlesThoracic endovascular aneurysm repair to treat recurrent lower limb ischemia secondary to occlusion of axillofemoral bypass. Int J Surg Case Rep. 2020 Feb 28;68:190-192 Authors: Tamaki M, Kitamura H, Koyama Y, Sawada K, Kawaguchi Y, Tokuda T, Okawa Y, Konakano K Abstract INTRODUCTION: A case of malperfusion in which the patient presented with aortic dissection is presented. PRESENTATION OF CASE: A 69-year-old man with an acute...
Wed Mar 18, 2020 14:44
Related ArticlesHydatid disease - An unusual cause of a breast cyst: Case report. Int J Surg Case Rep. 2020 Mar 09;68:178-179 Authors: Shekh ZA Abstract INTRODUCTION: Breast cysts are common and are usually due to fibrocystic disease of the breast. However, in endemic areas a breast cyst can be due to hydatid disease. This diagnosis is often made after surgical excision. Hydatid cysts, caused by the tapeworm Echinococcus granulosus, are common in endemic...
Wed Mar 18, 2020 14:44
Related ArticlesRetraction. Future Oncol. 2020 Mar 17;:1057 Authors: PMID: 32180451 [PubMed - as supplied by publisher]
Wed Mar 18, 2020 14:46
Related ArticlesGranulomatous prostatitis: a challenging differential diagnosis to take into consideration. Future Oncol. 2020 Mar 17;: Authors: Crocetto F, Barone B, Luca L, Creta M PMID: 32180450 [PubMed - as supplied by publisher]
Wed Mar 18, 2020 14:46
Related ArticlesLast-line local treatment with the Quad Shot regimen for previously irradiated head and neck cancers. Oral Oncol. 2020 Mar 14;104:104641 Authors: Fan D, Kang JJ, Fan M, Wang H, Lee A, Yu Y, Chen L, Jillian Tsai C, McBride SM, Riaz N, Gelblum DY, Neal BP, Fetten J, Dunn LA, Michel LS, Boyle JO, Cohen MA, Roman BR, Ganly I, Singh B, Wong RJ, Sherman EJ, Lee NY Abstract OBJECTIVES: Patients with prior irradiated head and neck cancer (HNC)...
Wed Mar 18, 2020 14:50
Related ArticlesUsing ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma. Aging (Albany NY). 2020 Mar 17;12: Authors: Meng Z, Ren D, Zhang K, Zhao J, Jin X, Wu H Abstract OBJECTIVE: The tumour microenvironment is one of the significant factors driving the carcinogenesis of Pancreatic adenocarcinoma (PAAD). However, the underlying mechanism of...
Wed Mar 18, 2020 14:50
Related ArticlesDigoxin Enhances the Anticancer Effect on Non-Small Cell Lung Cancer While Reducing the Cardiotoxicity of Adriamycin. Front Pharmacol. 2020;11:186 Authors: Wang Y, Ma Q, Zhang S, Liu H, Zhao B, Du B, Wang W, Lin P, Zhang Z, Zhong Y, Kong D Abstract Digoxin is widely used to treat heart failure. Epidemiological studies suggested it might be used as an anticancer drug or sensitizing agent for cancer therapy. Adriamycin is a well-known anticancer...
Wed Mar 18, 2020 14:50
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