Publication date: Available online 28 March 2020Source: The Journal of Emergency MedicineAuthor(s): Ming-Chan Wu, Yen-Hung Wu, Pin-Han Wang
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Publication date: Available online 28 March 2020Source: The Journal of Emergency MedicineAuthor(s): Drew Long, Matthew Hessel
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Publication date: Available online 27 March 2020Source: The Journal of Emergency MedicineAuthor(s): Spencer Masiewicz, Scott Gutovitz, Leslie Hart, Samuel Madden Leaman, Dietrich Jehle
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Publication date: Available online 27 March 2020Source: The Journal of Emergency MedicineAuthor(s): Burak Bekgöz, İshak Şan, Mehmet Ergin
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Cancers, Vol. 12, Pages 824: Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes Cancers doi: 10.3390/cancers12040824 Authors: Raghvendra Vishwakarma Kirk J. McManus Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately associated with cancer development and progression. The presence, extent, and level of CIN...
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Cancers, Vol. 12, Pages 823: The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and their Clinical Implications Cancers doi: 10.3390/cancers12040823 Authors: Devis Pascut Muhammad Yogi Pratama Niem V.T. Vo Rina Masadah Claudio Tiribelli The communication between hepatocellular carcinoma (HCC) cells and their microenvironment is an essential mechanism supporting or preventing tumor development and...
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Cancers, Vol. 12, Pages 822: Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy Cancers doi: 10.3390/cancers12040822 Authors: Saleh Bloukh Carpenter Alwohoush Bakeer Darwish Azab Gewirtz For the past two decades, cellular senescence has been recognized as a central component of the tumor cell response to chemotherapy and radiation. Traditionally, this form of senescence, termed Therapy-Induced Senescence (TIS), was linked to extensive...
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Cancers, Vol. 12, Pages 821: Metastatic Heterogeneity of Breast Cancer: Companion and Theranostic Approach in Nuclear Medicine Cancers doi: 10.3390/cancers12040821 Authors: Christopher Montemagno Gilles Pagès Breast cancer is the most common malignancy in women throughout the world. Metastatic dissemination to vital organs is the leading cause of breast cancer-related deaths. The treatment of metastases is mainly based on the primary tumor characteristics. However, breast cancer...
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Cancers, Vol. 12, Pages 820: Frequent FOXA1-Activating Mutations in Extramammary Paget’s Disease Cancers doi: 10.3390/cancers12040820 Authors: Takuya Takeichi Yusuke Okuno Takaaki Matsumoto Nobuyuki Tsunoda Kyogo Suzuki Kana Tanahashi Michihiro Kono Toyone Kikumori Yoshinao Muro Masashi Akiyama Extramammary Paget’s disease (EMPD) is a neoplastic skin disease of indeterminate origin with an unknown genetic cause. We performed a comprehensive...
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Cancers, Vol. 12, Pages 819: Early Triple Negative Breast Cancer: Conventional Treatment and Emerging Therapeutic Landscapes Cancers doi: 10.3390/cancers12040819 Authors: Anna Diana Francesca Carlino Elisena Franzese Olga Oikonomidou Carmen Criscitiello Ferdinando De Vita Fortunato Ciardiello Michele Orditura Triple negative breast cancers (TNBCs) are characterized by worse prognosis, higher propensity to earlier metastases, and shorter survival after...
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Cancers, Vol. 12, Pages 818: Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer Cancers doi: 10.3390/cancers12040818 Authors: Martins Oliveira Cavadas Pinto Cardoso Castro Sousa Pinto Silva Adão Loureiro Pedro Reis Pereira Oliveira Costa In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer...
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Cancers, Vol. 12, Pages 817: NK and NKT Cell-Mediated Immune Surveillance against Hematological Malignancies Cancers doi: 10.3390/cancers12040817 Authors: Shimizu Iyoda Yamasaki Kadowaki Tojo Fujii Recent cancer treatment modalities have been intensively focused on immunotherapy. The success of chimeric antigen receptor T cell therapy for treatment of refractory B cell acute lymphoblastic leukemia has pushed forward research on hematological malignancies....
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Cancers, Vol. 12, Pages 816: Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively Cancers doi: 10.3390/cancers12040816 Authors: Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong Gastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including Helicobacter pylori...
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Cancers, Vol. 12, Pages 813: Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme Cancers doi: 10.3390/cancers12040813 Authors: Vagiannis Novotna Skarka Kammerer Küpper Chen Guo Staud Hofman Ensartinib (X-396) is a promising tyrosine kinase inhibitor currently undergoing advanced clinical evaluation for the treatment of non-small cell lung...
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Cancers, Vol. 12, Pages 814: External Validation of an MRI-Derived Radiomics Model to Predict Biochemical Recurrence after Surgery for High-Risk Prostate Cancer Cancers doi: 10.3390/cancers12040814 Authors: Vincent Bourbonne Georges Fournier Martin Vallières François Lucia Laurent Doucet Valentin Tissot Gilles Cuvelier Stephane Hue Henri Le Penn Du Luc Perdriel Nicolas Bertrand Frederic Staroz Dimitris Visvikis Olivier Pradier Mathieu...
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Cancers, Vol. 12, Pages 815: Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and Polyps Cancers doi: 10.3390/cancers12040815 Authors: Egle Rebane-Klemm Laura Truu Leenu Reinsalu Marju Puurand Igor Shevchuk Vladimir Chekulayev Natalja Timohhina Kersti Tepp Jelena Bogovskaja Vladimir Afanasjev Külliki Suurmaa Vahur Valvere Tuuli Kaambre This study aimed to characterize the ATP-synthesis by oxidative phosphorylation...
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Cancers, Vol. 12, Pages 812: Personalized Medicine—Current and Emerging Predictive and Prognostic Biomarkers in Colorectal Cancer Cancers doi: 10.3390/cancers12040812 Authors: Christine Koulis Raymond Yap Rebekah Engel Thierry Jardé Simon Wilkins Gemma Solon Jeremy D. Shapiro Helen Abud Paul McMurrick Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and is heterogeneous both morphologically and molecularly. In an era of...
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Cancers, Vol. 12, Pages 811: An Organotypic Microcosm for the Pancreatic Tumor Microenvironment Cancers doi: 10.3390/cancers12040811 Authors: Miranda Lin Mei Gao Prakash K. Pandalai Michael J. Cavnar Joseph Kim Pancreatic duct adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths in the next few years. Unfortunately, the development of novel therapies for PDAC has been challenged by a uniquely complex tumor microenvironment....
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Cancers, Vol. 12, Pages 810: Liposomal TLR9 Agonist Combined with TLR2 Agonist-Fused Antigen Can Modulate Tumor Microenvironment through Dendritic Cells Cancers doi: 10.3390/cancers12040810 Authors: Kuan-Yin Shen Hsin-Yu Liu Wan-Lun Yan Chiao-Chieh Wu Ming-Hui Lee Chih-Hsing Leng Shih-Jen Liu Dendritic cells (DCs) are antigen-presenting cells involved in T cell activation and differentiation to regulate immune responses. Lipoimmunogens can be developed as...
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Cancers, Vol. 12, Pages 809: Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus Cancers doi: 10.3390/cancers12040809 Authors: Umma Habiba Elora Hossain Aya Yanagawa-Matsuda Abu Faem Mohammad Almas Chowdhury Masumi Tsuda Asad-uz- Zaman Shinya Tanaka Fumihiro Higashino The combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis...
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Cancers, Vol. 12, Pages 808: Outcomes According to MSKCC Risk Score with Focus on the Intermediate-Risk Group in Metastatic Renal Cell Carcinoma Patients Treated with First-Line Sunitinib: A Retrospective Analysis of 2390 Patients Cancers doi: 10.3390/cancers12040808 Authors: Ondrej Fiala Jindrich Finek Alexandr Poprach Bohuslav Melichar Jindrich Kopecký Milada Zemanova Katerina Kopeckova Tomas Mlcoch Tomas Dolezal Lenka Capkova Tomas Buchler ...
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Cancers, Vol. 12, Pages 806: Are Synapse-Like Structures a Possible Way for Crosstalk of Cancer with Its Microenvironment? Cancers doi: 10.3390/cancers12040806 Authors: Irina V Alekseenko Igor P Chernov Sergei V Kostrov Eugene D Sverdlov The failure of therapies directed at targets within cancer cells highlight the necessity for a paradigm change in cancer therapy. The attention of researchers has shifted towards the disruption of cancer cell interactions with the tumor...
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Cancers, Vol. 12, Pages 807: The Role of Positron Emission Tomography in Clinical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas Cancers doi: 10.3390/cancers12040807 Authors: Simone Serafini Cosimo Sperti Alessandra Rosalba Brazzale Diego Cecchin Pietro Zucchetta Elisa Sefora Pierobon Alberto Ponzoni Michele Valmasoni Lucia Moletta Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas represent a heterogeneous group...
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Cancers, Vol. 12, Pages 804: Hyperprogression Under Immune Checkpoint-Based Immunotherapy—Current Understanding, The Role of PD-1/PD-L1 Tumour-Intrinsic Signalling, Future Directions and a Potential Large Animal Model Cancers doi: 10.3390/cancers12040804 Authors: Kocikowski Dziubek Parys Immune evasion is a major challenge for the development of successful cancer treatments. One of the known mechanisms is the expression of immune checkpoints (ICs)—proteins regulating...
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Cancers, Vol. 12, Pages 805: Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities Cancers doi: 10.3390/cancers12040805 Authors: Alessandro Allegra Caterina Musolino Alessandro Tonacci Giovanni Pioggia Sebastiano Gangemi The human microbiota is made up of the fungi, bacteria, protozoa and viruses cohabiting within the human body. An altered microbiota can provoke diseases such as cancer. The mechanisms by which...
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Cancers, Vol. 12, Pages 801: Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells Cancers doi: 10.3390/cancers12040801 Authors: Peris-Torres Plaza-Calonge López-Domínguez Domínguez-García Barrientos-Durán Carmona-Sáez Rodríguez-Manzaneque Extracellular matrix remodeling within the tumor microenvironment has been recognized as a relevant dynamic...
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Cancers, Vol. 12, Pages 802: ER and PI3K Pathway Activity in Primary ER Positive Breast Cancer Is Associated with Progression-Free Survival of Metastatic Patients under First-Line Tamoxifen Cancers doi: 10.3390/cancers12040802 Authors: Sieuwerts Inda Smid van Ooijen van de Stolpe Martens Verhaegh : Estrogen receptor positive (ER+) breast cancer patients are eligible for hormonal treatment, but only around half respond. A test with higher specificity...
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Cancers, Vol. 12, Pages 803: Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1β in Human Immune Cells Cancers doi: 10.3390/cancers12040803 Authors: Suneesh Kumar Pachathundikandi Nicole Blaser Heiko Bruns Steffen Backert Helicobacter pylori persistently colonizes the human stomach, and is associated with inflammation-induced gastric cancer. Bacterial crosstalk with the host immune system produces various...
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Publication date: Available online 29 March 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Leandro Seiji Goto, André Vessoni Alexandrino, Camila Malvessi Pereira, Carla Silva Martins, Humberto D'Muniz Pereira, José Brandão-Neto, Maria Teresa Marques Novo-Mansur
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Publication date: June 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1868, Issue 6Author(s):
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Publication date: Available online 26 March 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Jogi Madhuprakash, T. Swaroopa Rani, Appa Rao Podile, Vincent G.H. Eijsink, Morten Sørlie
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Antibiotics, Vol. 9, Pages 145: Rifaximin Alleviates Endotoxemia with Decreased Serum Levels of Soluble CD163 and Mannose Receptor and Partial Modification of Gut Microbiota in Cirrhotic Patients Antibiotics doi: 10.3390/antibiotics9040145 Authors: Kaji Saikawa Takaya Fujinaga Furukawa Kitagawa Ozutsumi Kaya Tsuji Sawada Kawaratani Moriya Namisaki Akahane Mitoro Yoshiji Rifaximin is a poorly absorbable antibiotic...
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Antibiotics, Vol. 9, Pages 144: The Iron-chelator, N,N’-bis (2-hydroxybenzyl) Ethylenediamine-N,N’-Diacetic acid is an Effective Colistin Adjunct against Clinical Strains of Biofilm-Dwelling Pseudomonas aeruginosa Antibiotics doi: 10.3390/antibiotics9040144 Authors: Mettrick Hassan Lamont Reid Targeting the iron requirement of Pseudomonas aeruginosa may be an effective adjunctive for conventional antibiotic treatment against biofilm-dwelling P. aeruginosa. We, therefore,...
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Antibiotics, Vol. 9, Pages 143: Excretion of the Polymyxin Derivative NAB739 in Murine Urine Antibiotics doi: 10.3390/antibiotics9040143 Authors: Martti Vaara Timo Vaara Janis Kuka Eduards Sevostjanovs Solveiga Grinberga Maija Dambrova Edgars Liepinsh Extremely multiresistant strains of Enterobacteriaceae are emerging and spreading at a worrisome pace. Polymyxins are used as the last-resort therapy against such strains, in spite of their nephrotoxicity. We...
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