Myocardial ischemia/reperfusion (I/R) injury is a clinically severe complication, which can cause high rates of disability and mortality particularly in patients with myocardial infarction, yet the molecular mechanisms underlying this process remain unclear. This study aimed to explore the protective effects of β-sitosterol against myocardial I/R injury and to elucidate the underlying molecular mechanisms. Our results showed that hypoxia/reoxygenation (H/R) treatment suppressed cell viability, induced...
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The purpose of this review was to collect and systematize information on the role and importance of oxygen in winemaking. Both the positive and negative effects of oxygen are presented and discussed throughout the text. The review characterizes the subsequent stages of the wine production process, during which oxygen comes into contact with fruits, must, and finally wine. The impact of oxygen on the growth and metabolism of yeast, on the activity of enzymes, and on the final quality of wine was presented....
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The health monitoring and management have been accepted in modern industrial machinery for an intelligent industrial production. To timely and reliably assess the bearing performance degradation, a novel health monitoring method called feature clustering analysis (FCA) has been proposed in this study. Along with the working time going, this new monitored chart picked by FCA aims to describe the feature clustering distribution transition by a series of reference models. First, the data provided by...
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Objective. To evaluate the efficacy and safety of mesalamine in conjunction with probiotics for ulcerative colitis. Methods. Random controlled trials (RCTs) were searched in PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and VIP (VIP Database for Chinese Technical Periodicals) from inception to October 2019. Methodological quality was assessed by the Cochrane Collaboration tool. The quality of evidence was rated by the Grading of Recommendations, Assessment, Development,...
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A numerical solution for line contact elastohydrodynamic lubrication (EHL) occurring on the rough surface of heterogeneous materials with a group of particles is presented in this study. The film thickness disturbance caused by particles and roughness is considered into the solution system, and the film pressure between the contact gap generated by the particles and the surface roughness is obtained through a unified Reynold equation system. The inclusions buried in the matrix are made equivalent...
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Biodegradable poly(lactic acid) (PLA) filaments have been widely used in the fused deposition modeling (FDM) 3D printing technology. However, PLA has low toughness and low thermal resistance that affects printability and restricts its industrial applications. In this study, PLA was compounded with 0 to 40 wt% of poly(butylene adipate-co-terephthalate) (PBAT) and varied content of nano talc at 0 to 40 wt% in a twin screw extruder. The compounds were reextruded to filaments using a capillary rheometer....
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When the vibration signals of the rolling bearings contain strong interference noise, the spectrum division of the vibration signals is seriously disturbed by the noise. The traditional empirical wavelet transform (EWT) decomposes signals into a large number of components, and it is difficult to select suitable components that contain fault information. In order to address the problems above, in this paper, we proposed the improved empirical wavelet transform (IEWT) method. The simulation experiment...
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Background. Prior studies have shown a better prognosis with medullary colon cancer (MCC) compared to nonmedullary colon carcinomas (NMC); however, data are inconsistent and lacking the evaluation of treatments received. As we did not see similar survival outcomes, we aimed to retrospectively examine survival and receipt of treatment differences between MCC and NMC within the Geisinger Health System. Methods. The Cancer Registry was retrospectively reviewed for MCC and NMC from 2006 to 2017. Demographics...
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The rapid developments in sensor technology and mobile devices bring a flourish of social images, and large-scale social images have attracted increasing attention to researchers. Existing approaches generally rely on recognizing object instances individually with geo-tags, visual patterns, etc. However, the social image represents a web of interconnected relations; these relations between entities carry semantic meaning and help a viewer differentiate between instances of a substance. This article...
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Water-projectile-assisted injection molding (W-PAIM) is a novel molding process for plastic pipes with complicated shape. It utilizes high-pressure water as a power to push a solid projectile to penetrate through the melt to form a hollow space. In order to investigate the penetration behavior of the projectile during the water injection stage of W-PAIM process, numerical simulation of the water injection stage of a W-PAIM pipe with straight and curved segments was carried out. A turbulent flow for...
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In this work, analytical solution of simply supported sandwich arches considering permeation effect of adhesives is presented. The permeation layer is described by the functionally graded material, exponentially graded in the radial direction. The stresses and deformations of each layer are based on the two-dimensional (2D) elasticity theory in the polar coordinate. The governing equations of the arch are solved by the layer-wise method, which turns the differential equations with variable coefficients...
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This paper proposes a new no-equilibrium chaotic system that has the ability to yield infinitely many coexisting hidden attractors. Dynamic behaviors of the system with respect to the parameters and initial conditions are numerically studied. It shows that the system has chaotic, quasiperiodic, and periodic motions for different parameters and coexists with a large number of hidden attractors for different initial conditions. The circuit and microcontroller implementations of the system are given...
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Like several parts in the Middle East, the West Bank is in a significant water scarcity status. Palestinians use groundwater as the main water source, supplying more than 90% of the consumed water in the West Bank. The aim of this study is to enhance the knowledge on drinking water quality in the West Bank. Groundwater quality data was obtained from the Palestinian Water Authority, including the years 2015 and 2016, from the Northern six districts of the West Bank. The water quality data were analyzed...
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Intracerebral hemorrhage (ICH) has been becoming a serious public health problem. Pneumonia, occurring in 43% of all ICH patients, is a common complication heavily influencing outcome and accounting for more than 1/3 of the overall mortality in patients with ICH. Ambroxol may be an effective additional treatment for ICH patients with pneumonia. But its effect and potential mechanism on functional recovery post-ICH still remain elusive. In the present study, the results indicated that 35 mg/kg and...
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In this paper, we report that under wetting conditions (or modes) of nanowire (NW) growth, when a nonplanar crystallization front emerges under a catalyst droplet, a shift in the three-phase line (TPL) of the vapor–liquid–crystal interface occurs under thermodynamically stable conditions when the angle with respect to the droplet surface, termed the growth angle, is fixed. The growth angle of the NWs is determined not from a geometrical perspective but on the basis of the physical aspects of the...
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This paper covers the variation of electrical performance of air microstrip antennas due to its ground plane deformation. A typical sinusoidal function is utilized to characterize the shape of deformation, based on which different shapes of ground plane can be obtained by changing control parameters. From the simulation results by HFSS, there is a strong linear relationship between the offset of resonant frequency and the amplitude of deformation. The equivalent thickness of the air medium is introduced...
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Background. Diabetes and other metabolic abnormalities including high triglycerides (TGs) are commonly seen comorbid conditions in patients having nonalcoholic fatty liver disease (NAFLD). There is no approved pharmacotherapy for NAFLD, and life-style therapy plays a major role. Saroglitazar, the world’s first approved dual PPAR α/γ agonist, is approved in India for the treatment of diabetic dyslipidemia. The objective of this case series analysis was to evaluate the safety and effectiveness of saroglitazar...
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Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge...
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In this paper, a novel method combining electrochemical impedance spectroscopy (EIS) and phase shift was used to systematically study the effect of corrosion inhibitor (sodium succinate, sodium dodecyl benzene sulfonate, and new corrosion inhibitor, namely, bis [2-amino-3-(dodecyl dimethyl quaternary ammonium) propyl]-propylamine dichloro) on crack initiation and propagation of aluminum alloy during the slow strain rate tensile process. Using a variety of characterization methods to verify the feasibility...
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β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues. β-Endorphin induces endothelial dysfunction and is related to insulin resistance. We clarified the effects of β-endorphin on atherosclerosis. We assessed the effects of β-endorphin on the inflammatory response and monocyte adhesion in human umbilical vein endothelial cells (HUVECs), foam cell formation, and the inflammatory phenotype in THP-1 monocyte-derived macrophages, and...
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Clear cell renal cell carcinoma (ccRCC) is a major histological subtype of renal cell carcinoma and can be clinically divided into four stages according to the TNM criteria. Identifying clinical stage-related genes is beneficial for improving the early diagnosis and prognosis of ccRCC. By using bioinformatics analysis, we aim to identify clinical stage-relevant genes that are significantly associated with the development of ccRCC. First, we analyzed the gene expression microarray data sets: GSE53757...
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Background. Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of major adverse cardiovascular events (MACEs) in patients with CAD. Methods. Overall, 90 patients with CAD were enrolled between January and December 2012. The study’s primary endpoint...
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In this study, we explored the pharmacological mechanisms of Huangqin Tang (HQT; a traditional Chinese medicine formula) in ulcerative colitis (UC) and provided evidence for potential roles HQT plays by gene expression profiling. The UC rat model was made via a compound method (trinitrobenzene sulfonic acid plus ethanol). After a ten-day treatment, microarray analysis was performed from the colon segment of the rats. Biological functions and specific signaling pathways were enriched based on differentially...
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Ibrutinib is approved for the first-line treatment of chronic lymphocytic leukemia (CLL). A well-known side effect of ibrutinib therapy is increased bleeding risk, which ranges from mild mucocutaneous bleeding to rarely life-threatening hemorrhage. The increased bleeding tendency associated with ibrutinib is thought to be related to its effect on several platelet signaling pathways, which can be exacerbated in the setting of concurrent antiplatelet or anticoagulant therapy. We present an 82-year-old...
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Vehicle counting plays a significant role in vehicle behavior analysis and traffic incident detection for established video surveillance systems on expressway. Since the existing sensor method and the traditional image processing method have the problems of difficulty in installation, high cost, and low precision, a novel vehicle counting method is proposed, which realizes efficient counting based on multivehicle detection and multivehicle tracking. For multivehicle detection tasks, a construction...
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Background. From 2005 to 2016, the prevention and control of mumps in China have undergone three stages of transition. These include the use of MuCV as a self-supported vaccine, the introduction of one-dose MMR to the Expanded Program on Immunization (EPI), and the administration of two-dose MuCV following supplementary immunization activities (SIAs) using MM. Here, using surveillance data, we assessed the epidemiology of mumps during the three stages. Methods. Children in Quzhou of China born from...
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Objectives. Endothelial cell injury is a critical pathological change during the development of atherosclerosis. Here, we explored the effect of omentin-1 on free fatty acid- (FFA-) induced endothelial cell injury. Methods. An FFA-induced endothelial cell injury model was established to investigate the role of omentin-1 in this process. Cell proliferation was analyzed with the Cell Counting Kit assay and flow cytometry. Scratch and transwell assays were used to evaluate cell migration. Factors secreted...
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Background. Tinnitus is a symptom that is defined as a subjective perception of noise in an absence of external sound. It is an indicator of auditory system abnormalities. It can also be present in individuals without any hearing abnormalities. Difficulty to consternate, insomnia, and decreased speech discrimination are the most common symptoms related to tinnitus. Aim. To assess the magnitude and pattern with determinants of tinnitus among health science students at King Khalid University. Methodology....
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The aim of this paper is to critically analyze the composition of many inositol-based products currently used to treat Polycystic Ovary Syndrome (PCOS). Several different combinations of myo-inositol and D-chiro-inositol, with and without additional compounds such as micro- and macroelements, vitamins, and alpha-lipoic acid, have been formulated over the years. Such therapeutic proposals do not take various features of inositol stereoisomers into consideration. As an example, it is important to know...
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Background. TSC1-related signaling plays a pivotal role in intramembranous and endochondral ossification processes during skeletogenesis. This study was aimed at determining the significance of the TSC1 gene at different stages of spinal development. Materials and Methods. TSC1-floxed mice (TSC1flox/flox) were crossed with Prrx1-Cre or BGLAP-Cre transgenic mice or mesenchymal stem cell- and osteoblast-specific TSC1-deficient mice, respectively. Somatic and vertebral differences between WT and Prrx1-TSC1...
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Background. TCM considers that diabetes belongs to the scope of Xiaoke Bing. Compound prescriptions are characteristics of TCM. For a certain medicine, its compatibility with different medicines can exert different efficacies in different prescriptions. Using the TCM compound prescriptions containing Ginseng Radix ET Rhizoma in ancient books for Xiaoke Bing as an example, this study introduces new methods to investigate the rule of TCM compatibility. Methods. Frequency analysis was accomplished by...
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Malaria presents a diagnostic challenge in most tropical countries such as Rwanda. Microscopy remains the gold standard for diagnosing malaria, but it is labor intensive and depends upon the skill of the examiner. Malaria rapid diagnostic tests (RDTs) have been developed as an easy, convenient alternative to microscopy. This cross-sectional study was conducted at Rukara Health Center which is located in Eastern Province, Kayonza district, Rwanda. One hundred and fifty suspected cases of malaria,...
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In some cases, we hope to remove the electrospun nanofibrous mesh from the collector easily. But in some cases such as wound dressing, we observe that the in situ electrospun nanofibers can stick to the collector (e.g., skin). Therefore, the adhesion between the in situ electrospun web and the substrate becomes important in the performance and practical application of the electrospun material. In this paper, we reported a direct pulling method to measure the adhesion and understand the adhesion mechanism....
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Background. Hereditary spastic paraplegia type 3A (SPG3A) is a neurodegenerative disease inherited type of Hereditary spastic paraplegia (HSP). It is the second most frequent type of HSP which is characterized by progressive bilateral and mostly symmetric spasticity and weakness of the legs. SPG3A gene mutations and the phenotype-genotype correlations have not yet been recognized. The aim of this work was to categorize the most damaging SNPs in ATL1 gene and to predict their impact on the functional...
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Aiming at the influence of information, we investigate and analyze the sequential route choice behavior under dynamic reference points based on cumulative prospect theory in this paper. An experiment platform collecting the sequential route choices based on C/S structure is designed and four types of information are released to participants, respectively. Real-time travel time prediction methods are then proposed for travelers’ decision-making. Using nonlinear regression method, the parameters of...
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At present, the controllability of complex networks is a hot issue in complex networks domain. From the perspective of graph theory, in the paper quite a few pioneering works on the controllability of complex networks were introduced, and the latest progress of the controllability of complex networks was emphatically summarized. In addition, the paper mainly discussed the basic ideas and effective methods to enhance the structural controllability of complex networks and analyzed the advantages and...
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The capacity and ecological flows of ecosystem services as well as the demand for them are key areas of urban and rural ecological planning that have been studied using the spatial-explicit model as a decision support tool. This study develops a framework for mapping the relationships among the capacity of and demand for ecosystem services, ecological flows, and planning management. This is done by estimating the ecosystem services based on the space for recreation and environmental conditions and...
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Invertase and glucose oxidase are secreted by the hypopharyngeal glands of honeybees for the hydrolysis of sucrose and the preservation from microbial effects, respectively. It is also prominent to understand how the levels of invertase and glucose oxidase of raw honey samples are being influenced by different conditions because the behavior of these specific enzymes in raw honeys could be a marker for the quality parameters. On the basis of this expectation, three raw honey samples tagged as blossom,...
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Flaxseed is naturally a rich source of essential omega-3 fatty acid, α-linolenic acid (ALA), which exhibits nearly 57% of its entire fatty acid profile. Oxidation of omega-3 fatty acids during processing and storage results in reduced shelf stability of food products and limited health potentials. Spray-drying is considered a processing technique to shield omega-3 fatty acids from oxidative damage. For the purpose, the extracted flaxseed oil (FSO) together with the emulsifier (flaxseed meal polysaccharide...
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